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AR098880A2 - Solución protectora para prevenir daños isquémicos en los órganos o en sistemas celulares aislados o en componentes de tejido después de la perfusión, operación, transplante o crio-conservación y subsiguiente reperfusión - Google Patents

Solución protectora para prevenir daños isquémicos en los órganos o en sistemas celulares aislados o en componentes de tejido después de la perfusión, operación, transplante o crio-conservación y subsiguiente reperfusión

Info

Publication number
AR098880A2
AR098880A2 ARP140104816A ARP140104816A AR098880A2 AR 098880 A2 AR098880 A2 AR 098880A2 AR P140104816 A ARP140104816 A AR P140104816A AR P140104816 A ARP140104816 A AR P140104816A AR 098880 A2 AR098880 A2 AR 098880A2
Authority
AR
Argentina
Prior art keywords
mmol
concentration
electrolyte
protective solution
contained
Prior art date
Application number
ARP140104816A
Other languages
English (en)
Original Assignee
Dr Franz Köhler Chemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Franz Köhler Chemie Gmbh filed Critical Dr Franz Köhler Chemie Gmbh
Publication of AR098880A2 publication Critical patent/AR098880A2/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10Preservation of living parts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10Preservation of living parts
    • A01N1/12Chemical aspects of preservation
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10Preservation of living parts
    • A01N1/12Chemical aspects of preservation
    • A01N1/122Preservation or perfusion media
    • A01N1/126Physiologically active agents, e.g. antioxidants or nutrients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Surgery (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)

Abstract

Una solución protectora para prevenir daños isquémicos en los órganos, o en sistemas celulares aislados, o en componentes de tejido después de la perfusión, operación, trasplante, o crio-conservación y subsiguiente reperfusión, que comprende un electrolito seleccionado del grupo que consiste en iones alcalinos y iones alcalino-térreos, un buffer, un poliol y/o un sacárido, en donde dicha solución tiene una osmolaridad de 290 mosm/L a 350 mosm/L, como también un pH con un valor de 6,8 a 7,4 y comprende ácido 3,4 dimetoxi-N-metiIbenzohidroxámico y/o una sal del mismo, dicha composición además comprende N-acetilhistidina como un agente buffer en combinación con arginina, con un contenido aniónico de aspartato, en la cual el ácido 3,4-dimetoxi-N-metilbenzohidroxámico y/o una sal del mismo está comprendido en una cantidad de hasta 10 mmol/L, en la cual la N-acetilhistidina está comprendida en una concentración de 30 mmol/L a 265 mmol/L, en la cual el sodio está contenido deliberadamente como un electrolito a una concentración de 10 mmol/L a 80 mmol/L, en la cual el potasio está contenido deliberadamente como un electrolito a una concentración de 5 mmol/L a 25 mmol/L, en la cual el magnesio está contenido deliberadamente como un electrolito a una concentración de 3,5 mmol/L a 27 mmol/L, en la cual el calcio está contenido deliberadamente como un electrolito a una concentración de 0,005 mmol/L a 0,095 mmol/L, en donde el aspartato está contenido a una concentración de hasta 140 mmol/L, y en donde el a-cetoglutarato está contenido a una concentración de 1 mmol/L a 9 mmol/L. Reivindicación 2: Solución protectora de acuerdo con la reivindicación 1, caracterizada porque comprende una adición de un derivado del ácido 6-hidroxi-2,5,7,8-tetrametilcromán-2-carboxílico, preferentemente del metil éster respectivo. Reivindicación 3: Solución protectora de acuerdo con una cualquiera de las reivindicaciones precedentes, caracterizada porque tiene un contenido de catión de lisina y/o derivado de lisina, preferentemente dipéptidos que contienen lisina. Reivindicación 5: Solución protectora de acuerdo con una cualquiera de las reivindicaciones 2 a 4, caracterizada porque el derivado del ácido 6-hidroxi-2,5,7,8-tetrametiIcromán-2-carboxílico, preferentemente como el derivado de metil éster, está comprendido en una concentración de hasta aproximadamente 10 mmoI/L.
ARP140104816A 2002-05-17 2014-12-19 Solución protectora para prevenir daños isquémicos en los órganos o en sistemas celulares aislados o en componentes de tejido después de la perfusión, operación, transplante o crio-conservación y subsiguiente reperfusión AR098880A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10222561A DE10222561B4 (de) 2002-05-17 2002-05-17 Protektive Lösung zur Verhinderung von Ischämieschäden

Publications (1)

Publication Number Publication Date
AR098880A2 true AR098880A2 (es) 2016-06-22

Family

ID=29265373

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP030101726A AR039819A1 (es) 2002-05-17 2003-05-16 Solucion protectora para evitar danos isquemicos en organos
ARP140104816A AR098880A2 (es) 2002-05-17 2014-12-19 Solución protectora para prevenir daños isquémicos en los órganos o en sistemas celulares aislados o en componentes de tejido después de la perfusión, operación, transplante o crio-conservación y subsiguiente reperfusión

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP030101726A AR039819A1 (es) 2002-05-17 2003-05-16 Solucion protectora para evitar danos isquemicos en organos

Country Status (13)

Country Link
US (2) US7977383B2 (es)
EP (2) EP1362511B1 (es)
JP (1) JP4603246B2 (es)
KR (2) KR101014990B1 (es)
CN (1) CN100448440C (es)
AR (2) AR039819A1 (es)
AT (2) ATE446676T1 (es)
BR (1) BRPI0301159B8 (es)
CA (1) CA2429097C (es)
DE (4) DE10222561B4 (es)
DK (1) DK1859679T3 (es)
ES (2) ES2335145T3 (es)
MX (1) MXPA03004315A (es)

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DE10222561B4 (de) 2002-05-17 2009-12-10 Dr. Franz Köhler Chemie GmbH Protektive Lösung zur Verhinderung von Ischämieschäden
EP1744761A4 (en) 2004-04-28 2010-01-13 Molecules For Health Inc METHOD FOR THE TREATMENT OR PREVENTION OF RESTENOSIS AND OTHER PROLIFERATIVE VASCULAR DISORDER
US9237744B2 (en) * 2004-05-26 2016-01-19 National University Corporation Kagawa University Preservative solution for cells, tissues and organs containing rare sugar and preservative method thereof
DE102007026392A1 (de) * 2007-06-06 2008-12-11 Bayer Healthcare Ag Lösungen für die Perfusion und Konservierung von Organen und Geweben
US9526707B2 (en) 2007-08-13 2016-12-27 Howard L. Elford Methods for treating or preventing neuroinflammation or autoimmune diseases
US8835104B2 (en) 2007-12-20 2014-09-16 Fenwal, Inc. Medium and methods for the storage of platelets
EP2611291B1 (en) * 2010-09-01 2020-03-25 Perfusion Fluid Technologies, Inc. Perfusion composition
AU2012240016B2 (en) 2011-04-07 2016-11-10 Fenwal, Inc. Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates
BRPI1101935B1 (pt) * 2011-04-15 2017-12-12 Universidade Federal De Minas Gerais Antioxidant composition for preservation of organs and fabrics
DE102012005177A1 (de) 2012-03-16 2013-09-19 Bitop Ag Organlagerlösung
NL2010010C2 (en) * 2012-12-19 2014-06-23 Sulfateq B V Compounds for protection of cells.
CN103238586B (zh) * 2013-03-28 2014-03-26 辽宁亿灵科创生物医药科技有限公司 一种心肌脏器保存液制备方法
EP2821081A1 (en) * 2013-07-05 2015-01-07 ResuSciTec GmbH Protective solution for preventing or reducing reperfusion injury of the brain and the whole body
MX2021011641A (es) 2013-12-24 2023-03-10 Durect Corp Usos de sulfatos de colesterol oxigenados (soc).
US10285962B2 (en) 2016-05-01 2019-05-14 The Regents Of The University Of California Glutarate compounds for treating ischemia-reperfusion injuries
DE102016125414A1 (de) 2016-12-22 2018-06-28 Bitop Ag Zusammensetzung enthaltend N-Acetyldiaminobuttersäure
CN110536687B (zh) * 2018-03-27 2022-12-16 华东理工大学 N-羟基吡啶酮类化合物及其用途
KR20200069995A (ko) 2018-12-08 2020-06-17 이은지 접이식 빗자루
US20220322656A1 (en) * 2019-08-28 2022-10-13 The Regents Of The University Of Michigan Preservation of organs for transplant and non-transplant surgeries
WO2022006133A2 (en) * 2020-06-29 2022-01-06 The Regents Of The University Of Michigan Histone-acetylation-modulating agents for the treatment and prevention of organ injury
EP4248959A1 (en) * 2022-03-22 2023-09-27 Dr. Franz Köhler Chemie GmbH Preparation for reduction of pathological iron overload

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Also Published As

Publication number Publication date
JP4603246B2 (ja) 2010-12-22
ATE503383T1 (de) 2011-04-15
US7977383B2 (en) 2011-07-12
DE50313573D1 (de) 2011-05-12
US9603354B2 (en) 2017-03-28
EP1362511B1 (de) 2011-03-30
US20030215781A1 (en) 2003-11-20
DE50312079D1 (de) 2009-12-10
CA2429097C (en) 2013-06-18
EP1362511A1 (de) 2003-11-19
KR20030089495A (ko) 2003-11-21
ES2335145T3 (es) 2010-03-22
CN100448440C (zh) 2009-01-07
JP2004002418A (ja) 2004-01-08
ATE446676T1 (de) 2009-11-15
DE10222561A1 (de) 2003-12-04
CN1480132A (zh) 2004-03-10
DK1859679T3 (da) 2010-03-15
US20110300237A1 (en) 2011-12-08
BRPI0301159B8 (pt) 2021-05-25
DE10262084B4 (de) 2009-12-24
EP1859679A1 (de) 2007-11-28
KR101014990B1 (ko) 2011-02-16
EP1859679B1 (de) 2009-10-28
DE10222561B4 (de) 2009-12-10
MXPA03004315A (es) 2005-02-14
AR039819A1 (es) 2005-03-02
BRPI0301159B1 (pt) 2018-05-15
KR20100093023A (ko) 2010-08-24
CA2429097A1 (en) 2003-11-17
BR0301159A (pt) 2004-08-17
KR101061293B1 (ko) 2011-08-31
ES2362867T3 (es) 2011-07-14

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