AR031905A1 - Peptidos diarilicos como inhibidores de ns3-serina proteasa en hepatitis de virus c - Google Patents
Peptidos diarilicos como inhibidores de ns3-serina proteasa en hepatitis de virus cInfo
- Publication number
- AR031905A1 AR031905A1 ARP010105721A ARP010105721A AR031905A1 AR 031905 A1 AR031905 A1 AR 031905A1 AR P010105721 A ARP010105721 A AR P010105721A AR P010105721 A ARP010105721 A AR P010105721A AR 031905 A1 AR031905 A1 AR 031905A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- cycloalkyl
- present
- heteroaryl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 208000006454 hepatitis Diseases 0.000 title 1
- 231100000283 hepatitis Toxicity 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- -1 enantiomers Chemical class 0.000 abstract 28
- 125000000217 alkyl group Chemical group 0.000 abstract 21
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 13
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 11
- 125000003118 aryl group Chemical group 0.000 abstract 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 8
- 125000001072 heteroaryl group Chemical group 0.000 abstract 8
- 229910052760 oxygen Inorganic materials 0.000 abstract 8
- 125000003342 alkenyl group Chemical group 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 7
- 125000000623 heterocyclic group Chemical group 0.000 abstract 7
- 229910052757 nitrogen Inorganic materials 0.000 abstract 7
- 125000004414 alkyl thio group Chemical group 0.000 abstract 6
- 125000005110 aryl thio group Chemical group 0.000 abstract 6
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 5
- 125000003282 alkyl amino group Chemical group 0.000 abstract 5
- 125000000304 alkynyl group Chemical group 0.000 abstract 5
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 5
- 125000004104 aryloxy group Chemical group 0.000 abstract 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 5
- 125000005213 alkyl heteroaryl group Chemical group 0.000 abstract 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 4
- 125000001769 aryl amino group Chemical group 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 3
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 abstract 3
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 3
- 125000005100 aryl amino carbonyl group Chemical group 0.000 abstract 3
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
- 239000004202 carbamide Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- 229910052698 phosphorus Inorganic materials 0.000 abstract 3
- 239000011593 sulfur Substances 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
- 125000005422 alkyl sulfonamido group Chemical group 0.000 abstract 2
- 125000004422 alkyl sulphonamide group Chemical group 0.000 abstract 2
- 125000005281 alkyl ureido group Chemical group 0.000 abstract 2
- 125000003368 amide group Chemical group 0.000 abstract 2
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 2
- 125000005421 aryl sulfonamido group Chemical group 0.000 abstract 2
- 125000004421 aryl sulphonamide group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 2
- 125000005226 heteroaryloxycarbonyl group Chemical group 0.000 abstract 2
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 abstract 2
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 2
- 239000011574 phosphorus Substances 0.000 abstract 2
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 abstract 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000006325 2-propenyl amino group Chemical group [H]C([H])=C([H])C([H])([H])N([H])* 0.000 abstract 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000001397 3-pyrrolyl group Chemical group [H]N1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- KDDQRKBRJSGMQE-UHFFFAOYSA-N 4-thiazolyl Chemical group [C]1=CSC=N1 KDDQRKBRJSGMQE-UHFFFAOYSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 125000004947 alkyl aryl amino group Chemical group 0.000 abstract 1
- 150000001346 alkyl aryl ethers Chemical class 0.000 abstract 1
- 150000004789 alkyl aryl sulfoxides Chemical class 0.000 abstract 1
- 150000005215 alkyl ethers Chemical class 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 150000008378 aryl ethers Chemical class 0.000 abstract 1
- 125000005135 aryl sulfinyl group Chemical group 0.000 abstract 1
- 125000005362 aryl sulfone group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005222 heteroarylaminocarbonyl group Chemical group 0.000 abstract 1
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 abstract 1
- 125000005150 heteroarylsulfinyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004437 phosphorous atom Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Un compuesto, incluyendo enantiomeros, estereoisomeros, rotomeros y tautomeros de dicho compuesto, y sales, solvatos o derivados de los mismos farmacéuticamente aceptable, donde dicho compuesto tiene la estructura general que se muestra en la formula (1) en la cual X e Y están independientemente seleccionados de las porciones: alquilo, alquil-arilo, heteroalquilo, heteroarilo, aril-heteroarilo, alquil-heteroarilo, cicloalquilo, éter alquílico, éter alquil-arílico, éter arílico, alquil amino, aril amino, alquil-aril amino, alquil tio, alquil-aril tio, aril tio, alquil sulfona, alquil-aril sulfona, aril sulfona, sulfoxido de alquil-alquilo, sulfoxido de alquil-arilo, alquil amida, alquil aril amida, aril amida, alquil sulfonamida, alquil-aril sulfonamida, aril sulfonamida, alquil urea, alquil-aril urea, aril urea, carbamato de alquilo, carbamato de alquil-arilo, carbamato de arilo, alquil-hidrazida, alquil-aril hidrazida, alquil hidroxamida, alquil-aril hidroxamida, alquil sulfonilo, aril sulfonilo, heteroalquil sulfonilo, heteroaril sulfonilo, alquil carbonilo, aril carbonilo, heteroalquil carbonilo, heteroaril carbonilo, alcoxicarbonilo, ariloxicarbonilo, heteroariloxicarbonilo, alquilaminocarbonilo, arilaminocarbonilo, heteroarilaminocarbonilo o una combinacion de los mismos con la condicion de que X e Y pueden estar opcionalmente adicionalmente sustituidos con X11 o X12; X11 es alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquil-alquilo, heterociclilo, heterociclilalquilo, arilo, alquilarilo, arilalquilo, heteroarilo, alquilheteroarilo, o heteroarilalquilo con la condicion de que X11 puede estar opcionalmente adicionalmente sustituido con X12; X12 es hidroxi, alcoxi, ariloxi, tio, alquiltio, ariltio, amino, alquilamino, arilamino, alquilsulfonilo, arilsulfonilo, alquilsulfonamido, arilsulfonamido, carboxi, carbalcoxi, carboxamido, alcoxicarbonilamino, alcoxicarboniloxi, alquilureido, arilureido, halogeno, ciano o nitro, con la condicion de que dicho alquilo, alcoxi y arilo pueden estar opcionalmente adicionalmente sustituidos con porciones independientemente seleccionadas de X12; W puede estar presente o ausente; y si W está presente, W está seleccionada de C=O, C=S o SO2; Q puede estar presente o ausente y cuando Q está presente, Q es CH, N, P, (CH2)p (CHR)p, (CRR')p, O, RNR, S, o SO2; y cuando Q está ausente, M está también ausente, A está directamente ligado a X; A es O, CH2, (CHR)p, (CHR-CHR')p, (CRR')p, NR, S, SO2 o un enlace; U está seleccionado entre O, N o CH; E es CH, N o CR o un doble enlace hacia A, L o G; G puede estar presente o ausente, y cuando G está presente, G es (CH2)p, (CHR)p o (CRR')p; y cuando G está ausente, J está presente y E está directamente conectado al átomo de carbono al que estaba conectado G; J puede estar ausente o presente , y cuando J está presente, J es (CH2)P, (CHR)P o (CRR')P, SO2, NH, NR u O; y cuando J está ausente, G está presente y L está directamente ligado a nitrogeno; L puede estar presente o ausente, y cuando L está presente, L es CH, CR, O, S O NR; y cuando L está ausente, entonces M puede estar ausente o presente, y si M está presente estando Lausente, entonces M está directa e independientemente ligado a E; y J está directa e independientemente ligado a E; M puede estar presente o ausente, y cuando M está presente, M es O, NR, S, SO2, (CH2)p, (CHR)p, (CHR-CHR')p, o (CRR')p; p es un numero de 0 a 6; R y R' están independientemente seleccionados del grupo que consiste en H, alquilo C1-10; alquenilo C2-10; cicloalquilo C3-8; heterocicloalquilo C3-8; alcoxi, ariloxi, alquiltio, ariltio, amino, amido, ciano, nitro; (cicloalquil)-alquilo y (heterocicloalquil)alquilo, donde dicho cicloalquilo está constituido por tres a ocho átomos de carbono, y cero a seis átomos de oxígeno, nitrogeno, azufre, o fosforo, y dicho alquilo es de uno a seis átomos de carbono; arilo; heteroarilo; alquil-arilo; y alquil-heteroarilo; donde dichas porciones alquilo, heteroalquilo, alquenilo, heteroalquenilo, arilo, heteroarilo, cicloalquilo, y heterocicloalquilo pueden estar opcionalmente sustituidas, donde dicho término "sustituido", se refiere a la sustitucion opcional y apropiada con una o más porciones seleccionadas del grupo que consiste en: alquilo, alquenilo, alquinilo, arilo, aralquilo, cicloalquilo, heterocíclico, halogeno, hidroxi, tio, alcoxi, ariloxi, alquiltio, ariltio, amino, amido, ciano, nitro sulfonamido; y P1a, P1b, P1' y P3 están independientemente seleccionados de: H, alquilo C1-10 de cadena recta o ramificada, alquenilo C2-10 de cadena recta o ramificada y cicloalquilo C3-8, heterocíclico C3-8; (cicloalquil)-alquilo o (heterociclil)alquilo, donde dicho cicloalquilo está constituido por tres a ocho átomos de carbono y cero a seis átomos de oxígeno, nitrogeno, azufre o fosforo, y dicho alquilo es de 1 a 6 átomos de carbono; arilo, heteroarilo, arilalquilo o heteroarilalquilo, donde dicho alquilo es de 1 a 6 átomos de carbono; donde dichas porciones alquilo, alquenilo, cicloalquilo, heterociclilo; (cicloalquil)alquilo y (heterociclil)alquilo pueden estar opcionalmente sustituidas con R", y además dicha P1a y P1b pueden estar opcionalmente unidos entre sí para formar un anillo espirocíclico o espiroheterocíclico, donde dicho anillo espirocíclico o espiroheterocíclico que contiene cero a seis átomos de oxígeno, nitrogeno, azufre o fosforo, puede estar adicionalmente sustituido opcionalmente con R"; R" es una porcion hidroxi, alcoxi, ariloxi, tio, alquiltio, ariltio, amino, alquilamino, arilamino, alquilsulfonilo, arilsulfonilo, alquilsulfonamido, arilsulfonamido, carboxi, carbalcoxi, carboxamido, alcoxicarbonilamino, alcoxicarboniloxi, alquilureido, arilureido, halogeno, ciano, o nitro con la condicion de que la porcion alquilo, alcoxi y arilo puede estar opcionalmente adicionalmente sustituidas con porciones independientemente seleccionadas de R"; Z es O, NH o NR'''; R''' es una porcion alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquil-alquilo, heterociclilo, heterociclilalquilo, arilo, alquilarilo, arilalquilo, heteroarilo, alquilheteroarilo, o heteroarilalquilo, con la condicion de que R''' puede estar adicionalmente opcionalmente sustituida con R"; Ar1 y Ar2 están independientemente seleccionados de fenilo; 2-piridilo, 3-piridilo, 4-piridilo o sus N-oxidos correspondientes; 2-tiofenilo; 3-tiofenilo; 2-furanilo; 3-furanilo; 2-pirrolilo; 3-pirrolilo; 2-imidazolilo; 3-(4-imidazolilo); 3-(1,2,4-triazolilo), 5-tetrazolilo; 2-tiazolilo; 4-tiazolilo; 2-oxazolilo; o 4-oxazolilo; cualquiera o ambos de los cuales pueden estar opcionalmente sustituidos con R1; R1 es H, halogeno, ciano, nitro, CF3, Si(alquilo)3, alquilo inferior de cadena recta o ramificada, alquenilo, alquinilo, cicloalquilo, cicloalquil-alquilo, arilo, alquilarilo, arilalquilo, heteroarilo, hidroxi, alcoxi, ariloxi, alcoxicarboniloxi, (alquilamino)carboniloxi, mercapto, alquiltio, ariltio, alquilsulfinilo, heterociclilsulfinilo, arilsulfinilo, heteroarilsulfinilo, alquilsulfonilo, heterociclilsulfonilo, arilsulfonilo, heteroarilsulfonilo, alquilcarbonilo, arilcarbonilo, carboxi, alcoxicarbonilo, ariloxicarbonilo, heteroariloxicarbonilo, alquilaminocarbonilo, arilaminocarbonilo, amino, alquilamino, arilamino, alquilsulfonamida, arilsulfonamida, alcoxicarbonilamino, alquilureido, o arilureido; P4 es H, alquilo lineal o ramificado, arilalquilo o arilo; y R2 es H, ciano, CF3, alquilo inferior de cadena recta o ramificada, alquenilo, alquinilo, cicloalquilo, cicloalquil-alquilo, arilo, alquilarilo, arilalquilo, heteroarilo, alquilsulfonilo, arilsulfonilo, carboxi, alcoxicarbonilo, ariloxicarbonilo, alquilaminocarbonilo, (alilamino)carbonilo o arilaminocarbonilo. Son utiles como inhibidores de NS3-serina proteasa.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25486900P | 2000-12-12 | 2000-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR031905A1 true AR031905A1 (es) | 2003-10-08 |
Family
ID=22965900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010105721A AR031905A1 (es) | 2000-12-12 | 2001-12-10 | Peptidos diarilicos como inhibidores de ns3-serina proteasa en hepatitis de virus c |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6911428B2 (es) |
| EP (1) | EP1343807B1 (es) |
| JP (1) | JP4368581B2 (es) |
| KR (1) | KR20030091946A (es) |
| CN (1) | CN1301994C (es) |
| AR (1) | AR031905A1 (es) |
| AT (1) | ATE430166T1 (es) |
| AU (2) | AU2002236591B2 (es) |
| CA (1) | CA2430458A1 (es) |
| DE (1) | DE60138567D1 (es) |
| ES (1) | ES2324594T3 (es) |
| HK (1) | HK1054394B (es) |
| HU (1) | HUP0303436A2 (es) |
| IL (1) | IL155842A0 (es) |
| MX (1) | MXPA03005219A (es) |
| PE (1) | PE20020691A1 (es) |
| WO (1) | WO2002048172A2 (es) |
| ZA (1) | ZA200304382B (es) |
Families Citing this family (169)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69709671T2 (de) | 1996-10-18 | 2002-08-22 | Vertex Pharmaceuticals Inc., Cambridge | Inhibitoren von serinproteasen, insbesondere von ns3-protease des hepatitis-c-virus |
| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| MY140819A (en) | 2002-06-28 | 2010-01-29 | Idenix Caymans Ltd | Modified 2' and 3'-nucleoside prodrugs for treating flaviviridae |
| EP1408031A1 (en) * | 2002-10-09 | 2004-04-14 | 3 D Gene Pharma | Pyrolidine derivatives useful in treatment of hepatitis C virus infection |
| CA2734052A1 (en) | 2003-05-30 | 2005-01-13 | Pharmasset, Inc. | Modified fluorinated nucleoside analogues |
| CN1852915A (zh) | 2003-07-25 | 2006-10-25 | 艾登尼科斯（开曼）有限公司 | 治疗包括丙型肝炎的黄病毒科病毒所致疾病的嘌呤核苷类似物 |
| EP1664090A2 (en) | 2003-08-26 | 2006-06-07 | Schering Corporation | Novel peptidomimetic ns3-serine protease inhibitors of hepatitis c virus |
| UY28500A1 (es) | 2003-09-05 | 2005-04-29 | Vertex Pharma | Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc. |
| BRPI0414814A (pt) | 2003-09-26 | 2006-11-14 | Schering Corp | inibidores macrocìclicos de protease de serina ns3 de vìrus de hepatite c |
| CN1902216A (zh) | 2003-11-20 | 2007-01-24 | 先灵公司 | 丙肝病毒ns3蛋白酶的去肽化抑制剂 |
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| US20170135990A1 (en) | 2014-03-05 | 2017-05-18 | Idenix Pharmaceuticals Llc | Pharmaceutical compositions comprising a 5,5-fused heteroarylene flaviviridae inhibitor and their use for treating or preventing flaviviridae infection |
| EP3114122A1 (en) | 2014-03-05 | 2017-01-11 | Idenix Pharmaceuticals LLC | Solid forms of a flaviviridae virus inhibitor compound and salts thereof |
| EP3113763A1 (en) | 2014-03-05 | 2017-01-11 | Idenix Pharmaceuticals LLC | Solid prodrug forms of 2'-chloro-2'-methyl uridine for hcv |
| WO2015161137A1 (en) | 2014-04-16 | 2015-10-22 | Idenix Pharmaceuticals, Inc. | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
| WO2016003812A1 (en) | 2014-07-02 | 2016-01-07 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and uses therof |
| CN105153005A (zh) * | 2015-08-05 | 2015-12-16 | 上海瑞博化学有限公司 | 一种4-羰基-脯氨酸衍生物的制备方法 |
| WO2018050631A1 (en) * | 2016-09-13 | 2018-03-22 | Haplogen Gmbh | Antiviral compounds |
| AU2019207625A1 (en) | 2018-01-09 | 2020-07-30 | Ligand Pharmaceuticals, Inc. | Acetal compounds and therapeutic uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341629C (en) | 1987-11-18 | 2012-05-08 | Chiron Corporation | Hepatitis c diagnostics and vaccines |
| EP0381216B1 (en) | 1989-02-01 | 1995-12-27 | Asahi Glass Company Ltd. | Hydrochlorofluorocarbon azeotropic or azeotropic-like mixture |
| EP1304335B1 (en) | 1990-04-04 | 2009-06-10 | Novartis Vaccines and Diagnostics, Inc. | Hepatitis C virus protease |
| AU4156197A (en) | 1996-08-21 | 1998-03-06 | Hybridon, Inc. | Oligonucleotide prodrugs |
| DE69709671T2 (de) | 1996-10-18 | 2002-08-22 | Vertex Pharmaceuticals Inc., Cambridge | Inhibitoren von serinproteasen, insbesondere von ns3-protease des hepatitis-c-virus |
| GB9623908D0 (en) | 1996-11-18 | 1997-01-08 | Hoffmann La Roche | Amino acid derivatives |
| AR022061A1 (es) | 1998-08-10 | 2002-09-04 | Boehringer Ingelheim Ca Ltd | Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos. |
| US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| NZ521456A (en) * | 2000-04-19 | 2004-07-30 | Schering Corp | Macrocyclic NS3-Serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties |
| ATE461207T1 (de) * | 2000-07-21 | 2010-04-15 | Schering Corp | Peptide als inhibitoren der ns3-serinprotease des hepatitis c virus |
| US7169760B2 (en) * | 2000-07-21 | 2007-01-30 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
-
2001
- 2001-12-10 HU HU0303436A patent/HUP0303436A2/hu unknown
- 2001-12-10 CA CA002430458A patent/CA2430458A1/en not_active Abandoned
- 2001-12-10 CN CNB018204759A patent/CN1301994C/zh not_active Expired - Fee Related
- 2001-12-10 JP JP2002549703A patent/JP4368581B2/ja not_active Expired - Fee Related
- 2001-12-10 EP EP01986126A patent/EP1343807B1/en not_active Expired - Lifetime
- 2001-12-10 HK HK03106692.5A patent/HK1054394B/en not_active IP Right Cessation
- 2001-12-10 KR KR10-2003-7007731A patent/KR20030091946A/ko not_active Withdrawn
- 2001-12-10 MX MXPA03005219A patent/MXPA03005219A/es active IP Right Grant
- 2001-12-10 ES ES01986126T patent/ES2324594T3/es not_active Expired - Lifetime
- 2001-12-10 AU AU2002236591A patent/AU2002236591B2/en not_active Expired - Fee Related
- 2001-12-10 IL IL15584201A patent/IL155842A0/xx unknown
- 2001-12-10 DE DE60138567T patent/DE60138567D1/de not_active Expired - Lifetime
- 2001-12-10 AT AT01986126T patent/ATE430166T1/de not_active IP Right Cessation
- 2001-12-10 US US10/013,071 patent/US6911428B2/en not_active Expired - Fee Related
- 2001-12-10 AU AU3659102A patent/AU3659102A/xx active Pending
- 2001-12-10 AR ARP010105721A patent/AR031905A1/es unknown
- 2001-12-10 WO PCT/US2001/047383 patent/WO2002048172A2/en not_active Ceased
- 2001-12-11 PE PE2001001236A patent/PE20020691A1/es not_active Application Discontinuation
-
2003
- 2003-06-04 ZA ZA200304382A patent/ZA200304382B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004532812A (ja) | 2004-10-28 |
| US6911428B2 (en) | 2005-06-28 |
| WO2002048172A2 (en) | 2002-06-20 |
| JP4368581B2 (ja) | 2009-11-18 |
| DE60138567D1 (de) | 2009-06-10 |
| HUP0303436A2 (hu) | 2004-01-28 |
| HK1054394B (en) | 2009-09-25 |
| IL155842A0 (en) | 2003-12-23 |
| EP1343807A2 (en) | 2003-09-17 |
| CA2430458A1 (en) | 2002-06-20 |
| US20020147139A1 (en) | 2002-10-10 |
| KR20030091946A (ko) | 2003-12-03 |
| CN1301994C (zh) | 2007-02-28 |
| CN1501942A (zh) | 2004-06-02 |
| MXPA03005219A (es) | 2003-09-25 |
| EP1343807B1 (en) | 2009-04-29 |
| ZA200304382B (en) | 2004-09-13 |
| AU3659102A (en) | 2002-06-24 |
| WO2002048172A3 (en) | 2003-06-19 |
| ES2324594T3 (es) | 2009-08-11 |
| PE20020691A1 (es) | 2002-08-03 |
| AU2002236591B2 (en) | 2005-07-14 |
| HK1054394A1 (en) | 2003-11-28 |
| ATE430166T1 (de) | 2009-05-15 |
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