AR005945A1 - Composicion farmaceutica para la modulacion inmunitaria - Google Patents
Composicion farmaceutica para la modulacion inmunitariaInfo
- Publication number
- AR005945A1 AR005945A1 ARP970100701A ARP970100701A AR005945A1 AR 005945 A1 AR005945 A1 AR 005945A1 AR P970100701 A ARP970100701 A AR P970100701A AR P970100701 A ARP970100701 A AR P970100701A AR 005945 A1 AR005945 A1 AR 005945A1
- Authority
- AR
- Argentina
- Prior art keywords
- peptide
- pharmaceutical composition
- adjuvant
- cells
- vaccine
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000036039 immunity Effects 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 239000002671 adjuvant Substances 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 230000002519 immonomodulatory effect Effects 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 108010039918 Polylysine Proteins 0.000 abstract 1
- 102000004338 Transferrin Human genes 0.000 abstract 1
- 108090000901 Transferrin Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 125000000837 carbohydrate group Chemical group 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 230000035515 penetration Effects 0.000 abstract 1
- 229920000724 poly(L-arginine) polymer Polymers 0.000 abstract 1
- 229920001308 poly(aminoacid) Polymers 0.000 abstract 1
- 108010011110 polyarginine Proteins 0.000 abstract 1
- 229920000656 polylysine Polymers 0.000 abstract 1
- 230000002787 reinforcement Effects 0.000 abstract 1
- 239000012581 transferrin Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Composición farmacéutica que contiene al menos un péptido de acción inmunomoduladora junto con un adyuvante. El péptido se deriva de un agentepatógeno o de un antígeno de tumores. El adyuvante tiene la capacidad de aumentar lafijación del péptido a las células del individuo a tratar o lapenetración del péptido en las células y de determinar un refuerzo de la acción inmunomoduladora del péptido. Adyuvantes preferidos son poliaminoácidosde carácter básico, talescomo poliarg inina o polilisina que eventualmente están conjugados con un ligando celular, por ejemplo un resto de hidrato decarbono o transferrina. La composición sirve sobre todo para la aplicación como vacuna, por ejemplo como vacunacontra tumores.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19607044A DE19607044A1 (de) | 1996-02-24 | 1996-02-24 | Tumorvakzine und Verfahren zu ihrer Herstellung |
| DE19638313A DE19638313C2 (de) | 1996-09-19 | 1996-09-19 | Pharmazeutische Zusammensetzung für die Immunmodulation |
| DE19648687A DE19648687A1 (de) | 1996-11-25 | 1996-11-25 | Pharmazeutische Zusammensetzung für die Immunmodulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR005945A1 true AR005945A1 (es) | 1999-07-21 |
Family
ID=27215945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970100701A AR005945A1 (es) | 1996-02-24 | 1997-02-21 | Composicion farmaceutica para la modulacion inmunitaria |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US7105162B1 (es) |
| EP (1) | EP0881906B2 (es) |
| JP (1) | JP4184433B2 (es) |
| KR (1) | KR100457647B1 (es) |
| CN (1) | CN1177610C (es) |
| AR (1) | AR005945A1 (es) |
| AT (1) | ATE274350T1 (es) |
| AU (1) | AU722264B2 (es) |
| BG (1) | BG63682B1 (es) |
| BR (1) | BR9707694A (es) |
| CA (1) | CA2243559C (es) |
| CO (1) | CO4600681A1 (es) |
| CZ (1) | CZ295396B6 (es) |
| DE (1) | DE59711873D1 (es) |
| DK (1) | DK0881906T4 (es) |
| EE (1) | EE04481B1 (es) |
| ES (1) | ES2225951T5 (es) |
| HR (1) | HRP970100B1 (es) |
| HU (1) | HU224410B1 (es) |
| ID (1) | ID16038A (es) |
| IL (1) | IL125361A (es) |
| MY (1) | MY119276A (es) |
| NO (1) | NO983850L (es) |
| NZ (1) | NZ332020A (es) |
| PE (1) | PE55398A1 (es) |
| PL (1) | PL189413B1 (es) |
| PT (1) | PT881906E (es) |
| RO (1) | RO119344B1 (es) |
| RS (1) | RS50101B (es) |
| SI (1) | SI0881906T2 (es) |
| SK (1) | SK284582B6 (es) |
| TR (1) | TR199801649T2 (es) |
| TW (1) | TW585774B (es) |
| WO (1) | WO1997030721A1 (es) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO4600681A1 (es) | 1996-02-24 | 1998-05-08 | Boehringer Ingelheim Pharma | Composicion farmaceutica para la modulacion inmunitaria |
| DE19803453A1 (de) | 1998-01-30 | 1999-08-12 | Boehringer Ingelheim Int | Vakzine |
| EP1061951B1 (en) * | 1998-02-25 | 2003-08-27 | THE GOVERNMENT OF THE UNITED STATES, as represented by THE SECRETARY OF THE ARMY | Use of skin penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response induced by adp-ribosylating exotoxin |
| ES2283053T3 (es) * | 1998-04-20 | 2007-10-16 | Torrey Pines Institute For Molecular Studies | Inmunoestimulacion topica para inducir la migracion celular de langerhans. |
| EP2204186B1 (en) * | 1999-02-17 | 2016-04-06 | CSL Limited | Immunogenic complexes and methods relating thereto |
| DE19909503A1 (de) * | 1999-03-04 | 2000-09-07 | Boehringer Ingelheim Int | Tumorassoziiertes Antigen |
| US6809179B1 (en) | 1999-08-04 | 2004-10-26 | Boehringer Ingelheim International Gmbh | Tumor-associated antigen (R11) |
| AT408721B (de) | 1999-10-01 | 2002-02-25 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung enthaltend ein antigen |
| AT409085B (de) * | 2000-01-28 | 2002-05-27 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen |
| US20020009491A1 (en) * | 2000-02-14 | 2002-01-24 | Rothbard Jonathan B. | Compositions and methods for enhancing drug delivery across biological membranes and tissues |
| AT409762B (de) * | 2000-04-13 | 2002-11-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung von zytokin sekretierenden zellen |
| AT410173B (de) | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
| KR20020014459A (ko) * | 2000-08-18 | 2002-02-25 | 서진호 | 양이온성 아미노산이 부가된 융합단백질 및 이를 이용한생물공정의 개선방법 |
| US7244438B2 (en) | 2001-01-05 | 2007-07-17 | Intercell Ag | Uses for polycationic compounds |
| EP1347776A2 (en) * | 2001-01-05 | 2003-10-01 | Intercell Biomedizinische Forschungs- und Entwicklungs AG | Anti-inflammatory use of polycationic compounds |
| WO2002053184A2 (en) * | 2001-01-05 | 2002-07-11 | Intercell Ag | Uses for polycationic compounds as vaccine adjuvants |
| AT410798B (de) | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
| FR2824326B1 (fr) * | 2001-05-04 | 2004-03-19 | Commissariat Energie Atomique | Melange de peptides issus des proteines e6 et/ou e7 de papillomavirus et leurs applications |
| US20050250716A1 (en) * | 2001-12-07 | 2005-11-10 | Intercell Ag | Immunostimulatory oligodeoxynucleotides |
| US20050221350A1 (en) * | 2002-05-29 | 2005-10-06 | Toni Weinschenk | Method for identifying immunoreactive peptides |
| CA2484941A1 (en) | 2002-07-24 | 2004-02-05 | Intercell Ag | Antigens encoded by alternative reading frame from pathogenic viruses |
| AU2003258672B2 (en) | 2002-09-13 | 2008-10-30 | Intercell Ag | Method for isolating hepatitis C virus peptides |
| JP5116971B2 (ja) | 2002-10-15 | 2013-01-09 | インターセル アーゲー | Ｂ群連鎖球菌の接着因子をコードする核酸、ｂ群連鎖球菌の接着因子、およびその使用 |
| EP2287311A1 (en) | 2003-03-04 | 2011-02-23 | Intercell AG | Streptococcus pyogenes antigens |
| ATE485056T1 (de) | 2003-03-24 | 2010-11-15 | Intercell Ag | Verbesserte impfstoffe |
| DE602004024179D1 (de) | 2003-03-31 | 2009-12-31 | Intercell Ag | Staphylococcus epidermidis antigene |
| EP2336357A1 (en) | 2003-04-15 | 2011-06-22 | Intercell AG | S. pneumoniae antigens |
| CN101914552A (zh) | 2003-05-07 | 2010-12-15 | 英特塞尔股份公司 | 无乳链球菌抗原ⅰ和ⅱ |
| EP1629005A2 (en) | 2003-05-30 | 2006-03-01 | Intercell AG | Enterococcus antigens |
| AU2004255456B2 (en) | 2003-07-11 | 2010-06-24 | Intercell Ag | HCV vaccines |
| EP1722819B1 (en) | 2004-03-12 | 2007-12-26 | Intercell AG | Method for solubilising peptide mixtures |
| DE102004038134B4 (de) | 2004-08-05 | 2013-07-25 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Multivalente Chelatoren zum Modifizieren und Organisieren von Zielmolekülen, Verfahren zu ihrer Herstellung sowie ihre Verwendung |
| US9573979B2 (en) | 2004-09-24 | 2017-02-21 | Susanne Modrow | Modified VP1-capsid protein of parvovirus B19 |
| AU2005298742B2 (en) * | 2004-10-29 | 2010-08-12 | Intercell Ag | HCV vaccines for chronic HCV patients |
| US7785612B2 (en) * | 2005-04-20 | 2010-08-31 | Taiho Pharmaceutical Co., Ltd. | Polyamino acid for use as adjuvant |
| EP1887084A1 (en) * | 2006-08-10 | 2008-02-13 | International Investment and Patents SA | Plasmids with immunological action |
| CA2661224A1 (en) | 2006-09-15 | 2008-03-20 | Intercell Ag | Borrelia antigens |
| JP2008174490A (ja) * | 2007-01-18 | 2008-07-31 | Nitto Denko Corp | 抗原性ペプチドを主成分とする薬剤 |
| WO2008135446A2 (en) | 2007-05-02 | 2008-11-13 | Intercell Ag | Klebsiella antigens |
| KR100748265B1 (ko) * | 2007-06-15 | 2007-08-10 | (주)성문엔지니어링 | 공동주택에 배선된 전선의 합선방지구조 |
| EP2511291A3 (en) | 2007-06-18 | 2012-11-07 | Intercell AG | Chlamydia antigens |
| CA2695399C (en) | 2007-08-02 | 2017-10-17 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope influenza vaccines |
| RU2494737C2 (ru) * | 2008-03-27 | 2013-10-10 | Нестек С.А. | Способы увеличения абсорбции пептидов, пептидомиметиков и других субстратов гастроинтестинального транспортного белка |
| JP2012510289A (ja) | 2008-12-03 | 2012-05-10 | プロティア ワクチン テクノロジーズ リミテッド | グルタミルｔＲＮＡ合成酵素（ＧｔＳ）フラグメント |
| US8617574B2 (en) | 2009-02-13 | 2013-12-31 | Valneva Austria Gmbh | Nontypable Haemophilus influenzae antigens |
| EP2470205A1 (en) * | 2009-08-27 | 2012-07-04 | Novartis AG | Adjuvant comprising aluminium, oligonucleotide and polycation |
| AU2010314992B2 (en) | 2009-11-09 | 2016-09-15 | Spotlight Technology Partners Llc | Polysaccharide based hydrogels |
| US8795727B2 (en) | 2009-11-09 | 2014-08-05 | Spotlight Technology Partners Llc | Fragmented hydrogels |
| WO2011067758A2 (en) | 2009-12-02 | 2011-06-09 | Protea Vaccine Technologies Ltd. | Immunogenic fragments and multimers from streptococcus pneumoniae proteins |
| WO2011101465A1 (en) | 2010-02-19 | 2011-08-25 | Intercell Ag | Ic31 nanoparticles |
| AU2011360572B2 (en) | 2011-02-22 | 2017-03-02 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines |
| RU2478399C2 (ru) * | 2011-06-16 | 2013-04-10 | Государственное научное учреждение Всероссийский научно-исследовательский институт бруцеллеза и туберкулеза животных Российской академии сельскохозяйственных наук (ГНУ ВНИИБТЖ Россельхозакадемии) | Способ получения специфического иммуномодулятора |
| US20140271723A1 (en) * | 2013-03-15 | 2014-09-18 | Saint Louis University | Adjuvant compositions and methods of using thereof |
| WO2016056596A1 (ja) | 2014-10-07 | 2016-04-14 | 日本電気株式会社 | Ｈｓｐ７０由来のペプチド、これを用いた癌の治療又は予防のための医薬組成物、免疫誘導剤、及び抗原提示細胞の製造方法 |
| WO2016183486A1 (en) | 2015-05-13 | 2016-11-17 | Agenus Inc. | Vaccines for treatment and prevention of cancer |
| JP6559898B2 (ja) * | 2015-12-16 | 2019-08-14 | ヒュヴェット・バイオ・インコーポレイテッド | スクアレンを含む両親媒性ポリアミノ酸高分子に基づくワクチンの免疫補助剤組成物 |
| CN109072227A (zh) * | 2016-03-15 | 2018-12-21 | 组库创世纪株式会社 | 用于免疫治疗的监测和诊断及治疗剂的设计 |
| EP3463440A4 (en) * | 2016-05-27 | 2020-04-15 | Etubics Corporation | NEOEPITOP VACCINE COMPOSITIONS AND METHOD FOR USE THEREOF |
| RU2759728C2 (ru) | 2016-10-11 | 2021-11-17 | Ситлимик Инк. | Лекарственное средство |
| CN107469067B (zh) * | 2017-09-05 | 2018-06-19 | 浙江大学 | 一种多肽及其改造体在制备免疫调节药物中的应用 |
| TW202012430A (zh) | 2018-04-26 | 2020-04-01 | 美商艾吉納斯公司 | 熱休克蛋白質－結合之胜肽組成物及其使用方法 |
| CN110870912A (zh) * | 2018-08-31 | 2020-03-10 | 成都夸常奥普医疗科技有限公司 | 亚甲蓝类染料作为疫苗佐剂的应用、包含该佐剂的疫苗及其应用 |
| CN110870913A (zh) * | 2018-08-31 | 2020-03-10 | 成都夸常奥普医疗科技有限公司 | 氨基酸类营养素作为疫苗佐剂的应用以及包含氨基酸营养素作为佐剂的疫苗 |
| CN117860879A (zh) * | 2024-01-10 | 2024-04-12 | 广州医科大学附属肿瘤医院 | 一种纳米疫苗递送系统及其制备方法和应用 |
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| US4847240A (en) * | 1978-01-16 | 1989-07-11 | The Trustees Of Boston University | Method of effecting cellular uptake of molecules |
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| US6022544A (en) * | 1983-01-24 | 2000-02-08 | The John Hopkins University | Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry |
| US4956273A (en) * | 1985-10-24 | 1990-09-11 | Southwest Foundation For Biomedical Research | Synthetic peptides and method of use for diagnosis and vaccination for AIDS and ARC |
| IL82841A (en) * | 1986-06-13 | 1992-11-15 | Oncogen | Ligands and in vitro methods for augmenting b-cell proliferation |
| EP0346022B1 (en) * | 1988-06-10 | 1996-02-14 | United Biomedical, Inc. | Peptide fragments of HIV |
| ATE147633T1 (de) * | 1988-10-27 | 1997-02-15 | Univ Minnesota | Immunhilfsmittel aus liposome enthaltend lymphokin il -2 |
| EP0510054A1 (en) | 1990-01-05 | 1992-10-28 | United Biomedical, Inc. | Hiv-1 core protein fragments |
| US6235525B1 (en) | 1991-05-23 | 2001-05-22 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-3 and uses thereof |
| US5342774A (en) | 1991-05-23 | 1994-08-30 | Ludwig Institute For Cancer Research | Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1 |
| EP0636028B1 (en) | 1992-04-03 | 2004-03-03 | The Regents Of The University Of California | Self-assembling polynucleotide delivery system comprising an amphiphatic cationic peptide |
| EP0658113B1 (en) | 1992-08-31 | 2004-10-20 | Ludwig Institute For Cancer Research | Isolated nonapeptide derived from mage-3 gene and presented by hla-a1, and uses thereof |
| US5571711A (en) * | 1993-06-17 | 1996-11-05 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules coding for BAGE tumor rejection antigen precursors |
| US5409703A (en) * | 1993-06-24 | 1995-04-25 | Carrington Laboratories, Inc. | Dried hydrogel from hydrophilic-hygroscopic polymer |
| CZ5191U1 (cs) * | 1993-07-12 | 1996-09-12 | Aliatros Medical, A.S. | Farmaceutický prostředek pro imunomodulační a adjuvantní léčbu |
| JP2828391B2 (ja) * | 1993-10-29 | 1998-11-25 | 東燃株式会社 | オリゴ糖を表面に有するリポソーム |
| US6660276B1 (en) * | 1994-02-16 | 2003-12-09 | The University Of Virginia Patent Foundation | Peptides recognized by melanoma-specific cytotoxic lymphocytes, and uses therefor |
| US6001809A (en) * | 1994-07-11 | 1999-12-14 | Elan Pharmaceuticals, Inc. | Inhibitors of leukocyte adhesion |
| UY24367A1 (es) † | 1995-11-23 | 2000-10-31 | Boehringer Ingelheim Int | Vacunas contra tumores y procedimiento para su produccion |
| CO4600681A1 (es) | 1996-02-24 | 1998-05-08 | Boehringer Ingelheim Pharma | Composicion farmaceutica para la modulacion inmunitaria |
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