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NO20020348D0 - Peptid acceptor ligeringsmetoder - Google Patents

Peptid acceptor ligeringsmetoder

Info

Publication number
NO20020348D0
NO20020348D0 NO20020348A NO20020348A NO20020348D0 NO 20020348 D0 NO20020348 D0 NO 20020348D0 NO 20020348 A NO20020348 A NO 20020348A NO 20020348 A NO20020348 A NO 20020348A NO 20020348 D0 NO20020348 D0 NO 20020348D0
Authority
NO
Norway
Prior art keywords
peptide acceptor
ligation methods
acceptor ligation
methods
peptide
Prior art date
Application number
NO20020348A
Other languages
English (en)
Other versions
NO20020348L (no
Inventor
Markus Kurz
Peter Lohse
Richard Wagner
Original Assignee
Phylos Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phylos Inc filed Critical Phylos Inc
Publication of NO20020348D0 publication Critical patent/NO20020348D0/no
Publication of NO20020348L publication Critical patent/NO20020348L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/30Nucleotides
    • C12P19/34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K17/00Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02Peptides being immobilised on, or in, an organic carrier
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1062Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1075Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO20020348A 1999-07-27 2002-01-23 Peptid acceptor ligeringsmetoder NO20020348L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14583499P 1999-07-27 1999-07-27
PCT/US2000/019653 WO2001007657A1 (en) 1999-07-27 2000-07-19 Peptide acceptor ligation methods

Publications (2)

Publication Number Publication Date
NO20020348D0 true NO20020348D0 (no) 2002-01-23
NO20020348L NO20020348L (no) 2002-01-23

Family

ID=22514769

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20020348A NO20020348L (no) 1999-07-27 2002-01-23 Peptid acceptor ligeringsmetoder

Country Status (16)

Country Link
US (3) US6429300B1 (no)
EP (2) EP1196637B1 (no)
JP (2) JP4766808B2 (no)
KR (1) KR20020033743A (no)
AT (2) ATE360706T1 (no)
AU (2) AU781783B2 (no)
CA (2) CA2693274C (no)
CY (1) CY1113185T1 (no)
DE (1) DE60034566T2 (no)
DK (2) DK1196637T3 (no)
ES (2) ES2383332T3 (no)
HK (1) HK1045334A1 (no)
IL (1) IL147037A0 (no)
NO (1) NO20020348L (no)
PT (2) PT1870417E (no)
WO (1) WO2001007657A1 (no)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2383332T3 (es) * 1999-07-27 2012-06-20 Bristol-Myers Squibb Company Procedimiento de ligación de aceptores de péptidos
KR20020065644A (ko) 2000-01-11 2002-08-13 나노겐 인코포레이티드 기판 표면 결합용의 다수의 부착 잔기를 갖는 생분자
JP2003530094A (ja) * 2000-03-31 2003-10-14 メモレック シュトッフェル ゲゼルシャフト ミット ベシュレンクテル ハフツング メディツィニッシューモレクラー エントヴィクルンク,ケルン 核酸の抽出方法
US20040229271A1 (en) * 2000-05-19 2004-11-18 Williams Richard B. Compositions and methods for the identification and selection of nucleic acids and polypeptides
US7410761B2 (en) * 2000-05-19 2008-08-12 Proteonova, Inc. System for rapid identification and selection of nucleic acids and polypeptides, and method thereof
US6962781B1 (en) 2000-05-19 2005-11-08 Proteonova, Inc. In vitro evolution of nucleic acids and encoded polypeptide
ATE415489T1 (de) * 2000-08-11 2008-12-15 Nanogen Recognomics Gmbh Hydrazidbausteine und hydratin-modifizierte biomoleküle
US7129229B2 (en) 2000-08-11 2006-10-31 Nanogen Recognomics Gmbh Hydrazide building blocks and hydrazide modified biomolecules
JP4963142B2 (ja) * 2000-12-14 2012-06-27 学校法人慶應義塾 遺伝子型と表現型の対応付け分子とその構成要素、および対応付け分子の製造方法と利用方法
US20060234231A1 (en) * 2001-06-20 2006-10-19 Nuevolution A/S Microarrays displaying encoded molecules
EP1401850A1 (en) 2001-06-20 2004-03-31 Nuevolution A/S Nucleoside derivatives for library preparation
US6893822B2 (en) 2001-07-19 2005-05-17 Nanogen Recognomics Gmbh Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
WO2003012146A1 (en) * 2001-07-31 2003-02-13 Phylos, Inc. Modular assembly of nucleic acid-protein fusion multimers
DE10147074A1 (de) * 2001-09-25 2003-05-08 Beru Ag Verfahren zum Betreiben einer aus mehreren Heizelementen bestehenden mehrstufigen elektrischen Heizung
AU2002356984A1 (en) * 2001-11-16 2003-06-10 Proteonova, Inc. Selection and evolution of nucleic acids and polypeptides
WO2003045975A2 (en) * 2001-11-27 2003-06-05 Compound Therapeutics, Inc. Solid-phase immobilization of proteins and peptides
DE20200926U1 (de) * 2002-01-23 2002-04-18 Hegenscheidt-MFD GmbH & Co. KG, 41812 Erkelenz Festwalzgerät einer Festwalzmaschine für Kurbelwellen
CA2518626A1 (en) * 2002-03-15 2003-09-25 Nuevolution A/S An improved method for synthesising templated molecules
AU2003218630A1 (en) * 2002-03-15 2003-09-29 Nuevolution A/S A building block capable of functional entity transfer to nucleophil
US20050221318A1 (en) * 2002-03-15 2005-10-06 Gouliaev Alex H Building block forming a c-c bond upon reaction
AU2003218629A1 (en) * 2002-03-15 2003-09-29 Nuevolution A/S A building block forming a c-c or a c-hetero atom bond uponreaction
EP1539980B1 (en) 2002-08-01 2016-02-17 Nuevolution A/S Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules
AU2003256857A1 (en) * 2002-08-08 2004-02-25 Dharmacon, Inc. Short interfering rnas having a hairpin structure containing a non-nucleotide loop
DK2348124T3 (en) 2002-10-30 2014-03-10 Nuevolution As Synthesis of a bifunctional complex
EP1756277B1 (en) 2002-12-19 2009-12-02 Nuevolution A/S Quasirandom structure and function guided synthesis methods
EP1597394A2 (en) * 2003-02-21 2005-11-23 Nuevolution A/S A method for obtaining structural information about an encoded molecule
WO2004074429A2 (en) 2003-02-21 2004-09-02 Nuevolution A/S Method for producing second-generation library
DK1608748T3 (da) * 2003-03-20 2009-06-29 Nuevolution As Ligeringskodning af små molekyler
WO2004110964A2 (en) * 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)
US20050095627A1 (en) * 2003-09-03 2005-05-05 The Salk Institute For Biological Studies Multiple antigen detection assays and reagents
DE602004023960D1 (de) 2003-09-18 2009-12-17 Nuevolution As Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
JP4885729B2 (ja) * 2003-11-20 2012-02-29 サノフィ パストゥール インコーポレイテッド 百日咳毒素を精製する方法およびそれに有用なペプチド
MXPA06006406A (es) 2003-12-05 2007-03-21 Adnexus Therapeutics Inc Inhibidores de receptores de factor de crecimiento endotelial vascular tipo 2.
JP2007513631A (ja) * 2003-12-12 2007-05-31 プロテオノヴァ、 インコーポレイテッド 核酸およびポリペプチドを選択する系ならびに方法
EP1723255B1 (en) * 2004-02-17 2010-12-29 Nuevolution A/S Method for enrichment involving elimination by mismatch hybridisation
DK1730277T3 (da) * 2004-03-22 2010-03-01 Nuevolution As Kodning ved ligering under anvendelse af byggebloksoligonukleotider
CA2467321A1 (en) * 2004-05-14 2005-11-14 Paul J. Santerre Polymeric coupling agents and pharmaceutically-active polymers made therefrom
EP1816192B1 (en) * 2004-10-15 2012-12-12 National Institute of Advanced Industrial Science and Technology LINKER FOR CONSTRUCTING mRNA-PUROMYCIN-PROTEIN CONJUGATE
EP1846432A4 (en) 2005-01-12 2008-11-19 Proteonova Inc METHOD FOR MANUFACTURING TARGETED THERAPEUTIC AGENTS
US10206998B2 (en) 2005-01-12 2019-02-19 Proteonova, Inc. Modular targeted therapeutic agents and methods of making same
ES2547554T3 (es) 2005-11-16 2015-10-07 Ambrx, Inc. Métodos y composiciones que comprenden aminoácidos no naturales
DK1957644T3 (da) 2005-12-01 2011-03-28 Nuevolution As Enzymatiske kodnings metoder til effektiv syntese af store biblioteker
US7749957B2 (en) 2006-04-06 2010-07-06 E.I. Du Pont De Nemours And Company Clay-binding peptides and methods of use
MX2009005466A (es) 2006-11-22 2009-08-17 Adnexus A Bristol Myers Sqibb Terapeuticos dirigidos a base de proteinas manipuladas para receptores de tirosina cinasas, incluyendo receptor de factor de crecimiento tipo insulina-i.
JP2010517583A (ja) 2007-02-12 2010-05-27 プロテオノヴァ、 インコーポレイテッド mRNAに連結された可溶性ランダムポリペプチドのライブラリーの生成
US7951559B2 (en) * 2007-07-25 2011-05-31 E.I. Du Pont De Nemours And Company Recombinant peptide production using a cross-linkable solubility tag
US7829311B2 (en) 2007-07-25 2010-11-09 E.I. Du Pont De Nemours And Company Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate
US7678883B2 (en) * 2007-07-25 2010-03-16 E.I. Du Pont De Nemours And Company Solubility tags for the expression and purification of bioactive peptides
US7794963B2 (en) 2007-11-02 2010-09-14 E.I. Du Pont De Nemours And Company Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins
CA2707483A1 (en) 2007-11-30 2009-06-11 Wolfgang Fraunhofer Protein formulations and methods of making same
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
WO2009102421A2 (en) 2008-02-14 2009-08-20 Bristol-Myers Squibb Company Targeted therapeutics based on engineered proteins that bind egfr
EP2283132B1 (en) * 2008-05-02 2016-10-26 Epicentre Technologies Corporation Selective 5' ligation tagging of rna
JP6192891B2 (ja) 2008-05-02 2017-09-06 ノバルティス アーゲー 改善されたフィブロネクチンベースの結合分子およびそれらの使用
JP2011520961A (ja) 2008-05-22 2011-07-21 ブリストル−マイヤーズ スクイブ カンパニー 多価フィブロネクチンをベースとする足場ドメインタンパク質
ES2752025T3 (es) * 2008-07-25 2020-04-02 Wagner Richard W Métodos de cribado de proteínas
US8916504B2 (en) * 2008-09-30 2014-12-23 Abbvie Inc. Methods of RNA display
TWI496582B (zh) 2008-11-24 2015-08-21 必治妥美雅史谷比公司 雙重專一性之egfr/igfir結合分子
US20100158846A1 (en) * 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Hair-binding peptides
US20100158822A1 (en) 2008-12-18 2010-06-24 E .I. Du Pont De Nemours And Company Peptides that bind to silica-coated particles
US8287845B2 (en) * 2008-12-18 2012-10-16 E I Du Pont De Nemours And Company Hair-binding peptides
US20100158837A1 (en) 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Iron oxide-binding peptides
US8481678B2 (en) 2009-03-30 2013-07-09 E I Du Pont De Nemours And Company Peptide-based tooth whitening reagents
US20100247590A1 (en) * 2009-03-30 2010-09-30 Johnson & Johnson Peptide-Based Systems For Delivery Of Cosmetic Agents
JP5733784B2 (ja) * 2009-09-24 2015-06-10 国立大学法人埼玉大学 cDNA/mRNA−タンパク質連結体の効率的合成法
WO2011051327A2 (en) 2009-10-30 2011-05-05 Novartis Ag Small antibody-like single chain proteins
WO2011051466A1 (en) 2009-11-02 2011-05-05 Novartis Ag Anti-idiotypic fibronectin-based binding molecules and uses thereof
WO2011092233A1 (en) 2010-01-29 2011-08-04 Novartis Ag Yeast mating to produce high-affinity combinations of fibronectin-based binders
CN102770767A (zh) 2010-02-10 2012-11-07 诺瓦提斯公司 用于肌肉生长的方法和组合物
EP2555795B1 (en) * 2010-04-09 2016-07-13 Universiteit Utrecht Holding B.V. Recombinant multimeric influenza proteins
EP3540059A1 (en) 2010-04-16 2019-09-18 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
TW201138808A (en) 2010-05-03 2011-11-16 Bristol Myers Squibb Co Serum albumin binding molecules
EP3091028A1 (en) 2010-05-26 2016-11-09 Bristol-Myers Squibb Company Fibronectin based scaffold proteins having improved stability
CN107903321A (zh) 2010-07-30 2018-04-13 诺华有限公司 纤连蛋白摇篮分子和其库
DE102010056289A1 (de) 2010-12-24 2012-06-28 Geneart Ag Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken
EP3798236B1 (en) 2011-03-15 2022-08-10 X-Body, Inc. Antibody screening methods
CN103732738A (zh) 2011-04-28 2014-04-16 小利兰斯坦福大学托管委员会 与样品相关的多核苷酸的鉴定
WO2013019794A1 (en) 2011-08-01 2013-02-07 The General Hospital Corporation Protein and peptide libraries
KR102132997B1 (ko) 2011-10-11 2020-07-14 메디뮨 엘엘씨 Cd40l 특이적 tn3 유래 스카폴드 및 이의 사용 방법
EP3712173B1 (en) 2011-12-05 2023-07-12 X-Body, Inc. Pdgf receptor beta binding polypeptides
WO2014142020A1 (ja) * 2013-03-13 2014-09-18 国立大学法人東京大学 核酸リンカー
MX374317B (es) 2013-06-28 2025-03-06 X Body Inc Selecciones fenotípicas, descubrimiento del antígeno objetivo y uso de los mismos para la identificación de epítopes objetivo específicos de células objetivo.
CN103382579B (zh) * 2013-07-06 2015-10-21 中国科学院成都生物研究所 一种体外筛选多肽的方法
WO2015042528A1 (en) 2013-09-23 2015-03-26 X-Body Biosciences, Inc. Methods and compositions for generation of binding agents against cell surface antigens
EP3090049B1 (en) * 2013-12-31 2017-10-18 F. Hoffmann-La Roche AG Enrichment of full-length oligonucleotides via transcription/translation-mediated purification
WO2015120058A2 (en) 2014-02-05 2015-08-13 Molecular Templates, Inc. Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity
SG11201607820QA (en) 2014-03-20 2016-10-28 Bristol Myers Squibb Co Serum albumin-binding fibronectin type iii domains
JP6478392B2 (ja) * 2014-12-26 2019-03-06 国立研究開発法人産業技術総合研究所 核酸リンカー
AU2016228806B2 (en) 2015-03-12 2020-10-22 Medimmune, Llc Method of purifying albumin-fusion proteins
WO2017053617A1 (en) 2015-09-23 2017-03-30 Bristol-Myers Squibb Company Fast-off rate serum albumin binding fibronectin type iii domains
SG10201911917WA (en) 2016-05-02 2020-01-30 Encodia Inc Macromolecule analysis employing nucleic acid encoding
WO2017218858A1 (en) * 2016-06-15 2017-12-21 Genecapture, Inc. Compositions, methods and devices comprising stem-loop captor molecules
MA45491A (fr) 2016-06-27 2019-05-01 Juno Therapeutics Inc Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés
WO2018005559A1 (en) 2016-06-27 2018-01-04 Juno Therapeutics, Inc. Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
RU2731211C1 (ru) 2017-03-21 2020-08-31 Фуджифилм Корпорэйшн Пептидное соединение и способ его получения, композиция для скринингового использования и способ отбора пептидного соединения
CA3081441C (en) * 2017-10-31 2023-08-29 Encodia, Inc. Kits for analysis using nucleic acid encoding and/or label
CN111386127A (zh) 2017-11-30 2020-07-07 阿拉基斯医疗公司 核酸结合光探针和其用途
KR20200121816A (ko) 2018-02-02 2020-10-26 리플 테라퓨틱스 코포레이션 스테로이드 이량체를 포함하는 유리 제제 및 이의 용도
TWI830718B (zh) * 2018-02-09 2024-02-01 日商住友化學股份有限公司 核酸分子之製造方法
CN111971396A (zh) * 2018-03-30 2020-11-20 住友化学株式会社 单链rna的制造方法
WO2019236644A1 (en) * 2018-06-05 2019-12-12 Arrakis Therapeutics, Inc. Encoded libraries and methods of use for screening nucleic acid targets
WO2020154815A1 (en) 2019-02-01 2020-08-06 Ripple Therapeutics Corporation Crystalline forms of dexamethasone dimers and uses thereof
US20220347305A1 (en) 2019-08-07 2022-11-03 Ripple Therapeutics Corporation Controlled release drug dimers
CA3176134A1 (en) 2020-05-01 2021-11-04 Ripple Therapeutics Corporation Heterodimer compositions and methods for the treatment of ocular disorders

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391723A (en) * 1989-05-31 1995-02-21 Neorx Corporation Oligonucleotide conjugates
US5843701A (en) * 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
AU8124694A (en) * 1993-10-29 1995-05-22 Affymax Technologies N.V. In vitro peptide and antibody display libraries
DE19646372C1 (de) * 1995-11-11 1997-06-19 Evotec Biosystems Gmbh Genotyp und Phänotyp koppelnde Verbindung
EP0862656B1 (en) * 1995-11-21 2001-03-07 Yale University Unimolecular segment amplification and detection
US6117635A (en) * 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5842701A (en) * 1996-10-08 1998-12-01 Smith International, Inc. Dual functioning seal for rock bits
AU729690B2 (en) 1996-10-10 2001-02-08 Henrik Garoff Alphavirus-retrovirus vectors
EP0962527B1 (en) * 1996-10-17 2004-08-04 Mitsubishi Chemical Corporation Molecule that homologizes genotype and phenotype and utilization thereof
RU2233878C2 (ru) * 1997-01-21 2004-08-10 Дзе Дженерал Хоспитал Корпорейшн Способ отбора желательного белка и нуклеиновой кислоты, средства для его осуществления
US6261804B1 (en) * 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
US5935791A (en) * 1997-09-23 1999-08-10 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
JP3889927B2 (ja) * 1997-12-22 2007-03-07 セローノ ジェネティクス インスティテュート ソシエテ アノニム 前立腺癌遺伝子
US5985575A (en) * 1998-05-20 1999-11-16 Wisconsin Alumni Research Foundation Tethered function assay for protein function
ES2383332T3 (es) * 1999-07-27 2012-06-20 Bristol-Myers Squibb Company Procedimiento de ligación de aceptores de péptidos
EP1212452B1 (en) * 1999-08-27 2013-07-17 Bristol-Myers Squibb Company Methods for encoding and sorting in vitro translated proteins

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AU6111200A (en) 2001-02-13
PT1196637E (pt) 2007-07-04
US7790421B2 (en) 2010-09-07
ES2284508T3 (es) 2007-11-16
AU2005211548A1 (en) 2005-10-13
CA2377468C (en) 2010-04-20
PT1870417E (pt) 2012-06-01
US20020182687A1 (en) 2002-12-05
NO20020348L (no) 2002-01-23
EP1870417A2 (en) 2007-12-26
DK1196637T3 (da) 2007-07-30
IL147037A0 (en) 2002-08-14
WO2001007657A1 (en) 2001-02-01
JP2010284172A (ja) 2010-12-24
EP1870417B9 (en) 2012-08-01
HK1112007A1 (en) 2008-08-22
HK1045334A1 (zh) 2002-11-22
DE60034566D1 (de) 2007-06-06
CY1113185T1 (el) 2016-04-13
ATE551352T1 (de) 2012-04-15
ES2383332T3 (es) 2012-06-20
EP1870417A3 (en) 2008-06-11
EP1196637A4 (en) 2003-11-12
CA2377468A1 (en) 2001-02-01
US20060246549A1 (en) 2006-11-02
US7078197B2 (en) 2006-07-18
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KR20020033743A (ko) 2002-05-07
JP5512463B2 (ja) 2014-06-04
JP2003505094A (ja) 2003-02-12
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US6429300B1 (en) 2002-08-06
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