AR038618A1 - Forma poliformica cristalina de clorhidratos de irinotecan - Google Patents
Forma poliformica cristalina de clorhidratos de irinotecanInfo
- Publication number
- AR038618A1 AR038618A1 ARP030100656A ARP030100656A AR038618A1 AR 038618 A1 AR038618 A1 AR 038618A1 AR P030100656 A ARP030100656 A AR P030100656A AR P030100656 A ARP030100656 A AR P030100656A AR 038618 A1 AR038618 A1 AR 038618A1
- Authority
- AR
- Argentina
- Prior art keywords
- polyform
- irinotecan
- hydraulic
- approximately
- chloride
- Prior art date
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 title 1
- 239000013078 crystal Substances 0.000 title 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 title 1
- 229960004768 irinotecan Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229960000779 irinotecan hydrochloride Drugs 0.000 abstract 1
- GURKHSYORGJETM-WAQYZQTGSA-N irinotecan hydrochloride (anhydrous) Chemical compound Cl.C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 GURKHSYORGJETM-WAQYZQTGSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Reivindicación 1: Una forma polimórfica de clorhidrato de irinotecan cristalino de fórmula (1), caracterizada porque brinda un patrón de difracción de rayos X de polvo que comprende valores de ángulo 2 tetha de aproximadamente 9,15; aproximadamente 10,00; aproximadamente 11,80; aproximadamente 12,20; aproximadamente 13,00 y aproximadamente 13,40. Un procedimiento para preparar esta forma polimórfica, composiciones farmacéuticas que la contienen como ingrediente activo, y el empleo de la misma y de sus composiciones farmacéuticas como agente terapéutico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36068402P | 2002-03-01 | 2002-03-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR038618A1 true AR038618A1 (es) | 2005-01-19 |
Family
ID=27789001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030100656A AR038618A1 (es) | 2002-03-01 | 2003-02-28 | Forma poliformica cristalina de clorhidratos de irinotecan |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1487840B1 (es) |
| JP (1) | JP2005525367A (es) |
| KR (1) | KR20040091083A (es) |
| CN (1) | CN1276923C (es) |
| AR (1) | AR038618A1 (es) |
| AT (1) | ATE364610T1 (es) |
| AU (1) | AU2003215594A1 (es) |
| BR (1) | BR0308133A (es) |
| CA (1) | CA2477926A1 (es) |
| DE (1) | DE60314378T2 (es) |
| DK (1) | DK1487840T3 (es) |
| ES (1) | ES2287495T3 (es) |
| IL (1) | IL163820A0 (es) |
| MX (1) | MXPA04008484A (es) |
| NO (1) | NO20044138L (es) |
| NZ (1) | NZ534999A (es) |
| PE (1) | PE20030923A1 (es) |
| PL (1) | PL372318A1 (es) |
| PT (1) | PT1487840E (es) |
| RU (1) | RU2300535C2 (es) |
| TW (1) | TWI270374B (es) |
| WO (1) | WO2003074527A1 (es) |
| ZA (1) | ZA200406927B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7488825B2 (en) | 2003-02-25 | 2009-02-10 | Kabushiki Kaisha Yakult Honsha | Method for preparing polymorphism of irinotecan hydrochloride |
| ES2245891B1 (es) * | 2004-07-09 | 2006-11-16 | Clinmet S.L. | "metodo para la obtencion de un excipiente universal para la administracion oral de principios activos farmaceuticos y composiciones de excipientes resultantes del metodo". |
| US7799921B2 (en) | 2004-12-21 | 2010-09-21 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Stereoselective process and crystalline forms of a camptothecin |
| PL1846412T3 (pl) | 2005-02-07 | 2010-03-31 | Fermion Oy | Sposób wytwarzania 7-etylo-10-hydroksykamptotecyny |
| EP1928883B1 (en) * | 2005-02-08 | 2013-10-30 | Fermion Oy | Process for the preparation of irinotecan hydrochloride |
| JP5133703B2 (ja) | 2005-02-08 | 2013-01-30 | フェルミオン オサケ ユキチュア | ［１，４’］ビピペリジニル−１’−カルボニルクロリドまたはその塩酸塩の製造方法 |
| ATE460162T1 (de) * | 2005-09-20 | 2010-03-15 | Scinopharm Singapore Pte Ltd | Neue kristallformen von irinotecan-hydrochlorid |
| CN101318964B (zh) * | 2007-06-07 | 2010-12-15 | 上海迪赛诺医药发展有限公司 | 盐酸伊立替康新晶型及其制备方法 |
| FR2918279B1 (fr) * | 2007-07-05 | 2010-10-22 | Aventis Pharma Sa | Combinaisons antitumorales contenant un agent inhibiteur de vegf et de l'irinotecan |
| IT1391757B1 (it) * | 2008-11-11 | 2012-01-27 | Antibioticos Spa | Irinotecan cloridrato cristallino e metodi per la sua preparazione |
| CN101659667B (zh) * | 2009-09-07 | 2011-11-02 | 重庆泰濠制药有限公司 | 一种盐酸伊立替康的纯化方法 |
| US8546573B2 (en) | 2009-11-18 | 2013-10-01 | Cadila Healthcare Limited | Process for the preparation of 7-ethyl-10-[4-(1-piperidino)-1-piperdino] carbonyloxy-camptothecin hydrochloride trihydrate |
| JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
| CN102866126B (zh) * | 2011-07-05 | 2016-03-23 | 重庆华邦制药有限公司 | 一种定量测定化合物中晶型比例的方法 |
| CN102311443B (zh) * | 2011-08-24 | 2014-07-16 | 上海北卡医药技术有限公司 | 盐酸伊立替康的新晶型及其制备方法 |
| RU2529831C2 (ru) * | 2012-11-30 | 2014-09-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) | Способ лечения рака толстой кишки |
| EA035674B1 (ru) | 2014-07-18 | 2020-07-24 | Санофи | Способ определения того, является ли пациент, предположительно страдающий от рака, кандидатом для терапии афлиберцептом |
| KR102293907B1 (ko) * | 2015-06-30 | 2021-08-26 | 한미약품 주식회사 | 이리노테칸 함유 경구용 고형제제 및 그 제조방법 |
| KR102066402B1 (ko) * | 2017-12-22 | 2020-01-15 | 대화제약 주식회사 | 이리노테칸 또는 그의 약제학적으로 허용가능한 염을 포함하는 경구투여용 약제학적 조성물 |
| US10919905B2 (en) | 2019-05-16 | 2021-02-16 | Scinopharm Taiwan, Ltd. | Polymorphism for irinotecan free base |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6019790A (ja) * | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| IT1282673B1 (it) * | 1996-02-23 | 1998-03-31 | Ist Naz Stud Cura Dei Tumori | Derivati della camptotecina e loro uso come agenti antitumorali |
| GB9918885D0 (en) * | 1999-08-10 | 1999-10-13 | Pharmacia & Upjohn Spa | Pharmaceutical formulations in hydroxypropymethycellulose capsules |
-
2003
- 2003-02-26 WO PCT/EP2003/001948 patent/WO2003074527A1/en not_active Ceased
- 2003-02-26 CA CA002477926A patent/CA2477926A1/en not_active Abandoned
- 2003-02-26 BR BR0308133-8A patent/BR0308133A/pt not_active IP Right Cessation
- 2003-02-26 PL PL03372318A patent/PL372318A1/xx not_active Application Discontinuation
- 2003-02-26 KR KR10-2004-7013621A patent/KR20040091083A/ko not_active Withdrawn
- 2003-02-26 DK DK03743335T patent/DK1487840T3/da active
- 2003-02-26 AU AU2003215594A patent/AU2003215594A1/en not_active Abandoned
- 2003-02-26 EP EP03743335A patent/EP1487840B1/en not_active Expired - Lifetime
- 2003-02-26 JP JP2003572995A patent/JP2005525367A/ja not_active Withdrawn
- 2003-02-26 NZ NZ534999A patent/NZ534999A/en unknown
- 2003-02-26 MX MXPA04008484A patent/MXPA04008484A/es not_active Application Discontinuation
- 2003-02-26 CN CNB038072726A patent/CN1276923C/zh not_active Expired - Fee Related
- 2003-02-26 IL IL16382003A patent/IL163820A0/xx unknown
- 2003-02-26 AT AT03743335T patent/ATE364610T1/de not_active IP Right Cessation
- 2003-02-26 RU RU2004129307/04A patent/RU2300535C2/ru not_active IP Right Cessation
- 2003-02-26 DE DE60314378T patent/DE60314378T2/de not_active Expired - Fee Related
- 2003-02-26 PT PT03743335T patent/PT1487840E/pt unknown
- 2003-02-26 ES ES03743335T patent/ES2287495T3/es not_active Expired - Lifetime
- 2003-02-27 TW TW092104194A patent/TWI270374B/zh not_active IP Right Cessation
- 2003-02-28 PE PE2003000196A patent/PE20030923A1/es not_active Application Discontinuation
- 2003-02-28 AR ARP030100656A patent/AR038618A1/es unknown
-
2004
- 2004-08-31 ZA ZA200406927A patent/ZA200406927B/en unknown
- 2004-09-29 NO NO20044138A patent/NO20044138L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60314378D1 (en) | 2007-07-26 |
| TWI270374B (en) | 2007-01-11 |
| PT1487840E (pt) | 2007-09-11 |
| EP1487840B1 (en) | 2007-06-13 |
| IL163820A0 (en) | 2005-12-18 |
| NZ534999A (en) | 2007-03-30 |
| PE20030923A1 (es) | 2003-10-29 |
| DE60314378T2 (de) | 2008-02-28 |
| PL372318A1 (en) | 2005-07-11 |
| RU2300535C2 (ru) | 2007-06-10 |
| JP2005525367A (ja) | 2005-08-25 |
| ES2287495T3 (es) | 2007-12-16 |
| EP1487840A1 (en) | 2004-12-22 |
| TW200303753A (en) | 2003-09-16 |
| AU2003215594A1 (en) | 2003-09-16 |
| HK1075044A1 (en) | 2005-12-02 |
| ZA200406927B (en) | 2006-06-28 |
| KR20040091083A (ko) | 2004-10-27 |
| MXPA04008484A (es) | 2004-12-06 |
| CA2477926A1 (en) | 2003-09-12 |
| NO20044138L (no) | 2004-11-29 |
| CN1642958A (zh) | 2005-07-20 |
| BR0308133A (pt) | 2005-01-04 |
| DK1487840T3 (da) | 2007-07-16 |
| CN1276923C (zh) | 2006-09-27 |
| RU2004129307A (ru) | 2005-04-10 |
| WO2003074527A1 (en) | 2003-09-12 |
| ATE364610T1 (de) | 2007-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |