[go: up one dir, main page]

NO971546L - Reumatoid artritt-middel inneholdende IL-6-antagonist som aktiv bestanddel - Google Patents

Reumatoid artritt-middel inneholdende IL-6-antagonist som aktiv bestanddel

Info

Publication number
NO971546L
NO971546L NO971546A NO971546A NO971546L NO 971546 L NO971546 L NO 971546L NO 971546 A NO971546 A NO 971546A NO 971546 A NO971546 A NO 971546A NO 971546 L NO971546 L NO 971546L
Authority
NO
Norway
Prior art keywords
rheumatoid arthritis
antagonist
active ingredient
agent containing
arthritis agent
Prior art date
Application number
NO971546A
Other languages
English (en)
Other versions
NO321089B1 (no
NO971546D0 (no
Inventor
Tadamitsu Kishimoto
Masahiko Mihara
Yoichiro Moriya
Yoshiyuki Ohsugi
Original Assignee
Chugai Pharmaceutical Co Ltd
Tadamitsu Kishimoto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=17112746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO971546(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chugai Pharmaceutical Co Ltd, Tadamitsu Kishimoto filed Critical Chugai Pharmaceutical Co Ltd
Publication of NO971546D0 publication Critical patent/NO971546D0/no
Publication of NO971546L publication Critical patent/NO971546L/no
Publication of NO321089B1 publication Critical patent/NO321089B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • C07K16/248IL-6
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO19971546A 1994-10-07 1997-04-04 Anvendelse av et interleukin-6 antistoff eller interleukin-6 reseptorantistoff for fremstilling av en farmasoytisk blanding for behandling av unormal synovialcelle-vekst. NO321089B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP24403594 1994-10-07
PCT/JP1995/001144 WO1996011020A1 (en) 1994-10-07 1995-06-07 Rheumatoid arthritis remedy containing il-6 antagonist as active ingredient

Publications (3)

Publication Number Publication Date
NO971546D0 NO971546D0 (no) 1997-04-04
NO971546L true NO971546L (no) 1997-06-04
NO321089B1 NO321089B1 (no) 2006-03-13

Family

ID=17112746

Family Applications (4)

Application Number Title Priority Date Filing Date
NO19971546A NO321089B1 (no) 1994-10-07 1997-04-04 Anvendelse av et interleukin-6 antistoff eller interleukin-6 reseptorantistoff for fremstilling av en farmasoytisk blanding for behandling av unormal synovialcelle-vekst.
NO20055446A NO20055446L (no) 1994-10-07 2005-11-17 Anvendelse av et interleukin-6 reseptorantistoff for fremstilling av en farmasoytisk blanding for behandlingav kronisk reumatoid artritt
NO2009009C NO2009009I2 (no) 1994-10-07 2009-05-04 Tocilizumab
NO2018017C NO2018017I1 (no) 1994-10-07 2018-05-23 Interleukin-6 (IL-6) reseptor antistoff (Krav 1 i NO321089). Forlenget SPC

Family Applications After (3)

Application Number Title Priority Date Filing Date
NO20055446A NO20055446L (no) 1994-10-07 2005-11-17 Anvendelse av et interleukin-6 reseptorantistoff for fremstilling av en farmasoytisk blanding for behandlingav kronisk reumatoid artritt
NO2009009C NO2009009I2 (no) 1994-10-07 2009-05-04 Tocilizumab
NO2018017C NO2018017I1 (no) 1994-10-07 2018-05-23 Interleukin-6 (IL-6) reseptor antistoff (Krav 1 i NO321089). Forlenget SPC

Country Status (18)

Country Link
EP (3) EP2107070A1 (no)
JP (1) JP3067987B2 (no)
KR (1) KR100306517B1 (no)
CN (2) CN101361972B (no)
AT (1) ATE552012T1 (no)
AU (1) AU700819B2 (no)
CA (1) CA2201781C (no)
CZ (1) CZ296919B6 (no)
DK (1) DK0783893T3 (no)
ES (1) ES2384222T3 (no)
FI (1) FI120721B (no)
HU (1) HU223602B1 (no)
LU (1) LU92048I2 (no)
NO (4) NO321089B1 (no)
PL (1) PL186506B1 (no)
PT (1) PT783893E (no)
RU (1) RU2147443C1 (no)
WO (1) WO1996011020A1 (no)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998042377A1 (fr) 1997-03-21 1998-10-01 Chugai Seiyaku Kabushiki Kaisha Substances servant a la prevention ou au traitement de maladies liees a la cellule-t sensibilisee contenant comme principe actif des antagonistes de l'il-6
KR20080027967A (ko) * 1997-08-15 2008-03-28 츄가이 세이야꾸 가부시키가이샤 항 인터루킨-6 수용체 항체를 유효성분으로서 함유하는전신성 홍반성 낭창의 예방 및/또는 치료제
ES2299241T3 (es) 1998-03-17 2008-05-16 Chugai Seiyaku Kabushiki Kaisha Preventivos o remedios para enfermedades intestinales inflamatorias que contienen anticuerpos antagonistas del receptor il-6.
NZ501772A (en) 1998-04-17 2002-10-25 Suntory Ltd Gene encoding protein having aurone synthesizing activity
EP1334731B1 (en) 2000-10-25 2008-02-27 Chugai Seiyaku Kabushiki Kaisha Preventives or remedies for psoriasis containing as the active ingredient il-6 antagonist
US20050074434A1 (en) * 2001-02-23 2005-04-07 Tomoaki Hoshino Remedies for metabolic bone diseases
UA80091C2 (en) * 2001-04-02 2007-08-27 Chugai Pharmaceutical Co Ltd Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
ES2314040T3 (es) * 2001-04-05 2009-03-16 Immuno-Biological Laboratories Co., Ltd. Anticuerpo anti-osteopontina y su uso.
PL213311B1 (pl) 2002-02-14 2013-02-28 Chugai Pharmaceutical Co Ltd Preparat roztworu zawierajacego przeciwcialo
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
JP2007104901A (ja) * 2004-01-16 2007-04-26 Astellas Pharma Inc 関節リウマチ治療薬のスクリーニング法
WO2005080429A2 (en) * 2004-02-11 2005-09-01 Warner-Lambert Company Llc Methods of treating osteoarthritis with anti-il-6 or anti-il6 receptor antibodies
AR048335A1 (es) 2004-03-24 2006-04-19 Chugai Pharmaceutical Co Ltd Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo
RU2293560C2 (ru) * 2005-03-09 2007-02-20 Лидия Николаевна Долгова Способ лечения хронических гонартритов у больных остеоартрозом
RU2293559C2 (ru) * 2005-03-09 2007-02-20 Лидия Николаевна Долгова Способ подготовки к любрикантной терапии
WO2006106905A1 (ja) 2005-03-31 2006-10-12 Chugai Seiyaku Kabushiki Kaisha 会合制御によるポリペプチド製造方法
PA8672101A1 (es) * 2005-04-29 2006-12-07 Centocor Inc Anticuerpos anti-il-6, composiciones, métodos y usos
BRPI0616446A2 (pt) * 2005-09-28 2011-06-21 Cytos Biotechnology Ag composição contendo conjugados de interleucina-1, vacina, uso da vacina, composição farmacêutica, processo para a produção da composição ou da vacina, bem como medicamento
US8470316B2 (en) 2005-10-14 2013-06-25 Chugai Seiyaku Kabushiki Kaisha Agents for suppressing damage to transplanted islets after islet transplantation
CA2626688C (en) 2005-10-21 2017-10-03 Chugai Seiyaku Kabushiki Kaisha Agents for treating cardiopathy
AR057582A1 (es) 2005-11-15 2007-12-05 Nat Hospital Organization Agentes para suprimir la induccion de linfocitos t citotoxicos
CN101370521A (zh) 2006-01-27 2009-02-18 学校法人庆应义塾 伴有脉络膜血管生成的疾病的治疗药
JP5144499B2 (ja) 2006-03-31 2013-02-13 中外製薬株式会社 二重特異性抗体を精製するための抗体改変方法
DK2006381T3 (en) 2006-03-31 2016-02-22 Chugai Pharmaceutical Co Ltd PROCEDURE FOR REGULATING ANTIBODIES BLOOD PHARMACOKINETICS
US9260516B2 (en) 2006-04-07 2016-02-16 Osaka University Method for promoting muscle regeneration by administering an antibody to the IL-6 receptor
US8080248B2 (en) 2006-06-02 2011-12-20 Regeneron Pharmaceuticals, Inc. Method of treating rheumatoid arthritis with an IL-6R antibody
MX2008014804A (es) 2006-06-02 2009-01-27 Regeneron Pharma Anticuerpos de afinidad elevada a receptor de il-6 humano.
WO2008019061A2 (en) 2006-08-03 2008-02-14 Vaccinex, Inc. Anti-il-6 monoclonal antibodies and uses thereof
JP2010095445A (ja) * 2006-12-27 2010-04-30 Tokyo Medical & Dental Univ Il−6アンタゴニストを有効成分とする炎症性筋疾患治療剤
WO2008090901A1 (ja) 2007-01-23 2008-07-31 Shinshu University 慢性拒絶反応抑制剤
DK2202245T3 (en) 2007-09-26 2016-11-21 Chugai Pharmaceutical Co Ltd A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR
PE20140132A1 (es) 2007-09-26 2014-02-14 Chugai Pharmaceutical Co Ltd Anticuerpo anti-receptor de il-6
ES2566957T3 (es) 2007-09-26 2016-04-18 Chugai Seiyaku Kabushiki Kaisha Región constante de anticuerpo modificado
KR20160074019A (ko) 2007-12-05 2016-06-27 추가이 세이야쿠 가부시키가이샤 항nr10 항체 및 그의 이용
UA121453C2 (uk) 2008-04-11 2020-06-10 Чугей Сейяку Кабусікі Кайся Спосіб одержання фармацевтичної композиції, яка містить антитіло
ES2564635T3 (es) 2008-05-13 2016-03-28 Novimmune Sa Anticuerpos anti-IL-6/IL-6R y métodos de uso de los mismos
CN104906581A (zh) * 2008-06-05 2015-09-16 国立研究开发法人国立癌症研究中心 神经浸润抑制剂
US8188235B2 (en) 2008-06-18 2012-05-29 Pfizer Inc. Antibodies to IL-6 and their uses
TWI440469B (zh) 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
TWI682995B (zh) 2009-03-19 2020-01-21 日商中外製藥股份有限公司 抗體恆定區域改變體
EP2409991B1 (en) 2009-03-19 2017-05-03 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
WO2010131733A1 (ja) 2009-05-15 2010-11-18 中外製薬株式会社 抗axl抗体
CN104825487A (zh) * 2009-05-18 2015-08-12 香港大学 治疗炎症性关节炎的组合物和方法
JP5837821B2 (ja) 2009-09-24 2015-12-24 中外製薬株式会社 抗体定常領域改変体
JO3417B1 (ar) 2010-01-08 2019-10-20 Regeneron Pharma الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
TWI505838B (zh) 2010-01-20 2015-11-01 Chugai Pharmaceutical Co Ltd Stabilized antibody solution containing
WO2011108714A1 (ja) 2010-03-04 2011-09-09 中外製薬株式会社 抗体定常領域改変体
EP2578233B1 (en) 2010-05-28 2017-04-26 National Cancer Center Therapeutic agent for pancreatic cancer
US9539322B2 (en) 2010-05-28 2017-01-10 National University Corporation Hokkaido University Method of enhancing an antitumor T cell response by administering an anti-IL-6 receptor antibody
EP4029881A1 (en) 2010-11-08 2022-07-20 F. Hoffmann-La Roche AG Subcutaneously administered anti-il-6 receptor antibody
PH12013500974A1 (en) 2010-11-17 2013-07-08 Chugai Pharmaceutical Co Ltd Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii
KR102385507B1 (ko) 2010-11-30 2022-04-12 추가이 세이야쿠 가부시키가이샤 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자
JP4987117B2 (ja) 2010-12-27 2012-07-25 中外製薬株式会社 Il−6アンタゴニストを有効成分として含有する血中mmp−3濃度低下剤
CA2827923C (en) 2011-02-25 2021-11-23 Chugai Seiyaku Kabushiki Kaisha Fc.gamma.riib-specific fc antibody
JP6322411B2 (ja) 2011-09-30 2018-05-09 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
TW201817745A (zh) 2011-09-30 2018-05-16 日商中外製藥股份有限公司 具有促進抗原清除之FcRn結合域的治療性抗原結合分子
TWI589299B (zh) 2011-10-11 2017-07-01 再生元醫藥公司 用於治療類風濕性關節炎之組成物及其使用方法
WO2013087914A1 (en) 2011-12-16 2013-06-20 Synthon Biopharmaceuticals B.V. EXPRESSION OF SECRETORY IgA ANTIBODIES IN DUCKWEED
WO2013176471A1 (ko) 2012-05-21 2013-11-28 한국생명공학연구원 곰보배추의 추출물 또는 이의 분획물을 유효성분으로 포함하는, stat3 매개 질환의 예방 또는 치료용 약학적 조성물
JP6442404B2 (ja) 2013-06-11 2018-12-19 国立研究開発法人国立精神・神経医療研究センター 再発寛解型多発性硬化症(rrms)患者の治療予後予測方法、及び新規治療適応判断方法
SG10201803449VA (en) 2013-09-27 2018-05-30 Chugai Pharmaceutical Co Ltd Method for producing polypeptide heteromultimer
US9017678B1 (en) 2014-07-15 2015-04-28 Kymab Limited Method of treating rheumatoid arthritis using antibody to IL6R
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
US9765135B2 (en) 2014-12-19 2017-09-19 Chugai Seiyaku Kabushiki Kaisha Anti-C5 antibodies
JP6227191B1 (ja) 2014-12-19 2017-11-08 中外製薬株式会社 抗ミオスタチン抗体、変異Fc領域を含むポリペプチド、および使用方法
CN114773470A (zh) 2015-02-05 2022-07-22 中外制药株式会社 包含离子浓度依赖性的抗原结合结构域的抗体,fc区变体,il-8-结合抗体及其应用
WO2016136933A1 (ja) 2015-02-27 2016-09-01 中外製薬株式会社 Il-6関連疾患治療用組成物
JP7082484B2 (ja) 2015-04-01 2022-06-08 中外製薬株式会社 ポリペプチド異種多量体の製造方法
WO2016186154A1 (ja) 2015-05-19 2016-11-24 国立研究開発法人国立精神・神経医療研究センター 多発性硬化症(ms)患者の新規治療適用判断方法
US11174317B2 (en) 2015-06-04 2021-11-16 National Center Of Neurology And Psychiatry Therapeutic agent for mental illness comprising IL-6 inhibitor as active ingredient
KR20180073680A (ko) 2015-11-03 2018-07-02 사노피 바이오테크놀로지, 소시에떼 빠르 악씨옹 셍쁠리피에 포도막염 및 황반 부종의 치료를 위한 il6r 항체를 포함하는 조성물 및 이를 이용하는 방법
EP3394098A4 (en) 2015-12-25 2019-11-13 Chugai Seiyaku Kabushiki Kaisha ANTI-MYOSTATIN ANTIBODIES AND METHOD OF USE
WO2017115773A1 (ja) 2015-12-28 2017-07-06 中外製薬株式会社 Fc領域含有ポリペプチドの精製を効率化するための方法
RU2746754C2 (ru) 2016-03-14 2021-04-20 Чугаи Сейяку Кабусики Кайся Индуцирующее повреждение клеток терапевтическое лекарственное средство, предназначенное для противораковой терапии
UA126900C2 (uk) 2016-04-28 2023-02-22 Чугаі Сейяку Кабусікі Кайся Антитіловмісний препарат
IL264626B (en) 2016-08-05 2022-07-01 Chugai Pharmaceutical Co Ltd Composition for prophylaxis or treatment of il-8 related diseases
CN108339118A (zh) * 2017-01-23 2018-07-31 瑞阳(苏州)生物科技有限公司 治疗或预防阻塞性睡眠呼吸暂停的药物组合物
US11851486B2 (en) 2017-05-02 2023-12-26 National Center Of Neurology And Psychiatry Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils
US20200369774A1 (en) 2017-09-13 2020-11-26 Jiangsu Hengrui Medicine Co., Ltd. Il-6r antibody and antigen binding fragment thereof and medical use
EP3698808B1 (en) 2017-10-20 2025-01-01 Hyogo College Of Medicine Anti-il-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion
JPWO2019088143A1 (ja) 2017-11-01 2020-11-12 中外製薬株式会社 生物活性が低下した抗体バリアントおよびアイソフォーム
MX2021002422A (es) 2018-08-29 2021-07-15 Regeneron Pharma Métodos y composiciones para el tratamiento de sujetos que padecen artritis reumatoide.
CN109517064B (zh) * 2018-10-10 2020-05-08 北京汇智和源生物技术有限公司 白介素-6的人源化单克隆抗体、其编码基因及应用
TW202521583A (zh) 2019-01-31 2025-06-01 法商賽諾菲生物技術公司 用於治療幼年原發性關節炎之組成物及方法
WO2020178193A1 (en) 2019-03-01 2020-09-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Method of treatment of sarcoidosis
TW202106712A (zh) 2019-04-24 2021-02-16 美商再生元醫藥公司 類風溼性關節炎之診斷及治療方法
MA56116A (fr) 2019-06-04 2022-04-13 Stefano Fiore Compositions et procédés de traitement de la douleur chez des sujets atteints de polyarthrite rhumatoïde

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171840A (en) 1988-01-22 1992-12-15 Tadamitsu Kishimoto Receptor protein for human B cell stimulatory factor-2
EP0399429A1 (en) * 1989-05-22 1990-11-28 Toray Industries, Inc. Anti-human interleukin-6 monoclonal antibody
JP2998976B2 (ja) * 1989-07-20 2000-01-17 忠三 岸本 ヒトインタ―ロイキン―6レセプターに対する抗体
JP2898064B2 (ja) 1989-08-03 1999-05-31 忠三 岸本 ヒトgp130蛋白質
DE3939706C1 (no) * 1989-12-01 1991-03-21 Centre Regional De Transfusion Sanguine, Besancon, Fr
JPH0747547B2 (ja) * 1989-12-04 1995-05-24 シェリング・コーポレーション 敗血症性ショック治療用医薬組成物
JP2898040B2 (ja) 1990-01-26 1999-05-31 忠三 岸本 gp130蛋白質に対する抗体
US5210075A (en) 1990-02-16 1993-05-11 Tanabe Seiyaku Co., Ltd. Interleukin 6 antagonist peptides
JPH0489433A (ja) 1990-07-27 1992-03-23 Hitachi Chem Co Ltd 免疫調節剤
JP2947924B2 (ja) * 1990-11-21 1999-09-13 信和化工株式会社 光学異性体用分離剤
JPH04187645A (ja) * 1990-11-22 1992-07-06 Chuzo Kishimoto インターロイキン―6作用抑制剤
JP3370324B2 (ja) * 1991-04-25 2003-01-27 中外製薬株式会社 ヒトインターロイキン−6受容体に対する再構成ヒト抗体
JPH05300338A (ja) 1992-04-17 1993-11-12 Ricoh Co Ltd 複合機
JPH05304986A (ja) * 1992-04-28 1993-11-19 Tosoh Corp gp130蛋白質に対するモノクロ−ナル抗体
FR2694767B1 (fr) * 1992-08-13 1994-10-21 Innotherapie Lab Sa Anticorps monoclonaux anti-IL6R, et leurs applications.
JPH06134617A (ja) 1992-10-23 1994-05-17 Amada Co Ltd 鋸盤の鋸刃テンション自動調整装置
JP3525221B2 (ja) * 1993-02-17 2004-05-10 味の素株式会社 免疫抑制剤

Also Published As

Publication number Publication date
NO321089B1 (no) 2006-03-13
EP2077120A3 (en) 2009-07-15
NO2018017I1 (no) 2018-05-23
CZ103497A3 (en) 1997-08-13
NO2009009I2 (no) 2013-03-18
FI120721B (fi) 2010-02-15
NO971546D0 (no) 1997-04-04
CA2201781C (en) 2010-01-12
EP2077120A2 (en) 2009-07-08
JP3067987B2 (ja) 2000-07-24
KR100306517B1 (ko) 2001-11-30
FI971404A0 (fi) 1997-04-04
EP0783893B1 (en) 2012-04-04
CN101601861A (zh) 2009-12-16
CA2201781A1 (en) 1996-04-18
EP0783893A4 (en) 1998-04-22
HUT77036A (hu) 1998-03-02
ATE552012T1 (de) 2012-04-15
PT783893E (pt) 2012-05-24
JPH08208514A (ja) 1996-08-13
NO2009009I1 (no) 2009-05-11
HU223602B1 (hu) 2004-10-28
PL186506B1 (pl) 2004-01-30
CN101361972A (zh) 2009-02-11
PL319574A1 (en) 1997-08-18
NO20055446L (no) 1997-06-04
LU92048I2 (fr) 2012-09-20
WO1996011020A1 (en) 1996-04-18
CZ296919B6 (cs) 2006-07-12
HK1127497A1 (en) 2009-09-25
AU2630395A (en) 1996-05-02
RU2147443C1 (ru) 2000-04-20
AU700819B2 (en) 1999-01-14
FI971404L (fi) 1997-06-03
DK0783893T3 (da) 2012-05-29
CN101361972B (zh) 2011-05-25
EP0783893A1 (en) 1997-07-16
EP2107070A1 (en) 2009-10-07
ES2384222T3 (es) 2012-07-02

Similar Documents

Publication Publication Date Title
NO971546L (no) Reumatoid artritt-middel inneholdende IL-6-antagonist som aktiv bestanddel
DK1334731T3 (da) Forebyggende eller terapeutisk middel mod psoriasis omfattende anti-IL-6-receptorantistof som aktiv bestanddel
ATE350060T1 (de) Mittel zur vorbeugung oder behandlung von pankreatitis die anti-il-6 receptor antikörper als aktive komponente enthalten
ATE180773T1 (de) N-sulfonyl-2-oxoindol-derivate mit einer affinität für die vasopressin und/oder ocytocin rezeptoren
ES2172657T3 (es) Inhibidores de trombina.
DK0601386T3 (da) Sulfonamider
RU97108276A (ru) Лечебные средства против хронического ревматоидного артрита, содержащие антагонист il-6 в качестве эффективного компонента
NO954694D0 (no) Doseringsform for antidepressiva
DE69714698D1 (de) Endothelin-antagonisten
NO942618L (no) Imidazolderivater og deres anvendelse som cytokin-inhibitorer
DE69839992D1 (de) Vorbeugende- oder Heilmittel zur Behandlung von Multipler Sklerose, mit antagonistischen anti-IL6-Rezeptor Antikörpern als Wirkstoff
ES2044840T3 (es) Composiciones estabilizadas del activador del plasminogeno de tejido humano.
PT97615A (pt) Metodo para atingir um efeito terapeutico sinergistico com composicoes terapeuticas contendo pelo menos dois agentes terapeuticos seleccionados a partir de um inibidor de renina, um inibidor de enzima de conversao de angiotensina i e um antagonista de angiotensina ii
FI960727A0 (fi) Neurokiniiniantagonisteina käyttökelpoiset heterosyklit
NO976074D0 (no) To- og treverdige småmolekylinhibitorer for selektin
UA27748C2 (uk) Похідні піримідину, що мають активність антагоністів ангіотензину іі, спосіб їх отримання та фармацевтична композиція
ES2167457T3 (es) Nuevo uso medicinal de un antagonista de 5ht3.
BR0015980A (pt) Agente para profilaxia ou tratamento do glaucoma, e, uso de um antagonista de angiotensina ii
ES8801912A1 (es) Procedimiento para la obtencion de benzopiranos sustituidos.
ES2088128T3 (es) Aminosulfonilureas inhibidoras de acat.
NO962406L (no) Farmasöytisk formulering for profylakse henholdsvis for behandling av en forgiftning ved fosfororganiske kolinesterasehemmere
DE69932434D1 (de) Prophylaxe und Behandlung von autoimmunen Entmyelinisierungserkrankungen durch Fas-antagonisten
EA199600048A3 (ru) N,n-диэтил-8,8-дипропил-2-азаспиро[4,5]декан-2-пропанамин дималеат, фармацевтическая композиция на его основе и способ индуцирования иммуномодуляции
ITTO930018A0 (it) Dispositivo di controllo attivo delle vibrazioni periodiche generate da un motore.
MX9702532A (es) Composiciones farmaceuticas para el tratamiento de la rinitis.

Legal Events

Date Code Title Description
SPCG Granted supplementary protection certificate

Free format text: PRODUCT NAME: ROACTEMRA - TOCILIZUMAB; REG. NO/DATE: EU108492001-006 20090206

Spc suppl protection certif: 2009009

Filing date: 20090504

Extension date: 20200607

MK1K Patent expired
SPCE Application to extend a supplementary protection certificate (spc)

Free format text: PRODUCT NAME: INTERLEUKIN-6 (IL-6) RESEPTOR ANTISTOFF; NAT. REG. NO/DATE: EU/1/08/492/001/NO-006 20090116; FIRST REG. NO/DATE: EU/1/08/492/001-006 20090116

Spc suppl protection certif: 2018017

Filing date: 20180523

SPCY Withdrawal, rejection or dismissal of a request for extension of a supplementary protection certificate

Free format text: PRODUCT NAME: INTERLEUKIN-6 (IL-6) RESEPTOR ANTISTOFF

Spc suppl protection certif: 2018017

SPCX Expiry of an spc

Free format text: PRODUCT NAME: TOCILIZUMAB

Spc suppl protection certif: 2009009

Effective date: 20200607