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NO990012L - Nye erytromyciner og fremgangsmÕte for deres fremstilling - Google Patents

Nye erytromyciner og fremgangsmÕte for deres fremstilling

Info

Publication number
NO990012L
NO990012L NO990012A NO990012A NO990012L NO 990012 L NO990012 L NO 990012L NO 990012 A NO990012 A NO 990012A NO 990012 A NO990012 A NO 990012A NO 990012 L NO990012 L NO 990012L
Authority
NO
Norway
Prior art keywords
preparation
methods
erythromycins
new
new erythromycins
Prior art date
Application number
NO990012A
Other languages
English (en)
Norwegian (no)
Other versions
NO990012D0 (no
Inventor
Peter Francis Leadlay
James Staunton
Jesus Cortes
Michael Stephen Pacey
Original Assignee
Biotica Tech Ltd
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9614189.0A external-priority patent/GB9614189D0/en
Priority claimed from GBGB9710962.3A external-priority patent/GB9710962D0/en
Application filed by Biotica Tech Ltd, Pfizer filed Critical Biotica Tech Ltd
Publication of NO990012D0 publication Critical patent/NO990012D0/no
Publication of NO990012L publication Critical patent/NO990012L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO990012A 1996-07-05 1999-01-04 Nye erytromyciner og fremgangsmÕte for deres fremstilling NO990012L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9614189.0A GB9614189D0 (en) 1996-07-05 1996-07-05 Polyketides and their synthesis
US2418896P 1996-08-19 1996-08-19
GBGB9710962.3A GB9710962D0 (en) 1997-05-28 1997-05-28 Polyketides and their synthesis
PCT/GB1997/001810 WO1998001571A2 (en) 1996-07-05 1997-07-04 Erythromycins and process for their preparation

Publications (2)

Publication Number Publication Date
NO990012D0 NO990012D0 (no) 1999-01-04
NO990012L true NO990012L (no) 1999-02-23

Family

ID=27268361

Family Applications (1)

Application Number Title Priority Date Filing Date
NO990012A NO990012L (no) 1996-07-05 1999-01-04 Nye erytromyciner og fremgangsmÕte for deres fremstilling

Country Status (28)

Country Link
EP (3) EP0910633B1 (is)
JP (2) JP4173551B2 (is)
KR (1) KR20000023579A (is)
CN (1) CN1179046C (is)
AP (1) AP1029A (is)
AT (2) ATE451455T1 (is)
AU (2) AU731301B2 (is)
BG (1) BG103133A (is)
BR (1) BR9710209A (is)
CA (2) CA2259463A1 (is)
DE (2) DE69739688D1 (is)
DK (2) DK0910633T3 (is)
EA (1) EA001744B1 (is)
EE (1) EE03976B1 (is)
ES (2) ES2337424T3 (is)
GB (1) GB2331518B (is)
GE (1) GEP20012348B (is)
IL (1) IL127916A0 (is)
IS (1) IS4940A (is)
NO (1) NO990012L (is)
NZ (1) NZ333861A (is)
OA (1) OA10952A (is)
PL (1) PL331285A1 (is)
PT (1) PT909327E (is)
SI (1) SI0910633T1 (is)
SK (1) SK182498A3 (is)
TR (1) TR199900006T2 (is)
WO (2) WO1998001571A2 (is)

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US6927057B2 (en) 1993-09-20 2005-08-09 Kosan Biosciences Macrolide analogs
US6500960B1 (en) 1995-07-06 2002-12-31 Stanford University (Board Of Trustees Of The Leland Stanford Junior University) Method to produce novel polyketides
US6558942B1 (en) 1994-05-06 2003-05-06 The Leland Stanford Junior University Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US20030170725A1 (en) 1993-09-20 2003-09-11 Chaitan Khosla Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
CA2226221C (en) 1995-07-06 2001-05-08 The Leland Stanford Junior University Cell-free synthesis of polyketides
EP0870053A4 (en) 1995-12-19 2002-09-11 Univ Minnesota METABOLIC METHOD FOR PRODUCING POLYHYDROXYALKANOATE MONOMER SYNTHASES
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US6503741B1 (en) 1998-05-28 2003-01-07 Kosan Biosciences, Inc. Polyketide synthase genes from Streptomyces venezuelae
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US6902913B2 (en) 1997-04-30 2005-06-07 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
AU732909B2 (en) 1997-04-30 2001-05-03 Board Of Trustees Of The Leland Stanford Junior University Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
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US7001748B2 (en) 1999-02-09 2006-02-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of making polyketides using hybrid polyketide synthases
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JP2020501519A (ja) 2016-10-28 2020-01-23 ギンゴー バイオワークス， インコーポレイテッド 化合物の生産のための組成物および方法
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AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
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US6060234A (en) * 1991-01-17 2000-05-09 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
ES2164713T3 (es) * 1993-09-20 2002-03-01 Univ Leland Stanford Junior Produccion recombinante de nuevos poliquetidos.
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides

Also Published As

Publication number Publication date
NZ333861A (en) 2000-08-25
EP2182067A2 (en) 2010-05-05
PT909327E (pt) 2005-10-31
CA2259420C (en) 2007-09-18
GB2331518A (en) 1999-05-26
DK0910633T3 (da) 2010-03-29
WO1998001546A2 (en) 1998-01-15
DK0909327T3 (da) 2005-09-26
OA10952A (en) 2002-02-25
AU3450997A (en) 1998-02-02
AU731301B2 (en) 2001-03-29
GB9900156D0 (en) 1999-02-24
IL127916A0 (en) 1999-11-30
ES2244001T3 (es) 2005-12-01
TR199900006T2 (xx) 1999-04-21
JP4173551B2 (ja) 2008-10-29
EP0909327A2 (en) 1999-04-21
KR20000023579A (ko) 2000-04-25
EA001744B1 (ru) 2001-08-27
GEP20012348B (en) 2001-01-25
AP9901444A0 (en) 1999-03-31
WO1998001571A2 (en) 1998-01-15
WO1998001546A3 (en) 1998-04-09
DE69733416D1 (de) 2005-07-07
SI0910633T1 (sl) 2010-04-30
ATE451455T1 (de) 2009-12-15
BR9710209A (pt) 2000-01-11
EA199900087A1 (ru) 1999-08-26
PL331285A1 (en) 1999-07-05
EP0909327B1 (en) 2005-06-01
JP2000516450A (ja) 2000-12-12
EP0910633B1 (en) 2009-12-09
SK182498A3 (en) 2000-05-16
EE9900014A (et) 1999-08-16
AU3451497A (en) 1998-02-02
EP0910633A2 (en) 1999-04-28
CN1179046C (zh) 2004-12-08
ATE296893T1 (de) 2005-06-15
IS4940A (is) 1999-01-04
ES2337424T3 (es) 2010-04-23
WO1998001571A3 (en) 1998-02-19
GB2331518B (en) 2001-03-14
JP2000511063A (ja) 2000-08-29
DE69733416T2 (de) 2006-04-27
CA2259463A1 (en) 1998-01-15
AU731654B2 (en) 2001-04-05
DE69739688D1 (de) 2010-01-21
EP2182067A3 (en) 2010-07-14
EE03976B1 (et) 2003-02-17
AP1029A (en) 2001-12-11
NO990012D0 (no) 1999-01-04
CA2259420A1 (en) 1998-01-15
CN1229438A (zh) 1999-09-22
BG103133A (en) 2000-04-28

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