AR055666A1 - Inhibidores inntr - Google Patents
Inhibidores inntrInfo
- Publication number
- AR055666A1 AR055666A1 ARP060104260A ARP060104260A AR055666A1 AR 055666 A1 AR055666 A1 AR 055666A1 AR P060104260 A ARP060104260 A AR P060104260A AR P060104260 A ARP060104260 A AR P060104260A AR 055666 A1 AR055666 A1 AR 055666A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halogen
- haloalkyl
- inntr
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
- C07D273/04—Six-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Reivindicacion 1: Un compuesto de acuerdo con la formula (1), en la que X1 es O, NR8 o CH2; R1 es H, halogeno, alquilo C1-6 o alcoxi C1-6; R2 es H o halogeno; R3 es fenilo opcionalmente sustituido con 1 a 3 sustituyentes independientemente seleccionados del grupo que consiste de alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-8, halogeno, cano o nitro; R4 es A1 o A2; R5 y R6 son independientemente H, alquilo C1-10, haloalquilo C1-6, hidroxialquilo C1-6 o fenilo opcionalmente sustituido con 1 a 3 grupos independientemente seleccionados en cada caso del grupo consistente de alquilo C1-6, alcoxi C1-6, haloalquilo C1-6, halogeno, hidroxi, nitro y ciano, o R5 y R6 juntos son (CH2)n; R7 es h, alquilo C1-10 o fenilo; R8 es H o alquilo c1-6; n es de 2 a 4; y sales farmacéuticamente aceptables de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72233505P | 2005-09-30 | 2005-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR055666A1 true AR055666A1 (es) | 2007-08-29 |
Family
ID=37685915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060104260A AR055666A1 (es) | 2005-09-30 | 2006-09-28 | Inhibidores inntr |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7625897B2 (es) |
| EP (1) | EP1937651B1 (es) |
| JP (1) | JP2009510013A (es) |
| KR (1) | KR20080064957A (es) |
| CN (1) | CN101273020A (es) |
| AR (1) | AR055666A1 (es) |
| AT (1) | ATE418545T1 (es) |
| AU (1) | AU2006298853A1 (es) |
| BR (1) | BRPI0617205A2 (es) |
| CA (1) | CA2623728A1 (es) |
| DE (1) | DE602006004473D1 (es) |
| ES (1) | ES2317584T3 (es) |
| IL (1) | IL190081A0 (es) |
| TW (1) | TW200800923A (es) |
| WO (1) | WO2007039463A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7834178B2 (en) * | 2006-03-01 | 2010-11-16 | Bristol-Myers Squibb Company | Triazine 11-beta hydroxysteroid dehydrogenase type 1 inhibitors |
| GB0610680D0 (en) * | 2006-05-31 | 2006-07-12 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
| CL2007002105A1 (es) * | 2006-07-21 | 2008-02-22 | Hoffmann La Roche | Compuestos derivados de 2-[3-(3-cianofenoxi)(fenoxi o fenilsulfanil)]-n-fenil acetamida, inhibidores de la transcriptasa inversa del vih; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar u |
| CN101501002B (zh) * | 2006-08-16 | 2012-06-27 | 弗·哈夫曼-拉罗切有限公司 | 非核苷逆转录酶抑制剂 |
| CN101679294B (zh) * | 2007-05-30 | 2012-08-08 | 弗·哈夫曼-拉罗切有限公司 | 非核苷逆转录酶抑制剂 |
| JP2010530863A (ja) * | 2007-06-22 | 2010-09-16 | エフ．ホフマン−ラ ロシュ アーゲー | 非ヌクレオシド逆転写酵素阻害剤としての尿素及びカルバマート誘導体 |
| WO2009080534A1 (en) * | 2007-12-21 | 2009-07-02 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| TWI490214B (zh) * | 2008-05-30 | 2015-07-01 | 艾德克 上野股份有限公司 | 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途 |
| SG172778A1 (en) * | 2008-12-22 | 2011-08-29 | Hoffmann La Roche | Heterocyclic antiviral compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0835104A4 (en) | 1995-06-30 | 1999-10-20 | Smithkline Beecham Corp | USE OF STAT 5 SH2 DOMAINE SPECIFIC COMPOUNDS TO PROMOTE ERYTHROPOSIS |
| CN1136197C (zh) * | 1996-05-30 | 2004-01-28 | 霍夫曼-拉罗奇有限公司 | 新的哒嗪酮衍生物 |
| MXPA05010081A (es) * | 2003-03-24 | 2005-11-23 | Hoffmann La Roche | Bencil-piridazinonas como inhibidores de transcriptasa inversa. |
| TW200505441A (en) * | 2003-03-24 | 2005-02-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitorsⅠ |
| CN1934092A (zh) * | 2004-03-23 | 2007-03-21 | 弗·哈夫曼-拉罗切有限公司 | 非核苷逆转录酶抑制剂 |
-
2006
- 2006-09-20 CN CNA2006800353153A patent/CN101273020A/zh active Pending
- 2006-09-20 ES ES06793671T patent/ES2317584T3/es active Active
- 2006-09-20 JP JP2008532729A patent/JP2009510013A/ja active Pending
- 2006-09-20 EP EP06793671A patent/EP1937651B1/en not_active Not-in-force
- 2006-09-20 AT AT06793671T patent/ATE418545T1/de not_active IP Right Cessation
- 2006-09-20 AU AU2006298853A patent/AU2006298853A1/en not_active Abandoned
- 2006-09-20 DE DE602006004473T patent/DE602006004473D1/de active Active
- 2006-09-20 KR KR1020087010129A patent/KR20080064957A/ko not_active Withdrawn
- 2006-09-20 WO PCT/EP2006/066541 patent/WO2007039463A1/en not_active Ceased
- 2006-09-20 BR BRPI0617205-9A patent/BRPI0617205A2/pt not_active Application Discontinuation
- 2006-09-20 CA CA002623728A patent/CA2623728A1/en not_active Abandoned
- 2006-09-27 TW TW095135814A patent/TW200800923A/zh unknown
- 2006-09-28 AR ARP060104260A patent/AR055666A1/es not_active Application Discontinuation
- 2006-09-29 US US11/541,011 patent/US7625897B2/en not_active Expired - Fee Related
-
2008
- 2008-03-11 IL IL190081A patent/IL190081A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2623728A1 (en) | 2007-04-12 |
| CN101273020A (zh) | 2008-09-24 |
| ATE418545T1 (de) | 2009-01-15 |
| DE602006004473D1 (de) | 2009-02-05 |
| IL190081A0 (en) | 2008-08-07 |
| EP1937651A1 (en) | 2008-07-02 |
| ES2317584T3 (es) | 2009-04-16 |
| KR20080064957A (ko) | 2008-07-10 |
| WO2007039463A1 (en) | 2007-04-12 |
| TW200800923A (en) | 2008-01-01 |
| JP2009510013A (ja) | 2009-03-12 |
| EP1937651B1 (en) | 2008-12-24 |
| US7625897B2 (en) | 2009-12-01 |
| BRPI0617205A2 (pt) | 2011-07-19 |
| US20070078128A1 (en) | 2007-04-05 |
| AU2006298853A1 (en) | 2007-04-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |