PE2099A1 - Derivados de acido hidroxamico - Google Patents
Derivados de acido hidroxamicoInfo
- Publication number
- PE2099A1 PE2099A1 PE1997000874A PE00087497A PE2099A1 PE 2099 A1 PE2099 A1 PE 2099A1 PE 1997000874 A PE1997000874 A PE 1997000874A PE 00087497 A PE00087497 A PE 00087497A PE 2099 A1 PE2099 A1 PE 2099A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- aryl
- formula
- compounds
- piridyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: R1 ES A-(O-(CR5H)n)m-O-CH2-; R2 ES ALQUILO C3-C12, ALQUENILO C3-C12, ENTRE OTROS, DE PREFERENCIA ES CICLOHEXILO, FENILO, 4-METILFENILO, 4-METOXIFENILO o ISOBUTILO; R3 ES ALQUILO C1-C10 OPCIONALMENTE SUSTITUIDO, ARILO C6-C14 o INDOLILMETILO, DE PREFERENCIA ES BENCILO o t-BUTILO; R4 ES METILO, PIRIDILO o X-Y, EN DONDE "X" ES MORFOLINO, PIRIDILO o ARILO; "Y" ES ALQUILENO C1-C12, DONDE HASTA CUATRO (-CH2-) ESTAN REEMPLAZADAS OPCIONALMENTE CON -CO-, -NH-, -SO2- u -O-; R4 DE PREFERENCIA ES METILO o MORFOLINOCARBONIL-ALQUILO C1-C6; R5 ES H, ALQUILO C1-C10 OPCIONALMENTE SUSTITUIDO, ALQUENILO C2-C6, ENTRE OTROS; "A" ES H, ALQUILO C1-C10, ARILO C6-C14, ARILO C6-C14(ALQUILO C1-C6), ENTRE OTROS; n ES 1; 2; 3 o 4; m ES 0; 1; 2 o 3. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION Y A LOS COMPUESTOS INTERMEDIOS DE FORMULA (III) Y (IV). LOS COMPUESTOS DE FORMULA (I) ACTUAN INHIBIENDO LA LIBERACION DEL FACTOR DE NECROSIS TUMORAL (TNFO), A TRAVES DE LA SUPRESION DE LA ENZIMA CONVERTASA DEL TNF, SIENDO UTILES EN EL TRATAMIENTO DE INFECCIONES AGUDAS, CAQUEXIA, ENTRE OTROS; e INHIBIENDO LAS ENZIMAS METALOPROTEASAS DE MATRIZ, POR EJEMPLO, COLAGENASA, ESTROMELISINA Y GELATINASA, SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE, OSTEOARTRITIS, ENTRE OTROS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9620572.9A GB9620572D0 (en) | 1996-10-02 | 1996-10-02 | Organic compounds |
| GBGB9706667.4A GB9706667D0 (en) | 1997-04-02 | 1997-04-02 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE2099A1 true PE2099A1 (es) | 1999-02-08 |
Family
ID=26310147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997000874A PE2099A1 (es) | 1996-10-02 | 1997-09-30 | Derivados de acido hidroxamico |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP0929517B1 (es) |
| JP (1) | JP3444898B2 (es) |
| KR (1) | KR20000048811A (es) |
| CN (1) | CN1101807C (es) |
| AR (1) | AR009103A1 (es) |
| AT (1) | ATE219050T1 (es) |
| AU (1) | AU726065B2 (es) |
| BR (1) | BR9712255A (es) |
| CA (1) | CA2267415A1 (es) |
| CO (1) | CO4900034A1 (es) |
| CZ (1) | CZ113999A3 (es) |
| DE (1) | DE69713354T2 (es) |
| DK (1) | DK0929517T3 (es) |
| ES (1) | ES2178759T3 (es) |
| HU (1) | HUP9903892A3 (es) |
| ID (1) | ID22212A (es) |
| IL (1) | IL129166A0 (es) |
| MY (1) | MY127926A (es) |
| NO (1) | NO313457B1 (es) |
| NZ (1) | NZ334908A (es) |
| PE (1) | PE2099A1 (es) |
| PL (1) | PL188518B1 (es) |
| PT (1) | PT929517E (es) |
| RU (1) | RU2196131C2 (es) |
| SI (1) | SI0929517T1 (es) |
| SK (1) | SK43099A3 (es) |
| TR (1) | TR199900725T2 (es) |
| WO (1) | WO1998014424A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003294917A1 (en) * | 2002-12-20 | 2004-07-14 | Novartis Ag | Device and method for delivering mmp inhibitors |
| EP2287326A1 (en) | 2003-08-08 | 2011-02-23 | Arriva Pharmaceuticals, Inc. | Methods of protein production in yeast |
| CA2559062A1 (en) | 2004-03-09 | 2005-09-22 | Arriva Pharmaceuticals, Inc. | Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor |
| CN1951912B (zh) * | 2005-10-18 | 2010-05-05 | 上海五洲药业股份有限公司 | 手性脂环烃异羟肟酸衍生物的制备方法 |
| GB0818907D0 (en) * | 2008-10-15 | 2008-11-19 | Isis Innovation | Histone lysine demethylase inhibitors |
| KR102410199B1 (ko) * | 2016-04-18 | 2022-06-17 | 프라운호퍼-게젤샤프트 츄어 푀르더룽 데어 안게반텐 포르슝에.파우. | 새로운 메프린 알파 및 베타 저해제 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK77487A (da) * | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
| GB9223904D0 (en) * | 1992-11-13 | 1993-01-06 | British Bio Technology | Inhibition of cytokine production |
| NZ278627A (en) * | 1994-01-20 | 1997-04-24 | British Biotech Pharm | Carboxylic and hydroxamic acid derivatives and pharmaceutical compositions |
| NZ278632A (en) * | 1994-01-22 | 1998-04-27 | British Biotech Pharm | 3-aza-4-oxoheptan-1,7-dioic acid 1-amide (and 7-hydroxamic acid) derivatives |
| GB9416897D0 (en) * | 1994-08-20 | 1994-10-12 | British Biotech Pharm | Metalloproteinase inhibitors |
| GB9423914D0 (en) * | 1994-11-26 | 1995-01-11 | British Biotech Pharm | Polyether derivatives as metalloproteinase inhibitors |
-
1997
- 1997-09-30 KR KR1019990702806A patent/KR20000048811A/ko not_active Ceased
- 1997-09-30 CZ CZ991139A patent/CZ113999A3/cs unknown
- 1997-09-30 SK SK430-99A patent/SK43099A3/sk unknown
- 1997-09-30 ID IDW990143D patent/ID22212A/id unknown
- 1997-09-30 AT AT97909339T patent/ATE219050T1/de not_active IP Right Cessation
- 1997-09-30 CN CN97198511A patent/CN1101807C/zh not_active Expired - Fee Related
- 1997-09-30 NZ NZ334908A patent/NZ334908A/xx unknown
- 1997-09-30 CA CA002267415A patent/CA2267415A1/en not_active Abandoned
- 1997-09-30 PL PL97332477A patent/PL188518B1/pl not_active IP Right Cessation
- 1997-09-30 SI SI9730357T patent/SI0929517T1/xx unknown
- 1997-09-30 ES ES97909339T patent/ES2178759T3/es not_active Expired - Lifetime
- 1997-09-30 PE PE1997000874A patent/PE2099A1/es not_active Application Discontinuation
- 1997-09-30 TR TR1999/00725T patent/TR199900725T2/xx unknown
- 1997-09-30 BR BR9712255A patent/BR9712255A/pt not_active Application Discontinuation
- 1997-09-30 AU AU47068/97A patent/AU726065B2/en not_active Ceased
- 1997-09-30 AR ARP970104491A patent/AR009103A1/es unknown
- 1997-09-30 WO PCT/EP1997/005376 patent/WO1998014424A1/en not_active Ceased
- 1997-09-30 DE DE69713354T patent/DE69713354T2/de not_active Expired - Lifetime
- 1997-09-30 EP EP97909339A patent/EP0929517B1/en not_active Expired - Lifetime
- 1997-09-30 HU HU9903892A patent/HUP9903892A3/hu unknown
- 1997-09-30 DK DK97909339T patent/DK0929517T3/da active
- 1997-09-30 RU RU99108792/04A patent/RU2196131C2/ru not_active IP Right Cessation
- 1997-09-30 JP JP51623698A patent/JP3444898B2/ja not_active Expired - Fee Related
- 1997-09-30 PT PT97909339T patent/PT929517E/pt unknown
- 1997-09-30 IL IL12916697A patent/IL129166A0/xx not_active IP Right Cessation
- 1997-10-01 CO CO97057298A patent/CO4900034A1/es unknown
- 1997-10-01 MY MYPI97004587A patent/MY127926A/en unknown
-
1999
- 1999-03-30 NO NO19991559A patent/NO313457B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |