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AR052156A1 - Fenil-metanonas bi- y triciclicas sustituidas para el tratamiento de trastornos neurologicos y neuropsiquiatricos - Google Patents

Fenil-metanonas bi- y triciclicas sustituidas para el tratamiento de trastornos neurologicos y neuropsiquiatricos

Info

Publication number
AR052156A1
AR052156A1 ARP050105207A ARP050105207A AR052156A1 AR 052156 A1 AR052156 A1 AR 052156A1 AR P050105207 A ARP050105207 A AR P050105207A AR P050105207 A ARP050105207 A AR P050105207A AR 052156 A1 AR052156 A1 AR 052156A1
Authority
AR
Argentina
Prior art keywords
lower alkyl
halogen
substituted
neurological
treatment
Prior art date
Application number
ARP050105207A
Other languages
English (en)
Inventor
Synese Jolidon
Robert Narquizian
Roger David Norcross
Emmanuel Pinard
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR052156A1 publication Critical patent/AR052156A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente se refiere a compuesto de la formula general (1), en la que la formula (2) es un grupo de formulas (3) a (8), R1 es un heterociclo no aromático o es OR' o N(R'')2; R' es alquilo inferior, alquilo inferior sustituido por halogeno o es - (CH2)n-cicloalquilo; R'' es alquilo inferior; R2 es NO2, CN o SO2R''; R3 es hidrogeno, halogeno, alquilo inferior, alcoxi inferior o alquilo inferior sustituido por halogeno; R4 es hidrogeno, alquilo inferior, fenilo sustituido por halogeno o CF3 o es un heterociclo aromático de cinco o seis eslabones; R5/R6 son hidrogeno, halogeno, alquilo inferior, alcoxi inferior o son alquilo inferior o alcoxi inferior sustituido por halogeno; R7 es hidrogeno o alquilo inferior; n es 0, 1 o 2; y sus sales de adicion de ácido farmacéuticamente activas para el tratamiento de trastornos neurologicos y neuropsiquiátricos.
ARP050105207A 2004-12-15 2005-12-13 Fenil-metanonas bi- y triciclicas sustituidas para el tratamiento de trastornos neurologicos y neuropsiquiatricos AR052156A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04106597 2004-12-15

Publications (1)

Publication Number Publication Date
AR052156A1 true AR052156A1 (es) 2007-03-07

Family

ID=35841863

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050105207A AR052156A1 (es) 2004-12-15 2005-12-13 Fenil-metanonas bi- y triciclicas sustituidas para el tratamiento de trastornos neurologicos y neuropsiquiatricos

Country Status (20)

Country Link
US (1) US7375226B2 (es)
EP (1) EP1828200B1 (es)
JP (1) JP4709849B2 (es)
KR (1) KR100883003B1 (es)
CN (1) CN100586951C (es)
AR (1) AR052156A1 (es)
AT (1) ATE457989T1 (es)
AU (1) AU2005315914B2 (es)
BR (1) BRPI0519054A2 (es)
CA (1) CA2590316A1 (es)
DE (1) DE602005019465D1 (es)
ES (1) ES2338139T3 (es)
IL (1) IL183592A0 (es)
MX (1) MX2007006896A (es)
NO (1) NO20072833L (es)
NZ (1) NZ555476A (es)
RU (1) RU2007121768A (es)
TW (1) TWI299041B (es)
WO (1) WO2006063709A1 (es)
ZA (1) ZA200705044B (es)

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US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
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US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
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Also Published As

Publication number Publication date
CN101076532A (zh) 2007-11-21
NO20072833L (no) 2007-07-17
WO2006063709A1 (en) 2006-06-22
IL183592A0 (en) 2007-09-20
ZA200705044B (en) 2008-09-25
DE602005019465D1 (de) 2010-04-01
TWI299041B (en) 2008-07-21
US20060128713A1 (en) 2006-06-15
KR20070086196A (ko) 2007-08-27
ATE457989T1 (de) 2010-03-15
MX2007006896A (es) 2007-06-26
TW200634017A (en) 2006-10-01
ES2338139T3 (es) 2010-05-04
CA2590316A1 (en) 2006-06-22
JP2008523126A (ja) 2008-07-03
NZ555476A (en) 2009-09-25
CN100586951C (zh) 2010-02-03
BRPI0519054A2 (pt) 2008-12-23
EP1828200B1 (en) 2010-02-17
US7375226B2 (en) 2008-05-20
KR100883003B1 (ko) 2009-02-12
JP4709849B2 (ja) 2011-06-29
RU2007121768A (ru) 2009-01-27
AU2005315914A1 (en) 2006-06-22
EP1828200A1 (en) 2007-09-05
AU2005315914B2 (en) 2011-03-03

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