AR037329A1 - Compuestos pirazolo pirimidinona, procedimientos para la preparacion de los mismos, composiciones farmaceuticas de los mismos y usos de los mismos en la preparacion de medicamentos - Google Patents
Compuestos pirazolo pirimidinona, procedimientos para la preparacion de los mismos, composiciones farmaceuticas de los mismos y usos de los mismos en la preparacion de medicamentosInfo
- Publication number
- AR037329A1 AR037329A1 ARP020104152A ARP020104152A AR037329A1 AR 037329 A1 AR037329 A1 AR 037329A1 AR P020104152 A ARP020104152 A AR P020104152A AR P020104152 A ARP020104152 A AR P020104152A AR 037329 A1 AR037329 A1 AR 037329A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- independently selected
- same
- preparation
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 11
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- -1 pyrazol pyrimidinone compound Chemical class 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- QDLAGTHXVHQKRE-UHFFFAOYSA-N lichenxanthone Natural products COC1=CC(O)=C2C(=O)C3=C(C)C=C(OC)C=C3OC2=C1 QDLAGTHXVHQKRE-UHFFFAOYSA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Gynecology & Obstetrics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Pregnancy & Childbirth (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un compuesto pirazolo pirimidinona de acuerdo con la fórmula (1), una sal, un solvato o profármaco farmacéuticamente aceptable de éste, en el que: R1 es H o alquilo C1-6 en el que R1 se une bien a N1 o N2; R2 es alquilo C1-6 opcionalmente sustituido con hidroxi o alcoxi; cicloalquilo C3-7 opcionalmente sustituido con alquilo, hidroxi o alcoxi; un heterociclo saturado de 5-6 miembros opcionalmente sustituido con alquilo, hidroxi o alcoxi, het1 o Ar1; R3 es alquilo C1-6 opcionalmente sustituido con 1 ó 2 grupos independientemente seleccionados entre: Ar2, cicloalquilo C3-7 opcionalmente sustituido con alquilo C1-6; OAr2, SAr2; NHC(O) alquilo C1-6; het2; xanteno; y naftaleno; en los que Ar1 y Ar2 son independientemente grupos de fórmula (2), en la que R4, R5 y R6 se seleccionan independientemente de entre: hidrógeno, halo, fenoxi, fenilo, CF3, OCF3, R7, SR7 y OR7, en los que R7 es alquilo C1-6 opcionalmente sustituido con het3 o por un grupo fenilo opcionalmente sustituido con 1, 2 ó 3 grupos independientemente seleccionados entre halo, CF3, OCF3, alquilo C1-6 y alcoxi C1-6: o en la que R4 y R5 se combinan para formar una unión de 3 ó 4 átomos, y en la citada unión se pueden incorporar 1 ó 2 heteroátomos independientemente seleccionados entre O, S y N; y en el que het1, het2 y het3, que pueden ser iguales o distintos, son heterociclos aromáticos de 5-6 miembros que contienen 1, 2 ó 3 heteroátomos, independientemente seleccionados entre O, S y N, los citados heterociclos opcionalmente sustituidos por 1, 2 ó 3 sustituyentes, se seleccionan independientemente entre alquilo C1-6, halo y fenilo opcionalmente sustituido con 1, 2 ó 3 grupos independientemente seleccionados entre halo y alquilo C1-6; con las condiciones de que cuando: a) R1 está unido a N1, R1 es alquilo C1-6 y R2 es propilo, entonces R3 no es etilo sustituido con Ar1, y b) esta unido a N1, R1 es alquilo C1-6 y R2 es metilo, entonces R3 no es alquilo C1-4 sustituido con Ar1, procedimientos para la preparación de los mismos, composiciones farmacéuticas de los mismos y uso de los mismos en la preparación de medicamentos útiles para tratar trastornos cardiovasculares.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0126395A GB0126395D0 (en) | 2001-11-02 | 2001-11-02 | Pyrazolo[4,3]pyrimidine derivatives and their use in treating disease |
| GB0130695A GB0130695D0 (en) | 2001-12-21 | 2001-12-21 | Pyrazola[4,3]pyrimidine |
| GB0216761A GB0216761D0 (en) | 2002-07-18 | 2002-07-18 | PDE9 Inhibitors for treating cardiovascular disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR037329A1 true AR037329A1 (es) | 2004-11-03 |
Family
ID=27256310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020104152A AR037329A1 (es) | 2001-11-02 | 2002-10-31 | Compuestos pirazolo pirimidinona, procedimientos para la preparacion de los mismos, composiciones farmaceuticas de los mismos y usos de los mismos en la preparacion de medicamentos |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1440073A1 (es) |
| JP (1) | JP2005511575A (es) |
| AR (1) | AR037329A1 (es) |
| BR (1) | BR0214096A (es) |
| CA (1) | CA2466824A1 (es) |
| DO (1) | DOP2002000482A (es) |
| HN (1) | HN2002000317A (es) |
| MX (1) | MXPA04004171A (es) |
| PA (1) | PA8557401A1 (es) |
| PE (1) | PE20030702A1 (es) |
| SV (1) | SV2004001373A (es) |
| TW (1) | TW200300081A (es) |
| UY (1) | UY27522A1 (es) |
| WO (1) | WO2003037899A1 (es) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2459161A1 (en) | 2001-08-31 | 2003-03-13 | The Rockefeller University | Phosphodiesterase activity and regulation of phosphodiesterase 1b-mediated signaling in brain |
| ATE447577T1 (de) | 2001-12-06 | 2009-11-15 | Merck & Co Inc | Mitotische kinesin-hemmer |
| DE10238724A1 (de) | 2002-08-23 | 2004-03-04 | Bayer Ag | Alkyl-substituierte Pyrazolpyrimidine |
| DE10238723A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Phenyl-substituierte Pyrazolyprimidine |
| DE10238722A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse |
| US7141669B2 (en) | 2003-04-23 | 2006-11-28 | Pfizer Inc. | Cannabiniod receptor ligands and uses thereof |
| US8044060B2 (en) | 2003-05-09 | 2011-10-25 | Boehringer Ingelheim International Gmbh | 6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory |
| DE10320785A1 (de) * | 2003-05-09 | 2004-11-25 | Bayer Healthcare Ag | 6-Arylmethyl-substituierte Pyrazolopyrimidine |
| DE102004004142A1 (de) * | 2003-05-09 | 2004-11-25 | Bayer Healthcare Ag | 6-Cyclylmethyl- und 6-Alkylmethyl-substituierte Pyrazolopyrimidine |
| JP2006525966A (ja) * | 2003-05-09 | 2006-11-16 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | ６−シクリルメチル−および６−アルキルメチル置換ピラゾロピリミジン類 |
| DE10328479A1 (de) * | 2003-06-25 | 2005-01-13 | Bayer Ag | 6-Arylamino-5-cyano-4-pyrimidinone |
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| US3939161A (en) * | 1973-10-29 | 1976-02-17 | Abbott Laboratories | 1,3-Dimethyl- 1H-pyrazolo(4,3-D) pyrimidine-7 (6H)-ones |
| US4666908A (en) * | 1985-04-05 | 1987-05-19 | Warner-Lambert Company | 5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use |
| GB9722520D0 (en) * | 1997-10-24 | 1997-12-24 | Pfizer Ltd | Compounds |
| DE19838705A1 (de) * | 1998-08-26 | 2000-03-02 | Bayer Ag | Neue Dihydro-(1,2,3)-triazolo-[4,5-d]pyrimidin-7-one |
| IL139454A0 (en) * | 1999-11-08 | 2001-11-25 | Pfizer | Compounds for the treatment of female sexual dysfunction |
| JP2004534733A (ja) * | 2001-02-05 | 2004-11-18 | ドクター・レディーズ・ラボラトリーズ・リミテッド | 血中コレステロール低下剤剤としてのアリール置換アルキルカルボン酸 |
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2002
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- 2002-10-09 DO DO2002000482A patent/DOP2002000482A/es unknown
- 2002-10-22 MX MXPA04004171A patent/MXPA04004171A/es unknown
- 2002-10-22 CA CA002466824A patent/CA2466824A1/en not_active Abandoned
- 2002-10-22 JP JP2003540180A patent/JP2005511575A/ja active Pending
- 2002-10-22 EP EP02777623A patent/EP1440073A1/en not_active Withdrawn
- 2002-10-22 WO PCT/IB2002/004385 patent/WO2003037899A1/en not_active Ceased
- 2002-10-22 BR BR0214096-9A patent/BR0214096A/pt not_active IP Right Cessation
- 2002-10-29 PA PA20028557401A patent/PA8557401A1/es unknown
- 2002-10-30 PE PE2002001070A patent/PE20030702A1/es not_active Application Discontinuation
- 2002-10-30 UY UY27522A patent/UY27522A1/es not_active Application Discontinuation
- 2002-10-31 AR ARP020104152A patent/AR037329A1/es unknown
- 2002-11-01 SV SV2002001373A patent/SV2004001373A/es not_active Application Discontinuation
- 2002-11-01 TW TW091132424A patent/TW200300081A/zh unknown
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| PE20030702A1 (es) | 2003-08-21 |
| UY27522A1 (es) | 2003-06-30 |
| JP2005511575A (ja) | 2005-04-28 |
| BR0214096A (pt) | 2004-09-28 |
| DOP2002000482A (es) | 2003-05-31 |
| SV2004001373A (es) | 2004-01-07 |
| TW200300081A (en) | 2003-05-16 |
| WO2003037899A1 (en) | 2003-05-08 |
| PA8557401A1 (es) | 2003-11-12 |
| HN2002000317A (es) | 2003-05-21 |
| MXPA04004171A (es) | 2004-09-06 |
| EP1440073A1 (en) | 2004-07-28 |
| CA2466824A1 (en) | 2003-05-08 |
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