AR051906A2 - Analogos proteicos relacionados con la hormona paratiroides - Google Patents
Analogos proteicos relacionados con la hormona paratiroidesInfo
- Publication number
- AR051906A2 AR051906A2 ARP060100191A ARP060100191A AR051906A2 AR 051906 A2 AR051906 A2 AR 051906A2 AR P060100191 A ARP060100191 A AR P060100191A AR P060100191 A ARP060100191 A AR P060100191A AR 051906 A2 AR051906 A2 AR 051906A2
- Authority
- AR
- Argentina
- Prior art keywords
- hpthrp
- aib29
- lys26
- cha23
- nle30
- Prior art date
Links
- 229940088597 hormone Drugs 0.000 title 1
- 239000005556 hormone Substances 0.000 title 1
- 108090000445 Parathyroid hormone Proteins 0.000 abstract 1
- 102000003982 Parathyroid hormone Human genes 0.000 abstract 1
- 239000000199 parathyroid hormone Substances 0.000 abstract 1
- 229960001319 parathyroid hormone Drugs 0.000 abstract 1
- 108010067557 parathyroid hormone (1-34)amide Proteins 0.000 abstract 1
- RRBCHMCWWOHRQL-UMXFMPSGSA-N parathyroid hormone (1-34)amide Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)C1=CN=CN1 RRBCHMCWWOHRQL-UMXFMPSGSA-N 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Reivindicacion 1: Un análogo proteico relacionado con la hormona paratiroidea de la formula caracterizado porque comprende: [Cha22,23, Glu25, Lys26,30, Leu28, Aib29] hPTHrP(1-34)NH2; [Cha22,23, Glu25, Lys26,30, Aib29] hPTHrP(1-34)NH2; [Glu22,25, Leu23,28,31, Lys26, Aib29, Nle30] hPTHrP(1-34)NH2; [Glu22,25, Leu23,28,30,31, Lys26, Aib29] hPTHrP(1-34)NH2; [Glu22,25,29, Leu23,28,30,31, Lys26] hPTHrP(1-34)NH2; [Glu22,25,29, Leu23,28,31, Lys26, Nle30] hPTHrP(1-34)NH2; [Ser1, Ile5, Met8, Asn10, Leu11,23,28,31, His14, Cha15, Glu22,25, Lys26,30, Aib29] hPTHrP(1-34)NH2; [Glu22,25, Cha23, Lys26, Leu28,31, Aib29, Nle30] hPTHrP(1-34)NH2, [Cha22,23, Glu25, Lys26,30, Leu28,31, Aib29] hPTHrP(1-34)NH2; [Cha22, Leu23,28,31, Glu25,29, Lys26, Nle30] hPTHrP(1-34)NH2; [Cha7,11,15] hPTHrP(1-34)NH2; [Cha7,8,15] hPTHrP(1-34)NH2; [Glu22, Cha23, Aib25,29, Lys26,30, Leu28,31] hPTHrP(1-34)NH2; [Glu22, Cha23, Aib25,29, Lys26, Leu28] hPTHrP(1-34)NH2; [Glu22, Leu23,28, Aib25,29, Lys26] hPTHrP(1-34)NH2; [Aib29]hPTHrP(1-34)NH2; [Glu22,25, Cha23, Lys26, Leu28,31, Aib29, Nle30] hPTHrP(1-34)NH2; [Glu22,25, Cha23, Lys26,30, Aib29, Leu31] hPTHrP(1-34)NH2; [Glu22,25, Leu23,28,31, Lys26, Aib29,30] hPTHrP(1-34)NH2; [Glu22,25, Leu23,28,31, Lys26, Aib29] hPTHrP(1-34)NH2; [Glu22,25, Leu23,28,31, Aib26,29, Lys30] hPTHrP(1-34)NH2; [Glu22,25, Cha23, Lys26,30, Leu28,31, Aib29] hPTHrP(1-34)NH2; [Glu22,25, Cha23, Lys26,30, Aib29]hPTHrP(1-34)NH2; [Glu22,25, Cha23, Lys26,30, Leu28, Aib29] hPTHrP(1-34)NH2; o [Leu27, Aib29] hPTH(1-34)NH2; o una sal farmacéuticamente aceptable de los mismos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/779,768 US5969095A (en) | 1995-07-13 | 1997-01-07 | Analogs of parathyroid hormone |
| US08/813,534 US5955574A (en) | 1995-07-13 | 1997-03-07 | Analogs of parathyroid hormone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR051906A2 true AR051906A2 (es) | 2007-02-14 |
Family
ID=27119618
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100058A AR011517A1 (es) | 1997-01-07 | 1998-01-06 | Analogos proteicos relacionados con la hormona paratiroides |
| ARP030100515A AR038552A2 (es) | 1997-01-07 | 2003-02-17 | Analogos proteicos relacionados con la hormona paratiroides |
| ARP060100191A AR051906A2 (es) | 1997-01-07 | 2006-01-18 | Analogos proteicos relacionados con la hormona paratiroides |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100058A AR011517A1 (es) | 1997-01-07 | 1998-01-06 | Analogos proteicos relacionados con la hormona paratiroides |
| ARP030100515A AR038552A2 (es) | 1997-01-07 | 2003-02-17 | Analogos proteicos relacionados con la hormona paratiroides |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5955574A (es) |
| EP (3) | EP2206725A1 (es) |
| JP (1) | JP3963482B2 (es) |
| KR (2) | KR100497709B1 (es) |
| CN (1) | CN1137898C (es) |
| AR (3) | AR011517A1 (es) |
| AT (2) | ATE471342T1 (es) |
| AU (1) | AU741584B2 (es) |
| BR (1) | BR9714200A (es) |
| CA (1) | CA2276614C (es) |
| CZ (2) | CZ301497B6 (es) |
| DE (2) | DE69735603T2 (es) |
| DK (2) | DK1645566T3 (es) |
| ES (2) | ES2258286T3 (es) |
| HU (1) | HUP9904596A3 (es) |
| IL (1) | IL130794A0 (es) |
| NO (1) | NO993341L (es) |
| NZ (1) | NZ336610A (es) |
| PL (1) | PL191898B1 (es) |
| PT (2) | PT1645566E (es) |
| RU (1) | RU2198182C2 (es) |
| SI (2) | SI1645566T1 (es) |
| WO (1) | WO1998030590A2 (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6544949B1 (en) * | 1995-07-13 | 2003-04-08 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Analogs of parathyroid hormone |
| US7410948B2 (en) * | 1995-07-13 | 2008-08-12 | Societe De Conseils De Recherches Et D'applications Scientifiques, Sas | Analogs of parathyroid hormone |
| ATE297754T1 (de) | 1997-09-09 | 2005-07-15 | Hoffmann La Roche | Heilung von bruchverletzungen unter verwendung von pthrp analogen |
| ATE392431T1 (de) * | 1998-05-05 | 2008-05-15 | Sod Conseils Rech Applic | Pth2 rezeptor selektive verbindungen |
| PL345583A1 (en) * | 1998-07-20 | 2001-12-17 | Sod Conseils Rech Applic | Peptide analogues of pacap |
| US6660843B1 (en) † | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US6489297B1 (en) | 2000-02-18 | 2002-12-03 | Dabur Research Foundation | Vasoactive intestinal peptide analogs |
| US20050124537A1 (en) * | 2000-04-27 | 2005-06-09 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| US6756480B2 (en) * | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| ATE356631T1 (de) | 2001-06-01 | 2007-04-15 | Novartis Pharma Gmbh | Orale verabreichung von parathyroidhormon und calcitonin |
| JP4837888B2 (ja) | 2001-07-23 | 2011-12-14 | ザ ジェネラル ホスピタル コーポレイション | コンホメーションが拘束された副甲状腺ホルモン（ｐｔｈ）類似体 |
| CA2534577A1 (en) * | 2003-08-06 | 2005-02-24 | Rhodia, Inc. | Method for promoting bone growth |
| AU2006315132A1 (en) | 2005-11-10 | 2007-05-24 | Board Of Control Of Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
| US7803770B2 (en) * | 2006-10-03 | 2010-09-28 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
| USRE49444E1 (en) | 2006-10-03 | 2023-03-07 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
| RS56164B1 (sr) * | 2006-10-03 | 2017-11-30 | Radius Health Inc | Stabilna kompozicija koja sadrži pthrp i njene upotrebe |
| PL2084183T3 (pl) * | 2006-10-13 | 2010-10-29 | Lilly Co Eli | Pegylowane pth jako modulatory receptora pth i ich zastosowania |
| CN104072606B (zh) | 2007-08-01 | 2017-09-22 | 总医院有限公司 | 利用g蛋白偶联受体和相关组合物的筛选方法 |
| WO2010111617A2 (en) | 2009-03-27 | 2010-09-30 | Van Andel Research Institute | Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use |
| JP2013512688A (ja) | 2009-12-07 | 2013-04-18 | ミシガン テクノロジカル ユニバーシティ | クロクマの副甲状腺ホルモン及びクロクマの副甲状腺ホルモンを使用する方法 |
| MX342898B (es) | 2010-05-12 | 2016-10-18 | Radius Health Inc * | Regimen terapéutico de la sal de diclorhidrato del (r) -6-(2-(etil (4-2(etilamino) etil) bencil) amino)-4-metoxifenil)-5, 6,7,8-tetrahidronaftaleno-2-ol. |
| KR101900078B1 (ko) | 2010-05-13 | 2018-09-18 | 더 제너럴 하스피탈 코포레이션 | 부갑상선 호르몬 아날로그 및 그의 용도 |
| ES2550319T3 (es) | 2010-09-28 | 2015-11-06 | Radius Health, Inc | Moduladores selectivos del receptor de andrógenos |
| SI3122426T1 (sl) | 2014-03-28 | 2023-04-28 | Duke University | Zdravljenje raka dojk z uporabo selektivnih modulatorjev estrogenskih receptorjev |
| IL255189B2 (en) | 2015-04-29 | 2024-04-01 | Radius Pharmaceuticals Inc | A combination of rad1901 and a cdk4/6 inhibitor for use in treating cancer |
| CN108025042A (zh) * | 2015-07-06 | 2018-05-11 | 董正欣 | PTHrP类似物的新型制剂 |
| CA3027563C (en) | 2016-06-22 | 2024-07-02 | Ellipses Pharma Ltd | AR+ METHODS FOR BREAST CANCER TREATMENT |
| ES2981967T3 (es) | 2017-01-05 | 2024-10-14 | Radius Pharmaceuticals Inc | Formas polimórficas de RAD1901-2HCl |
| US10996208B2 (en) | 2017-04-28 | 2021-05-04 | Radius Health, Inc. | Abaloparatide formulations and methods of testing, storing, modifying, and using same |
| WO2020010216A1 (en) | 2018-07-04 | 2020-01-09 | Radius Pharmaceuticals, Inc. | Polymorphic forms of rad 1901-2hcl |
| PH12021551950A1 (en) | 2019-02-12 | 2022-05-23 | Radius Pharmaceuticals Inc | Processes and compounds |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| FR2550204B1 (fr) * | 1983-08-05 | 1987-11-13 | Toyo Jozo Kk | Derives peptidiques de (nle8,nle1b, tyr34)-h-pth |
| EP0293158A3 (en) * | 1987-05-26 | 1990-05-09 | Merck & Co. Inc. | Parathyroid hormone antagonists |
| WO1990010067A1 (de) * | 1989-02-23 | 1990-09-07 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Pth-varianten kodierende dna-sequenzen, pth-varianten, expressionsvektor, bakterieller wirt, verwendung und therapeutische zusammensetzung |
| CA2040264A1 (en) * | 1990-04-12 | 1991-10-13 | Tatsuhiko Kanmera | Parathyroid hormone antagonists |
| JPH0532696A (ja) * | 1990-09-28 | 1993-02-09 | Takeda Chem Ind Ltd | 副甲状腺ホルモン誘導体 |
| WO1993006846A1 (en) * | 1991-10-10 | 1993-04-15 | Pang Peter K T | Parathyroid hormone analogues and use in osteoporosis treatment |
| US5434246A (en) * | 1992-03-19 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Parathyroid hormone derivatives |
| CA2098639A1 (en) * | 1992-06-19 | 1993-12-20 | K. Anne Kronis | Bone stimulating, non-vasoactive parathyroid hormone variants |
| US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| US5821225A (en) * | 1992-07-14 | 1998-10-13 | Syntex (U.S.A.) Inc. | Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp |
| AU672790B2 (en) * | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
| CZ293425B6 (cs) | 1993-01-06 | 2004-04-14 | Kinerton Limited | Polyester obsahující jednu nebo více volných karboxylových skupin a přípravek tento polyester obsahující |
| CN1070500C (zh) * | 1993-07-13 | 2001-09-05 | 森德克斯(美国)股份有限公司 | 甲状旁腺激素类似物和甲状旁腺激素相关肽：合成和治疗骨质疏松症的用途 |
| CA2205959A1 (en) * | 1994-12-19 | 1996-06-27 | Michael Chorev | Continuous low-dose administration of parathyroid hormone or its agonist |
| CA2178894A1 (en) * | 1995-06-15 | 1996-12-16 | Tsunehiko Fukuda | Parathyroid hormone derivatives and their use |
| US5723577A (en) * | 1995-07-13 | 1998-03-03 | Biomeasure Inc. | Analogs of parathyroid hormone |
-
1997
- 1997-03-07 US US08/813,534 patent/US5955574A/en not_active Expired - Lifetime
- 1997-12-08 DE DE69735603T patent/DE69735603T2/de not_active Expired - Lifetime
- 1997-12-08 ES ES97951595T patent/ES2258286T3/es not_active Expired - Lifetime
- 1997-12-08 AU AU55199/98A patent/AU741584B2/en not_active Ceased
- 1997-12-08 SI SI9730795T patent/SI1645566T1/sl unknown
- 1997-12-08 NZ NZ336610A patent/NZ336610A/en not_active IP Right Cessation
- 1997-12-08 CZ CZ20050594A patent/CZ301497B6/cs not_active IP Right Cessation
- 1997-12-08 HU HU9904596A patent/HUP9904596A3/hu unknown
- 1997-12-08 PL PL334438A patent/PL191898B1/pl not_active IP Right Cessation
- 1997-12-08 CN CNB971819157A patent/CN1137898C/zh not_active Expired - Fee Related
- 1997-12-08 DE DE69739912T patent/DE69739912D1/de not_active Expired - Lifetime
- 1997-12-08 PT PT05026436T patent/PT1645566E/pt unknown
- 1997-12-08 PT PT97951595T patent/PT948541E/pt unknown
- 1997-12-08 EP EP10156965A patent/EP2206725A1/en not_active Withdrawn
- 1997-12-08 CA CA002276614A patent/CA2276614C/en not_active Expired - Fee Related
- 1997-12-08 ES ES05026436T patent/ES2347154T3/es not_active Expired - Lifetime
- 1997-12-08 JP JP53086598A patent/JP3963482B2/ja not_active Expired - Fee Related
- 1997-12-08 KR KR10-1999-7006165A patent/KR100497709B1/ko not_active Expired - Fee Related
- 1997-12-08 KR KR1020057003295A patent/KR100699422B1/ko not_active Expired - Fee Related
- 1997-12-08 IL IL13079497A patent/IL130794A0/xx not_active IP Right Cessation
- 1997-12-08 EP EP05026436A patent/EP1645566B1/en not_active Expired - Lifetime
- 1997-12-08 AT AT05026436T patent/ATE471342T1/de active
- 1997-12-08 RU RU99117145/04A patent/RU2198182C2/ru not_active IP Right Cessation
- 1997-12-08 DK DK05026436.5T patent/DK1645566T3/da active
- 1997-12-08 WO PCT/US1997/022498 patent/WO1998030590A2/en not_active Ceased
- 1997-12-08 AT AT97951595T patent/ATE321784T1/de active
- 1997-12-08 CZ CZ0239899A patent/CZ298937B6/cs not_active IP Right Cessation
- 1997-12-08 SI SI9730730T patent/SI0948541T1/sl unknown
- 1997-12-08 EP EP97951595A patent/EP0948541B1/en not_active Expired - Lifetime
- 1997-12-08 DK DK97951595T patent/DK0948541T3/da active
- 1997-12-08 BR BR9714200-0A patent/BR9714200A/pt not_active IP Right Cessation
-
1998
- 1998-01-06 AR ARP980100058A patent/AR011517A1/es active IP Right Grant
-
1999
- 1999-07-06 NO NO993341A patent/NO993341L/no not_active Application Discontinuation
-
2003
- 2003-02-17 AR ARP030100515A patent/AR038552A2/es active IP Right Grant
-
2006
- 2006-01-18 AR ARP060100191A patent/AR051906A2/es unknown
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