PE20030923A1 - Forma polimorfica cristalina de clorhidrato de irinotecan - Google Patents
Forma polimorfica cristalina de clorhidrato de irinotecanInfo
- Publication number
- PE20030923A1 PE20030923A1 PE2003000196A PE2003000196A PE20030923A1 PE 20030923 A1 PE20030923 A1 PE 20030923A1 PE 2003000196 A PE2003000196 A PE 2003000196A PE 2003000196 A PE2003000196 A PE 2003000196A PE 20030923 A1 PE20030923 A1 PE 20030923A1
- Authority
- PE
- Peru
- Prior art keywords
- refers
- polymorphic form
- irinotecan hydrochloride
- irinotecan
- crystalline polymorphic
- Prior art date
Links
- 229960000779 irinotecan hydrochloride Drugs 0.000 title abstract 2
- GURKHSYORGJETM-WAQYZQTGSA-N irinotecan hydrochloride (anhydrous) Chemical compound Cl.C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 GURKHSYORGJETM-WAQYZQTGSA-N 0.000 title abstract 2
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 238000002441 X-ray diffraction Methods 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000002329 infrared spectrum Methods 0.000 abstract 1
- 229960004768 irinotecan Drugs 0.000 abstract 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UNA FORMA POLIMORFICA DE CLORHIDRATO DE IRINOTECAN CRISTALINO DE FORMULA I CARACTERIZADO POR UN PATRON DE DIFRACCION DE RAYOS X DE POLVO QUE COMPRENDE VALORES DE ANGULO 2 THETA 9,15; 10,00; 11,80; 12,20; 13,00; 13,40. PRESENTA ADEMAS UN ESPECTRO INFRARROJO QUE CONTIENE PICOS EN 1757, 1712 Y 1667 cm-1. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA PREPARAR EL POLIMORFO QUE CONSISTE EN AGITAR DURANTE UN TIEPMO DE 2 A 48 HORAS UNA SUSPENSION ACUOSA DEL CLORHIDRATO DE IRINOTECAN COMO FORMA b O COMO AMORFO EN ACETONITRILO O EN ACETONA. SE REFIERE ADEMAS A UNA COMPOSICION FARMACEUTICA UTIL PARA EL TRATAMIENTO DE CANCER
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36068402P | 2002-03-01 | 2002-03-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030923A1 true PE20030923A1 (es) | 2003-10-29 |
Family
ID=27789001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000196A PE20030923A1 (es) | 2002-03-01 | 2003-02-28 | Forma polimorfica cristalina de clorhidrato de irinotecan |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1487840B1 (es) |
| JP (1) | JP2005525367A (es) |
| KR (1) | KR20040091083A (es) |
| CN (1) | CN1276923C (es) |
| AR (1) | AR038618A1 (es) |
| AT (1) | ATE364610T1 (es) |
| AU (1) | AU2003215594A1 (es) |
| BR (1) | BR0308133A (es) |
| CA (1) | CA2477926A1 (es) |
| DE (1) | DE60314378T2 (es) |
| DK (1) | DK1487840T3 (es) |
| ES (1) | ES2287495T3 (es) |
| IL (1) | IL163820A0 (es) |
| MX (1) | MXPA04008484A (es) |
| NO (1) | NO20044138L (es) |
| NZ (1) | NZ534999A (es) |
| PE (1) | PE20030923A1 (es) |
| PL (1) | PL372318A1 (es) |
| PT (1) | PT1487840E (es) |
| RU (1) | RU2300535C2 (es) |
| TW (1) | TWI270374B (es) |
| WO (1) | WO2003074527A1 (es) |
| ZA (1) | ZA200406927B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4566128B2 (ja) * | 2003-02-25 | 2010-10-20 | 株式会社ヤクルト本社 | イリノテカン塩酸塩の結晶多形の製造方法 |
| ES2245891B1 (es) * | 2004-07-09 | 2006-11-16 | Clinmet S.L. | "metodo para la obtencion de un excipiente universal para la administracion oral de principios activos farmaceuticos y composiciones de excipientes resultantes del metodo". |
| KR101355121B1 (ko) | 2004-12-21 | 2014-01-24 | 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. | 캄토테신의 입체선택적 방법 및 결정성 형태 |
| DE602006009901D1 (de) | 2005-02-07 | 2009-12-03 | Fermion Oy | Verfahren zur herstellung von 7-ethyl-10-hydroxycamptothecin |
| EP1928883B1 (en) | 2005-02-08 | 2013-10-30 | Fermion Oy | Process for the preparation of irinotecan hydrochloride |
| JP5133703B2 (ja) | 2005-02-08 | 2013-01-30 | フェルミオン オサケ ユキチュア | ［１，４’］ビピペリジニル−１’−カルボニルクロリドまたはその塩酸塩の製造方法 |
| AU2006292328B2 (en) * | 2005-09-20 | 2012-12-20 | Scinopharm Singapore Pte, Ltd. | Novel crystal forms of irinotecan hydrochloride |
| CN101318964B (zh) * | 2007-06-07 | 2010-12-15 | 上海迪赛诺医药发展有限公司 | 盐酸伊立替康新晶型及其制备方法 |
| FR2918279B1 (fr) * | 2007-07-05 | 2010-10-22 | Aventis Pharma Sa | Combinaisons antitumorales contenant un agent inhibiteur de vegf et de l'irinotecan |
| IT1391757B1 (it) * | 2008-11-11 | 2012-01-27 | Antibioticos Spa | Irinotecan cloridrato cristallino e metodi per la sua preparazione |
| CN101659667B (zh) * | 2009-09-07 | 2011-11-02 | 重庆泰濠制药有限公司 | 一种盐酸伊立替康的纯化方法 |
| US8546573B2 (en) | 2009-11-18 | 2013-10-01 | Cadila Healthcare Limited | Process for the preparation of 7-ethyl-10-[4-(1-piperidino)-1-piperdino] carbonyloxy-camptothecin hydrochloride trihydrate |
| JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
| CN102866126B (zh) * | 2011-07-05 | 2016-03-23 | 重庆华邦制药有限公司 | 一种定量测定化合物中晶型比例的方法 |
| CN102311443B (zh) * | 2011-08-24 | 2014-07-16 | 上海北卡医药技术有限公司 | 盐酸伊立替康的新晶型及其制备方法 |
| RU2529831C2 (ru) * | 2012-11-30 | 2014-09-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) | Способ лечения рака толстой кишки |
| MX375557B (es) | 2014-07-18 | 2025-03-06 | Sanofi Sa | Método para predecir el resultado de un tratamiento con aflibercept de un paciente que se sospecha que padece un cáncer. |
| KR102293907B1 (ko) * | 2015-06-30 | 2021-08-26 | 한미약품 주식회사 | 이리노테칸 함유 경구용 고형제제 및 그 제조방법 |
| KR102066402B1 (ko) * | 2017-12-22 | 2020-01-15 | 대화제약 주식회사 | 이리노테칸 또는 그의 약제학적으로 허용가능한 염을 포함하는 경구투여용 약제학적 조성물 |
| US10919905B2 (en) | 2019-05-16 | 2021-02-16 | Scinopharm Taiwan, Ltd. | Polymorphism for irinotecan free base |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6019790A (ja) * | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| IT1282673B1 (it) * | 1996-02-23 | 1998-03-31 | Ist Naz Stud Cura Dei Tumori | Derivati della camptotecina e loro uso come agenti antitumorali |
| GB9918885D0 (en) * | 1999-08-10 | 1999-10-13 | Pharmacia & Upjohn Spa | Pharmaceutical formulations in hydroxypropymethycellulose capsules |
-
2003
- 2003-02-26 JP JP2003572995A patent/JP2005525367A/ja not_active Withdrawn
- 2003-02-26 WO PCT/EP2003/001948 patent/WO2003074527A1/en not_active Ceased
- 2003-02-26 CN CNB038072726A patent/CN1276923C/zh not_active Expired - Fee Related
- 2003-02-26 KR KR10-2004-7013621A patent/KR20040091083A/ko not_active Withdrawn
- 2003-02-26 NZ NZ534999A patent/NZ534999A/en unknown
- 2003-02-26 CA CA002477926A patent/CA2477926A1/en not_active Abandoned
- 2003-02-26 BR BR0308133-8A patent/BR0308133A/pt not_active IP Right Cessation
- 2003-02-26 PL PL03372318A patent/PL372318A1/xx not_active Application Discontinuation
- 2003-02-26 IL IL16382003A patent/IL163820A0/xx unknown
- 2003-02-26 DK DK03743335T patent/DK1487840T3/da active
- 2003-02-26 AT AT03743335T patent/ATE364610T1/de not_active IP Right Cessation
- 2003-02-26 ES ES03743335T patent/ES2287495T3/es not_active Expired - Lifetime
- 2003-02-26 DE DE60314378T patent/DE60314378T2/de not_active Expired - Fee Related
- 2003-02-26 EP EP03743335A patent/EP1487840B1/en not_active Expired - Lifetime
- 2003-02-26 RU RU2004129307/04A patent/RU2300535C2/ru not_active IP Right Cessation
- 2003-02-26 PT PT03743335T patent/PT1487840E/pt unknown
- 2003-02-26 MX MXPA04008484A patent/MXPA04008484A/es not_active Application Discontinuation
- 2003-02-26 AU AU2003215594A patent/AU2003215594A1/en not_active Abandoned
- 2003-02-27 TW TW092104194A patent/TWI270374B/zh not_active IP Right Cessation
- 2003-02-28 PE PE2003000196A patent/PE20030923A1/es not_active Application Discontinuation
- 2003-02-28 AR ARP030100656A patent/AR038618A1/es unknown
-
2004
- 2004-08-31 ZA ZA200406927A patent/ZA200406927B/en unknown
- 2004-09-29 NO NO20044138A patent/NO20044138L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PT1487840E (pt) | 2007-09-11 |
| PL372318A1 (en) | 2005-07-11 |
| JP2005525367A (ja) | 2005-08-25 |
| ES2287495T3 (es) | 2007-12-16 |
| AR038618A1 (es) | 2005-01-19 |
| RU2004129307A (ru) | 2005-04-10 |
| NO20044138L (no) | 2004-11-29 |
| KR20040091083A (ko) | 2004-10-27 |
| DE60314378D1 (en) | 2007-07-26 |
| NZ534999A (en) | 2007-03-30 |
| TW200303753A (en) | 2003-09-16 |
| ATE364610T1 (de) | 2007-07-15 |
| DE60314378T2 (de) | 2008-02-28 |
| CN1276923C (zh) | 2006-09-27 |
| CN1642958A (zh) | 2005-07-20 |
| WO2003074527A1 (en) | 2003-09-12 |
| HK1075044A1 (en) | 2005-12-02 |
| MXPA04008484A (es) | 2004-12-06 |
| RU2300535C2 (ru) | 2007-06-10 |
| BR0308133A (pt) | 2005-01-04 |
| CA2477926A1 (en) | 2003-09-12 |
| EP1487840A1 (en) | 2004-12-22 |
| ZA200406927B (en) | 2006-06-28 |
| DK1487840T3 (da) | 2007-07-16 |
| TWI270374B (en) | 2007-01-11 |
| IL163820A0 (en) | 2005-12-18 |
| EP1487840B1 (en) | 2007-06-13 |
| AU2003215594A1 (en) | 2003-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |