AR009103A1 - Un derivado del acido hidroxamico, un procedimiento para fabricarlo, una composicion farmaceutica que lo comprende y compuestos utiles como intermedios - Google Patents
Un derivado del acido hidroxamico, un procedimiento para fabricarlo, una composicion farmaceutica que lo comprende y compuestos utiles como intermediosInfo
- Publication number
- AR009103A1 AR009103A1 ARP970104491A ARP970104491A AR009103A1 AR 009103 A1 AR009103 A1 AR 009103A1 AR P970104491 A ARP970104491 A AR P970104491A AR P970104491 A ARP970104491 A AR P970104491A AR 009103 A1 AR009103 A1 AR 009103A1
- Authority
- AR
- Argentina
- Prior art keywords
- aryl
- amino
- alkyl
- hydroxy
- substituted
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 3
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical class C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 hydroxy- Chemical class 0.000 abstract 8
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000005915 C6-C14 aryl group Chemical group 0.000 abstract 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical class 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000005122 aminoalkylamino group Chemical group 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
- 125000006301 indolyl methyl group Chemical group 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Abstract
Un derivado del ácido hidroxámico que es una (7-N-hidroxi) diamida de ácido 3-imino-4-oxo-6 (oximetil)-heptan-1,7-dioico, en forma libre o de salfarmacéuticamente aceptable. Prefentemente el derivado responde a la formula (1), donde R1 es unsusti tuyente de la formula A-(O-(CR5H)n) m-O-CH2- en lacual n es 1, 2, 3 o 4, m es 0, 1, 2 o 3 ; cada R5 es independientemente H, alquilo (opcionalmente hidroxi-, alcoxi C1-6-, amino-alquilamino C1-6 arilo(opcionalmente hidroxi-alcoxi C1-6-,amino-, a lquilamino C1-6, halo- o ciano- sustituido) C6-14 o (arilo) C6-a4 alquilo C1-6; A es hidrogeno, alquilo C1-10,arilo C6-14, arilo C6-14 (alquilo C1-6) (arilo C6-14) carbonilo o (alquilo C1-10) carbonilo; R2 es alquilo C3-12, alqueniloC3-12, cicloa lquilo (opcionalmentehidroxi-alcoxi C1-6-, amino- o alquilamino C1-6-sustituido) C3-7 arilo C5-14 o arilo C5-14 (alquilo C1-6) donde los grupos arilo están opcionalmentesustituidos por hidroxi, alquilo C1-6-, alcoxi C1-6-, amino-,halo-, o ciano-; R3 es alquilo, (opcionalmente hidroxi- o alcoxi C1-6- amino alquilamino C1-6-,tiol-, alquilmercapto C1-6-, o hidroxi protegido-, amino-, o tiol-sustituido) C1-10, arilo (opcionalmente hidroxi-, ariloxi C6-14- o alcoxi C1-6-, amino-alquilamino C1-6- amino-alquilamino C1-6-, halo- o ciano-sustituido) C6-14 o indolilmetilo; R4 es metilo, piridilo o un sustituyente de la formula X-Y,donde X es morfolino, piridilo o arilo; e Y es alquileno C1-12, donde hasta cuatro de lasunidades de metilen o (-CH2-) están reemplazadas opcionalmente con-CO-, -NH-, -SO2- u O-; en forma libre o de sal farmacéuticamente aceptable. Los derivados son utiles como fármacos como por ejemplo para la supresion de laliberacion del TNF ypara el tratamiento de e nfermedades autoinmunes e inflamatorias, como por ejemplo, esclerosis multiple y artritis reumatoide.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9620572.9A GB9620572D0 (en) | 1996-10-02 | 1996-10-02 | Organic compounds |
| GBGB9706667.4A GB9706667D0 (en) | 1997-04-02 | 1997-04-02 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR009103A1 true AR009103A1 (es) | 2000-03-08 |
Family
ID=26310147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970104491A AR009103A1 (es) | 1996-10-02 | 1997-09-30 | Un derivado del acido hidroxamico, un procedimiento para fabricarlo, una composicion farmaceutica que lo comprende y compuestos utiles como intermedios |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP0929517B1 (es) |
| JP (1) | JP3444898B2 (es) |
| KR (1) | KR20000048811A (es) |
| CN (1) | CN1101807C (es) |
| AR (1) | AR009103A1 (es) |
| AT (1) | ATE219050T1 (es) |
| AU (1) | AU726065B2 (es) |
| BR (1) | BR9712255A (es) |
| CA (1) | CA2267415A1 (es) |
| CO (1) | CO4900034A1 (es) |
| CZ (1) | CZ113999A3 (es) |
| DE (1) | DE69713354T2 (es) |
| DK (1) | DK0929517T3 (es) |
| ES (1) | ES2178759T3 (es) |
| HU (1) | HUP9903892A3 (es) |
| ID (1) | ID22212A (es) |
| IL (1) | IL129166A0 (es) |
| MY (1) | MY127926A (es) |
| NO (1) | NO313457B1 (es) |
| NZ (1) | NZ334908A (es) |
| PE (1) | PE2099A1 (es) |
| PL (1) | PL188518B1 (es) |
| PT (1) | PT929517E (es) |
| RU (1) | RU2196131C2 (es) |
| SI (1) | SI0929517T1 (es) |
| SK (1) | SK43099A3 (es) |
| TR (1) | TR199900725T2 (es) |
| WO (1) | WO1998014424A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003294917A1 (en) * | 2002-12-20 | 2004-07-14 | Novartis Ag | Device and method for delivering mmp inhibitors |
| EP2287326A1 (en) | 2003-08-08 | 2011-02-23 | Arriva Pharmaceuticals, Inc. | Methods of protein production in yeast |
| CA2559062A1 (en) | 2004-03-09 | 2005-09-22 | Arriva Pharmaceuticals, Inc. | Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor |
| CN1951912B (zh) * | 2005-10-18 | 2010-05-05 | 上海五洲药业股份有限公司 | 手性脂环烃异羟肟酸衍生物的制备方法 |
| GB0818907D0 (en) * | 2008-10-15 | 2008-11-19 | Isis Innovation | Histone lysine demethylase inhibitors |
| KR102410199B1 (ko) * | 2016-04-18 | 2022-06-17 | 프라운호퍼-게젤샤프트 츄어 푀르더룽 데어 안게반텐 포르슝에.파우. | 새로운 메프린 알파 및 베타 저해제 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK77487A (da) * | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
| GB9223904D0 (en) * | 1992-11-13 | 1993-01-06 | British Bio Technology | Inhibition of cytokine production |
| NZ278627A (en) * | 1994-01-20 | 1997-04-24 | British Biotech Pharm | Carboxylic and hydroxamic acid derivatives and pharmaceutical compositions |
| NZ278632A (en) * | 1994-01-22 | 1998-04-27 | British Biotech Pharm | 3-aza-4-oxoheptan-1,7-dioic acid 1-amide (and 7-hydroxamic acid) derivatives |
| GB9416897D0 (en) * | 1994-08-20 | 1994-10-12 | British Biotech Pharm | Metalloproteinase inhibitors |
| GB9423914D0 (en) * | 1994-11-26 | 1995-01-11 | British Biotech Pharm | Polyether derivatives as metalloproteinase inhibitors |
-
1997
- 1997-09-30 KR KR1019990702806A patent/KR20000048811A/ko not_active Ceased
- 1997-09-30 CZ CZ991139A patent/CZ113999A3/cs unknown
- 1997-09-30 SK SK430-99A patent/SK43099A3/sk unknown
- 1997-09-30 ID IDW990143D patent/ID22212A/id unknown
- 1997-09-30 AT AT97909339T patent/ATE219050T1/de not_active IP Right Cessation
- 1997-09-30 CN CN97198511A patent/CN1101807C/zh not_active Expired - Fee Related
- 1997-09-30 NZ NZ334908A patent/NZ334908A/xx unknown
- 1997-09-30 CA CA002267415A patent/CA2267415A1/en not_active Abandoned
- 1997-09-30 PL PL97332477A patent/PL188518B1/pl not_active IP Right Cessation
- 1997-09-30 SI SI9730357T patent/SI0929517T1/xx unknown
- 1997-09-30 ES ES97909339T patent/ES2178759T3/es not_active Expired - Lifetime
- 1997-09-30 PE PE1997000874A patent/PE2099A1/es not_active Application Discontinuation
- 1997-09-30 TR TR1999/00725T patent/TR199900725T2/xx unknown
- 1997-09-30 BR BR9712255A patent/BR9712255A/pt not_active Application Discontinuation
- 1997-09-30 AU AU47068/97A patent/AU726065B2/en not_active Ceased
- 1997-09-30 AR ARP970104491A patent/AR009103A1/es unknown
- 1997-09-30 WO PCT/EP1997/005376 patent/WO1998014424A1/en not_active Ceased
- 1997-09-30 DE DE69713354T patent/DE69713354T2/de not_active Expired - Lifetime
- 1997-09-30 EP EP97909339A patent/EP0929517B1/en not_active Expired - Lifetime
- 1997-09-30 HU HU9903892A patent/HUP9903892A3/hu unknown
- 1997-09-30 DK DK97909339T patent/DK0929517T3/da active
- 1997-09-30 RU RU99108792/04A patent/RU2196131C2/ru not_active IP Right Cessation
- 1997-09-30 JP JP51623698A patent/JP3444898B2/ja not_active Expired - Fee Related
- 1997-09-30 PT PT97909339T patent/PT929517E/pt unknown
- 1997-09-30 IL IL12916697A patent/IL129166A0/xx not_active IP Right Cessation
- 1997-10-01 CO CO97057298A patent/CO4900034A1/es unknown
- 1997-10-01 MY MYPI97004587A patent/MY127926A/en unknown
-
1999
- 1999-03-30 NO NO19991559A patent/NO313457B1/no not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |