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AR057209A1 - Compuestos para el tratamiento de trastornos inflamatorios y enfermedades microbianas - Google Patents

Compuestos para el tratamiento de trastornos inflamatorios y enfermedades microbianas

Info

Publication number
AR057209A1
AR057209A1 ARP060105293A ARP060105293A AR057209A1 AR 057209 A1 AR057209 A1 AR 057209A1 AR P060105293 A ARP060105293 A AR P060105293A AR P060105293 A ARP060105293 A AR P060105293A AR 057209 A1 AR057209 A1 AR 057209A1
Authority
AR
Argentina
Prior art keywords
heterocyclyl
aryl
heteroaryl
alkyl
unsubstituted
Prior art date
Application number
ARP060105293A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AR057209A1 publication Critical patent/AR057209A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
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Abstract

Reivindicacion 1: Un compuesto de formula (1) o una sal, solvato o éster farmacéuticamente aceptable del mismo, en donde: (i) cada uno de R1 y R2 es independientemente H o alquilo, (ii) R3 y R4 tomados conjuntamente con el N al cual ellos se muestran unidos son heterociclilo o heteroarilo, teniendo dicho heterociclilo o heteroarilo 1-3 heteroátomos que incluyen dicho N, estando dicho heterociclilo o heteroarilo opcionalmente fusionado con arilo, heteroarilo, cicloalquilo, o heterociclilo; en donde dicho heterociclilo o heteroarilo que comprende R3 y R4 está sustituido con uno o dos sustituyentes, estando cada sustituyente independientemente seleccionado del grupo que consiste en arilo y alquinilo; en donde dicho sustituyente arilo está sin sustituir o está opcionalmente sustituido con uno o dos restos independientemente seleccionados del grupo que consiste en un resto perhaloalquilo, halo, alquilo, alcoxi, ciano, perhaloalcoxi, y alquinilo, en donde dicho resto alquinilo está sustituido con un radical arilo; en donde dicho sustituyente alquinilo está sustituido con un resto arilo, en donde dicho resto arilo está sin sustituir u opcionalmente sustituido con uno a tres radicales seleccionados del grupo que consiste en perhaloalquilo, halo, alquilo, alcoxi, ciano, y perhaloalcoxi; y (iii) cada uno de R5 y R6 es alquilo, o alternativamente R4 y R5 tomados conjuntamente con el N al cual ellos se muestran unidos son heterociclilo que tiene 1-3 heteroátomos que incluyen dicho n; en donde dicho heterociclilo que comprende R5 y R6 está sin sustituir u opcionalmente sustituido con un sustituyente arilo; en donde dicho sustituyente arilo está sin sustituir u opcionalmente sustituido con uno a tres restos independientemente seleccionados del grupo que consiste en perhaloalquilo, halo, alquilo, alcoxi, ciano, y perhaloalcoxi; con la salvedad de que el sustituyente arilo de dicho heterociclilo o heteroarilo que comprende R3 y R4 puede estar sin sustituir u opcionalmente independientemente sustituido con uno a tres restos independientemente seleccionados del grupo que consiste en perhaloalquilo, halo, alquilo, alcoxi, ciano, y perhaloalcoxi solamente cuando R5, R6 tomados conjuntamente con el N al cual R5 y R6 se muestran unidos son heterociclilo.
ARP060105293A 2005-12-01 2006-11-30 Compuestos para el tratamiento de trastornos inflamatorios y enfermedades microbianas AR057209A1 (es)

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