[go: up one dir, main page]

NO307340B1 - Krystallinsk hydroklorid av (R)-(-)-2-{N-[4-(1,1-dioksido-3- okso-2,3-dihydro-benzisotiazol-2-yl)-butyl]-aminometyl}-kroman, legemiddel inneholdende samme, samt fremstilling og anvendelse av samme - Google Patents

Krystallinsk hydroklorid av (R)-(-)-2-{N-[4-(1,1-dioksido-3- okso-2,3-dihydro-benzisotiazol-2-yl)-butyl]-aminometyl}-kroman, legemiddel inneholdende samme, samt fremstilling og anvendelse av samme

Info

Publication number
NO307340B1
NO307340B1 NO964950A NO964950A NO307340B1 NO 307340 B1 NO307340 B1 NO 307340B1 NO 964950 A NO964950 A NO 964950A NO 964950 A NO964950 A NO 964950A NO 307340 B1 NO307340 B1 NO 307340B1
Authority
NO
Norway
Prior art keywords
same
benzisothiazol
dioxido
chroman
aminomethyl
Prior art date
Application number
NO964950A
Other languages
English (en)
Norwegian (no)
Other versions
NO964950D0 (no
NO964950L (no
Inventor
Alfons Grunenberg
Oliver Brehm
Michael Conrad
Dietrich Seidel
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO964950D0 publication Critical patent/NO964950D0/no
Publication of NO964950L publication Critical patent/NO964950L/no
Publication of NO307340B1 publication Critical patent/NO307340B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
NO964950A 1995-11-22 1996-11-21 Krystallinsk hydroklorid av (R)-(-)-2-{N-[4-(1,1-dioksido-3- okso-2,3-dihydro-benzisotiazol-2-yl)-butyl]-aminometyl}-kroman, legemiddel inneholdende samme, samt fremstilling og anvendelse av samme NO307340B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19543478A DE19543478A1 (de) 1995-11-22 1995-11-22 Kristallines Hydrochlorid von {(R)-(-)-2- N-[4-(1,1-Dioxido-3-oxo-2,3-dihydrobenzisothiazol-2-yl)-buytl]-aminomethyl}-chroman

Publications (3)

Publication Number Publication Date
NO964950D0 NO964950D0 (no) 1996-11-21
NO964950L NO964950L (no) 1997-05-23
NO307340B1 true NO307340B1 (no) 2000-03-20

Family

ID=7778081

Family Applications (1)

Application Number Title Priority Date Filing Date
NO964950A NO307340B1 (no) 1995-11-22 1996-11-21 Krystallinsk hydroklorid av (R)-(-)-2-{N-[4-(1,1-dioksido-3- okso-2,3-dihydro-benzisotiazol-2-yl)-butyl]-aminometyl}-kroman, legemiddel inneholdende samme, samt fremstilling og anvendelse av samme

Country Status (32)

Country Link
US (1) US5830908A (es)
EP (1) EP0775704B1 (es)
JP (1) JPH09143180A (es)
KR (1) KR970027079A (es)
CN (1) CN1086703C (es)
AR (1) AR004961A1 (es)
AT (1) ATE201872T1 (es)
AU (1) AU712922B2 (es)
BR (1) BR9605646A (es)
CA (1) CA2190700A1 (es)
CZ (1) CZ289730B6 (es)
DE (2) DE19543478A1 (es)
DK (1) DK0775704T3 (es)
EE (1) EE9600183A (es)
ES (1) ES2159342T3 (es)
GR (1) GR3036505T3 (es)
HU (1) HUP9603237A3 (es)
IL (1) IL119647A (es)
MX (1) MX9605741A (es)
MY (1) MY132473A (es)
NO (1) NO307340B1 (es)
NZ (1) NZ299780A (es)
PL (1) PL317090A1 (es)
PT (1) PT775704E (es)
RU (1) RU2181723C2 (es)
SG (1) SG44989A1 (es)
SI (1) SI0775704T1 (es)
SK (1) SK150096A3 (es)
TR (1) TR199600930A2 (es)
TW (1) TW449595B (es)
UA (1) UA45338C2 (es)
ZA (1) ZA969753B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854217A (en) * 1992-09-28 1998-12-29 Bearsden Bio, Inc. Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE102005035891A1 (de) * 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
NZ573360A (en) 2006-05-04 2012-08-31 Boehringer Ingelheim Int Polymorphic forms of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
RU2569749C2 (ru) * 2007-08-17 2015-11-27 Бёрингер Ингельхайм Интернациональ Гмбх Производные пурина, предназначенные для применения для лечения заболеваний, связанных с баф (белок-активатор фибробластов)
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
KR20200118243A (ko) 2008-08-06 2020-10-14 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
EA031225B1 (ru) * 2008-08-15 2018-12-28 Бёрингер Ингельхайм Интернациональ Гмбх Ингибиторы дпп-4 для заживления ран
AU2009290911A1 (en) 2008-09-10 2010-03-18 Boehringer Ingelheim International Gmbh Combination therapy for the treatment of diabetes and related conditions
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
MX2011006713A (es) 2008-12-23 2011-07-13 Boehringer Ingelheim Int Formas salinas de compuesto organico.
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
AU2010323068B2 (en) 2009-11-27 2015-09-03 Boehringer Ingelheim International Gmbh Treatment of genotyped diabetic patients with DPP-IV inhibitors such as linagliptin
KR101927068B1 (ko) 2010-05-05 2018-12-10 베링거 인겔하임 인터내셔날 게엠베하 체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법
WO2011161161A1 (en) 2010-06-24 2011-12-29 Boehringer Ingelheim International Gmbh Diabetes therapy
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
WO2013010964A1 (en) 2011-07-15 2013-01-24 Boehringer Ingelheim International Gmbh Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
EP2849754B1 (en) 2012-05-14 2022-09-14 Boehringer Ingelheim International GmbH Linagliptin, a xanthine derivative as dpp-4 inhibitor, for use in the treatment of sirs and/or sepsis
EP2849755A1 (en) 2012-05-14 2015-03-25 Boehringer Ingelheim International GmbH A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
ES2950384T3 (es) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Uso médico de un inhibidor de DPP-4
JP2019517542A (ja) 2016-06-10 2019-06-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング リナグリプチンおよびメトホルミンの組合せ

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4748182A (en) * 1986-03-05 1988-05-31 Merrell Dow Pharmaceuticals Inc. Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives and their use as anti-hypertensive and anxiolytic agents
US5300523A (en) * 1988-07-28 1994-04-05 Bayer Aktiengesellschaft Substituted aminomethyltetralins and their heterocyclic analogues
DE3901814A1 (de) 1988-07-28 1990-02-01 Bayer Ag Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
DE4138756A1 (de) * 1991-11-26 1993-05-27 Troponwerke Gmbh & Co Kg Kombination mit neuroprotektiver wirkung

Also Published As

Publication number Publication date
TW449595B (en) 2001-08-11
DE19543478A1 (de) 1997-05-28
NO964950D0 (no) 1996-11-21
PL317090A1 (en) 1997-05-26
CN1086703C (zh) 2002-06-26
RU2181723C2 (ru) 2002-04-27
AR004961A1 (es) 1999-04-07
CA2190700A1 (en) 1997-05-23
UA45338C2 (uk) 2002-04-15
CZ342896A3 (en) 1997-06-11
HUP9603237A3 (en) 1998-12-28
NO964950L (no) 1997-05-23
IL119647A (en) 1999-12-22
SK150096A3 (en) 1997-08-06
CZ289730B6 (cs) 2002-03-13
ATE201872T1 (de) 2001-06-15
DK0775704T3 (da) 2001-07-23
SI0775704T1 (en) 2001-08-31
BR9605646A (pt) 1998-08-18
CN1152574A (zh) 1997-06-25
EP0775704A1 (de) 1997-05-28
HU9603237D0 (en) 1997-01-28
HUP9603237A2 (hu) 1998-01-28
PT775704E (pt) 2001-09-28
NZ299780A (en) 1998-09-24
GR3036505T3 (en) 2001-11-30
TR199600930A2 (tr) 1997-06-21
US5830908A (en) 1998-11-03
AU7177296A (en) 1997-05-29
IL119647A0 (en) 1997-02-18
KR970027079A (ko) 1997-06-24
DE59607040D1 (de) 2001-07-12
SG44989A1 (en) 1997-12-19
EE9600183A (et) 1997-06-16
JPH09143180A (ja) 1997-06-03
AU712922B2 (en) 1999-11-18
MX9605741A (es) 1997-05-31
ES2159342T3 (es) 2001-10-01
MY132473A (en) 2007-10-31
ZA969753B (en) 1997-03-25
EP0775704B1 (de) 2001-06-06

Similar Documents

Publication Publication Date Title
NO307340B1 (no) Krystallinsk hydroklorid av (R)-(-)-2-{N-[4-(1,1-dioksido-3- okso-2,3-dihydro-benzisotiazol-2-yl)-butyl]-aminometyl}-kroman, legemiddel inneholdende samme, samt fremstilling og anvendelse av samme
ITRM920237A1 (it) Perfezionato impiego di medicinali broncodilatatori b2.
HUT67023A (en) Monohydrate of 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-pierazinyl]ethyl}-6-chloro-1,3-dihydro-2h-indole-5-one hydrochloride and pharmaceutical compositions containing that
NO305903B1 (no) Benzonitriler og benzofluorider, legemidler bestående av forbindelsene, farmasöytiske preparater inneholdende forbindelsene, samt anvendelse av forbindelsene for fremstilling av farmasöytiske preparater
NZ328387A (en) 4-[2-(n-(heteroaryl)-hydrazonoethyloxy)]benzoyl-2-benzyloxy-carbonylamino-alanine derivatives and medicaments containing them
EP0861238A4 (en) HEXAHYDRO-5-IMINO-1,4-HETEROAZEPINE DERIVATIVES AS INHIBITORS OF NITROGEN OXIDE SYTHASE
EP0823255A4 (en) Pharmaceutical composition containing sucralfate
FI935825A7 (fi) 2,4-substituoidut 5-(N-substituoitu-sulfamoyyli)-bentsoyyliguanidiinit, menetelmä niiden valmistamiseksi, niiden käyttö lääkeaineena tai diagnostisena aineena sekä niitä sisältävä lääkeaine
DE69604720D1 (de) Fasererzeugnis enthaltend pyroelektrischen Wirkstoff
NO20001717D0 (no) Serotonin-inneholdende formulering for oral administrering og anvendelse av samme
HUP9901212A3 (en) N-[2-(3-alkoxy-phenoxy)-ethyl]-dialkylamine derivatives, pharmaceutical compositions containing the same and their use as local anaesthetics
IL117989A (en) N-(1-(3,5-bisfluoromethylbenzoyl)-2- benzyl-piperidin-4-YL)-4-oxo-4H-1- benzopyran-2 carboxamides their preparation and pharmaceutical compositions comprising them
ATE211911T1 (de) Tiagabinhydrochlorid enthaltendes arzneimittel und verfahren zu dessen herstellung
NO960699L (no) Antimigren 1,2,5-tiadiazolderivater av indolylalkylpyridinyl- og -pyrimidinylpiperaziner
BR9605046B1 (pt) compostos n-(pirimidinl)-benzenossulfonamida e preparação farmacêutica contendo as mesmas.
DE69627855D1 (de) Orales mittel gegen rheumatische arthritis und funktionelles nahrungsmittel
HUP9801068A2 (hu) 1,2,3,4-Tetrahidro-2-naftil-amin-származékok, ezek előállítása és alkalmazása, valamint ilyen származékokat tartalmazó gyógyászati készítmények
IL105774A (en) N-(substituted 2-pyridyl)-6-chloro-4-hydroxy-2-methyl-2h-thieno 2, 3-e9-1, 2-thiazine-3-carboxamide, 1, 1-dioxides their preparation and pharmaceutical compositions containing them
DE59410107D1 (de) Chinoxaline und arzneimittel daraus
HUP9900863A3 (en) 4,4-(disubstituted)cyclohexan-1-ol derivatives pharmaceutical compositions containing these compounds and use thereof
NO306993B1 (no) Piperidinylmetyloksyzolidin-2-on-derivater, farmasoeytiske preparater som inneholder slike, samt anvendelse av forbindelsene til fremstilling av legemidler
NO982105D0 (no) Nye mellomprodukter og deres anvendelse for fremstilling av N,N'-broslÕtte bisindolylmaleimider
KR970001311A (ko) 에틸 아미도 플루오렌 유도체 및 이를 함유한 약제조성물
DE69521347D1 (de) Ketonitrilderivate, antibaktrielle mittel und sie enthaltende arzneimittel
FR2718027B1 (fr) Produit destiné au traitement et à la prévention des alopécies.

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN MAY 2003