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AP2013007070A0 - Imidazo[5,1-f][1,2,4] triazines for the treatment of neurological disorders - Google Patents

Imidazo[5,1-f][1,2,4] triazines for the treatment of neurological disorders

Info

Publication number
AP2013007070A0
AP2013007070A0 AP2013007070A AP2013007070A AP2013007070A0 AP 2013007070 A0 AP2013007070 A0 AP 2013007070A0 AP 2013007070 A AP2013007070 A AP 2013007070A AP 2013007070 A AP2013007070 A AP 2013007070A AP 2013007070 A0 AP2013007070 A0 AP 2013007070A0
Authority
AP
ARIPO
Prior art keywords
triazines
imidazo
treatment
neurological disorders
neurological
Prior art date
Application number
AP2013007070A
Other languages
English (en)
Inventor
Eddie Yang
John Michael Humphrey
Christopher John Helal
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45755439&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2013007070(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of AP2013007070A0 publication Critical patent/AP2013007070A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AP2013007070A 2011-02-23 2012-02-09 Imidazo[5,1-f][1,2,4] triazines for the treatment of neurological disorders AP2013007070A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161445617P 2011-02-23 2011-02-23
PCT/IB2012/050589 WO2012114222A1 (en) 2011-02-23 2012-02-09 IMIDAZO[5,1-f][1,2,4]TRIAZINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS

Publications (1)

Publication Number Publication Date
AP2013007070A0 true AP2013007070A0 (en) 2013-08-31

Family

ID=45755439

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2013007070A AP2013007070A0 (en) 2011-02-23 2012-02-09 Imidazo[5,1-f][1,2,4] triazines for the treatment of neurological disorders

Country Status (31)

Country Link
US (2) US8598155B2 (ja)
EP (1) EP2681218A1 (ja)
JP (1) JP5543039B2 (ja)
KR (1) KR101548443B1 (ja)
CN (1) CN103391941A (ja)
AP (1) AP2013007070A0 (ja)
AR (1) AR085304A1 (ja)
AU (1) AU2012221828C1 (ja)
BR (1) BR112013021366A2 (ja)
CA (1) CA2825699A1 (ja)
CL (1) CL2013002125A1 (ja)
CO (1) CO6751271A2 (ja)
CR (1) CR20130371A (ja)
CU (1) CU20130107A7 (ja)
DO (1) DOP2013000194A (ja)
EA (1) EA022586B1 (ja)
EC (1) ECSP13012892A (ja)
GT (1) GT201300206A (ja)
IL (1) IL227716A0 (ja)
MA (1) MA34922B1 (ja)
MX (1) MX2013009684A (ja)
NI (1) NI201300071A (ja)
PE (1) PE20140236A1 (ja)
PH (1) PH12013501556A1 (ja)
SG (1) SG192576A1 (ja)
TN (1) TN2013000349A1 (ja)
TW (1) TWI469983B (ja)
UA (1) UA106692C2 (ja)
UY (1) UY33916A (ja)
WO (1) WO2012114222A1 (ja)
ZA (1) ZA201306348B (ja)

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JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
JP6263606B2 (ja) * 2013-05-02 2018-01-17 ファイザー・インク Ｐｄｅ１０阻害剤としてのイミダゾ−トリアジン誘導体
US9815796B2 (en) 2013-12-23 2017-11-14 Merck Sharp & Dohme Corp. Pyrimidone carboxamide compounds as PDE2 inhibitors
JP6696904B2 (ja) 2014-01-08 2020-05-20 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 製剤および医薬組成物
PL3597649T3 (pl) * 2014-04-23 2022-04-04 Dart Neuroscience Llc Kompozycje zawierające podstawione związki [1,2,4]triazolo[1,5-a]pirymidyn-7-ylowe jako inhibitory pde2
WO2016073424A1 (en) 2014-11-05 2016-05-12 Dart Neuroscience, Llc Substituted 5-methyl-[1, 2, 4] triazolo [1,5-a) pyrimidin-2-amine compounds as pde2 inhibitors
JP6608933B2 (ja) 2014-12-06 2019-11-20 イントラ−セルラー・セラピーズ・インコーポレイテッド 有機化合物
KR102557603B1 (ko) * 2014-12-06 2023-07-19 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
CN104525240A (zh) * 2014-12-10 2015-04-22 河北工业大学 硝酸铁作为催化剂在苯与羟胺盐反应一步法制苯胺反应中的应用方法
JP2017538769A (ja) 2014-12-22 2017-12-28 ファイザー・インク プロスタグランジンｅｐ３受容体の拮抗薬
TWI713497B (zh) * 2015-02-26 2020-12-21 南韓商愛思開生物製藥股份有限公司 咪唑并嘧啶及咪唑并三衍生物及包含該衍生物之醫藥組成物
WO2016145614A1 (en) 2015-03-17 2016-09-22 Merck Sharp & Dohme Corp. Triazolyl pyrimidinone compounds as pde2 inhibitors
WO2016154081A1 (en) 2015-03-26 2016-09-29 Merck Sharp & Dohme Corp. Pyrazolyl pyrimidinone compounds as pde2 inhibitors
EP3291817B1 (en) 2015-05-05 2019-10-02 Merck Sharp & Dohme Corp. Heteroaryl-pyrimidinone compounds as pde2 inhibitors
WO2016183741A1 (en) 2015-05-15 2016-11-24 Merck Sharp & Dohme Corp. Pyrimidinone amide compounds as pde2 inhibitors
WO2016191935A1 (en) 2015-05-29 2016-12-08 Merck Sharp & Dohme Corp. 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors
WO2016192083A1 (en) 2015-06-04 2016-12-08 Merck Sharp & Dohme Corp. Dihydropyrazolopyrimidinone compounds as pde2 inhibitors
EP3313852B1 (en) 2015-06-25 2021-01-20 Merck Sharp & Dohme Corp. Substituted pyrazolo/imidazolo bicyclic compounds as pde2 inhibitors
WO2017004134A1 (en) * 2015-06-29 2017-01-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof
WO2017000276A1 (en) * 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Bicyclic heterocyclic compounds as pde2 inhibitors
WO2017000277A1 (en) 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Substituted triazolo bicycliccompounds as pde2 inhibitors
UA122423C2 (uk) * 2015-11-02 2020-11-10 Янссен Фармацевтика Нв [1,2,4]ТРИАЗОЛО[1,5-a]ПІРИМІДИН-7-ІЛЬНА СПОЛУКА
CN105669680B (zh) * 2016-03-24 2018-02-23 南京药捷安康生物科技有限公司 吡咯并[2,1‑f][1,2,4]三嗪‑4(1H)‑酮衍生物类PDE9A抑制剂
WO2018065288A1 (de) 2016-10-07 2018-04-12 Bayer Cropscience Aktiengesellschaft 2-[2-phenyl-1-(sulfonylmethyl)vinyl]-imidazo[4,5-b]pyridin-derivate und verwandte verbindungen als schädlingsbekämpfungsmittel im pflanzenschutz
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JP7516365B2 (ja) * 2018-10-23 2024-07-16 イントラ－セルラー・セラピーズ・インコーポレイテッド 新規化合物
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Also Published As

Publication number Publication date
GT201300206A (es) 2015-02-19
KR101548443B1 (ko) 2015-08-28
US9200000B2 (en) 2015-12-01
TWI469983B (zh) 2015-01-21
CL2013002125A1 (es) 2013-12-20
SG192576A1 (en) 2013-09-30
US8598155B2 (en) 2013-12-03
TW201247673A (en) 2012-12-01
AR085304A1 (es) 2013-09-18
AU2012221828C1 (en) 2015-10-01
EP2681218A1 (en) 2014-01-08
KR20130132612A (ko) 2013-12-04
AU2012221828B2 (en) 2015-05-28
DOP2013000194A (es) 2014-01-31
PE20140236A1 (es) 2014-03-14
US20140066622A1 (en) 2014-03-06
US20120214791A1 (en) 2012-08-23
ZA201306348B (en) 2014-04-30
CA2825699A1 (en) 2012-08-30
CO6751271A2 (es) 2013-09-16
IL227716A0 (en) 2013-09-30
PH12013501556A1 (en) 2017-10-25
EA201390971A1 (ru) 2014-02-28
JP5543039B2 (ja) 2014-07-09
NZ613373A (en) 2015-04-24
WO2012114222A1 (en) 2012-08-30
ECSP13012892A (es) 2013-10-31
UY33916A (es) 2012-09-28
CR20130371A (es) 2013-09-18
CN103391941A (zh) 2013-11-13
UA106692C2 (uk) 2014-09-25
TN2013000349A1 (fr) 2015-01-20
MA34922B1 (fr) 2014-02-01
EA022586B1 (ru) 2016-01-29
CU20130107A7 (es) 2013-09-27
NI201300071A (es) 2014-02-12
BR112013021366A2 (pt) 2016-09-13
JP2014506589A (ja) 2014-03-17
MX2013009684A (es) 2013-10-28

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