IL163820A0 - Crystalline polymorphic form of irinotecan hydrochloride - Google Patents
Crystalline polymorphic form of irinotecan hydrochlorideInfo
- Publication number
- IL163820A0 IL163820A0 IL16382003A IL16382003A IL163820A0 IL 163820 A0 IL163820 A0 IL 163820A0 IL 16382003 A IL16382003 A IL 16382003A IL 16382003 A IL16382003 A IL 16382003A IL 163820 A0 IL163820 A0 IL 163820A0
- Authority
- IL
- Israel
- Prior art keywords
- polymorphic form
- irinotecan hydrochloride
- crystalline polymorphic
- crystalline
- irinotecan
- Prior art date
Links
- 229960000779 irinotecan hydrochloride Drugs 0.000 title 1
- GURKHSYORGJETM-WAQYZQTGSA-N irinotecan hydrochloride (anhydrous) Chemical compound Cl.C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 GURKHSYORGJETM-WAQYZQTGSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36068402P | 2002-03-01 | 2002-03-01 | |
| PCT/EP2003/001948 WO2003074527A1 (en) | 2002-03-01 | 2003-02-26 | Crystalline polymorphic form of irinotecan hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL163820A0 true IL163820A0 (en) | 2005-12-18 |
Family
ID=27789001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16382003A IL163820A0 (en) | 2002-03-01 | 2003-02-26 | Crystalline polymorphic form of irinotecan hydrochloride |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1487840B1 (xx) |
| JP (1) | JP2005525367A (xx) |
| KR (1) | KR20040091083A (xx) |
| CN (1) | CN1276923C (xx) |
| AR (1) | AR038618A1 (xx) |
| AT (1) | ATE364610T1 (xx) |
| AU (1) | AU2003215594A1 (xx) |
| BR (1) | BR0308133A (xx) |
| CA (1) | CA2477926A1 (xx) |
| DE (1) | DE60314378T2 (xx) |
| DK (1) | DK1487840T3 (xx) |
| ES (1) | ES2287495T3 (xx) |
| IL (1) | IL163820A0 (xx) |
| MX (1) | MXPA04008484A (xx) |
| NO (1) | NO20044138L (xx) |
| NZ (1) | NZ534999A (xx) |
| PE (1) | PE20030923A1 (xx) |
| PL (1) | PL372318A1 (xx) |
| PT (1) | PT1487840E (xx) |
| RU (1) | RU2300535C2 (xx) |
| TW (1) | TWI270374B (xx) |
| WO (1) | WO2003074527A1 (xx) |
| ZA (1) | ZA200406927B (xx) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004076460A1 (ja) * | 2003-02-25 | 2004-09-10 | Kabushiki Kaisha Yakult Honsha | イリノテカン塩酸塩の結晶多形の製造方法 |
| ES2245891B1 (es) * | 2004-07-09 | 2006-11-16 | Clinmet S.L. | "metodo para la obtencion de un excipiente universal para la administracion oral de principios activos farmaceuticos y composiciones de excipientes resultantes del metodo". |
| BRPI0515832A (pt) | 2004-12-21 | 2008-08-05 | Sigma Tau Ind Farmaceuti | processo estereosseletivo e formas cristalinas de uma camptotecina |
| ATE446299T1 (de) | 2005-02-07 | 2009-11-15 | Fermion Oy | Verfahren zur herstellung von 7-ethyl-10- hydroxycamptothecin |
| WO2006084941A2 (en) * | 2005-02-08 | 2006-08-17 | Fermion Oy | Process for the preparation of irinotecan hydrochloride |
| CA2591071C (en) | 2005-02-08 | 2014-04-29 | Fermion Oy | Process for producing [1,4'] bipiperidinyl-1'-carbonyl chloride or hydrochloride thereof |
| KR101150504B1 (ko) * | 2005-09-20 | 2012-07-09 | 시노팜 싱가포르 피티이 리미티드 | 이리노테칸 염산염의 신규의 결정형 |
| CN101318964B (zh) * | 2007-06-07 | 2010-12-15 | 上海迪赛诺医药发展有限公司 | 盐酸伊立替康新晶型及其制备方法 |
| FR2918279B1 (fr) * | 2007-07-05 | 2010-10-22 | Aventis Pharma Sa | Combinaisons antitumorales contenant un agent inhibiteur de vegf et de l'irinotecan |
| IT1391757B1 (it) * | 2008-11-11 | 2012-01-27 | Antibioticos Spa | Irinotecan cloridrato cristallino e metodi per la sua preparazione |
| CN101659667B (zh) * | 2009-09-07 | 2011-11-02 | 重庆泰濠制药有限公司 | 一种盐酸伊立替康的纯化方法 |
| US8546573B2 (en) | 2009-11-18 | 2013-10-01 | Cadila Healthcare Limited | Process for the preparation of 7-ethyl-10-[4-(1-piperidino)-1-piperdino] carbonyloxy-camptothecin hydrochloride trihydrate |
| JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
| CN102866126B (zh) * | 2011-07-05 | 2016-03-23 | 重庆华邦制药有限公司 | 一种定量测定化合物中晶型比例的方法 |
| CN102311443B (zh) * | 2011-08-24 | 2014-07-16 | 上海北卡医药技术有限公司 | 盐酸伊立替康的新晶型及其制备方法 |
| RU2529831C2 (ru) * | 2012-11-30 | 2014-09-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) | Способ лечения рака толстой кишки |
| HUE043951T2 (hu) | 2014-07-18 | 2019-09-30 | Sanofi Sa | Eljárás rákgyanús beteg aflibercepttel történõ kezelése kimenetének elõrejelzésére |
| KR102293907B1 (ko) | 2015-06-30 | 2021-08-26 | 한미약품 주식회사 | 이리노테칸 함유 경구용 고형제제 및 그 제조방법 |
| KR102066402B1 (ko) * | 2017-12-22 | 2020-01-15 | 대화제약 주식회사 | 이리노테칸 또는 그의 약제학적으로 허용가능한 염을 포함하는 경구투여용 약제학적 조성물 |
| US10919905B2 (en) | 2019-05-16 | 2021-02-16 | Scinopharm Taiwan, Ltd. | Polymorphism for irinotecan free base |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6019790A (ja) * | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| IT1282673B1 (it) * | 1996-02-23 | 1998-03-31 | Ist Naz Stud Cura Dei Tumori | Derivati della camptotecina e loro uso come agenti antitumorali |
| GB9918885D0 (en) * | 1999-08-10 | 1999-10-13 | Pharmacia & Upjohn Spa | Pharmaceutical formulations in hydroxypropymethycellulose capsules |
-
2003
- 2003-02-26 AU AU2003215594A patent/AU2003215594A1/en not_active Abandoned
- 2003-02-26 EP EP03743335A patent/EP1487840B1/en not_active Expired - Lifetime
- 2003-02-26 WO PCT/EP2003/001948 patent/WO2003074527A1/en not_active Ceased
- 2003-02-26 ES ES03743335T patent/ES2287495T3/es not_active Expired - Lifetime
- 2003-02-26 KR KR10-2004-7013621A patent/KR20040091083A/ko not_active Withdrawn
- 2003-02-26 AT AT03743335T patent/ATE364610T1/de not_active IP Right Cessation
- 2003-02-26 BR BR0308133-8A patent/BR0308133A/pt not_active IP Right Cessation
- 2003-02-26 CA CA002477926A patent/CA2477926A1/en not_active Abandoned
- 2003-02-26 RU RU2004129307/04A patent/RU2300535C2/ru not_active IP Right Cessation
- 2003-02-26 MX MXPA04008484A patent/MXPA04008484A/es not_active Application Discontinuation
- 2003-02-26 PT PT03743335T patent/PT1487840E/pt unknown
- 2003-02-26 IL IL16382003A patent/IL163820A0/xx unknown
- 2003-02-26 JP JP2003572995A patent/JP2005525367A/ja not_active Withdrawn
- 2003-02-26 CN CNB038072726A patent/CN1276923C/zh not_active Expired - Fee Related
- 2003-02-26 DK DK03743335T patent/DK1487840T3/da active
- 2003-02-26 DE DE60314378T patent/DE60314378T2/de not_active Expired - Fee Related
- 2003-02-26 NZ NZ534999A patent/NZ534999A/en unknown
- 2003-02-26 PL PL03372318A patent/PL372318A1/xx not_active Application Discontinuation
- 2003-02-27 TW TW092104194A patent/TWI270374B/zh not_active IP Right Cessation
- 2003-02-28 PE PE2003000196A patent/PE20030923A1/es not_active Application Discontinuation
- 2003-02-28 AR ARP030100656A patent/AR038618A1/es unknown
-
2004
- 2004-08-31 ZA ZA200406927A patent/ZA200406927B/en unknown
- 2004-09-29 NO NO20044138A patent/NO20044138L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20044138L (no) | 2004-11-29 |
| PT1487840E (pt) | 2007-09-11 |
| PL372318A1 (en) | 2005-07-11 |
| BR0308133A (pt) | 2005-01-04 |
| KR20040091083A (ko) | 2004-10-27 |
| RU2300535C2 (ru) | 2007-06-10 |
| AR038618A1 (es) | 2005-01-19 |
| ATE364610T1 (de) | 2007-07-15 |
| ZA200406927B (en) | 2006-06-28 |
| CN1276923C (zh) | 2006-09-27 |
| MXPA04008484A (es) | 2004-12-06 |
| RU2004129307A (ru) | 2005-04-10 |
| DE60314378T2 (de) | 2008-02-28 |
| AU2003215594A1 (en) | 2003-09-16 |
| TWI270374B (en) | 2007-01-11 |
| DK1487840T3 (da) | 2007-07-16 |
| HK1075044A1 (en) | 2005-12-02 |
| CA2477926A1 (en) | 2003-09-12 |
| JP2005525367A (ja) | 2005-08-25 |
| EP1487840B1 (en) | 2007-06-13 |
| CN1642958A (zh) | 2005-07-20 |
| EP1487840A1 (en) | 2004-12-22 |
| NZ534999A (en) | 2007-03-30 |
| TW200303753A (en) | 2003-09-16 |
| PE20030923A1 (es) | 2003-10-29 |
| DE60314378D1 (en) | 2007-07-26 |
| ES2287495T3 (es) | 2007-12-16 |
| WO2003074527A1 (en) | 2003-09-12 |
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