MXPA06011890A - Derivados de pirimidina para tratar el crecimiento celular anomalo. - Google Patents

Derivados de pirimidina para tratar el crecimiento celular anomalo.

Info

Publication number: MXPA06011890A
Authority: MX; Mexico
Prior art keywords: ylamino; methyl; alkyl; dihydro; trifluoromethyl
Prior art date: 2004-05-14

Application number

MXPA06011890A

Other languages

English (en)

Spanish (es)

Inventor

Michael Joseph Luzzio

John Charles Kath

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-14

Filing date

2005-05-02

Publication date

2006-12-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34966230&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA06011890(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-05-02 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2006-12-14 Publication of MXPA06011890A publication Critical patent/MXPA06011890A/es

Links

230000002159 abnormal effect Effects 0.000 title claims abstract description 32
230000010261 cell growth Effects 0.000 title claims abstract description 31
229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title abstract description 5
150000003230 pyrimidines Chemical class 0.000 title abstract description 5
150000001875 compounds Chemical class 0.000 claims abstract description 253
238000000034 method Methods 0.000 claims abstract description 40
241000124008 Mammalia Species 0.000 claims abstract description 26
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 15
-1 Methyl- [2- (2-oxo-2,3-dihydro-1 H -indol-5-ylamino) -5-trifluoromethyl-pyrimidin-4-yl] -amino Chemical group 0.000 claims description 489
229910052739 hydrogen Inorganic materials 0.000 claims description 214
239000001257 hydrogen Substances 0.000 claims description 214
125000000753 cycloalkyl group Chemical group 0.000 claims description 187
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 187
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 155
229910052736 halogen Inorganic materials 0.000 claims description 143
150000002367 halogens Chemical class 0.000 claims description 143
125000004093 cyano group Chemical group *C#N 0.000 claims description 124
125000000217 alkyl group Chemical group 0.000 claims description 103
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 78
125000001424 substituent group Chemical group 0.000 claims description 55
150000003839 salts Chemical class 0.000 claims description 36
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 34
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 33
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 25
239000002253 acid Substances 0.000 claims description 22
CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 claims description 20
125000003118 aryl group Chemical group 0.000 claims description 19
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239000000651 prodrug Substances 0.000 claims description 19
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 15
125000004122 cyclic group Chemical group 0.000 claims description 13
125000001072 heteroaryl group Chemical group 0.000 claims description 13
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 13
239000012453 solvate Substances 0.000 claims description 13
125000004429 atom Chemical group 0.000 claims description 12
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125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 11
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 9
229910006074 SO2NH2 Inorganic materials 0.000 claims description 7
229910052757 nitrogen Inorganic materials 0.000 claims description 7
125000000565 sulfonamide group Chemical group 0.000 claims description 7
125000004433 nitrogen atom Chemical group N* 0.000 claims description 5
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125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 claims description 4
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 3
150000003254 radicals Chemical class 0.000 claims description 3
ZHWLRRNXARLYFB-UHFFFAOYSA-N 5-[[4-(3-methylsulfonylpropylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one Chemical compound C1=C(C(F)(F)F)C(NCCCS(=O)(=O)C)=NC(NC=2C=C3CC(=O)NC3=CC=2)=N1 ZHWLRRNXARLYFB-UHFFFAOYSA-N 0.000 claims description 2
125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims description 2
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125000006529 (C3-C6) alkyl group Chemical group 0.000 claims 1
PTHNEPHPWJGZPC-UHFFFAOYSA-N 5-[[4-[(1-methylsulfonylpiperidin-4-yl)amino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one Chemical compound C1CN(S(=O)(=O)C)CCC1NC1=NC(NC=2C=C3CC(=O)NC3=CC=2)=NC=C1C(F)(F)F PTHNEPHPWJGZPC-UHFFFAOYSA-N 0.000 claims 1
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LHWVEFRNRHPEDE-INIZCTEOSA-N 5-[[4-[[(2s)-1-hydroxy-3-phenylpropan-2-yl]amino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one Chemical compound C([C@@H](CO)NC=1C(=CN=C(NC=2C=C3CC(=O)NC3=CC=2)N=1)C(F)(F)F)C1=CC=CC=C1 LHWVEFRNRHPEDE-INIZCTEOSA-N 0.000 claims 1
NIEOCVAXHYUMAL-CYBMUJFWSA-N 5-[[4-[[(3r)-1-methylsulfonylpiperidin-3-yl]amino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one Chemical compound C1N(S(=O)(=O)C)CCC[C@H]1NC1=NC(NC=2C=C3CC(=O)NC3=CC=2)=NC=C1C(F)(F)F NIEOCVAXHYUMAL-CYBMUJFWSA-N 0.000 claims 1
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VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
210000004291 uterus Anatomy 0.000 description 1
210000001215 vagina Anatomy 0.000 description 1
229960002004 valdecoxib Drugs 0.000 description 1
239000002525 vasculotropin inhibitor Substances 0.000 description 1
229940099039 velcade Drugs 0.000 description 1
229960003636 vidarabine Drugs 0.000 description 1
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
229960004528 vincristine Drugs 0.000 description 1
OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
229960002066 vinorelbine Drugs 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
229940087652 vioxx Drugs 0.000 description 1
210000003905 vulva Anatomy 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1
239000012130 whole-cell lysate Substances 0.000 description 1
239000002023 wood Substances 0.000 description 1
239000012224 working solution Substances 0.000 description 1
BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
229960001600 xylazine Drugs 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011592 zinc chloride Substances 0.000 description 1
235000005074 zinc chloride Nutrition 0.000 description 1
XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 description 1
229960004276 zoledronic acid Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

MXPA06011890A 2004-05-14 2005-05-02 Derivados de pirimidina para tratar el crecimiento celular anomalo. MXPA06011890A (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US57131204P	2004-05-14	2004-05-14
PCT/IB2005/001201 WO2005111023A1 (fr)	2004-05-14	2005-05-02	Derives de pyrimidine pour le traitement de la croissance cellulaire anormale

Publications (1)

Publication Number	Publication Date
MXPA06011890A true MXPA06011890A (es)	2006-12-14

Family

ID=34966230

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MXPA06011890A MXPA06011890A (es)	2004-05-14	2005-05-02	Derivados de pirimidina para tratar el crecimiento celular anomalo.

Country Status (27)

Country	Link
EP (1)	EP1751143A1 (fr)
JP (1)	JP4099212B2 (fr)
KR (1)	KR100886990B1 (fr)
CN (2)	CN102127058A (fr)
AP (1)	AP2241A (fr)
AR (1)	AR049097A1 (fr)
AU (2)	AU2005243397A1 (fr)
BR (1)	BRPI0511138A (fr)
CA (1)	CA2566707A1 (fr)
CR (1)	CR8749A (fr)
EA (1)	EA200601796A1 (fr)
EC (1)	ECSP066997A (fr)
GE (1)	GEP20104875B (fr)
GT (1)	GT200500113A (fr)
IL (1)	IL178828A0 (fr)
MA (1)	MA28583B1 (fr)
MX (1)	MXPA06011890A (fr)
NL (2)	NL1029045C2 (fr)
NO (1)	NO20064576L (fr)
NZ (1)	NZ550448A (fr)
PA (1)	PA8632601A1 (fr)
PE (1)	PE20060240A1 (fr)
TN (1)	TNSN06370A1 (fr)
TW (1)	TWI303635B (fr)
UY (1)	UY28894A1 (fr)
WO (1)	WO2005111023A1 (fr)
ZA (1)	ZA200608394B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4812763B2 (ja) *	2004-05-18	2011-11-09	ライジェルファーマシューティカルズ，インコーポレイテッド	シクロアルキル置換ピリミジンジアミン化合物およびそれらの用途
US20070032514A1 (en) *	2005-07-01	2007-02-08	Zahn Stephan K	2,4-diamino-pyrimidines as aurora inhibitors
RS20080272A (sr) *	2005-12-21	2009-07-15	Pfizer Products Inc.,	Derivati pirimidina za tretman neprirodnog rasta ćelija
JP4782239B2 (ja) *	2007-04-18	2011-09-28	ファイザー・プロダクツ・インク	異常細胞増殖治療のためのスルホニルアミド誘導体
BRPI0814432A2 (pt) *	2007-07-17	2017-05-09	Rigel Pharmaceuticals Inc	pirimidinadiaminas substituídas por amina cíclica como inibidores de pkc
US8461147B2 (en) *	2007-12-03	2013-06-11	Boehringer Ingelheim International Gmbh	Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation
EA029131B1 (ru) *	2008-05-21	2018-02-28	Ариад Фармасьютикалз, Инк.	Фосфорсодержащие производные в качестве ингибиторов киназы
US8410126B2 (en) *	2009-05-29	2013-04-02	Boehringer Ingelheim International Gmbh	Pyrimidine inhibitors of PKTK2
WO2011018517A1 (fr)	2009-08-14	2011-02-17	Boehringer Ingelheim International Gmbh	Préparation régiosélective de dérivés de 2-amino-5-trifluorométhylpyrimidine
US8933227B2 (en)	2009-08-14	2015-01-13	Boehringer Ingelheim International Gmbh	Selective synthesis of functionalized pyrimidines
US20120244141A1 (en)	2010-09-28	2012-09-27	Boehringer Ingelheim International Gmbh	Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors
WO2014174745A1 (fr) *	2013-04-26	2014-10-30	国立大学法人京都大学	INHIBITEUR D'Eg5
CN109608444B (zh) *	2018-11-27	2022-02-11	中国药科大学	含异吲哚啉酮的erk抑制剂及其制备方法与用途
CN111732548B (zh) *	2020-06-11	2022-06-17	浙江大学	N2-氨甲酰芳环-2-氨基嘧啶类衍生物及其医药用途
WO2024140671A1 (fr) *	2022-12-29	2024-07-04	南京昕瑞再生医药科技有限公司	Dérivé tricyclique fusionné, composition pharmaceutique le comprenant et son utilisation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9721437D0 (en) *	1997-10-10	1997-12-10	Glaxo Group Ltd	Heteroaromatic compounds and their use in medicine
AR042586A1 (es)	2001-02-15	2005-06-29	Sugen Inc	3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
WO2003030909A1 (fr) *	2001-09-25	2003-04-17	Bayer Pharmaceuticals Corporation	2- et 4-aminopyrimidines n-substituees par un noyau bicyclique utilisees comme inhibiteurs de kinases dans le traitement du cancer
AU2003285614B2 (en) *	2002-12-20	2009-05-14	Pfizer Products, Inc.	Pyrimidine derivatives for the treatment of abnormal cell growth
UA80767C2 (en) *	2002-12-20	2007-10-25	Pfizer Prod Inc	Pyrimidine derivatives for the treatment of abnormal cell growth

2005
- 2005-05-02 MX MXPA06011890A patent/MXPA06011890A/es unknown
- 2005-05-02 BR BRPI0511138-2A patent/BRPI0511138A/pt not_active IP Right Cessation
- 2005-05-02 EA EA200601796A patent/EA200601796A1/ru unknown
- 2005-05-02 WO PCT/IB2005/001201 patent/WO2005111023A1/fr not_active Ceased
- 2005-05-02 AU AU2005243397A patent/AU2005243397A1/en not_active Abandoned
- 2005-05-02 KR KR1020067023767A patent/KR100886990B1/ko not_active Expired - Lifetime
- 2005-05-02 CN CN2011100212904A patent/CN102127058A/zh active Pending
- 2005-05-02 AP AP2006003790A patent/AP2241A/xx active
- 2005-05-02 GE GEAP20059703A patent/GEP20104875B/en unknown
- 2005-05-02 CN CNA2005800155302A patent/CN1953974A/zh active Pending
- 2005-05-02 JP JP2007512557A patent/JP4099212B2/ja not_active Expired - Lifetime
- 2005-05-02 CA CA002566707A patent/CA2566707A1/fr not_active Abandoned
- 2005-05-02 EP EP05732043A patent/EP1751143A1/fr not_active Withdrawn
- 2005-05-02 NZ NZ550448A patent/NZ550448A/en not_active IP Right Cessation
- 2005-05-11 PA PA20058632601A patent/PA8632601A1/es unknown
- 2005-05-11 TW TW094115237A patent/TWI303635B/zh not_active IP Right Cessation
- 2005-05-12 UY UY28894A patent/UY28894A1/es not_active Application Discontinuation
- 2005-05-12 PE PE2005000534A patent/PE20060240A1/es not_active Application Discontinuation
- 2005-05-13 NL NL1029045A patent/NL1029045C2/nl not_active IP Right Cessation
- 2005-05-13 GT GT200500113A patent/GT200500113A/es unknown
- 2005-05-13 AR ARP050101969A patent/AR049097A1/es not_active Application Discontinuation
2006
- 2006-05-19 NL NL1031845A patent/NL1031845C2/nl not_active IP Right Cessation
- 2006-10-06 ZA ZA200608394A patent/ZA200608394B/xx unknown
- 2006-10-09 NO NO20064576A patent/NO20064576L/no not_active Application Discontinuation
- 2006-10-23 IL IL178828A patent/IL178828A0/en unknown
- 2006-11-13 CR CR8749A patent/CR8749A/es not_active Application Discontinuation
- 2006-11-13 EC EC2006006997A patent/ECSP066997A/es unknown
- 2006-11-13 TN TNP2006000370A patent/TNSN06370A1/fr unknown
- 2006-11-14 MA MA29452A patent/MA28583B1/fr unknown
2009
- 2009-11-13 AU AU2009238255A patent/AU2009238255A1/en not_active Ceased

Also Published As

Publication number	Publication date
NO20064576L (no)	2006-11-07
WO2005111023A1 (fr)	2005-11-24
TWI303635B (en)	2008-12-01
GEP20104875B (en)	2010-01-11
MA28583B1 (fr)	2007-05-02
NL1029045A1 (nl)	2005-11-15
CA2566707A1 (fr)	2005-11-24
EP1751143A1 (fr)	2007-02-14
PA8632601A1 (es)	2006-06-02
TW200539871A (en)	2005-12-16
CN1953974A (zh)	2007-04-25
KR20070012477A (ko)	2007-01-25
NZ550448A (en)	2010-11-26
AP2006003790A0 (en)	2006-10-31
JP4099212B2 (ja)	2008-06-11
NL1031845A1 (nl)	2006-07-31
IL178828A0 (en)	2007-03-08
NL1031845C2 (nl)	2006-11-23
AR049097A1 (es)	2006-06-28
JP2007537234A (ja)	2007-12-20
ZA200608394B (en)	2008-05-28
KR100886990B1 (ko)	2009-03-04
AP2241A (en)	2011-06-01
BRPI0511138A (pt)	2007-11-27
TNSN06370A1 (fr)	2008-02-22
PE20060240A1 (es)	2006-04-01
AU2005243397A1 (en)	2005-11-24
ECSP066997A (es)	2007-02-28
CR8749A (es)	2006-12-05
CN102127058A (zh)	2011-07-20
AU2009238255A1 (en)	2009-12-03
NL1029045C2 (nl)	2006-06-02
GT200500113A (es)	2006-01-10
UY28894A1 (es)	2005-12-30
EA200601796A1 (ru)	2007-04-27

Publication	Publication Date	Title
US7208499B2 (en)	2007-04-24	Pyrimidine derivatives for the treatment of abnormal cell growth
US7109337B2 (en)	2006-09-19	Pyrimidine derivatives for the treatment of abnormal cell growth
EP1625121B1 (fr)	2010-02-24	Derives de pyrimidine destines au traitement de la croissance cellulaire anormale
US7145008B2 (en)	2006-12-05	Pyrimidine derivatives for the treatment of abnormal cell growth
NL2000375C2 (nl)	2008-01-03	Pyrimidinederivaten voor de behandeling van abnormale celgroei.
AU2009238255A1 (en)	2009-12-03	Pyrimidine derivatives for the treatment of abnormal cell growth
MXPA06013165A (es)	2007-02-13	Derivados de pirimidina para el tratamiento de crecimiento de celulas anormal.
US20060205945A1 (en)	2006-09-14	Pyrimidine derivatives for the treatment of abnormal cell growth
HK1105203A (en)	2008-02-06	Pyrimidine derivatives for the treatment of abnormal cell growth
HK1158210A (en)	2012-07-13	Pyrimidine derivatives for the treatment of abnormal cell growth