PE20091270A1 - Derivados de azetidinas con actividad sobre receptores cb1 y su preparacion - Google Patents
Derivados de azetidinas con actividad sobre receptores cb1 y su preparacionInfo
- Publication number
- PE20091270A1 PE20091270A1 PE2008002084A PE2008002084A PE20091270A1 PE 20091270 A1 PE20091270 A1 PE 20091270A1 PE 2008002084 A PE2008002084 A PE 2008002084A PE 2008002084 A PE2008002084 A PE 2008002084A PE 20091270 A1 PE20091270 A1 PE 20091270A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- phenyl
- benzamide
- chloro
- bis
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 2
- 150000001539 azetidines Chemical class 0.000 title 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- GEAXLHPORCRESC-UHFFFAOYSA-N chlorocyclohexatriene Chemical class ClC1=CC=C=C[CH]1 GEAXLHPORCRESC-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 abstract 2
- 208000027559 Appetite disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000003935 attention Effects 0.000 abstract 1
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical compound C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 abstract 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical class 0.000 abstract 1
- 230000001149 cognitive effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
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- Nutrition Science (AREA)
Abstract
REFERIDA A UN COMPUESTO DERIVADO DE AZETIDINA DE FORMULA (I), DONDE R ES ALQUILO C1-C6 O HALOALQUILO C1-C6; R' ES NR4R5, OR8; R4 Y R5 SON H, ALQUILO C1-C6 O JUNTOS FORMAN UN GRUPO HETEROCICLO TAL COMO AZETIDINA, PIRROLIDINA, AZEPAN, ENTRE OTROS; R8 ES H, ALQUILO C1-C6, FENILALQUILO C1-C6, ENTRE OTROS; A Y B SON UN ATOMO DE CARBONO OPCIONALMENTE SUSTITUIDOO CON H, ALQUILO C1-C6, ENTRE OTROS; R1 ES H O ALQUILO C1-C6; R2 Y R3 SON H, ALQUILO C1-C6, ENTRE OTROS; R6 Y R7 SON FENILO OPCIONALMENTE SUSTITUIDO POR H, HALO, ALCOXI C1-C6, ENTRE OTROS; Y ES H, CN, HALOGENO, ALQUILO C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-({1-[BIS-(4-CLORO-FENIL)-METIL]-AZETIDIN-3-IL}-METANOSULFONIL-AMINO)-N-((S)-1-CARBAMOIL-ETIL)-BENZAMIDA, 3-({1-[BIS-(4-CLORO-FENIL)-METIL]-AZETIDIN-3-IL}-METANOSULFONIL-AMINO)-N-CARBAMOILMETIL-5-FLUORO-BENZAMIDA, 3-({1-[BIS-(4-CLORO-FENIL)-METIL]-AZETIDIN-3-IL}-METANOSULFONIL-AMINO)-N-((S)-1-CARBAMOIL-ETIL)-5-FLUORO-BENZAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN ACTIVIDAD SOBRE LOS RECEPTORES CANNABINOIDES CB1 Y SON UTILES EN EL TRATAMIENTO DE TRANSTORNOS PSIQUIATRICOS, COGNITIVOS, DE LA ATENCION, ENFERMEDADES NEURODEGENERATIVAS, TRANSTORNOS DEL APETITO, ENTRE OTROS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0708830A FR2925051B1 (fr) | 2007-12-18 | 2007-12-18 | Derives d'azetidines,leur preparation et leur application en therapeutique |
| FR0802492A FR2930941B1 (fr) | 2008-05-06 | 2008-05-06 | Derives d'azetidines, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091270A1 true PE20091270A1 (es) | 2009-09-23 |
Family
ID=40935338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008002084A PE20091270A1 (es) | 2007-12-18 | 2008-12-16 | Derivados de azetidinas con actividad sobre receptores cb1 y su preparacion |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US8445478B2 (es) |
| EP (1) | EP2234966B1 (es) |
| JP (1) | JP5460614B2 (es) |
| KR (1) | KR20100098563A (es) |
| CN (1) | CN101945852B (es) |
| AR (1) | AR069700A1 (es) |
| AU (1) | AU2008351943B2 (es) |
| BR (1) | BRPI0822054A2 (es) |
| CA (1) | CA2709863A1 (es) |
| CL (1) | CL2008003780A1 (es) |
| CO (1) | CO6290755A2 (es) |
| CY (1) | CY1114991T1 (es) |
| DK (1) | DK2234966T3 (es) |
| EA (1) | EA019315B1 (es) |
| ES (1) | ES2439258T3 (es) |
| HR (1) | HRP20131168T1 (es) |
| IL (1) | IL206420A (es) |
| MA (1) | MA32019B1 (es) |
| PA (1) | PA8808101A1 (es) |
| PE (1) | PE20091270A1 (es) |
| PL (1) | PL2234966T3 (es) |
| PT (1) | PT2234966E (es) |
| SI (1) | SI2234966T1 (es) |
| TW (1) | TW200930360A (es) |
| UY (1) | UY31548A1 (es) |
| WO (1) | WO2009106708A2 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| FR2946650B1 (fr) * | 2009-06-16 | 2011-08-19 | Sanofi Aventis | Esters derives d'azetidines, leur preparation et leur application en therapeutique. |
| WO2012031220A2 (en) | 2010-09-03 | 2012-03-08 | University Of Florida Research Foundation, Inc. | Nicotine compounds and analogs thereof, synthetic methods of making compounds, and methods of use |
| GB201321601D0 (en) * | 2013-12-06 | 2014-01-22 | Canbex Therapeutics Ltd | Modulator |
| US11003343B2 (en) * | 2014-01-06 | 2021-05-11 | Lett.rs LLC | Electronic personal signature generation and distribution for personal communication |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2399791A1 (en) * | 2000-02-11 | 2001-08-16 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases |
| FR2805817B1 (fr) * | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | Compositions pharmaceutiques contenant des derives d'azetidine, les nouveaux derives d'azetidine et leur preparation |
| FR2814678B1 (fr) * | 2000-10-04 | 2002-12-20 | Aventis Pharma Sa | Association d'un antagoniste du recepteur cb1 et de sibutramine, les compositions pharmaceutiques les contenant et leur utilisation pour la traitement de l'obesite |
| ES2301833T3 (es) * | 2002-07-29 | 2008-07-01 | Hoffmann La Roche | Derivados de benzodioxol. |
| AU2004234125A1 (en) * | 2003-05-01 | 2004-11-11 | Vernalis Research Limited | Azetidinecarboxamide derivatives and their use in the treatment of CB1 receptor mediated disorders |
| DOP2006000273A (es) * | 2005-12-08 | 2007-10-15 | Aventis Pharma Inc | Uso de un antagonista de cb1 para tratar efectos secundarios y sintomas negativos de la esquizofrenia |
| AU2007226673A1 (en) * | 2006-03-10 | 2007-09-20 | Jenrin Discovery | Cannabinoid receptor antagonists/inverse agonists useful for treating obesity |
-
2008
- 2008-12-16 PE PE2008002084A patent/PE20091270A1/es not_active Application Discontinuation
- 2008-12-16 KR KR1020107015774A patent/KR20100098563A/ko not_active Ceased
- 2008-12-16 WO PCT/FR2008/001748 patent/WO2009106708A2/fr not_active Ceased
- 2008-12-16 CA CA2709863A patent/CA2709863A1/fr not_active Abandoned
- 2008-12-16 SI SI200831115T patent/SI2234966T1/sl unknown
- 2008-12-16 JP JP2010538830A patent/JP5460614B2/ja not_active Expired - Fee Related
- 2008-12-16 HR HRP20131168AT patent/HRP20131168T1/hr unknown
- 2008-12-16 ES ES08872952.0T patent/ES2439258T3/es active Active
- 2008-12-16 AU AU2008351943A patent/AU2008351943B2/en not_active Ceased
- 2008-12-16 EA EA201070758A patent/EA019315B1/ru not_active IP Right Cessation
- 2008-12-16 AR ARP080105459A patent/AR069700A1/es unknown
- 2008-12-16 DK DK08872952.0T patent/DK2234966T3/da active
- 2008-12-16 CN CN200880126985.5A patent/CN101945852B/zh not_active Expired - Fee Related
- 2008-12-16 PL PL08872952T patent/PL2234966T3/pl unknown
- 2008-12-16 EP EP08872952.0A patent/EP2234966B1/fr active Active
- 2008-12-16 BR BRPI0822054-9A patent/BRPI0822054A2/pt not_active IP Right Cessation
- 2008-12-16 PT PT88729520T patent/PT2234966E/pt unknown
- 2008-12-17 CL CL2008003780A patent/CL2008003780A1/es unknown
- 2008-12-17 PA PA20088808101A patent/PA8808101A1/es unknown
- 2008-12-18 UY UY31548A patent/UY31548A1/es not_active Application Discontinuation
- 2008-12-18 TW TW097149442A patent/TW200930360A/zh unknown
-
2010
- 2010-06-16 IL IL206420A patent/IL206420A/en not_active IP Right Cessation
- 2010-06-18 US US12/818,274 patent/US8445478B2/en not_active Expired - Fee Related
- 2010-06-18 CO CO10073795A patent/CO6290755A2/es not_active Application Discontinuation
- 2010-07-14 MA MA33018A patent/MA32019B1/fr unknown
-
2013
- 2013-04-23 US US13/868,602 patent/US20130237513A1/en not_active Abandoned
- 2013-12-11 CY CY20131101118T patent/CY1114991T1/el unknown
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