MA34922B1 - Imidazo[5,1-f][1,2,4] triazines pour le traitement de troubles neurologiques - Google Patents
Imidazo[5,1-f][1,2,4] triazines pour le traitement de troubles neurologiquesInfo
- Publication number
- MA34922B1 MA34922B1 MA36201A MA36201A MA34922B1 MA 34922 B1 MA34922 B1 MA 34922B1 MA 36201 A MA36201 A MA 36201A MA 36201 A MA36201 A MA 36201A MA 34922 B1 MA34922 B1 MA 34922B1
- Authority
- MA
- Morocco
- Prior art keywords
- triazines
- imidazo
- treatment
- neurological disorders
- disorders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'invention concerne des composés représentés par la formule (I) et des sels de ceux-ci pharmaceutiquement acceptables, des procédés de préparation d'intermédiaires utilisés pour préparer des compositions contenant lesdits composés et les utilisations de ces composés pour traiter une maladie ou un état sélectionné dans le groupe constitué par les troubles du système nerveux central, les troubles cognitifs, la schizophrénie, la démence et d'autres troubles chez un mammifère.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161445617P | 2011-02-23 | 2011-02-23 | |
| PCT/IB2012/050589 WO2012114222A1 (fr) | 2011-02-23 | 2012-02-09 | Imidazo[5,1-f][1,2,4] triazines pour traiter les troubles neurologiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA34922B1 true MA34922B1 (fr) | 2014-02-01 |
Family
ID=45755439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA36201A MA34922B1 (fr) | 2011-02-23 | 2013-08-23 | Imidazo[5,1-f][1,2,4] triazines pour le traitement de troubles neurologiques |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US8598155B2 (fr) |
| EP (1) | EP2681218A1 (fr) |
| JP (1) | JP5543039B2 (fr) |
| KR (1) | KR101548443B1 (fr) |
| CN (1) | CN103391941A (fr) |
| AP (1) | AP2013007070A0 (fr) |
| AR (1) | AR085304A1 (fr) |
| AU (1) | AU2012221828C1 (fr) |
| BR (1) | BR112013021366A2 (fr) |
| CA (1) | CA2825699A1 (fr) |
| CL (1) | CL2013002125A1 (fr) |
| CO (1) | CO6751271A2 (fr) |
| CR (1) | CR20130371A (fr) |
| CU (1) | CU20130107A7 (fr) |
| DO (1) | DOP2013000194A (fr) |
| EA (1) | EA022586B1 (fr) |
| EC (1) | ECSP13012892A (fr) |
| GT (1) | GT201300206A (fr) |
| IL (1) | IL227716A0 (fr) |
| MA (1) | MA34922B1 (fr) |
| MX (1) | MX2013009684A (fr) |
| NI (1) | NI201300071A (fr) |
| PE (1) | PE20140236A1 (fr) |
| PH (1) | PH12013501556A1 (fr) |
| SG (1) | SG192576A1 (fr) |
| TN (1) | TN2013000349A1 (fr) |
| TW (1) | TWI469983B (fr) |
| UA (1) | UA106692C2 (fr) |
| UY (1) | UY33916A (fr) |
| WO (1) | WO2012114222A1 (fr) |
| ZA (1) | ZA201306348B (fr) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12013501556A1 (en) * | 2011-02-23 | 2017-10-25 | Pfizer | IMIDAZO[5,1-f][1,2,4]TRIAZINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| TN2015000490A1 (fr) | 2013-05-02 | 2017-04-06 | Pfizer | Dérivés d'imidazo-triazine servant d' inhibiteurs de pde10 |
| US9815796B2 (en) | 2013-12-23 | 2017-11-14 | Merck Sharp & Dohme Corp. | Pyrimidone carboxamide compounds as PDE2 inhibitors |
| JP6696904B2 (ja) | 2014-01-08 | 2020-05-20 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 製剤および医薬組成物 |
| PT3597649T (pt) | 2014-04-23 | 2022-01-21 | Dart Neuroscience Llc | Composições contendo compostos substituidos de [1,2,4]triazolo[1,5-a] pirimidin-7il como inibidores de pde2 |
| EP3215508A1 (fr) | 2014-11-05 | 2017-09-13 | Dart NeuroScience (Cayman) Ltd. | Composés 5-méthyl-[1, 2, 4]-triazolo-[1,5-a)-pyrimidin-2-amines substitués utilisés comme inhibiteurs de pde2 |
| WO2016090380A1 (fr) | 2014-12-06 | 2016-06-09 | Intra-Cellular Therapies, Inc. | Composés organiques |
| HK1244427A1 (zh) | 2014-12-06 | 2018-08-10 | Intra-Cellular Therapies, Inc. | 有机化合物 |
| CN104525240A (zh) * | 2014-12-10 | 2015-04-22 | 河北工业大学 | 硝酸铁作为催化剂在苯与羟胺盐反应一步法制苯胺反应中的应用方法 |
| JP2017538769A (ja) | 2014-12-22 | 2017-12-28 | ファイザー・インク | プロスタグランジンep3受容体の拮抗薬 |
| TWI713497B (zh) * | 2015-02-26 | 2020-12-21 | 南韓商愛思開生物製藥股份有限公司 | 咪唑并嘧啶及咪唑并三衍生物及包含該衍生物之醫藥組成物 |
| WO2016145614A1 (fr) | 2015-03-17 | 2016-09-22 | Merck Sharp & Dohme Corp. | Composés de triazolyl pyrimidinone en tant qu'inhibiteurs de pde2 |
| US10287269B2 (en) | 2015-03-26 | 2019-05-14 | Merck Sharp & Dohme Corp. | Pyrazolyl pyrimidinone compounds as PDE2 inhibitors |
| WO2016179059A1 (fr) | 2015-05-05 | 2016-11-10 | Merck Sharp & Dohme Corp. | Composés d'hétéroaryl-pyrimidinone en tant qu'inhibiteurs de pde2 |
| WO2016183741A1 (fr) | 2015-05-15 | 2016-11-24 | Merck Sharp & Dohme Corp. | Composés de pyrimidinone amide en tant qu'inhibiteurs de pde2 |
| WO2016191935A1 (fr) | 2015-05-29 | 2016-12-08 | Merck Sharp & Dohme Corp. | Composés 6-alkyle dihydropyrazolopyrimidinone utilisés en tant qu'inhibiteurs de pde2 |
| WO2016192083A1 (fr) | 2015-06-04 | 2016-12-08 | Merck Sharp & Dohme Corp. | Composés dihydropyrazolopyrimidinone utilisés en tant qu'en tant qu'inhibiteurs de pde2 |
| WO2016209749A1 (fr) | 2015-06-25 | 2016-12-29 | Merck Sharp & Dohme Corp. | Composés bicycliques pyrazolo/imidazolo substitués en tant qu'inhibiteurs de pde2 |
| WO2017004134A1 (fr) * | 2015-06-29 | 2017-01-05 | Nimbus Iris, Inc. | Inhibiteurs d'irak et leurs utilisations |
| WO2017000277A1 (fr) | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Bicyclo-composés de triazole substitués utilisés en tant qu'inhibiteurs de pde2 |
| WO2017000276A1 (fr) * | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Composés hétérocycliques bicycliques utilisés en tant qu'inhibiteurs de pde2 |
| EP3371188B1 (fr) * | 2015-11-02 | 2019-10-23 | Janssen Pharmaceutica NV | Composé [1,2,4]triazolo[1,5-a]pyrimidin-7-yl |
| CN105669680B (zh) * | 2016-03-24 | 2018-02-23 | 南京药捷安康生物科技有限公司 | 吡咯并[2,1‑f][1,2,4]三嗪‑4(1H)‑酮衍生物类PDE9A抑制剂 |
| WO2018065288A1 (fr) | 2016-10-07 | 2018-04-12 | Bayer Cropscience Aktiengesellschaft | Dérivés de 2-[2-phényl-1-(sulfonylméthyl)vinyl]-imidazo[4,5-b]pyridine et composés apparentés utilisés comme pesticides en protection des plantes |
| AU2017353315B2 (en) | 2016-11-02 | 2021-09-16 | Janssen Pharmaceutica Nv | (1,2,4)triazolo(1,5-a)pyrimidine compounds as PDE2 inhibitors |
| CN109890824B (zh) | 2016-11-02 | 2022-05-24 | 詹森药业有限公司 | 作为pde2抑制剂的[1,2,4]三唑并[1,5-a]嘧啶化合物 |
| TWI764950B (zh) | 2016-11-02 | 2022-05-21 | 比利時商健生藥品公司 | Pde2抑制劑 |
| UY37556A (es) | 2017-01-10 | 2018-07-31 | Bayer Ag | Derivados heterocíclicos como pesticidas |
| EP3568395A1 (fr) | 2017-01-10 | 2019-11-20 | Bayer Aktiengesellschaft | Dérivés hétérocycliques utilisés comme pesticides |
| EP3713572B1 (fr) | 2017-11-23 | 2025-07-30 | Oslo University Hospital HF | Traitement de la tachycardie |
| CN108640923A (zh) * | 2018-07-09 | 2018-10-12 | 湖南天地恒制药有限公司 | 一种托法替布关键中间体的制备方法 |
| WO2020086650A2 (fr) * | 2018-10-23 | 2020-04-30 | Intra-Cellular Therapies, Inc. | Nouveaux composés |
| US11492362B1 (en) | 2022-02-17 | 2022-11-08 | King Abdulaziz University | Pyridine derivatives for the treatment of hyperproliferative diseases |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993012113A1 (fr) * | 1991-12-17 | 1993-06-24 | The Upjohn Company | 3-SUBSTITUE IMIDAZO (1,5-a) ET IMIDAZO (1,5-a)-TRIAZOLO (1,5-c) QUINOXALINES ET QUINAZOLINES AGISSANT SUR LE SYSTEME NERVEUX CENTRAL (SNC) |
| YU59100A (sh) * | 1999-10-11 | 2003-10-31 | Pfizer Inc. | Postupak za dobijanje pirazolo (4,3-d) pirimidin-7-ona-3-piridilsulfonil jedinjenja i njihova intermedijera |
| DE10130167A1 (de) | 2001-06-22 | 2003-01-02 | Bayer Ag | Imidazotriazine |
| DE10230604A1 (de) * | 2002-07-08 | 2004-01-29 | Bayer Ag | Heterocyclisch substituierte Imidazotriazine |
| DE10230605A1 (de) * | 2002-07-08 | 2004-01-29 | Bayer Ag | Substituierte Imidazotriazine |
| WO2005041957A1 (fr) * | 2003-10-29 | 2005-05-12 | Pfizer Products Inc. | Derives d'oxindole et leur utilisation comme inhibiteurs de la phosphodiesterase de type 2 |
| EP2308879A1 (fr) | 2004-04-02 | 2011-04-13 | OSI Pharmaceuticals, Inc. | Inhibiteurs hétérobicycliques de la protéine kinase à anneau bicyclique substitué en 6,6 |
| TW200613306A (en) | 2004-07-20 | 2006-05-01 | Osi Pharm Inc | Imidazotriazines as protein kinase inhibitors |
| DE102004038328A1 (de) * | 2004-08-06 | 2006-03-16 | Bayer Healthcare Ag | Neue Verwendungen von 2-Phenyl-substituierten Imidazotriazinon-Derivaten |
| DE602005023333D1 (de) | 2004-10-15 | 2010-10-14 | Takeda Pharmaceutical | Kinaseinhibitoren |
| WO2006072612A2 (fr) * | 2005-01-05 | 2006-07-13 | Nycomed Gmbh | Triazolophthalazines |
| EA012211B1 (ru) | 2005-01-07 | 2009-08-28 | Пфайзер Продактс Инк. | Гетероароматические соединения хинолинов и их применение в качестве ингибиторов pde10 |
| RS51843B (sr) | 2005-11-17 | 2012-02-29 | Osi Pharmaceuticals Llc. | KONDENZOVANI BICIKLIČNI m TOR INHIBITORI |
| JP5156644B2 (ja) | 2006-01-25 | 2013-03-06 | オーエスアイ・フアーマシユーテイカルズ・エル・エル・シー | 不飽和mTOR阻害剤 |
| EP1996193A2 (fr) | 2006-03-13 | 2008-12-03 | OSI Pharmaceuticals, Inc. | Traitement combiné avec un inhibiteur de kinase egfr et un agent sensibilisant les cellules tumorales aux effets des inhibiteurs de kinase egfr |
| ES2585902T3 (es) | 2006-09-22 | 2016-10-10 | Pharmacyclics Llc | Inhibidores de tirosina cinasa de Bruton |
| EP2178563A2 (fr) | 2007-07-06 | 2010-04-28 | OSI Pharmaceuticals, Inc. | Combinasion therapeutique anti-cancereuse comprenant un inhibiteur de mtorc1 ainsi que de mtorc2 |
| US7683575B2 (en) | 2007-07-18 | 2010-03-23 | Tesla Motors, Inc. | Method and apparatus for identifying and disconnecting short-circuited battery cells within a battery pack |
| BRPI0910232A2 (pt) | 2008-03-19 | 2015-09-29 | Osi Pharm Inc | formas de sais inibidores do mtor |
| WO2009143051A1 (fr) | 2008-05-19 | 2009-11-26 | Osi Pharmaceuticals, Inc. | Imidazopyrazines et imidazotriazines substituées |
| CA2764173A1 (fr) | 2009-07-09 | 2011-01-13 | OSI Pharmaceuticals, LLC | Procede de fabrication de 3-amino-5-oxo-4,5-dihydro-[1,2,4]triazines substituees |
| BR112012019302B1 (pt) | 2010-02-03 | 2022-06-21 | Incyte Holdings Corporation | Imidazo[1,2-b] [1,2,4]triazinas como inibidores de c-met, composição que as compreende e métodos in vitro de inibir a atividade de c-met cinase, de inibir a via de sinalização da hgf/c-met cinase em uma célula e de inibir a atividade proliferativa de uma célula |
| PH12013501556A1 (en) * | 2011-02-23 | 2017-10-25 | Pfizer | IMIDAZO[5,1-f][1,2,4]TRIAZINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS |
-
2012
- 2012-02-09 PH PH1/2013/501556A patent/PH12013501556A1/en unknown
- 2012-02-09 JP JP2013554958A patent/JP5543039B2/ja not_active Expired - Fee Related
- 2012-02-09 EA EA201390971A patent/EA022586B1/ru not_active IP Right Cessation
- 2012-02-09 MX MX2013009684A patent/MX2013009684A/es not_active Application Discontinuation
- 2012-02-09 AU AU2012221828A patent/AU2012221828C1/en not_active Ceased
- 2012-02-09 CN CN2012800101209A patent/CN103391941A/zh active Pending
- 2012-02-09 UA UAA201309471A patent/UA106692C2/uk unknown
- 2012-02-09 PE PE2013001976A patent/PE20140236A1/es not_active Application Discontinuation
- 2012-02-09 BR BR112013021366A patent/BR112013021366A2/pt not_active IP Right Cessation
- 2012-02-09 CA CA2825699A patent/CA2825699A1/fr not_active Abandoned
- 2012-02-09 AP AP2013007070A patent/AP2013007070A0/xx unknown
- 2012-02-09 KR KR1020137024689A patent/KR101548443B1/ko not_active Expired - Fee Related
- 2012-02-09 WO PCT/IB2012/050589 patent/WO2012114222A1/fr not_active Ceased
- 2012-02-09 SG SG2013055298A patent/SG192576A1/en unknown
- 2012-02-09 EP EP12705448.4A patent/EP2681218A1/fr not_active Withdrawn
- 2012-02-20 US US13/400,172 patent/US8598155B2/en active Active
- 2012-02-20 TW TW101105525A patent/TWI469983B/zh not_active IP Right Cessation
- 2012-02-22 UY UY0001033916A patent/UY33916A/es not_active Application Discontinuation
- 2012-02-22 AR ARP120100575A patent/AR085304A1/es unknown
-
2013
- 2013-07-24 CL CL2013002125A patent/CL2013002125A1/es unknown
- 2013-07-29 IL IL227716A patent/IL227716A0/en unknown
- 2013-07-30 CU CU2013000107A patent/CU20130107A7/es unknown
- 2013-07-31 CR CR20130371A patent/CR20130371A/es unknown
- 2013-08-19 TN TNP2013000349A patent/TN2013000349A1/fr unknown
- 2013-08-22 NI NI201300071A patent/NI201300071A/es unknown
- 2013-08-22 CO CO13199523A patent/CO6751271A2/es unknown
- 2013-08-22 ZA ZA2013/06348A patent/ZA201306348B/en unknown
- 2013-08-22 GT GT201300206A patent/GT201300206A/es unknown
- 2013-08-23 DO DO2013000194A patent/DOP2013000194A/es unknown
- 2013-08-23 MA MA36201A patent/MA34922B1/fr unknown
- 2013-09-23 EC ECSP13012892 patent/ECSP13012892A/es unknown
- 2013-11-01 US US14/069,640 patent/US9200000B2/en not_active Expired - Fee Related
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