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AR047902A1 - Compuestos como inhibidores de ns3 serina proteasa del virus de hepatitis c - Google Patents

Compuestos como inhibidores de ns3 serina proteasa del virus de hepatitis c

Info

Publication number
AR047902A1
AR047902A1 ARP050100720A ARP050100720A AR047902A1 AR 047902 A1 AR047902 A1 AR 047902A1 AR P050100720 A ARP050100720 A AR P050100720A AR P050100720 A ARP050100720 A AR P050100720A AR 047902 A1 AR047902 A1 AR 047902A1
Authority
AR
Argentina
Prior art keywords
alkyl
heterocyclyl
heteroaryl
aryl
cycloalkyl
Prior art date
Application number
ARP050100720A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AR047902A1 publication Critical patent/AR047902A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Compuestos los cuales tienen actividad inhibitoria de la proteasa del VHC así como también métodos para preparar ese tipo de compuestos. Entre otros, composiciones farmacéuticas que comprende ese tipo de compuestos así como también métodos para su utilizacion para tratar trastornos asociados con la proteasa de VHC. Reivindicacion 1: Un compuesto o enantiomeros, estereoisomeros, rotámeros, tautomeros, diastereomeros y racematos de dicho compuesto, o una sal, solvato o éster de dicho compuesto farmacéuticamente aceptable, teniendo dicho compuesto la estructura general mostrada en la formula (1), en la cual: R1 es H, OR8, NR9R10, o CHR9R10, en la cual R8, R9 y R10 pueden ser iguales o diferentes, siendo cada uno seleccionado independientemente del grupo formado por H, alquil-, alquenil-, alquinil-, aril-, heteroalquil-, heteroaril-, cicloalquil-, heterociclil-, arilalquil-, y heteroarilalquilo; A y M pueden ser iguales o diferentes, siendo cada uno seleccionado independientemente entre R, NR9R10, SR, SO2R, y halo; o A y M están conectados entre sí (en otras palabras A-E-L-M tomados en forma conjunta) de modo que la porcion de formula (2), que se muestra anteriormente en la formula (1) forma ya sea un cicloalquilo de tres, cuatro, seis u ocho miembros, un heterociclilo de cuatro a ocho miembros, un arilo de seis a diez miembros, o un heteroarilo de cinco a diez miembros; E es C(H) o C(R); L es C(H), C(R), CH2C(R), o C(R)CH2; R, R', R2, y R3 pueden ser iguales o diferentes, siendo cada uno seleccionado independientemente del grupo formado por H, alquil-, alquenil-, alquinil-, cicloalquil-, heteroalquil-, heterociclil-, aril-, heteroaril-, (cicloalquil)alquil-, (heterociclil)alquil-, aril-alquil- y heteroaril-alquil-; o alternativamente R y R' en NRR' están conectados entre sí de modo que NR9R10 forma un heterociclilo de cuatro a ocho miembros; Y se selecciona de las porciones de grupo formulas (3), donde Y30 e Y31 se seleccionan entre el grupo de formulas (3); X se selecciona entre O, NR15, N(C)R16, S, S(O) y SO2; G es NH o O; y R15, R16, R17, R18, R19, T1, T2, T3 y T4 pueden ser iguales o diferentes, siendo cada uno seleccionado independientemente del grupo formado por H, alquilo, heteroalquilo, alquenilo, heteroalquenilo, alquinilo, heteroalquinilo, cicloalquilo, heterociclilo, arilo, arilalquilo, heteroarilo y heteroarilalquilo, o alternativamente, R17 y R18 están conectados entre sí para formar un cicloalquilo o heterociclilo de tres a ocho miembros; donde cada uno de dicho alquilo, arilo, heteroarilo, cicloalquilo o heterociclilo puede estar no sustituido u opcionalmente independientemente sustituidos con una o más porciones seleccionados del grupo formado por: hidroxi, alcoxi, ariloxi, tio, alquiltio, ariltio, amino, amido, alquilamino, arilamino, alquilsulfonilo, arilsulfonilo, sulfonamido, alquilo, arilo, heteroarilo, alquilsulfonamido, arilsulfonamido, ceto, carboxi, carbalcoxi, carboxamido, alcoxicarbonilamino, alcoxicarboniloxi, alquilureido, arilureido, halo, ciano y nitro.
ARP050100720A 2004-02-27 2005-02-25 Compuestos como inhibidores de ns3 serina proteasa del virus de hepatitis c AR047902A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54850704P 2004-02-27 2004-02-27

Publications (1)

Publication Number Publication Date
AR047902A1 true AR047902A1 (es) 2006-03-01

Family

ID=34962171

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050100720A AR047902A1 (es) 2004-02-27 2005-02-25 Compuestos como inhibidores de ns3 serina proteasa del virus de hepatitis c

Country Status (16)

Country Link
US (3) US7192957B2 (es)
EP (1) EP1748983A2 (es)
JP (1) JP2007525510A (es)
KR (1) KR20060127162A (es)
CN (1) CN1946691A (es)
AR (1) AR047902A1 (es)
AU (1) AU2005222055A1 (es)
BR (1) BRPI0508095A (es)
CA (1) CA2557247A1 (es)
EC (1) ECSP066795A (es)
IL (1) IL177545A0 (es)
NO (1) NO20064356L (es)
RU (1) RU2006134005A (es)
TW (1) TW200602037A (es)
WO (1) WO2005087721A2 (es)
ZA (1) ZA200607104B (es)

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AU2005222055A1 (en) 2005-09-22
US7192957B2 (en) 2007-03-20
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RU2006134005A (ru) 2008-04-10
US20050288233A1 (en) 2005-12-29
US7759499B2 (en) 2010-07-20
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CN1946691A (zh) 2007-04-11
WO2005087721A2 (en) 2005-09-22
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TW200602037A (en) 2006-01-16
CA2557247A1 (en) 2005-09-22
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IL177545A0 (en) 2006-12-10
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