EE9900014A - Erütromütsiinid ja nende valmistamise protsess - Google Patents
Erütromütsiinid ja nende valmistamise protsessInfo
- Publication number
- EE9900014A EE9900014A EEP199900014A EE9900014A EE9900014A EE 9900014 A EE9900014 A EE 9900014A EE P199900014 A EEP199900014 A EE P199900014A EE 9900014 A EE9900014 A EE 9900014A EE 9900014 A EE9900014 A EE 9900014A
- Authority
- EE
- Estonia
- Prior art keywords
- erythromycins
- preparation
- Prior art date
Links
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Natural products O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Plant Pathology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9614189.0A GB9614189D0 (en) | 1996-07-05 | 1996-07-05 | Polyketides and their synthesis |
| US2418896P | 1996-08-19 | 1996-08-19 | |
| GBGB9710962.3A GB9710962D0 (en) | 1997-05-28 | 1997-05-28 | Polyketides and their synthesis |
| PCT/GB1997/001810 WO1998001571A2 (en) | 1996-07-05 | 1997-07-04 | Erythromycins and process for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE9900014A true EE9900014A (et) | 1999-08-16 |
| EE03976B1 EE03976B1 (et) | 2003-02-17 |
Family
ID=27268361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP199900014A EE03976B1 (et) | 1996-07-05 | 1997-07-04 | Erütromütsiinid ja nende valmistamise meetod |
Country Status (28)
| Country | Link |
|---|---|
| EP (3) | EP0910633B1 (et) |
| JP (2) | JP4173551B2 (et) |
| KR (1) | KR20000023579A (et) |
| CN (1) | CN1179046C (et) |
| AP (1) | AP1029A (et) |
| AT (2) | ATE451455T1 (et) |
| AU (2) | AU731301B2 (et) |
| BG (1) | BG103133A (et) |
| BR (1) | BR9710209A (et) |
| CA (2) | CA2259463A1 (et) |
| DE (2) | DE69739688D1 (et) |
| DK (2) | DK0910633T3 (et) |
| EA (1) | EA001744B1 (et) |
| EE (1) | EE03976B1 (et) |
| ES (2) | ES2337424T3 (et) |
| GB (1) | GB2331518B (et) |
| GE (1) | GEP20012348B (et) |
| IL (1) | IL127916A0 (et) |
| IS (1) | IS4940A (et) |
| NO (1) | NO990012L (et) |
| NZ (1) | NZ333861A (et) |
| OA (1) | OA10952A (et) |
| PL (1) | PL331285A1 (et) |
| PT (1) | PT909327E (et) |
| SI (1) | SI0910633T1 (et) |
| SK (1) | SK182498A3 (et) |
| TR (1) | TR199900006T2 (et) |
| WO (2) | WO1998001571A2 (et) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6063561A (en) * | 1991-01-17 | 2000-05-16 | Abbott Laboratories | Polyketide derivatives and recombinant methods for making same |
| US6060234A (en) * | 1991-01-17 | 2000-05-09 | Abbott Laboratories | Polyketide derivatives and recombinant methods for making same |
| US6927057B2 (en) | 1993-09-20 | 2005-08-09 | Kosan Biosciences | Macrolide analogs |
| US6500960B1 (en) | 1995-07-06 | 2002-12-31 | Stanford University (Board Of Trustees Of The Leland Stanford Junior University) | Method to produce novel polyketides |
| US6558942B1 (en) | 1994-05-06 | 2003-05-06 | The Leland Stanford Junior University | Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold |
| US20030170725A1 (en) | 1993-09-20 | 2003-09-11 | Chaitan Khosla | Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold |
| US5712146A (en) | 1993-09-20 | 1998-01-27 | The Leland Stanford Junior University | Recombinant combinatorial genetic library for the production of novel polyketides |
| US6495348B1 (en) | 1993-10-07 | 2002-12-17 | Regents Of The University Of Minnesota | Mitomycin biosynthetic gene cluster |
| CA2226221C (en) | 1995-07-06 | 2001-05-08 | The Leland Stanford Junior University | Cell-free synthesis of polyketides |
| EP0870053A4 (en) | 1995-12-19 | 2002-09-11 | Univ Minnesota | METABOLIC METHOD FOR PRODUCING POLYHYDROXYALKANOATE MONOMER SYNTHASES |
| US6271255B1 (en) | 1996-07-05 | 2001-08-07 | Biotica Technology Limited | Erythromycins and process for their preparation |
| US6399789B1 (en) | 1996-12-18 | 2002-06-04 | Kosan Biosciences, Inc. | Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides |
| US6503741B1 (en) | 1998-05-28 | 2003-01-07 | Kosan Biosciences, Inc. | Polyketide synthase genes from Streptomyces venezuelae |
| JP2008169226A (ja) * | 1997-04-30 | 2008-07-24 | Kosan Biosciences Inc | 足場としてモジュラー性ｐｋｓ遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー |
| US6902913B2 (en) | 1997-04-30 | 2005-06-07 | Kosan Biosciences, Inc. | Recombinant narbonolide polyketide synthase |
| AU732909B2 (en) | 1997-04-30 | 2001-05-03 | Board Of Trustees Of The Leland Stanford Junior University | Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold |
| US6117659A (en) | 1997-04-30 | 2000-09-12 | Kosan Biosciences, Inc. | Recombinant narbonolide polyketide synthase |
| NZ501998A (en) | 1997-07-10 | 2001-04-27 | Kosan Biosciences Inc | Production of polyketides in plants |
| AP1060A (en) | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
| JP2002508968A (ja) * | 1998-01-14 | 2002-03-26 | グラクソ グループ リミテッド | ポリケチドおよびその合成 |
| NZ509006A (en) * | 1998-05-28 | 2003-09-26 | Kosan Biosciences Inc | Recombinant narbonolide polyketide synthase |
| US6265202B1 (en) | 1998-06-26 | 2001-07-24 | Regents Of The University Of Minnesota | DNA encoding methymycin and pikromycin |
| GB9814006D0 (en) * | 1998-06-29 | 1998-08-26 | Biotica Tech Ltd | Polyketides and their synthesis |
| US6221641B1 (en) | 1998-07-02 | 2001-04-24 | Leland Stanford Junior University | Method for making polyketides |
| GB9814622D0 (en) * | 1998-07-06 | 1998-09-02 | Biotica Tech Ltd | Polyketides,their preparation,and materials for use therein |
| AU1447700A (en) | 1998-10-28 | 2000-05-15 | Kosan Biosciences, Inc. | Library of novel "unnatural" natural products |
| BR9914998A (pt) | 1998-11-03 | 2001-07-10 | Pfizer Prod Inc | Antibióticos macrólidos |
| EP1141275B1 (en) | 1999-01-05 | 2009-08-12 | Trustees Of Boston University | Improved nucleic acid cloning |
| US6358712B1 (en) | 1999-01-05 | 2002-03-19 | Trustee Of Boston University | Ordered gene assembly |
| CZ20012675A3 (cs) | 1999-01-27 | 2002-04-17 | Pfizer Products Inc. | Ketolidová antibiotika |
| AU2876300A (en) * | 1999-02-09 | 2000-08-29 | Board Of Trustees Of The Leland Stanford Junior University | Methods to mediate polyketide synthase module effectiveness |
| US7001748B2 (en) | 1999-02-09 | 2006-02-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of making polyketides using hybrid polyketide synthases |
| WO2000063224A2 (en) | 1999-04-16 | 2000-10-26 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6939861B2 (en) | 1999-04-16 | 2005-09-06 | Kosan Biosciences, Inc. | Amido macrolides |
| MXPA01010521A (es) | 1999-04-16 | 2003-08-19 | Johnson & Johnson | Antibacteriales de cetolidos. |
| US6590083B1 (en) | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
| US6514944B2 (en) | 1999-04-16 | 2003-02-04 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| CA2373117C (en) | 1999-05-24 | 2006-02-28 | Pfizer Products Inc. | 13-methyl-erythromycin derivatives |
| GB9912563D0 (en) * | 1999-05-28 | 1999-07-28 | Biotica Tech Ltd | Polyketides and their synthesis |
| WO2001034816A1 (en) * | 1999-10-29 | 2001-05-17 | Kosan Biosciences, Inc. | Rapamycin analogs |
| EP1101769A3 (en) | 1999-11-18 | 2001-10-24 | Pfizer Products Inc. | Nitrogen containing erythromycin derivatives |
| CA2399198A1 (en) | 2000-02-18 | 2001-08-23 | Christopher Carreras | Motilide compounds |
| EP1146051A3 (en) * | 2000-04-10 | 2001-10-31 | Pfizer Products Inc. | Erythromycin A derivatives |
| ATE453719T1 (de) | 2000-04-13 | 2010-01-15 | Biotica Tech Ltd | Glycosylierte hybrid-verbindungen, deren herstellung und verwendung |
| CN1633237B (zh) * | 2002-02-19 | 2010-05-26 | 道农业科学公司 | 新的产生spinosyn的聚酮合酶 |
| WO2004007709A2 (en) | 2002-07-16 | 2004-01-22 | Biotica Technology Limited | Production of polyketides |
| DK200201957A (da) | 2002-12-20 | 2003-01-20 | Alpharma Aps | 10-substituted erythromycin ketolides and methods of making |
| GB0230217D0 (en) * | 2002-12-27 | 2003-02-05 | Biotica Tech Ltd | Borrelidin-producing polyketide synthase and its uses |
| EP1638529B1 (en) | 2003-06-16 | 2016-08-10 | ANDRX Pharmaceuticals, LLC. | Oral extended-release composition |
| GB0327720D0 (en) | 2003-11-28 | 2003-12-31 | Biotica Tech Ltd | Erythromycins and process for their preparation |
| GB0417852D0 (en) | 2004-08-11 | 2004-09-15 | Biotica Tech Ltd | Production of polyketides and other natural products |
| US7582611B2 (en) * | 2005-05-24 | 2009-09-01 | Pfizer Inc. | Motilide compounds |
| WO2010034243A1 (en) | 2008-09-24 | 2010-04-01 | Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences | Novel gene cluster |
| GB0904540D0 (en) | 2009-03-17 | 2009-04-29 | Biotica Tech Ltd | Novel compounds and methods for their production |
| GB0914589D0 (en) | 2009-08-20 | 2009-09-30 | Biotica Tech Ltd | Novel compounds and methods for their production |
| WO2011098805A1 (en) | 2010-02-09 | 2011-08-18 | Biotica Technology Limited | Sanglifehrin based compounds |
| EP2533784B1 (en) | 2010-02-09 | 2015-04-22 | Neurovive Pharmaceutical AB | Sanglifehrin based compounds |
| WO2011098808A1 (en) | 2010-02-09 | 2011-08-18 | Biotica Technology Limited | Sanglifehrin based compounds |
| GB201118334D0 (en) | 2011-10-24 | 2011-12-07 | Biotica Tech Ltd | Novel dosage form |
| WO2013172782A1 (en) * | 2012-05-16 | 2013-11-21 | Nanyang Technological University | A polyketide synthase construct and its use in the preparation of polyketides |
| US10533016B2 (en) | 2015-01-09 | 2020-01-14 | Revolution Medicines, Inc. | Compounds that participate in cooperative binding and uses thereof |
| MA44680A (fr) | 2016-04-12 | 2019-02-20 | Warp Drive Bio Inc | Compositions et procédés pour la production de composés |
| WO2018020272A1 (en) | 2016-07-29 | 2018-02-01 | Isomerase Therapeutics Limited | Novel methods |
| KR102561694B1 (ko) * | 2016-10-28 | 2023-07-28 | 징코 바이오웍스, 인크. | 화합물의 생산을 위한 조성물 및 방법 |
| JP2020501519A (ja) | 2016-10-28 | 2020-01-23 | ギンゴー バイオワークス， インコーポレイテッド | 化合物の生産のための組成物および方法 |
| CN110678476A (zh) | 2017-02-22 | 2020-01-10 | 免疫系统调节控股有限公司 | 新型免疫刺激大环内酯 |
| EP3585796B1 (en) | 2017-02-22 | 2021-06-16 | ISR Immune System Regulation Holding AB (publ) | Novel immune stimulating macrolides |
| AU2019237257A1 (en) | 2018-03-23 | 2020-10-15 | ISR Immune System Regulation Holding AB (publ) | Combinations of macrolide compounds and immune checkpoint inhibitors |
| KR102705165B1 (ko) | 2019-01-22 | 2024-09-11 | 에오비안 파마슈티컬스, 인크. | Mtorc 조절제 및 이의 용도 |
| CN114901366A (zh) | 2019-11-04 | 2022-08-12 | 锐新医药公司 | Ras抑制剂 |
| PH12022550988A1 (en) | 2019-11-04 | 2023-10-09 | Revolution Medicines Inc | Ras inhibitors |
| KR20220109408A (ko) | 2019-11-04 | 2022-08-04 | 레볼루션 메디슨즈, 인크. | Ras 억제제 |
| IL301298A (en) | 2020-09-15 | 2023-05-01 | Revolution Medicines Inc | Indole derivatives as RAS inhibitors in cancer therapy |
| AR125787A1 (es) | 2021-05-05 | 2023-08-16 | Revolution Medicines Inc | Inhibidores de ras |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
| KR102775118B1 (ko) | 2022-07-26 | 2025-02-27 | 강원대학교산학협력단 | 에리트로마이신으로 로딩된 키토산 결합 닭뼈유래 수산화인회석 나노입자 및 그 제조방법 |
| CN117288869B (zh) * | 2023-11-24 | 2024-02-09 | 中国医学科学院医药生物技术研究所 | 一种原料药中对甲苯磺酸酯类杂质的检测方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993013663A1 (en) * | 1992-01-17 | 1993-07-22 | Abbott Laboratories | Method of directing biosynthesis of specific polyketides |
| US6060234A (en) * | 1991-01-17 | 2000-05-09 | Abbott Laboratories | Polyketide derivatives and recombinant methods for making same |
| ES2164713T3 (es) * | 1993-09-20 | 2002-03-01 | Univ Leland Stanford Junior | Produccion recombinante de nuevos poliquetidos. |
| US5712146A (en) * | 1993-09-20 | 1998-01-27 | The Leland Stanford Junior University | Recombinant combinatorial genetic library for the production of novel polyketides |
-
1997
- 1997-07-04 WO PCT/GB1997/001810 patent/WO1998001571A2/en not_active Ceased
- 1997-07-04 EE EEP199900014A patent/EE03976B1/et not_active IP Right Cessation
- 1997-07-04 BR BR9710209-1A patent/BR9710209A/pt not_active Application Discontinuation
- 1997-07-04 AT AT97930631T patent/ATE451455T1/de not_active IP Right Cessation
- 1997-07-04 PL PL97331285A patent/PL331285A1/xx unknown
- 1997-07-04 DE DE69739688T patent/DE69739688D1/de not_active Expired - Lifetime
- 1997-07-04 AU AU34509/97A patent/AU731301B2/en not_active Ceased
- 1997-07-04 JP JP50492598A patent/JP4173551B2/ja not_active Expired - Fee Related
- 1997-07-04 WO PCT/GB1997/001819 patent/WO1998001546A2/en not_active Ceased
- 1997-07-04 ES ES97930631T patent/ES2337424T3/es not_active Expired - Lifetime
- 1997-07-04 NZ NZ333861A patent/NZ333861A/xx unknown
- 1997-07-04 CA CA002259463A patent/CA2259463A1/en not_active Abandoned
- 1997-07-04 SK SK1824-98A patent/SK182498A3/sk unknown
- 1997-07-04 TR TR1999/00006T patent/TR199900006T2/xx unknown
- 1997-07-04 CA CA002259420A patent/CA2259420C/en not_active Expired - Fee Related
- 1997-07-04 EA EA199900087A patent/EA001744B1/ru not_active IP Right Cessation
- 1997-07-04 EP EP97930631A patent/EP0910633B1/en not_active Expired - Lifetime
- 1997-07-04 EP EP97930626A patent/EP0909327B1/en not_active Expired - Lifetime
- 1997-07-04 ES ES97930626T patent/ES2244001T3/es not_active Expired - Lifetime
- 1997-07-04 AT AT97930626T patent/ATE296893T1/de active
- 1997-07-04 EP EP09178121A patent/EP2182067A3/en not_active Withdrawn
- 1997-07-04 PT PT97930626T patent/PT909327E/pt unknown
- 1997-07-04 GE GEAP19974661A patent/GEP20012348B/en unknown
- 1997-07-04 DK DK97930631.3T patent/DK0910633T3/da active
- 1997-07-04 SI SI9730793T patent/SI0910633T1/sl unknown
- 1997-07-04 IL IL12791697A patent/IL127916A0/xx unknown
- 1997-07-04 DK DK97930626T patent/DK0909327T3/da active
- 1997-07-04 AU AU34514/97A patent/AU731654B2/en not_active Ceased
- 1997-07-04 GB GB9900156A patent/GB2331518B/en not_active Expired - Fee Related
- 1997-07-04 CN CNB97197649XA patent/CN1179046C/zh not_active Expired - Fee Related
- 1997-07-04 JP JP10504933A patent/JP2000511063A/ja not_active Withdrawn
- 1997-07-04 AP APAP/P/1999/001444A patent/AP1029A/en active
- 1997-07-04 DE DE69733416T patent/DE69733416T2/de not_active Expired - Lifetime
-
1999
- 1999-01-04 OA OA9900002A patent/OA10952A/en unknown
- 1999-01-04 NO NO990012A patent/NO990012L/no not_active Application Discontinuation
- 1999-01-04 IS IS4940A patent/IS4940A/is unknown
- 1999-01-05 KR KR1019997000024A patent/KR20000023579A/ko not_active Ceased
- 1999-01-29 BG BG103133A patent/BG103133A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB4A | Valid patent at the end of a year |
Effective date: 20031231 |
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| KB4A | Valid patent at the end of a year |
Effective date: 20041231 |
|
| MM4A | Lapsed by not paying the annual fees |
Effective date: 20040704 |