AR049097A1 - Derivados de pirimidina para tratar el crecimiento celular anomalo - Google Patents
Derivados de pirimidina para tratar el crecimiento celular anomaloInfo
- Publication number
- AR049097A1 AR049097A1 ARP050101969A ARP050101969A AR049097A1 AR 049097 A1 AR049097 A1 AR 049097A1 AR P050101969 A ARP050101969 A AR P050101969A AR P050101969 A ARP050101969 A AR P050101969A AR 049097 A1 AR049097 A1 AR 049097A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- heterocyclyl
- group
- heteroaryl
- Prior art date
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 49
- 125000000623 heterocyclic group Chemical group 0.000 abstract 35
- 125000000217 alkyl group Chemical group 0.000 abstract 15
- 125000001072 heteroaryl group Chemical group 0.000 abstract 15
- 125000001424 substituent group Chemical group 0.000 abstract 11
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 10
- 229910052736 halogen Inorganic materials 0.000 abstract 10
- 150000002367 halogens Chemical class 0.000 abstract 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 10
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 9
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 5
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 4
- 125000004122 cyclic group Chemical group 0.000 abstract 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 4
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 101100203602 Hypocrea jecorina (strain QM6a) sor7 gene Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 1
- 230000002547 anomalous effect Effects 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57131204P | 2004-05-14 | 2004-05-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR049097A1 true AR049097A1 (es) | 2006-06-28 |
Family
ID=34966230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050101969A AR049097A1 (es) | 2004-05-14 | 2005-05-13 | Derivados de pirimidina para tratar el crecimiento celular anomalo |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP1751143A1 (fr) |
| JP (1) | JP4099212B2 (fr) |
| KR (1) | KR100886990B1 (fr) |
| CN (2) | CN102127058A (fr) |
| AP (1) | AP2241A (fr) |
| AR (1) | AR049097A1 (fr) |
| AU (2) | AU2005243397A1 (fr) |
| BR (1) | BRPI0511138A (fr) |
| CA (1) | CA2566707A1 (fr) |
| CR (1) | CR8749A (fr) |
| EA (1) | EA200601796A1 (fr) |
| EC (1) | ECSP066997A (fr) |
| GE (1) | GEP20104875B (fr) |
| GT (1) | GT200500113A (fr) |
| IL (1) | IL178828A0 (fr) |
| MA (1) | MA28583B1 (fr) |
| MX (1) | MXPA06011890A (fr) |
| NL (2) | NL1029045C2 (fr) |
| NO (1) | NO20064576L (fr) |
| NZ (1) | NZ550448A (fr) |
| PA (1) | PA8632601A1 (fr) |
| PE (1) | PE20060240A1 (fr) |
| TN (1) | TNSN06370A1 (fr) |
| TW (1) | TWI303635B (fr) |
| UY (1) | UY28894A1 (fr) |
| WO (1) | WO2005111023A1 (fr) |
| ZA (1) | ZA200608394B (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4812763B2 (ja) * | 2004-05-18 | 2011-11-09 | ライジェル ファーマシューティカルズ， インコーポレイテッド | シクロアルキル置換ピリミジンジアミン化合物およびそれらの用途 |
| US20070032514A1 (en) * | 2005-07-01 | 2007-02-08 | Zahn Stephan K | 2,4-diamino-pyrimidines as aurora inhibitors |
| RS20080272A (sr) * | 2005-12-21 | 2009-07-15 | Pfizer Products Inc., | Derivati pirimidina za tretman neprirodnog rasta ćelija |
| JP4782239B2 (ja) * | 2007-04-18 | 2011-09-28 | ファイザー・プロダクツ・インク | 異常細胞増殖治療のためのスルホニルアミド誘導体 |
| BRPI0814432A2 (pt) * | 2007-07-17 | 2017-05-09 | Rigel Pharmaceuticals Inc | pirimidinadiaminas substituídas por amina cíclica como inibidores de pkc |
| US8461147B2 (en) * | 2007-12-03 | 2013-06-11 | Boehringer Ingelheim International Gmbh | Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation |
| EA029131B1 (ru) * | 2008-05-21 | 2018-02-28 | Ариад Фармасьютикалз, Инк. | Фосфорсодержащие производные в качестве ингибиторов киназы |
| US8410126B2 (en) * | 2009-05-29 | 2013-04-02 | Boehringer Ingelheim International Gmbh | Pyrimidine inhibitors of PKTK2 |
| WO2011018517A1 (fr) | 2009-08-14 | 2011-02-17 | Boehringer Ingelheim International Gmbh | Préparation régiosélective de dérivés de 2-amino-5-trifluorométhylpyrimidine |
| US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
| US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
| WO2014174745A1 (fr) * | 2013-04-26 | 2014-10-30 | 国立大学法人京都大学 | INHIBITEUR D'Eg5 |
| CN109608444B (zh) * | 2018-11-27 | 2022-02-11 | 中国药科大学 | 含异吲哚啉酮的erk抑制剂及其制备方法与用途 |
| CN111732548B (zh) * | 2020-06-11 | 2022-06-17 | 浙江大学 | N2-氨甲酰芳环-2-氨基嘧啶类衍生物及其医药用途 |
| WO2024140671A1 (fr) * | 2022-12-29 | 2024-07-04 | 南京昕瑞再生医药科技有限公司 | Dérivé tricyclique fusionné, composition pharmaceutique le comprenant et son utilisation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9721437D0 (en) * | 1997-10-10 | 1997-12-10 | Glaxo Group Ltd | Heteroaromatic compounds and their use in medicine |
| AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| WO2003030909A1 (fr) * | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- et 4-aminopyrimidines n-substituees par un noyau bicyclique utilisees comme inhibiteurs de kinases dans le traitement du cancer |
| AU2003285614B2 (en) * | 2002-12-20 | 2009-05-14 | Pfizer Products, Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| UA80767C2 (en) * | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
-
2005
- 2005-05-02 MX MXPA06011890A patent/MXPA06011890A/es unknown
- 2005-05-02 BR BRPI0511138-2A patent/BRPI0511138A/pt not_active IP Right Cessation
- 2005-05-02 EA EA200601796A patent/EA200601796A1/ru unknown
- 2005-05-02 WO PCT/IB2005/001201 patent/WO2005111023A1/fr not_active Ceased
- 2005-05-02 AU AU2005243397A patent/AU2005243397A1/en not_active Abandoned
- 2005-05-02 KR KR1020067023767A patent/KR100886990B1/ko not_active Expired - Lifetime
- 2005-05-02 CN CN2011100212904A patent/CN102127058A/zh active Pending
- 2005-05-02 AP AP2006003790A patent/AP2241A/xx active
- 2005-05-02 GE GEAP20059703A patent/GEP20104875B/en unknown
- 2005-05-02 CN CNA2005800155302A patent/CN1953974A/zh active Pending
- 2005-05-02 JP JP2007512557A patent/JP4099212B2/ja not_active Expired - Lifetime
- 2005-05-02 CA CA002566707A patent/CA2566707A1/fr not_active Abandoned
- 2005-05-02 EP EP05732043A patent/EP1751143A1/fr not_active Withdrawn
- 2005-05-02 NZ NZ550448A patent/NZ550448A/en not_active IP Right Cessation
- 2005-05-11 PA PA20058632601A patent/PA8632601A1/es unknown
- 2005-05-11 TW TW094115237A patent/TWI303635B/zh not_active IP Right Cessation
- 2005-05-12 UY UY28894A patent/UY28894A1/es not_active Application Discontinuation
- 2005-05-12 PE PE2005000534A patent/PE20060240A1/es not_active Application Discontinuation
- 2005-05-13 NL NL1029045A patent/NL1029045C2/nl not_active IP Right Cessation
- 2005-05-13 GT GT200500113A patent/GT200500113A/es unknown
- 2005-05-13 AR ARP050101969A patent/AR049097A1/es not_active Application Discontinuation
-
2006
- 2006-05-19 NL NL1031845A patent/NL1031845C2/nl not_active IP Right Cessation
- 2006-10-06 ZA ZA200608394A patent/ZA200608394B/xx unknown
- 2006-10-09 NO NO20064576A patent/NO20064576L/no not_active Application Discontinuation
- 2006-10-23 IL IL178828A patent/IL178828A0/en unknown
- 2006-11-13 CR CR8749A patent/CR8749A/es not_active Application Discontinuation
- 2006-11-13 EC EC2006006997A patent/ECSP066997A/es unknown
- 2006-11-13 TN TNP2006000370A patent/TNSN06370A1/fr unknown
- 2006-11-14 MA MA29452A patent/MA28583B1/fr unknown
-
2009
- 2009-11-13 AU AU2009238255A patent/AU2009238255A1/en not_active Ceased
Also Published As
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| NO20091012L (no) | Kinazolinon- og isokinolinonacetamid derivater |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |