AR004965A1 - Procedimiento de preparacion de derivados de fenilimidazolidina - Google Patents
Procedimiento de preparacion de derivados de fenilimidazolidinaInfo
- Publication number
- AR004965A1 AR004965A1 ARP960105163A ARP960105163A AR004965A1 AR 004965 A1 AR004965 A1 AR 004965A1 AR P960105163 A ARP960105163 A AR P960105163A AR P960105163 A ARP960105163 A AR P960105163A AR 004965 A1 AR004965 A1 AR 004965A1
- Authority
- AR
- Argentina
- Prior art keywords
- radicals
- esterified
- alkyl
- alkenyl
- aryl
- Prior art date
Links
- TVPNGVPSNXPYLT-UHFFFAOYSA-N 1-phenylimidazolidine Chemical class C1NCCN1C1=CC=CC=C1 TVPNGVPSNXPYLT-UHFFFAOYSA-N 0.000 title abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- -1 cyano, amino Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000004434 sulfur atom Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 150000003462 sulfoxides Chemical class 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000005133 alkynyloxy group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 150000003457 sulfones Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invencion tiene por objeto un procedimiento de preparacion de derivados de fenilimidazolidina de formula (I) en la que R1 y R2 son hidrogeno, halogeno,alquilo, alquenilo, alquinilo, alquiloxi, alqueniloxi, alquiniloxi fenilo, fenoxi, nitro,trifluormetilo, arilo, ciano, amino, monoalquilamino,dialquilamino o carboxi libre esterificado, amidificado o salidificado. R3 se escoge entre el atomo de hidrogeno y los radicales, alquilo, alquenilo,alquinilo, arilo y arilalquilo, estando todosestos radicales eventualmente sustituidos con uno o varios sustituyentes escogidos entre los atomos dehalogeno, lo radicales hidroxilo, eventualmente esterificado, eterificado o protegido, alcoxi, alqueniloxi, alquiniloxi, trifluorometilo,me rcapto, ciano,arilo, ariloxi, carboxi libre esterificado, amidificado o salificado, amino, mono, dialquilamino, ariltio y los radicales ciclicos que comprenden 3 a 4eslabones, estando ademas los radicales alquilo, alquenilo o alquinilo, eventualmente interrumpidos por uno o varios atomos de oxigeno, de nitrogeno ode azufre, estando todos los atomos de azufre eventualmente oxidados en forma de sulfoxido o de sulfona, estando ademas los radicales arilo y aralquiloeventualmentesustit uidos con un radical alquilo, alquenilo o alquinilo; R4 y R5 son o bien identicos o diferentes, representan un atomo de hidrogeno o unradical alquilo, eventualmente sustituido con uno o varios sustituyentes escogidos entre los atomosde halo geno, el radical hidroxilo, eventualmenteesterificado, esterificado o protegido y los radicales feniltio y alquiltio, en los que el atomo de azufre puede estar oxidado en forma de sulfoxido o sulfonay estando eventualmente sustituido con unoo varios radicales escogidos entre atomos de halogeno, y los radicales hidroxilo eventualmente esterificado,
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9513589A FR2741346B1 (fr) | 1995-11-16 | 1995-11-16 | Nouveau procede de preparation de derives phenylimidazolidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR004965A1 true AR004965A1 (es) | 1999-04-07 |
Family
ID=9484624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960105163A AR004965A1 (es) | 1995-11-16 | 1996-11-13 | Procedimiento de preparacion de derivados de fenilimidazolidina |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6107488A (es) |
| EP (1) | EP0877738B1 (es) |
| JP (1) | JP2000500150A (es) |
| KR (1) | KR100466991B1 (es) |
| CN (1) | CN1131219C (es) |
| AR (1) | AR004965A1 (es) |
| AT (1) | ATE240300T1 (es) |
| AU (1) | AU718832B2 (es) |
| BR (1) | BR9611573A (es) |
| CA (1) | CA2235335A1 (es) |
| CU (1) | CU22890A3 (es) |
| CZ (1) | CZ144498A3 (es) |
| DE (1) | DE69628203T2 (es) |
| DK (1) | DK0877738T3 (es) |
| EA (1) | EA002658B1 (es) |
| ES (1) | ES2193271T3 (es) |
| FR (1) | FR2741346B1 (es) |
| HU (1) | HUP9904034A3 (es) |
| IL (1) | IL124382A0 (es) |
| MX (1) | MX9803730A (es) |
| NO (1) | NO316514B1 (es) |
| PL (1) | PL189697B1 (es) |
| PT (1) | PT877738E (es) |
| SI (1) | SI0877738T1 (es) |
| TR (1) | TR199800865T2 (es) |
| TW (1) | TW404942B (es) |
| UA (1) | UA67720C2 (es) |
| WO (1) | WO1997018197A1 (es) |
| ZA (1) | ZA969442B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007514442A (ja) * | 2003-12-19 | 2007-06-07 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 前立腺癌治療を評価するための方法および物質 |
| NZ550102A (en) * | 2004-02-24 | 2010-10-29 | Univ California | Methods and materials for assessing prostate cancer therapies and compounds (thiohydantoine derivatives) |
| US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
| CN101454002B (zh) * | 2006-03-27 | 2011-06-08 | 加利福尼亚大学董事会 | 用于治疗前列腺癌和与雄激素受体相关的疾病的雄激素受体调节剂 |
| KR20160027254A (ko) | 2006-03-29 | 2016-03-09 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 디아릴티오히단토인 화합물 |
| JP5535925B2 (ja) | 2007-10-26 | 2014-07-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | アンドロゲン受容体調節物質としてのジアリールヒダントイン化合物 |
| CN102481294A (zh) | 2009-09-11 | 2012-05-30 | 拜耳医药股份有限公司 | 作为抗癌药物的取代(杂芳基甲基)乙内酰硫脲 |
| JP5749269B2 (ja) | 2009-09-15 | 2015-07-15 | マイラン・グループ | ネガ型輻射線感応性リソグラフィック印刷プレートのための輻射線感応性コーティング組成物用のコポリマー、前記コポリマーを含むポリマー粒子、及びコポリマーバインダー |
| CA2787083C (en) | 2010-02-16 | 2018-05-22 | Aragon Pharmaceuticals, Inc. | Androgen receptor modulators and uses thereof |
| WO2011006265A2 (en) | 2010-09-14 | 2011-01-20 | Mylan Group | Copolymers for near-infrared radiation-sensitive coating compositions for positive-working thermal lithographic printing plates |
| IL312316A (en) | 2012-09-26 | 2024-06-01 | Aragon Pharmaceuticals Inc | Antiandrogens for the treatment of castration-resistant prostate cancer without metastases |
| JOP20200097A1 (ar) | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
| TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
| CA3079135A1 (en) | 2017-10-16 | 2019-04-25 | Arturo Molina | Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer |
| CN108218784A (zh) * | 2018-01-16 | 2018-06-29 | 吴江信凯医药科技有限公司 | 一种尼鲁米特的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4916937B1 (es) * | 1970-01-21 | 1974-04-25 | ||
| JPS5136332B1 (es) * | 1970-12-09 | 1976-10-07 | ||
| CH544491A (de) * | 1971-03-16 | 1973-11-30 | Ciba Geigy Ag | Herbizides Mittel |
| MC1220A1 (fr) * | 1977-10-28 | 1979-07-20 | Hoffmann La Roche | Nouveaux derives d'imidazolidine |
| JPS57197268A (en) * | 1981-05-29 | 1982-12-03 | Sumitomo Chem Co Ltd | Substituted phenylhydantoin derivative, its preparation, and herbicide containing the same as active ingredient |
| JPS62298562A (ja) * | 1986-06-17 | 1987-12-25 | Nippon Kayaku Co Ltd | ブロモアニリン類の製造法 |
| FR2656302B1 (fr) * | 1989-12-22 | 1992-05-07 | Roussel Uclaf | Nouveau procede de preparation de l'anandron et derives de l'anandron. |
| US5411981A (en) * | 1991-01-09 | 1995-05-02 | Roussel Uclaf | Phenylimidazolidines having antiandrogenic activity |
| FR2694290B1 (fr) * | 1992-07-08 | 1994-09-02 | Roussel Uclaf | Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant. |
-
1995
- 1995-11-16 FR FR9513589A patent/FR2741346B1/fr not_active Expired - Fee Related
-
1996
- 1996-11-05 TW TW085113495A patent/TW404942B/zh not_active IP Right Cessation
- 1996-11-11 ZA ZA9609442A patent/ZA969442B/xx unknown
- 1996-11-13 AR ARP960105163A patent/AR004965A1/es unknown
- 1996-11-14 AU AU75773/96A patent/AU718832B2/en not_active Ceased
- 1996-11-14 CN CN96199660A patent/CN1131219C/zh not_active Expired - Fee Related
- 1996-11-14 EA EA199800378A patent/EA002658B1/ru not_active IP Right Cessation
- 1996-11-14 BR BR9611573A patent/BR9611573A/pt not_active Application Discontinuation
- 1996-11-14 DE DE69628203T patent/DE69628203T2/de not_active Expired - Fee Related
- 1996-11-14 JP JP9518630A patent/JP2000500150A/ja not_active Ceased
- 1996-11-14 ES ES96938306T patent/ES2193271T3/es not_active Expired - Lifetime
- 1996-11-14 PT PT96938306T patent/PT877738E/pt unknown
- 1996-11-14 CZ CZ981444A patent/CZ144498A3/cs unknown
- 1996-11-14 TR TR1998/00865T patent/TR199800865T2/xx unknown
- 1996-11-14 EP EP96938306A patent/EP0877738B1/fr not_active Expired - Lifetime
- 1996-11-14 KR KR10-1998-0703667A patent/KR100466991B1/ko not_active Expired - Fee Related
- 1996-11-14 UA UA98052491A patent/UA67720C2/uk unknown
- 1996-11-14 IL IL12438296A patent/IL124382A0/xx not_active IP Right Cessation
- 1996-11-14 WO PCT/FR1996/001794 patent/WO1997018197A1/fr not_active Ceased
- 1996-11-14 PL PL96326491A patent/PL189697B1/pl not_active IP Right Cessation
- 1996-11-14 US US09/068,846 patent/US6107488A/en not_active Expired - Fee Related
- 1996-11-14 HU HU9904034A patent/HUP9904034A3/hu unknown
- 1996-11-14 AT AT96938306T patent/ATE240300T1/de not_active IP Right Cessation
- 1996-11-14 CA CA002235335A patent/CA2235335A1/fr not_active Abandoned
- 1996-11-14 DK DK96938306T patent/DK0877738T3/da active
- 1996-11-14 SI SI9630547T patent/SI0877738T1/xx unknown
-
1998
- 1998-05-11 MX MX9803730A patent/MX9803730A/es unknown
- 1998-05-15 NO NO982237A patent/NO316514B1/no unknown
- 1998-05-18 CU CU1998059A patent/CU22890A3/es unknown
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