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AR039819A1 - Solucion protectora para evitar danos isquemicos en organos - Google Patents

Solucion protectora para evitar danos isquemicos en organos

Info

Publication number
AR039819A1
AR039819A1 ARP030101726A ARP030101726A AR039819A1 AR 039819 A1 AR039819 A1 AR 039819A1 AR P030101726 A ARP030101726 A AR P030101726A AR P030101726 A ARP030101726 A AR P030101726A AR 039819 A1 AR039819 A1 AR 039819A1
Authority
AR
Argentina
Prior art keywords
organs
avoid
ischemical
damages
protective solution
Prior art date
Application number
ARP030101726A
Other languages
English (en)
Original Assignee
Koehler Chemie Dr Franz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koehler Chemie Dr Franz filed Critical Koehler Chemie Dr Franz
Publication of AR039819A1 publication Critical patent/AR039819A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Surgery (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)

Abstract

Se describe una solución para evitar danos isquémicos en los órganos, o en sistemas celulares o partes de tejidos, aislados, después de la perfusión, operación, transplante o crio-conservación y subsiguiente perfusión, que a título de electrolitos contiene iones alcalinos y/o alcalino-térreos, un tampón como también un poliol y/o un azúcar, presenta una osmolaridad de aproximadamente 290 mosm/l a aproximadamente 350 mosm/l como también un pH de aproximadamente 6,8 a aproximadamente 7,4, y a la cual son adicionados ácido hidroxámico y/o uno o más derivados de ácido hidroxámico.
ARP030101726A 2002-05-17 2003-05-16 Solucion protectora para evitar danos isquemicos en organos AR039819A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10222561A DE10222561B4 (de) 2002-05-17 2002-05-17 Protektive Lösung zur Verhinderung von Ischämieschäden

Publications (1)

Publication Number Publication Date
AR039819A1 true AR039819A1 (es) 2005-03-02

Family

ID=29265373

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP030101726A AR039819A1 (es) 2002-05-17 2003-05-16 Solucion protectora para evitar danos isquemicos en organos
ARP140104816A AR098880A2 (es) 2002-05-17 2014-12-19 Solución protectora para prevenir daños isquémicos en los órganos o en sistemas celulares aislados o en componentes de tejido después de la perfusión, operación, transplante o crio-conservación y subsiguiente reperfusión

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP140104816A AR098880A2 (es) 2002-05-17 2014-12-19 Solución protectora para prevenir daños isquémicos en los órganos o en sistemas celulares aislados o en componentes de tejido después de la perfusión, operación, transplante o crio-conservación y subsiguiente reperfusión

Country Status (13)

Country Link
US (2) US7977383B2 (es)
EP (2) EP1362511B1 (es)
JP (1) JP4603246B2 (es)
KR (2) KR101014990B1 (es)
CN (1) CN100448440C (es)
AR (2) AR039819A1 (es)
AT (2) ATE446676T1 (es)
BR (1) BRPI0301159B8 (es)
CA (1) CA2429097C (es)
DE (4) DE10222561B4 (es)
DK (1) DK1859679T3 (es)
ES (2) ES2335145T3 (es)
MX (1) MXPA03004315A (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10222561B4 (de) 2002-05-17 2009-12-10 Dr. Franz Köhler Chemie GmbH Protektive Lösung zur Verhinderung von Ischämieschäden
EP1744761A4 (en) 2004-04-28 2010-01-13 Molecules For Health Inc METHOD FOR THE TREATMENT OR PREVENTION OF RESTENOSIS AND OTHER PROLIFERATIVE VASCULAR DISORDER
US9237744B2 (en) * 2004-05-26 2016-01-19 National University Corporation Kagawa University Preservative solution for cells, tissues and organs containing rare sugar and preservative method thereof
DE102007026392A1 (de) * 2007-06-06 2008-12-11 Bayer Healthcare Ag Lösungen für die Perfusion und Konservierung von Organen und Geweben
US9526707B2 (en) 2007-08-13 2016-12-27 Howard L. Elford Methods for treating or preventing neuroinflammation or autoimmune diseases
US8835104B2 (en) 2007-12-20 2014-09-16 Fenwal, Inc. Medium and methods for the storage of platelets
EP2611291B1 (en) * 2010-09-01 2020-03-25 Perfusion Fluid Technologies, Inc. Perfusion composition
AU2012240016B2 (en) 2011-04-07 2016-11-10 Fenwal, Inc. Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates
BRPI1101935B1 (pt) * 2011-04-15 2017-12-12 Universidade Federal De Minas Gerais Antioxidant composition for preservation of organs and fabrics
DE102012005177A1 (de) 2012-03-16 2013-09-19 Bitop Ag Organlagerlösung
NL2010010C2 (en) * 2012-12-19 2014-06-23 Sulfateq B V Compounds for protection of cells.
CN103238586B (zh) * 2013-03-28 2014-03-26 辽宁亿灵科创生物医药科技有限公司 一种心肌脏器保存液制备方法
EP2821081A1 (en) * 2013-07-05 2015-01-07 ResuSciTec GmbH Protective solution for preventing or reducing reperfusion injury of the brain and the whole body
MX2021011641A (es) 2013-12-24 2023-03-10 Durect Corp Usos de sulfatos de colesterol oxigenados (soc).
US10285962B2 (en) 2016-05-01 2019-05-14 The Regents Of The University Of California Glutarate compounds for treating ischemia-reperfusion injuries
DE102016125414A1 (de) 2016-12-22 2018-06-28 Bitop Ag Zusammensetzung enthaltend N-Acetyldiaminobuttersäure
CN110536687B (zh) * 2018-03-27 2022-12-16 华东理工大学 N-羟基吡啶酮类化合物及其用途
KR20200069995A (ko) 2018-12-08 2020-06-17 이은지 접이식 빗자루
US20220322656A1 (en) * 2019-08-28 2022-10-13 The Regents Of The University Of Michigan Preservation of organs for transplant and non-transplant surgeries
WO2022006133A2 (en) * 2020-06-29 2022-01-06 The Regents Of The University Of Michigan Histone-acetylation-modulating agents for the treatment and prevention of organ injury
EP4248959A1 (en) * 2022-03-22 2023-09-27 Dr. Franz Köhler Chemie GmbH Preparation for reduction of pathological iron overload

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH639270A5 (de) 1978-12-14 1983-11-15 Koehler Franz Dr Chemie Kg Protektive loesung fuer herz und niere.
DE3168925D1 (en) * 1980-12-23 1985-03-28 Koehler Chemie Dr Franz Protective solution for heart and kidney, and manufacturing process
US4419365A (en) 1981-12-21 1983-12-06 Ciba-Geigy Corporation Method of treating Alzheimer's disease
US4562006A (en) * 1984-01-11 1985-12-31 Warner-Lambert Company Cycloheptadiene derivatives
US4607053A (en) * 1984-05-17 1986-08-19 E. R. Squibb & Sons, Inc. Arylhydroxamates useful as antiallergy agents
US4604407A (en) * 1985-04-04 1986-08-05 E. R. Squibb & Sons, Inc. Hydroxamates
US4927571A (en) * 1987-05-18 1990-05-22 Liposome Technology, Inc. Preparation of injectable doxorubicin/liposome suspension
DK36389A (da) 1988-02-05 1989-08-06 Eastman Kodak Co Praeparat og fremgangsmaade til at forebygge vaevskader ved reperfusion
JPH11514326A (ja) 1990-03-30 1999-12-07 バイオメディカル フロンティアーズ インコーポレイテッド 液体蘇生用医薬物
EP0523037A4 (en) 1990-03-30 1993-07-28 Biomedical Frontiers, Inc. Fluid resuscitation
JP2768799B2 (ja) 1990-04-12 1998-06-25 株式会社大塚製薬工場 心筋保護液
WO1992004023A1 (en) * 1990-09-10 1992-03-19 Shug Austin L Composition and method for protecting the heart during reperfusion
JP2860301B2 (ja) 1990-09-19 1999-02-24 ヘキスト・マリオン・ルセル株式会社 臓器保存用溶液
GB9024820D0 (en) * 1990-11-15 1991-01-02 Davies Michael J Pharmaceutical compositions
US5498427A (en) * 1990-11-20 1996-03-12 Pasteur Merieux Serums Et Vaccines Solutions for the perfusion, preservation and reperfusion of organs
US5290766A (en) * 1991-02-18 1994-03-01 The National Heart Foundation Of New Zealand Cardioplegic compositions
US5405742A (en) * 1993-07-16 1995-04-11 Cyromedical Sciences, Inc. Solutions for tissue preservation and bloodless surgery and methods using same
WO1995005076A1 (en) * 1993-08-12 1995-02-23 The University Of North Carolina At Chapel Hill Rinse solution for organs and tissues
US6321909B1 (en) * 1997-02-13 2001-11-27 Sky High, Llc System for storing polyethylene glycol solutions
EP0938896A1 (en) * 1998-01-15 1999-09-01 Novartis AG Autoclavable pharmaceutical compositions containing a chelating agent
US6365338B1 (en) * 1999-04-27 2002-04-02 David A. Bull Organ preservative solution containing trehalose, anti-oxidant, cations and an energy source
DE10222561B4 (de) 2002-05-17 2009-12-10 Dr. Franz Köhler Chemie GmbH Protektive Lösung zur Verhinderung von Ischämieschäden

Also Published As

Publication number Publication date
JP4603246B2 (ja) 2010-12-22
ATE503383T1 (de) 2011-04-15
US7977383B2 (en) 2011-07-12
DE50313573D1 (de) 2011-05-12
US9603354B2 (en) 2017-03-28
EP1362511B1 (de) 2011-03-30
AR098880A2 (es) 2016-06-22
US20030215781A1 (en) 2003-11-20
DE50312079D1 (de) 2009-12-10
CA2429097C (en) 2013-06-18
EP1362511A1 (de) 2003-11-19
KR20030089495A (ko) 2003-11-21
ES2335145T3 (es) 2010-03-22
CN100448440C (zh) 2009-01-07
JP2004002418A (ja) 2004-01-08
ATE446676T1 (de) 2009-11-15
DE10222561A1 (de) 2003-12-04
CN1480132A (zh) 2004-03-10
DK1859679T3 (da) 2010-03-15
US20110300237A1 (en) 2011-12-08
BRPI0301159B8 (pt) 2021-05-25
DE10262084B4 (de) 2009-12-24
EP1859679A1 (de) 2007-11-28
KR101014990B1 (ko) 2011-02-16
EP1859679B1 (de) 2009-10-28
DE10222561B4 (de) 2009-12-10
MXPA03004315A (es) 2005-02-14
BRPI0301159B1 (pt) 2018-05-15
KR20100093023A (ko) 2010-08-24
CA2429097A1 (en) 2003-11-17
BR0301159A (pt) 2004-08-17
KR101061293B1 (ko) 2011-08-31
ES2362867T3 (es) 2011-07-14

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