NO944187L - Isokinoliner, fremgangsmåte for deres fremstilling og anvendelse - Google Patents

Isokinoliner, fremgangsmåte for deres fremstilling og anvendelse

Info

Publication number: NO944187L
Authority: NO; Norway
Prior art keywords: isoquinolines; preparation; methods
Prior art date: 1993-11-05

Application number

NO944187A

Other languages

English (en)

Other versions

NO944187D0 (no

NO302293B1 (no

Inventor

Reto Naef

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-05

Filing date

1994-11-03

Publication date

1995-05-08

1994-11-03 Application filed by Sandoz Ag filed Critical Sandoz Ag

1994-11-03 Publication of NO944187D0 publication Critical patent/NO944187D0/no

1995-05-08 Publication of NO944187L publication Critical patent/NO944187L/no

1998-02-16 Publication of NO302293B1 publication Critical patent/NO302293B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Pulmonology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO944187A 1993-11-05 1994-11-03 Isokinolinforbindelser og farmasöytisk preparat omfattende en sådan forbindelse NO302293B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB939322828A GB9322828D0 (en)	1993-11-05	1993-11-05	Organic compounds

Publications (3)

Publication Number	Publication Date
NO944187D0 NO944187D0 (no)	1994-11-03
NO944187L true NO944187L (no)	1995-05-08
NO302293B1 NO302293B1 (no)	1998-02-16

Family

ID=10744697

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO944187A NO302293B1 (no)	1993-11-05	1994-11-03	Isokinolinforbindelser og farmasöytisk preparat omfattende en sådan forbindelse

Country Status (25)

Country	Link
US (1)	US5747506A (no)
EP (1)	EP0664289A3 (no)
JP (1)	JPH07188176A (no)
KR (1)	KR950014073A (no)
CN (1)	CN1051998C (no)
AT (1)	AT404940B (no)
AU (1)	AU685852B2 (no)
CA (1)	CA2135000A1 (no)
CH (1)	CH688478A5 (no)
CZ (1)	CZ282329B6 (no)
DE (1)	DE4438737A1 (no)
FI (1)	FI945191L (no)
FR (1)	FR2711989B1 (no)
GB (2)	GB9322828D0 (no)
HU (1)	HU217120B (no)
IL (1)	IL111518A (no)
IT (1)	IT1273993B (no)
NO (1)	NO302293B1 (no)
NZ (1)	NZ264851A (no)
PE (1)	PE30395A1 (no)
PL (1)	PL178210B1 (no)
RU (1)	RU2144027C1 (no)
SK (1)	SK280298B6 (no)
TW (1)	TW353067B (no)
ZA (1)	ZA948738B (no)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9312853D0 (en)	1993-06-22	1993-08-04	Euro Celtique Sa	Chemical compounds
US5591776A (en)	1994-06-24	1997-01-07	Euro-Celtique, S.A.	Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5922751A (en)	1994-06-24	1999-07-13	Euro-Celtique, S.A.	Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US6166041A (en)	1995-10-11	2000-12-26	Euro-Celtique, S.A.	2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en)	1996-04-10	2000-06-13	Euro-Celtique S.A.	6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
ID19155A (id) *	1996-12-13	1998-06-18	Tanabe Seiyaku Co	Turunan-turunan piridin, pembuatannya dan intermediet untuk pembuatannya
US5919794A (en) *	1998-05-11	1999-07-06	Virginia Commonwealth University	Methods of using pharmaceutical tetrahydroisoquinolines
US6200771B1 (en) *	1998-10-15	2001-03-13	Cell Pathways, Inc.	Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia
IL132407A0 (en) *	1998-10-21	2001-03-19	Pfizer Prod Inc	Method for treating congestive heart failure
DE19930614A1 (de) *	1999-07-02	2001-01-04	Mann & Hummel Filter	Filtereinsatz
AU777012B2 (en)	1999-08-21	2004-09-30	Takeda Gmbh	Synergistic combination of PDE inhibitors and beta 2 adrenoceptor agonist
RU2189206C2 (ru) *	2000-02-04	2002-09-20	Ченцова Екатерина Валериановна	Способ лечения дефектов роговицы
JP2003526677A (ja) *	2000-03-14	2003-09-09	ザ・ユニバーシテイ・オブ・ウエスタン・オンタリオ	骨形成に影響を与える組成物および方法
CA2428527A1 (en)	2000-11-14	2002-05-23	Altana Pharma Ag	(dihydro)isoquinoline derivatives as phosphodiesterase inhibitors
AU2002224835A1 (en) *	2000-11-14	2002-05-27	Byk Gulden Lomberg Chemische Fabrik G.M.B.H.	Dihydroisoquinolines as novel phosphodiesterase inhibitors
US6727261B2 (en) *	2001-12-27	2004-04-27	Hoffman-La Roche Inc.	Pyrido[2,1-A]Isoquinoline derivatives
DE10229762A1 (de) *	2002-07-03	2004-01-22	Aventis Pharma Deutschland Gmbh	Pyrazoloisoquinolinenderivaten zur Inhibierung von NFkappaB-induzierende Kinase
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
DE10312963A1 (de) *	2003-03-24	2004-10-07	Aventis Pharma Deutschland Gmbh	Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament
JP2006522151A (ja)	2003-04-01	2006-09-28	アプライドリサーチシステムズエーアールエスホールディングナームロゼフェンノートシャップ	不妊症におけるホスホジエステラーゼ阻害剤
US7067529B2 (en) *	2003-05-19	2006-06-27	Hoffmann-La Roche Inc.	Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors
US7795385B2 (en) *	2004-12-17	2010-09-14	Bexar Global, Inc.	Use of bombesin/gastrin-releasing peptide antagonists for the treatment of inflammatory conditions, acute lung injury and bipolar disorder
WO2008151257A2 (en)	2007-06-04	2008-12-11	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2009149279A2 (en)	2008-06-04	2009-12-10	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2730603C (en)	2008-07-16	2019-09-24	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AU2009298981B2 (en) *	2008-10-02	2012-09-27	Asahi Kasei Pharma Corporation	8-substituted isoquinoline derivative and use thereof
KR20110071014A (ko)	2008-10-17	2011-06-27	위스콘신 얼럼나이 리서어치 화운데이션	생물학적으로 활성인 알파-베타 펩티드의 제조 방법
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
KR102034748B1 (ko)	2011-03-01	2019-10-21	시너지 파마슈티컬즈 인코포레이티드	구아닐레이트 사이클라제 c 작용제의 제조 방법
US9545446B2 (en)	2013-02-25	2017-01-17	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase and their uses
EP2970384A1 (en)	2013-03-15	2016-01-20	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
WO2014151200A2 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
AU2014274812B2 (en)	2013-06-05	2018-09-27	Bausch Health Ireland Limited	Ultra-pure agonists of guanylate cyclase C, method of making and using same
WO2015021358A2 (en)	2013-08-09	2015-02-12	Dominique Charmot	Compounds and methods for inhibiting phosphate transport
CN114340631A (zh)	2019-05-21	2022-04-12	阿德利克斯股份有限公司	用于降低患者的血清磷酸盐的组合

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB645139A (en) *	1946-10-22	1950-10-25	Servita Gyogyszeryar Es Vegyip	Improved process for the production of isoquinoline derivatives
GB1400425A (en) *	1971-09-22	1975-07-16	Rolland Sa A	Substituted 3-hydroxymethyl-isoquinolines and derivatives
US3878215A (en) *	1971-12-01	1975-04-15	Sandoz Ag	2-Alkyl-3-substituted-4-aryl isoquinolines
GB1407685A (en) *	1972-10-19	1975-09-24	Allen & Hanburys Ltd	Isoquinolinium compounds
US4018927A (en) *	1973-12-17	1977-04-19	The Regents Of The University Of Michigan	Treatment of proliferating skin diseases with papaverine alkaloids
KR840002104B1 (ko) *	1980-08-08	1984-11-15	부자 앙드레	신규 이소퀴놀린 유도체의 제법
HU183479B (en) *	1981-06-16	1984-05-28	Chinoin Gyogyszer Es Vegyeszet	Process for producing new 6,7-diethoxy-1-aracket-4-ethoxy-3-hydroxy-benzyl-bracket closed-3,4-dihydroisoquinolin
DE3244594A1 (de) *	1982-12-02	1984-06-07	Hoechst Ag, 6230 Frankfurt	1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung
GB8328052D0 (en) *	1983-10-20	1983-11-23	Beecham Group Plc	Compounds
US4761403A (en) *	1986-04-09	1988-08-02	Abbott Laboratories	Lipoxygenase inhibiting compounds
CA1330560C (en) *	1986-05-21	1994-07-05	Maurits E. A. Vandewalle	Di- and tetrahydroisoquinoline derivatives
HU196758B (en) *	1986-05-21	1989-01-30	Gyogyszerkutato Intezet	Process for production of 3-hidroxi-methil-quinolines and medical compositions containing them
GB8800397D0 (en) *	1988-01-08	1988-02-10	Sandoz Ltd	Improvements in/relating to organic compounds
GB9027055D0 (en) *	1990-12-13	1991-02-06	Sandoz Ltd	Organic compounds

1993
- 1993-11-05 GB GB939322828A patent/GB9322828D0/en active Pending
1994
- 1994-10-28 CH CH03226/94A patent/CH688478A5/de not_active IP Right Cessation
- 1994-10-28 FR FR9413108A patent/FR2711989B1/fr not_active Expired - Fee Related
- 1994-10-29 DE DE4438737A patent/DE4438737A1/de not_active Withdrawn
- 1994-11-01 EP EP94810628A patent/EP0664289A3/en not_active Withdrawn
- 1994-11-01 GB GB9421985A patent/GB2283488B/en not_active Expired - Fee Related
- 1994-11-03 IT ITRM940706A patent/IT1273993B/it active IP Right Grant
- 1994-11-03 CZ CZ942698A patent/CZ282329B6/cs not_active IP Right Cessation
- 1994-11-03 AU AU77610/94A patent/AU685852B2/en not_active Ceased
- 1994-11-03 PE PE1994254101A patent/PE30395A1/es not_active Application Discontinuation
- 1994-11-03 FI FI945191A patent/FI945191L/fi unknown
- 1994-11-03 KR KR1019940028732A patent/KR950014073A/ko not_active Ceased
- 1994-11-03 NZ NZ264851A patent/NZ264851A/en unknown
- 1994-11-03 IL IL11151894A patent/IL111518A/xx active IP Right Grant
- 1994-11-03 SK SK1319-94A patent/SK280298B6/sk unknown
- 1994-11-03 CA CA002135000A patent/CA2135000A1/en not_active Abandoned
- 1994-11-03 NO NO944187A patent/NO302293B1/no not_active IP Right Cessation
- 1994-11-04 JP JP6271172A patent/JPH07188176A/ja active Pending
- 1994-11-04 RU RU94040170A patent/RU2144027C1/ru active
- 1994-11-04 CN CN94118199A patent/CN1051998C/zh not_active Expired - Fee Related
- 1994-11-04 HU HU9403184A patent/HU217120B/hu not_active IP Right Cessation
- 1994-11-04 ZA ZA948738A patent/ZA948738B/xx unknown
- 1994-11-04 AT AT0204894A patent/AT404940B/de not_active IP Right Cessation
- 1994-11-04 PL PL94305705A patent/PL178210B1/pl unknown
- 1994-11-16 TW TW083110617A patent/TW353067B/zh active
1996
- 1996-12-20 US US08/771,556 patent/US5747506A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
RU2144027C1 (ru)	2000-01-10
CN1051998C (zh)	2000-05-03
ATA204894A (de)	1998-08-15
CH688478A5 (de)	1997-10-15
ITRM940706A0 (it)	1994-11-03
HU217120B (hu)	1999-11-29
SK280298B6 (sk)	1999-11-08
GB9322828D0 (en)	1993-12-22
HU9403184D0 (en)	1994-12-28
NZ264851A (en)	1996-04-26
TW353067B (en)	1999-02-21
RU94040170A (ru)	1996-10-10
AU7761094A (en)	1995-05-18
GB2283488A (en)	1995-05-10
CZ269894A3 (en)	1995-07-12
PL305705A1 (en)	1995-05-15
JPH07188176A (ja)	1995-07-25
KR950014073A (ko)	1995-06-15
GB9421985D0 (en)	1994-12-21
GB2283488B (en)	1997-12-03
HUT71350A (en)	1995-11-28
FI945191A7 (fi)	1995-05-06
IL111518A (en)	1999-06-20
AU685852B2 (en)	1998-01-29
NO944187D0 (no)	1994-11-03
HK1005776A1 (en)	1999-01-22
CZ282329B6 (cs)	1997-06-11
AT404940B (de)	1999-03-25
PE30395A1 (es)	1995-10-25
DE4438737A1 (de)	1995-05-11
EP0664289A3 (en)	1995-09-13
CN1106801A (zh)	1995-08-16
CA2135000A1 (en)	1995-05-06
ITRM940706A1 (it)	1996-05-03
FR2711989B1 (fr)	1996-06-14
EP0664289A2 (en)	1995-07-26
IT1273993B (it)	1997-07-14
FI945191A0 (fi)	1994-11-03
US5747506A (en)	1998-05-05
SK131994A3 (en)	1995-06-07
FR2711989A1 (fr)	1995-05-12
PL178210B1 (pl)	2000-03-31
IL111518A0 (en)	1995-01-24
ZA948738B (en)	1996-05-06
NO302293B1 (no)	1998-02-16
FI945191L (fi)	1995-05-06

Publication	Publication Date	Title
NO944187L (no)	1995-05-08	Isokinoliner, fremgangsmåte for deres fremstilling og anvendelse
NO942193D0 (no)	1994-06-10	Metallocener og fremgangsmåte til deres fremstilling og bruk
DK0740668T3 (da)	1999-05-03	Tetracykliske derivater, fremgangsmåde til deres fremstilling og deres anvendelse
NO933434D0 (no)	1993-09-27	Piperidinderivater, deres fremstilling og anvendelse
DK374389A (da)	1990-01-30	Arylbenzenoxazolidinoner, deres fremstilling og anvendelse
NO961071D0 (no)	1996-03-15	Kjemiske forbindelser, deres fremstilling og anvendelse
NO943682D0 (no)	1994-10-03	Imidazol-4-yl-piperidin-derivater, deres fremstilling og terapeutiske anvendelse
NO955326D0 (no)	1995-12-28	Isokinolinderivater, fremgangsmåte for deres fremstilling og terapeutiske anvendelse
NO943794D0 (no)	1994-10-07	4-difenylmethylpiperidinderivater, og fremgangsmåte for deres fremstilling
NO953673D0 (no)	1995-09-18	[1,2,4ÅTriazolo[4,3-aÅkinoksalinderivater, deres fremstilling og anvendelse
DK388989D0 (da)	1989-08-08	Acylcyanoguanidiner, deres fremstilling og anvendelse
DK435289D0 (da)	1989-09-01	Piperazindioner, deres fremstilling og anvendelse
NO941517L (no)	1994-10-28	2-amino-4-kinolin-dihydropyridiner, fremgangsmåter for deres fremstilling og deres anvendelse
DK60893D0 (da)	1993-05-26	Piperidinderivater, deres fremstilling og anvendelse
NO954763D0 (no)	1995-11-24	Piperidinderivater, deres fremstilling og anvendelse
NO933435D0 (no)	1993-09-27	Piperidinderivater, deres fremstilling og anvendelse
NO940130D0 (no)	1994-01-14	Benzimidazolderivater, fremgangsmaate for deres fremstilling og te rapeutisk anvendelse derav
DK360189A (da)	1990-01-22	S-adenosyl-methionin-decarboxylase-inhibitorer, deres fremstilling og anvendelse
DK225089D0 (da)	1989-05-08	2-adamantyl-4-isothiazolin-3-oner, deres fremstilling og anvendelse
NO955242D0 (no)	1995-12-22	Piperidinderivater, fremgangsmåte for fremstilling derav og deres terapeutiske anvendelse
DK60693D0 (da)	1993-05-26	Kemiske forbindelser, deres fremstilling og anvendelse
DK196389D0 (da)	1989-04-24	N-substituerede n-amino-pyrroler, deres fremstilling og anvendelse
NO972821D0 (no)	1997-06-18	1-C-perfluoralkylglycosider, deres fremstilling og anvendelse
NO965553D0 (no)	1996-12-23	Nye anidokinoksalin-dioner, deres fremstilling og anvendelse
DK60493D0 (da)	1993-05-26	Kemiske forbindelser, deres fremstilling og anvendelse

Legal Events

Date	Code	Title	Description
2002-07-08	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN MAY 2002