AR004672A1 - Derivados de la banzo(g)quinolina, proceso para prepararlos,su utilizacion como productos farmaceuticos, las composiciones farmaceuticas que los contieneny los metodos de tratamiento de la depresion, ansiedad y desordenes bipolares que utilizan dichos compuestos. - Google Patents
Derivados de la banzo(g)quinolina, proceso para prepararlos,su utilizacion como productos farmaceuticos, las composiciones farmaceuticas que los contieneny los metodos de tratamiento de la depresion, ansiedad y desordenes bipolares que utilizan dichos compuestos.Info
- Publication number
- AR004672A1 AR004672A1 ARP960103468A AR10346896A AR004672A1 AR 004672 A1 AR004672 A1 AR 004672A1 AR P960103468 A ARP960103468 A AR P960103468A AR 10346896 A AR10346896 A AR 10346896A AR 004672 A1 AR004672 A1 AR 004672A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- anxiety
- alkyl
- carbon atoms
- methods
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 208000019901 Anxiety disease Diseases 0.000 title abstract 2
- 208000020925 Bipolar disease Diseases 0.000 title abstract 2
- 230000036506 anxiety Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229940127557 pharmaceutical product Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- -1 R2 is H Chemical group 0.000 abstract 3
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/08—Aza-anthracenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invención proporciona compuestos de la fórmula (I), X es 0O ó H,H; Y es -CH2-, -O-,-NH- ó -S-, R1 es H o alquilo de 1 a 4 átomos de carbono, R2 es H,bencilo, pirimidilo, bis (4-fluorofenil)metilo o un grupo de las fórmulas (a), (b), (c),(d ), en donde R5 es H, o alquilo de 1 a 4 átomos de carbono, yR6, R7, R8 y R9 son independientemente H, OH, NO2, CF3, alquilo de 1 a 4 átomos de carbono, acetilo, CONR10R11, COOR12, [R11 y R12 que son independientementeH o alquilo de 1 a 4 átomosde ca rbono], CN ó (C1-4)alquilsulfonilo, R3 es H, alquilo de 1 a 4 átomos de carbono, (C1-4)alquilsulfonilo, trifluorometilsulfonilo o un grupo de la fórmula (II), en donde n es de 1 a 5 y m es de 1 a 3, en la forma de sal de adición de ácido ode bas e libre. Los compuestos de lafórmula (I) son útiles como productos farmacéuticos.Se describen además las composiciones farmacéuticas que contienen dichos compuestos (I) y los métodosde tratamiento de la depresión, ansiedad y desórdenesbipolares que utilizan dichcos compuestos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9513880.6A GB9513880D0 (en) | 1995-07-07 | 1995-07-07 | Organic compounds |
| GBGB9603988.8A GB9603988D0 (en) | 1996-02-26 | 1996-02-26 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR004672A1 true AR004672A1 (es) | 1999-03-10 |
Family
ID=26307342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960103468A AR004672A1 (es) | 1995-07-07 | 1996-07-05 | Derivados de la banzo(g)quinolina, proceso para prepararlos,su utilizacion como productos farmaceuticos, las composiciones farmaceuticas que los contieneny los metodos de tratamiento de la depresion, ansiedad y desordenes bipolares que utilizan dichos compuestos. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5885988A (es) |
| EP (1) | EP0839136B1 (es) |
| JP (1) | JPH11509197A (es) |
| KR (1) | KR19990028757A (es) |
| CN (1) | CN1193964A (es) |
| AR (1) | AR004672A1 (es) |
| AT (1) | ATE201199T1 (es) |
| AU (1) | AU703325B2 (es) |
| BR (1) | BR9609326A (es) |
| CA (1) | CA2224436A1 (es) |
| CO (1) | CO4750662A1 (es) |
| CZ (1) | CZ1698A3 (es) |
| DE (1) | DE69612852T2 (es) |
| DK (1) | DK0839136T3 (es) |
| ES (1) | ES2158327T3 (es) |
| GR (1) | GR3036346T3 (es) |
| HU (1) | HUP9802937A3 (es) |
| IL (1) | IL122854A (es) |
| NO (1) | NO310070B1 (es) |
| NZ (1) | NZ313606A (es) |
| PE (1) | PE1998A1 (es) |
| PL (1) | PL324106A1 (es) |
| PT (1) | PT839136E (es) |
| RU (1) | RU2158738C2 (es) |
| SK (1) | SK1798A3 (es) |
| TR (1) | TR199800011T1 (es) |
| TW (1) | TW357143B (es) |
| WO (1) | WO1997003054A1 (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9711043D0 (en) * | 1997-05-29 | 1997-07-23 | Ciba Geigy Ag | Organic compounds |
| CA2327695A1 (en) | 1998-04-08 | 1999-10-21 | Takeda Chemical Industries, Ltd. | Amine compounds, their production and their use as somatostatin receptor antagonists or agonists |
| CA2246791A1 (en) * | 1998-09-01 | 2000-03-01 | Alison Buchan | Treatment of endothelium with somatostatin analogues |
| ES2300151T3 (es) * | 1998-09-22 | 2008-06-01 | Astellas Pharma Inc. | Derivados de cianofenilo. |
| RU2221785C2 (ru) * | 1998-09-22 | 2004-01-20 | Яманоути Фармасьютикал Ко., Лтд. | Гетероциклическое производное, фармацевтическая композиция, его содержащая, и промежуточный продукт |
| GB9902938D0 (en) * | 1999-02-10 | 1999-03-31 | Novartis Ag | Organic compounds |
| PE20030240A1 (es) * | 2001-07-09 | 2003-04-16 | Novartis Ag | DERIVADOS DE BENZO [g] QUINOLINA |
| FI20031454A0 (fi) | 2003-10-06 | 2003-10-06 | Juvantia Pharma Ltd Oy | Selektiivisiä somatostatiinireseptori 1 ja/tai 4 -agonisteja ja -antagonisteja |
| KR100594234B1 (ko) | 2003-12-05 | 2006-06-30 | 삼성전자주식회사 | 편광 현상을 이용하여 해상도를 향상시킬 수 있는 포토마스크 및 그 제조방법 |
| AU2005286648A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| EP2316458A1 (en) | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| MX2007003325A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores estearoil-coa-desaturasa. |
| CN101084212A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶介导剂的用途 |
| CN101083993A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途 |
| US7777036B2 (en) | 2004-09-20 | 2010-08-17 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
| AU2005286793A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes |
| BRPI0611187A2 (pt) | 2005-06-03 | 2010-08-24 | Xenon Pharmaceuticals Inc | derivados aminotiazàis como inibidores da estearoil-coa desaturase humana |
| TWI404702B (zh) * | 2007-08-31 | 2013-08-11 | Lundbeck & Co As H | 兒茶酚胺衍生物和其前藥 |
| US8067410B2 (en) | 2008-06-27 | 2011-11-29 | H. Lundbeck A/S | Phenolic and catecholic amines and prodrugs thereof |
| US11136312B2 (en) | 2017-05-12 | 2021-10-05 | Board of Trustees of the Southern Illinois University | 3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof |
| US11912687B2 (en) | 2017-05-12 | 2024-02-27 | Board of Trustees of the Southern Illinois University | 3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof |
| MX2020005366A (es) | 2017-11-24 | 2020-08-13 | H Lundbeck As | Nuevos profarmacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson. |
| US11130775B2 (en) | 2019-05-20 | 2021-09-28 | H. Lundbeck A/S | Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11168056B2 (en) | 2019-05-20 | 2021-11-09 | H. Lundbeck A/S | Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol |
| US11104697B2 (en) | 2019-05-20 | 2021-08-31 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11111263B2 (en) | 2019-05-20 | 2021-09-07 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| CN113727974B (zh) | 2019-05-21 | 2025-01-07 | H.隆德贝克有限公司 | 用于治疗帕金森病的新儿茶酚胺前药 |
| EP3972970A1 (en) | 2019-05-21 | 2022-03-30 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's disease |
| WO2020234277A1 (en) | 2019-05-21 | 2020-11-26 | H. Lundbeck A/S | Catecholamine carbamate prodrugs for use in the treatment of parkinson s disease |
| WO2020234275A1 (en) | 2019-05-21 | 2020-11-26 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's diseases |
| JP7099717B2 (ja) | 2019-09-30 | 2022-07-12 | 株式会社理研バイオ | ソマトスタチン受容体 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH630902A5 (en) * | 1977-01-24 | 1982-07-15 | Sandoz Ag | Process for preparing novel derivatives of 1,2,3,4,4a,10b-hexahydrobenzo(f)isoquinoline. |
| ATE56958T1 (de) * | 1981-10-16 | 1990-10-15 | Sandoz Ag | 1,2,3,4,4a,5,10,10a-octahydrobenzo(g)chinolinderivate mit pharmazeutischer wirkung. |
| SU1109393A1 (ru) * | 1983-04-28 | 1984-08-23 | Ордена Трудового Красного Знамени Институт Физики Ан Бсср | Способ получени 9-диэтиламинобензо/ @ /феноксазинона-5 или его производных |
| NL194166C (nl) * | 1984-06-12 | 2001-08-03 | Novartis Ag | Naftoxazinen en bereiding en toepassing daarvan. Hexahydronaft[2,3-b]-1,4-oxazinen en farmaceutische preparaten die ze bevatten. |
| NL8702680A (nl) * | 1986-11-21 | 1988-06-16 | Sandoz Ag | Nieuwe benzogchinolinen en werkwijzen voor het bereiden en toepassen van deze verbindingen. |
| WO1993024471A1 (en) * | 1992-06-02 | 1993-12-09 | Whitby Research, Inc. | Substituted naphthoxazines useful as dopaminergics |
| WO1994021614A1 (en) * | 1993-03-24 | 1994-09-29 | Merck & Co., Inc. | SUBSTITUTED 3-PHENANTHRIDINONE DERIVATIVES AS 5α-REDUCTASE INHIBITORS |
| DE4329776A1 (de) * | 1993-09-03 | 1995-03-09 | Sandoz Ag | Naphthoxazine, ihre Herstellung und Verwendung |
-
1996
- 1996-06-12 TW TW085107047A patent/TW357143B/zh active
- 1996-07-05 NZ NZ313606A patent/NZ313606A/xx unknown
- 1996-07-05 DK DK96925672T patent/DK0839136T3/da active
- 1996-07-05 RU RU98102128/04A patent/RU2158738C2/ru active
- 1996-07-05 JP JP9505489A patent/JPH11509197A/ja active Pending
- 1996-07-05 HU HU9802937A patent/HUP9802937A3/hu unknown
- 1996-07-05 BR BR9609326A patent/BR9609326A/pt active Search and Examination
- 1996-07-05 CZ CZ9816A patent/CZ1698A3/cs unknown
- 1996-07-05 WO PCT/EP1996/002969 patent/WO1997003054A1/en not_active Ceased
- 1996-07-05 ES ES96925672T patent/ES2158327T3/es not_active Expired - Lifetime
- 1996-07-05 KR KR1019980700056A patent/KR19990028757A/ko not_active Ceased
- 1996-07-05 SK SK17-98A patent/SK1798A3/sk unknown
- 1996-07-05 EP EP96925672A patent/EP0839136B1/en not_active Expired - Lifetime
- 1996-07-05 PE PE1996000517A patent/PE1998A1/es not_active Application Discontinuation
- 1996-07-05 CA CA002224436A patent/CA2224436A1/en not_active Abandoned
- 1996-07-05 DE DE69612852T patent/DE69612852T2/de not_active Expired - Fee Related
- 1996-07-05 PL PL96324106A patent/PL324106A1/xx unknown
- 1996-07-05 TR TR1998/00011T patent/TR199800011T1/xx unknown
- 1996-07-05 AU AU66120/96A patent/AU703325B2/en not_active Ceased
- 1996-07-05 IL IL12285496A patent/IL122854A/xx not_active IP Right Cessation
- 1996-07-05 AR ARP960103468A patent/AR004672A1/es unknown
- 1996-07-05 CN CN96196551A patent/CN1193964A/zh active Pending
- 1996-07-05 AT AT96925672T patent/ATE201199T1/de not_active IP Right Cessation
- 1996-07-05 CO CO96035363A patent/CO4750662A1/es unknown
- 1996-07-05 PT PT96925672T patent/PT839136E/pt unknown
- 1996-07-05 US US08/983,535 patent/US5885988A/en not_active Expired - Fee Related
-
1998
- 1998-01-05 NO NO980043A patent/NO310070B1/no not_active IP Right Cessation
-
2001
- 2001-08-07 GR GR20010401198T patent/GR3036346T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0839136A1 (en) | 1998-05-06 |
| RU2158738C2 (ru) | 2000-11-10 |
| MX9710530A (es) | 1998-03-31 |
| TR199800011T1 (xx) | 1998-04-21 |
| ES2158327T3 (es) | 2001-09-01 |
| DE69612852D1 (de) | 2001-06-21 |
| HUP9802937A3 (en) | 2002-10-28 |
| PT839136E (pt) | 2001-09-28 |
| NO980043D0 (no) | 1998-01-05 |
| CZ1698A3 (cs) | 1998-04-15 |
| AU6612096A (en) | 1997-02-10 |
| AU703325B2 (en) | 1999-03-25 |
| CO4750662A1 (es) | 1999-03-31 |
| DE69612852T2 (de) | 2001-10-04 |
| KR19990028757A (ko) | 1999-04-15 |
| NO310070B1 (no) | 2001-05-14 |
| PL324106A1 (en) | 1998-05-11 |
| JPH11509197A (ja) | 1999-08-17 |
| WO1997003054A1 (en) | 1997-01-30 |
| TW357143B (en) | 1999-05-01 |
| NZ313606A (en) | 1999-07-29 |
| DK0839136T3 (da) | 2001-08-06 |
| CN1193964A (zh) | 1998-09-23 |
| EP0839136B1 (en) | 2001-05-16 |
| HUP9802937A2 (hu) | 1999-10-28 |
| IL122854A0 (en) | 1998-08-16 |
| GR3036346T3 (en) | 2001-11-30 |
| SK1798A3 (en) | 1998-06-03 |
| PE1998A1 (es) | 1998-02-14 |
| BR9609326A (pt) | 1999-05-25 |
| NO980043L (no) | 1998-01-05 |
| IL122854A (en) | 2000-12-06 |
| ATE201199T1 (de) | 2001-06-15 |
| CA2224436A1 (en) | 1997-01-30 |
| US5885988A (en) | 1999-03-23 |
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