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NO20073357L - 5-karboksamid substituerte tiazol derivater som reagerer med ionekanaler, i saerdeleshet med ionekanaler fra Kv familien - Google Patents

5-karboksamid substituerte tiazol derivater som reagerer med ionekanaler, i saerdeleshet med ionekanaler fra Kv familien

Info

Publication number
NO20073357L
NO20073357L NO20073357A NO20073357A NO20073357L NO 20073357 L NO20073357 L NO 20073357L NO 20073357 A NO20073357 A NO 20073357A NO 20073357 A NO20073357 A NO 20073357A NO 20073357 L NO20073357 L NO 20073357L
Authority
NO
Norway
Prior art keywords
ion channels
react
compounds
family
thiazole derivatives
Prior art date
Application number
NO20073357A
Other languages
English (en)
Inventor
Petra Blom
Jan Octaaf De Kerpel
Eric Pierre Paul Fourmaintraux
Titus Jan Kaletta
Dirk Leysen
Original Assignee
Devgen Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Devgen Nv filed Critical Devgen Nv
Publication of NO20073357L publication Critical patent/NO20073357L/no

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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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Abstract

Foreliggende oppfinnelse angår forbindelser som reagerer med ionekanaler. Særlig er oppfinnelsen rettet mot forbindelser som har strukturformel I, II, III eller IV stereoisomerer, tautomerer, rasemiske, promedikamenter, metabolitter derav eller et farmasøytisk akseptabelt salt eller solvat derav, der X, Y1, Y2, R''n, R3, R8, R9, R10, L1, L2, Ar1 og Ar2 er definert i krav 1. Oppfinnelsen angår også fremgangsmåter for fremstilling av nevnte forbindelser, farmasøytiske sammensetninger som omfatter nevnte forbindelser, og anvendelse av nevnte forbindelser i fremgangsmåter for behandling av det menneskelige og animalske legemet.
NO20073357A 2004-12-01 2007-06-29 5-karboksamid substituerte tiazol derivater som reagerer med ionekanaler, i saerdeleshet med ionekanaler fra Kv familien NO20073357L (no)

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US63207204P 2004-12-01 2004-12-01
EP04447268 2004-12-01
US68691205P 2005-06-03 2005-06-03
EP05077177 2005-09-22
PCT/EP2005/056390 WO2006058905A1 (en) 2004-12-01 2005-12-01 5-CARBOXAMIDO SUBSTITUTED THIAZOLE DERIVATIVES THAT INTERACT WITH ION CHANNELS, IN PARTICULAR WITH ION CHANNELS FROM THE Kv FAMILY

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