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NO312512B1 - Oksadiazoler, anvendelse derav, fremgangsmåte for deres fremstilling, samt farmasöytiske preparater - Google Patents

Oksadiazoler, anvendelse derav, fremgangsmåte for deres fremstilling, samt farmasöytiske preparater Download PDF

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Publication number
NO312512B1
NO312512B1 NO19991815A NO991815A NO312512B1 NO 312512 B1 NO312512 B1 NO 312512B1 NO 19991815 A NO19991815 A NO 19991815A NO 991815 A NO991815 A NO 991815A NO 312512 B1 NO312512 B1 NO 312512B1
Authority
NO
Norway
Prior art keywords
formula
group
phenyl
methyl
optionally
Prior art date
Application number
NO19991815A
Other languages
English (en)
Norwegian (no)
Other versions
NO991815L (no
NO991815D0 (no
Inventor
Michael Brenner
Roland Maier
Marion Wienrich
Thomas Weiser
Rainer Palluk
Wolf-Dietrich Bechtel
Angelo Sagrada
Helmut Ensinger
Uwe Pschorn
Raffaele Cesana
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO991815L publication Critical patent/NO991815L/no
Publication of NO991815D0 publication Critical patent/NO991815D0/no
Publication of NO312512B1 publication Critical patent/NO312512B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO19991815A 1996-10-18 1999-04-16 Oksadiazoler, anvendelse derav, fremgangsmåte for deres fremstilling, samt farmasöytiske preparater NO312512B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19643037A DE19643037A1 (de) 1996-10-18 1996-10-18 Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
PCT/EP1997/005693 WO1998017652A1 (de) 1996-10-18 1997-10-15 Oxadiazole, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Publications (3)

Publication Number Publication Date
NO991815L NO991815L (no) 1999-04-16
NO991815D0 NO991815D0 (no) 1999-04-16
NO312512B1 true NO312512B1 (no) 2002-05-21

Family

ID=7809114

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19991815A NO312512B1 (no) 1996-10-18 1999-04-16 Oksadiazoler, anvendelse derav, fremgangsmåte for deres fremstilling, samt farmasöytiske preparater

Country Status (31)

Country Link
US (1) US6277872B1 (es)
EP (1) EP0934288B1 (es)
JP (1) JP3333523B2 (es)
KR (1) KR20000049253A (es)
CN (1) CN1086698C (es)
AR (1) AR008496A1 (es)
AT (1) ATE315034T1 (es)
AU (1) AU737552B2 (es)
BG (1) BG103251A (es)
BR (1) BR9714354A (es)
CA (1) CA2268954C (es)
CO (1) CO4920253A1 (es)
CZ (1) CZ138099A3 (es)
DE (2) DE19643037A1 (es)
EE (1) EE9900147A (es)
ES (1) ES2256880T3 (es)
HR (1) HRP970553A2 (es)
HU (1) HUP0001652A3 (es)
ID (1) ID18613A (es)
IL (1) IL129315A0 (es)
NO (1) NO312512B1 (es)
NZ (1) NZ335598A (es)
PE (1) PE11199A1 (es)
PL (1) PL332432A1 (es)
RU (1) RU2182905C2 (es)
SK (1) SK49999A3 (es)
TR (1) TR199900848T2 (es)
TW (1) TW413678B (es)
WO (1) WO1998017652A1 (es)
YU (1) YU40997A (es)
ZA (1) ZA979220B (es)

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CN1245386C (zh) 2000-06-12 2006-03-15 卫材株式会社 1,2－二氢吡啶化合物及其制备方法和用途
HU228961B1 (en) * 2000-09-18 2013-07-29 Eisai R & D Man Co Triazinones and their use as active ingredients of pharmaceutical compositions
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MY151199A (en) 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
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HRP20050168A2 (en) 2002-08-23 2005-10-31 Rigel Pharmaceuticals Pyridyl substituted heterocycles useful for treating or preventing hcv infection
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US7326790B2 (en) 2003-05-02 2008-02-05 Rigel Pharmaceuticals, Inc. Diphenylisoxazole compounds and hydro isomers thereof
WO2004099164A1 (en) * 2003-05-02 2004-11-18 Rigel Pharmaceuticals, Inc. Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating hcv infection
US7220745B2 (en) 2003-05-15 2007-05-22 Rigel Pharmaceuticals Heterocyclic compounds useful to treat HCV
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AU2004303604B2 (en) 2003-12-24 2011-03-24 Prosidion Limited Heterocyclic derivatives as GPCR receptor agonists
US7514434B2 (en) 2004-02-23 2009-04-07 Rigel Pharmaceuticals, Inc. Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
CA2603959A1 (en) * 2005-04-08 2006-10-19 Eisai R & D Management Co., Ltd. Therapeutic agent for dyskinesia
JP2008540425A (ja) 2005-05-02 2008-11-20 ライジェル ファーマシューティカルズ， インコーポレイテッド 代謝可能部分を含む複素環式抗ウイルス性化合物およびその使用
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HUP0500920A2 (en) * 2005-10-05 2007-07-30 Richter Gedeon Nyrt Oxadiazole derivatives, process for their preparation and their use
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ES2862923T3 (es) 2008-06-09 2021-10-08 Univ Muenchen Ludwig Maximilians Nuevos fármacos para inhibir la agregación de proteínas implicadas en enfermedades relacionadas con enfermedades neurodegenerativas y/o agregación de proteínas
RU2398770C1 (ru) * 2009-03-27 2010-09-10 Учреждение Российской академии наук Институт молекулярной генетики РАН (ИМГ РАН) Меченная тритием 3-[5-(2-фторфенил)-1,2,4-оксадиазол-3-ил]бензойная кислота
WO2011047129A1 (en) * 2009-10-15 2011-04-21 Southern Research Institute Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such
CN104768949A (zh) * 2012-08-24 2015-07-08 特温蒂斯公司 苯并呋咱抗淀粉样蛋白化合物和方法
TR201910291T4 (tr) 2014-02-27 2019-07-22 Treventis Corp Benzofurazan içeren anti-amiloid bileşikleri.
BR112016022451B1 (pt) 2014-04-24 2021-03-30 Sumitomo Chemical Company, Limited Composto de diaril-azol e agente de controle de peste artrópoda
EP3197888A4 (en) * 2014-09-25 2018-03-14 University of Notre Dame du Lac Non-beta lactam antibiotics
CN107286174B (zh) * 2016-04-11 2020-08-18 上海勋和医药科技有限公司 取代2,4-(1h,3h)嘧啶二酮作为parp抑制剂及其应用
WO2018049404A1 (en) 2016-09-12 2018-03-15 University Of Notre Dame Du Lac Compounds for the treatment of clostridium difficile infection
JP7283699B2 (ja) 2017-05-12 2023-05-30 マックス－プランク－ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ 黒色腫の治療または予防において使用するためのフェニル－ヘテロ環－フェニル誘導体
US10676467B2 (en) 2017-06-30 2020-06-09 Washington University Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof
KR102912861B1 (ko) 2018-12-14 2026-01-15 에자이 알앤드디 매니지먼트 가부시키가이샤 1,2-디하이드로피리딘 화합물의 수성 기반 약학적 제형
EP4403185A4 (en) 2021-09-15 2025-10-08 Univ Of The Ryukyus PHARMACEUTICAL COMPOSITION INTENDED FOR USE IN THE TREATMENT OF EITHER THE DECLINE OF COGNITIVE FUNCTIONS OR OVERWEIGHT OR OBESITY
US20240398775A1 (en) 2021-09-15 2024-12-05 University Of The Ryukyus Pharmaceutical composition for use in treating cognitive decline or for use in treating overweight or obesity
EP4173485A1 (en) 2021-10-27 2023-05-03 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Protein aggregation inhibiting compounds for plant disease control

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Also Published As

Publication number Publication date
AU4867697A (en) 1998-05-15
RU2182905C2 (ru) 2002-05-27
ID18613A (id) 1998-04-23
US6277872B1 (en) 2001-08-21
HRP970553A2 (en) 1998-08-31
ZA979220B (en) 1998-04-20
EE9900147A (et) 1999-12-15
NZ335598A (en) 2001-06-29
NO991815L (no) 1999-04-16
HUP0001652A3 (en) 2002-12-28
ATE315034T1 (de) 2006-02-15
YU40997A (sh) 2000-10-30
BG103251A (bg) 2000-02-29
TW413678B (en) 2000-12-01
SK49999A3 (en) 1999-11-08
JP3333523B2 (ja) 2002-10-15
WO1998017652A1 (de) 1998-04-30
HUP0001652A2 (hu) 2001-01-29
TR199900848T2 (xx) 1999-06-21
IL129315A0 (en) 2000-02-17
CA2268954C (en) 2006-06-13
CN1086698C (zh) 2002-06-26
DE59712543D1 (de) 2006-03-30
CO4920253A1 (es) 2000-05-29
EP0934288B1 (de) 2006-01-04
JP2000505089A (ja) 2000-04-25
AU737552B2 (en) 2001-08-23
CN1233245A (zh) 1999-10-27
PE11199A1 (es) 1999-03-03
NO991815D0 (no) 1999-04-16
ES2256880T3 (es) 2006-07-16
EP0934288A1 (de) 1999-08-11
KR20000049253A (ko) 2000-07-25
CA2268954A1 (en) 1998-04-30
PL332432A1 (en) 1999-09-13
AR008496A1 (es) 2000-01-19
CZ138099A3 (cs) 1999-11-17
BR9714354A (pt) 2000-04-11
DE19643037A1 (de) 1998-04-23
HK1020956A1 (en) 2000-05-26

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