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AR040694A1 - Derivados de benzodioxol como antagonistas de los receptores cb1 - Google Patents

Derivados de benzodioxol como antagonistas de los receptores cb1

Info

Publication number
AR040694A1
AR040694A1 AR20030102682A ARP030102682A AR040694A1 AR 040694 A1 AR040694 A1 AR 040694A1 AR 20030102682 A AR20030102682 A AR 20030102682A AR P030102682 A ARP030102682 A AR P030102682A AR 040694 A1 AR040694 A1 AR 040694A1
Authority
AR
Argentina
Prior art keywords
phenyl
lower alkyl
hydroxy
independently
alkyl
Prior art date
Application number
AR20030102682A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR040694A1 publication Critical patent/AR040694A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07D491/10—Spiro-condensed systems

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Abstract

Reivindicación 1: Compuestos de la fórmula (1) en la que R1 y R2 con independencia entre sí son fenilo sin sustituir o fenilo mono-, di-, o trisustituido, con independencia entre sí, por hidroxi, alquilo inferior, alcoxi inferior, perfluor-alquilo inferior, alcanoilo, ciano o halógeno; R3 y R4 con independencia entre sí son H, halógeno, hidroxi, alquilo inferior, alcoxi inferior, perfluoralquilo inferior, alcanoilo o ciano; R5 es H o alquilo inferior; R6 es fenilo o fenil-alquilo inferior, en los que el resto fenilo puede estar eventualmente mono-, di- o trisustituido, con independencia entre sí, por alquilo inferior, alcoxi inferior, halógeno, perfluoralquilo inferior, hidroxi, alcanoilo o ciano; o R5 y R6 junto con el átomo de N al que están unidos forman un anillo heterocíclico saturado o insaturado, monocíclico de 5, 6 o 7 eslabones o bicíclico de 9 o 10 eslabones, que puede llevar eventualmente uno o dos heteroátomos adicionales, elegidos con independencia entre sí entre O, N y S, dicho anillo heterocíclico puede estar eventualmente mono-, di-, o trisustituido, con independencia entre sí, por alquilo inferior,(alcoxi inferior)carbonilo, hidroxi-alquilo inferior, alcanoilo, amino-alquilo inferior, hidroxi, alcoxi inferior, halógeno, perfluoralquilo inferior, ciano, heteroarilo, o por fenilo o fenil-alquilo inferior, en los que el resto fenilo puede estar eventualmente mono-, di-, o trisustituido, con independencia entre sí, por alquilo inferior, alcoxi inferior, halógeno, perfluor-alquilo inferior, hidroxi, alcanoilo o ciano. X es -CH2-, -C(O)- o -SO2-; y las sales farmacéuticamente aceptables de los mismos.
AR20030102682A 2002-07-29 2003-07-25 Derivados de benzodioxol como antagonistas de los receptores cb1 AR040694A1 (es)

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EP02016831 2002-07-29

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AR040694A1 true AR040694A1 (es) 2005-04-13

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EP (1) EP1532132B1 (es)
JP (1) JP4202319B2 (es)
KR (1) KR100741231B1 (es)
CN (1) CN100486973C (es)
AR (1) AR040694A1 (es)
AT (1) ATE389646T1 (es)
AU (1) AU2003250117B2 (es)
BR (1) BR0313041A (es)
CA (1) CA2493313C (es)
DE (1) DE60319837T2 (es)
ES (1) ES2301833T3 (es)
HR (1) HRP20050044A2 (es)
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UY (1) UY27918A1 (es)
WO (1) WO2004013120A1 (es)
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Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7365093B2 (en) * 1994-08-19 2008-04-29 Abbott Laboratories Endothelin antagonists
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