EE04481B1 - Peptiididel ja adjuvantidel baseeruv farmatseutiline kompositsioon immuunmodulatsiooni jaoks - Google Patents
Peptiididel ja adjuvantidel baseeruv farmatseutiline kompositsioon immuunmodulatsiooni jaoksInfo
- Publication number
- EE04481B1 EE04481B1 EE9800255A EE9800255A EE04481B1 EE 04481 B1 EE04481 B1 EE 04481B1 EE 9800255 A EE9800255 A EE 9800255A EE 9800255 A EE9800255 A EE 9800255A EE 04481 B1 EE04481 B1 EE 04481B1
- Authority
- EE
- Estonia
- Prior art keywords
- peptide
- pharmaceutical composition
- immune modulation
- based pharmaceutical
- adjuvant based
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19607044A DE19607044A1 (de) | 1996-02-24 | 1996-02-24 | Tumorvakzine und Verfahren zu ihrer Herstellung |
| DE19638313A DE19638313C2 (de) | 1996-09-19 | 1996-09-19 | Pharmazeutische Zusammensetzung für die Immunmodulation |
| DE19648687A DE19648687A1 (de) | 1996-11-25 | 1996-11-25 | Pharmazeutische Zusammensetzung für die Immunmodulation |
| PCT/EP1997/000828 WO1997030721A1 (de) | 1996-02-24 | 1997-02-21 | Pharmazeutische zusammensetzung für die immunmodulation beruhend auf peptiden und adjuvantien |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE9800255A EE9800255A (et) | 1999-02-15 |
| EE04481B1 true EE04481B1 (et) | 2005-06-15 |
Family
ID=27215945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EE9800255A EE04481B1 (et) | 1996-02-24 | 1997-02-21 | Peptiididel ja adjuvantidel baseeruv farmatseutiline kompositsioon immuunmodulatsiooni jaoks |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US7105162B1 (et) |
| EP (1) | EP0881906B2 (et) |
| JP (1) | JP4184433B2 (et) |
| KR (1) | KR100457647B1 (et) |
| CN (1) | CN1177610C (et) |
| AR (1) | AR005945A1 (et) |
| AT (1) | ATE274350T1 (et) |
| AU (1) | AU722264B2 (et) |
| BG (1) | BG63682B1 (et) |
| BR (1) | BR9707694A (et) |
| CA (1) | CA2243559C (et) |
| CO (1) | CO4600681A1 (et) |
| CZ (1) | CZ295396B6 (et) |
| DE (1) | DE59711873D1 (et) |
| DK (1) | DK0881906T4 (et) |
| EE (1) | EE04481B1 (et) |
| ES (1) | ES2225951T5 (et) |
| HR (1) | HRP970100B1 (et) |
| HU (1) | HU224410B1 (et) |
| ID (1) | ID16038A (et) |
| IL (1) | IL125361A (et) |
| MY (1) | MY119276A (et) |
| NO (1) | NO983850L (et) |
| NZ (1) | NZ332020A (et) |
| PE (1) | PE55398A1 (et) |
| PL (1) | PL189413B1 (et) |
| PT (1) | PT881906E (et) |
| RO (1) | RO119344B1 (et) |
| RS (1) | RS50101B (et) |
| SI (1) | SI0881906T2 (et) |
| SK (1) | SK284582B6 (et) |
| TR (1) | TR199801649T2 (et) |
| TW (1) | TW585774B (et) |
| WO (1) | WO1997030721A1 (et) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS50101B (sr) | 1996-02-24 | 2009-01-22 | Boehringer Ingelheim International Gmbh., | Farmaceutski preparati za imunomodulaciju |
| DE19803453A1 (de) * | 1998-01-30 | 1999-08-12 | Boehringer Ingelheim Int | Vakzine |
| DE69936355T2 (de) * | 1998-02-25 | 2008-02-21 | The Government Of The United States, As Represented By The Secretary Of The Army | Verwendung von Hautpenetrationsförderern und für die Zerstörung der oberen Hautschichten geeigneten Mitteln zur Erhöhung der transkutanen Immunantwort |
| CA2325818C (en) * | 1998-04-20 | 2008-09-02 | Torrey Pines Institute For Molecular Studies | Topical immunostimulation to induce langerhans cell migration |
| WO2000048630A1 (en) * | 1999-02-17 | 2000-08-24 | Csl Limited | Immunogenic complexes and methods relating thereto |
| DE19909503A1 (de) * | 1999-03-04 | 2000-09-07 | Boehringer Ingelheim Int | Tumorassoziiertes Antigen |
| US6809179B1 (en) | 1999-08-04 | 2004-10-26 | Boehringer Ingelheim International Gmbh | Tumor-associated antigen (R11) |
| AT408721B (de) | 1999-10-01 | 2002-02-25 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung enthaltend ein antigen |
| AT409085B (de) * | 2000-01-28 | 2002-05-27 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen |
| US20020009491A1 (en) * | 2000-02-14 | 2002-01-24 | Rothbard Jonathan B. | Compositions and methods for enhancing drug delivery across biological membranes and tissues |
| AT409762B (de) * | 2000-04-13 | 2002-11-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung von zytokin sekretierenden zellen |
| AT410173B (de) | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
| KR20020014459A (ko) * | 2000-08-18 | 2002-02-25 | 서진호 | 양이온성 아미노산이 부가된 융합단백질 및 이를 이용한생물공정의 개선방법 |
| US7244438B2 (en) | 2001-01-05 | 2007-07-17 | Intercell Ag | Uses for polycationic compounds |
| WO2002053185A2 (en) * | 2001-01-05 | 2002-07-11 | Intercell Ag | Anti-inflammatory use of polycationic compounds |
| WO2002053184A2 (en) * | 2001-01-05 | 2002-07-11 | Intercell Ag | Uses for polycationic compounds as vaccine adjuvants |
| AT410798B (de) | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
| FR2824326B1 (fr) * | 2001-05-04 | 2004-03-19 | Commissariat Energie Atomique | Melange de peptides issus des proteines e6 et/ou e7 de papillomavirus et leurs applications |
| US20050250716A1 (en) * | 2001-12-07 | 2005-11-10 | Intercell Ag | Immunostimulatory oligodeoxynucleotides |
| US20050221350A1 (en) * | 2002-05-29 | 2005-10-06 | Toni Weinschenk | Method for identifying immunoreactive peptides |
| AU2003254585A1 (en) | 2002-07-24 | 2004-02-16 | Intercell Ag | Antigens encoded by alternative reading frame from pathogenic viruses |
| AU2003258672B2 (en) | 2002-09-13 | 2008-10-30 | Intercell Ag | Method for isolating hepatitis C virus peptides |
| CN1705679B (zh) | 2002-10-15 | 2011-04-06 | 英特塞尔股份公司 | 编码b族链球菌粘着因子的核酸、b族链球菌的粘着因子和它们的用途 |
| CN102512670A (zh) | 2003-03-04 | 2012-06-27 | 英特塞尔股份公司 | 化脓链球菌抗原 |
| EP2345420B1 (en) | 2003-03-24 | 2016-01-06 | Valneva Austria GmbH | Use of a TH1 immune response inducing adjuvant for enhancing immune responses |
| AU2004226262A1 (en) | 2003-03-31 | 2004-10-14 | Intercell Ag | Staphylococcus epidermidis antigens |
| AU2004230244B2 (en) | 2003-04-15 | 2011-09-22 | Intercell Ag | S. pneumoniae antigens |
| JP2007535894A (ja) | 2003-05-07 | 2007-12-13 | インターツェル・アクチェンゲゼルシャフト | ストレプトコッカス・アガラクティエ抗原i+ii |
| CN102304527A (zh) | 2003-05-30 | 2012-01-04 | 英特塞尔股份公司 | 肠球菌抗原 |
| EP1648502B1 (en) | 2003-07-11 | 2010-12-01 | Intercell AG | Hcv vaccines |
| ATE381945T1 (de) | 2004-03-12 | 2008-01-15 | Intercell Ag | Verfahren zur solubilisierung von peptid- mischungen |
| DE102004038134B4 (de) | 2004-08-05 | 2013-07-25 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Multivalente Chelatoren zum Modifizieren und Organisieren von Zielmolekülen, Verfahren zu ihrer Herstellung sowie ihre Verwendung |
| US9573979B2 (en) | 2004-09-24 | 2017-02-21 | Susanne Modrow | Modified VP1-capsid protein of parvovirus B19 |
| CN101048172A (zh) * | 2004-10-29 | 2007-10-03 | 英特塞尔股份公司 | 用于慢性hcv患者的hcv疫苗 |
| EP1872793B1 (en) * | 2005-04-20 | 2012-10-10 | Mitsuru Akashi | Polyamino acid for use as adjuvant |
| EP1887084A1 (en) | 2006-08-10 | 2008-02-13 | International Investment and Patents SA | Plasmids with immunological action |
| EP2287176A1 (en) | 2006-09-15 | 2011-02-23 | Intercell AG | Borrelia antigens |
| JP2008174490A (ja) * | 2007-01-18 | 2008-07-31 | Nitto Denko Corp | 抗原性ペプチドを主成分とする薬剤 |
| EP2338902A1 (en) | 2007-05-02 | 2011-06-29 | Intercell AG | Klebsiella antigens |
| KR100748265B1 (ko) * | 2007-06-15 | 2007-08-10 | (주)성문엔지니어링 | 공동주택에 배선된 전선의 합선방지구조 |
| CA2690271A1 (en) | 2007-06-18 | 2008-12-24 | Intercell Ag | Chlamydia antigens |
| CN101795709B (zh) | 2007-08-02 | 2013-07-17 | 彼昂德瓦克斯医药有限公司 | 多亚基多表位流感疫苗 |
| WO2009120378A2 (en) * | 2008-03-27 | 2009-10-01 | Nestec S.A. | Methods for increasing absorption of peptides, peptidomimetics, and other gastrointestinal transport protein substrates |
| CN102239253A (zh) | 2008-12-03 | 2011-11-09 | 普罗蒂亚维仕尼科技有限公司 | 谷氨酰tRNA合成酶(GtS)片段 |
| US8617574B2 (en) | 2009-02-13 | 2013-12-31 | Valneva Austria Gmbh | Nontypable Haemophilus influenzae antigens |
| WO2011024071A1 (en) * | 2009-08-27 | 2011-03-03 | Novartis Ag | Adjuvant comprising aluminium, oligonucleotide and polycation |
| CA2780274C (en) | 2009-11-09 | 2018-06-26 | Spotlight Technology Partners Llc | Fragmented hydrogels |
| AU2010314992B2 (en) | 2009-11-09 | 2016-09-15 | Spotlight Technology Partners Llc | Polysaccharide based hydrogels |
| WO2011067758A2 (en) | 2009-12-02 | 2011-06-09 | Protea Vaccine Technologies Ltd. | Immunogenic fragments and multimers from streptococcus pneumoniae proteins |
| WO2011101465A1 (en) | 2010-02-19 | 2011-08-25 | Intercell Ag | Ic31 nanoparticles |
| AU2011360572B2 (en) | 2011-02-22 | 2017-03-02 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines |
| RU2478399C2 (ru) * | 2011-06-16 | 2013-04-10 | Государственное научное учреждение Всероссийский научно-исследовательский институт бруцеллеза и туберкулеза животных Российской академии сельскохозяйственных наук (ГНУ ВНИИБТЖ Россельхозакадемии) | Способ получения специфического иммуномодулятора |
| US20140271723A1 (en) * | 2013-03-15 | 2014-09-18 | Saint Louis University | Adjuvant compositions and methods of using thereof |
| BR112017006969A2 (pt) | 2014-10-07 | 2017-12-19 | Cytlimic Inc | peptídeo derivado de hsp70, composição farmacêutica para o tratamento ou a prevenção de câncer usando o mesmo, indutor de imunidade e método de produção de célula apresentadora de antígeno |
| US10568948B2 (en) | 2015-05-13 | 2020-02-25 | Agenus Inc. | Vaccines for treatment and prevention of cancer |
| US20200138939A1 (en) * | 2015-12-16 | 2020-05-07 | Huvet Bio, Inc. | Vaccine adjuvant composition based on amphiphilic polyamino acid polymer, containing squalene |
| US12065699B2 (en) | 2016-03-15 | 2024-08-20 | Repertoire Genesis Incorporation | Monitoring and diagnosis for immunotherapy, and design for therapeutic agent |
| EP3463440A4 (en) * | 2016-05-27 | 2020-04-15 | Etubics Corporation | NEO-EPITOPE-BASED VACCINE COMPOSITIONS AND METHODS OF USE |
| ES2972560T3 (es) | 2016-10-11 | 2024-06-13 | Nec Corp | Medicamento que comprende un agonista de receptores tipo Toll, proteína LAG-3, un péptido derivado de HSP70 y un péptido derivado de GPC3 |
| CN107469067B (zh) * | 2017-09-05 | 2018-06-19 | 浙江大学 | 一种多肽及其改造体在制备免疫调节药物中的应用 |
| CA3096909A1 (en) | 2018-04-26 | 2019-10-31 | Agenus Inc. | Heat shock protein-binding peptide compositions and methods of use thereof |
| CN110870912A (zh) * | 2018-08-31 | 2020-03-10 | 成都夸常奥普医疗科技有限公司 | 亚甲蓝类染料作为疫苗佐剂的应用、包含该佐剂的疫苗及其应用 |
| CN110870913A (zh) * | 2018-08-31 | 2020-03-10 | 成都夸常奥普医疗科技有限公司 | 氨基酸类营养素作为疫苗佐剂的应用以及包含氨基酸营养素作为佐剂的疫苗 |
| CN117860879A (zh) * | 2024-01-10 | 2024-04-12 | 广州医科大学附属肿瘤医院 | 一种纳米疫苗递送系统及其制备方法和应用 |
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| US4847240A (en) * | 1978-01-16 | 1989-07-11 | The Trustees Of Boston University | Method of effecting cellular uptake of molecules |
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