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AR074990A1 - Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina - Google Patents

Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina

Info

Publication number
AR074990A1
AR074990A1 ARP100100022A ARP100100022A AR074990A1 AR 074990 A1 AR074990 A1 AR 074990A1 AR P100100022 A ARP100100022 A AR P100100022A AR P100100022 A ARP100100022 A AR P100100022A AR 074990 A1 AR074990 A1 AR 074990A1
Authority
AR
Argentina
Prior art keywords
dpp
patients
diabetes
inhibitor
glycemic control
Prior art date
Application number
ARP100100022A
Other languages
English (en)
Inventor
Klaus Dugi
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40374917&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR074990(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR074990A1 publication Critical patent/AR074990A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Ciertos inhibidores de DPP-4 son particularmente adecuados para mejorar el control glucémico en pacientes con diabetes de tipo 2 con un control glucémico inadecuado a pesar de la terapia con metformina. Reivindicacion 1: Un inhibidor de DPP-4 para mejorar el control glucémico en pacientes con diabetes de tipo 2 con un control glucémico inadecuado a pesar de la terapia con metformina, caracterizado porque dicho inhibidor de DPP-4 se administra a dichos pacientes por vía oral en una cantidad de 1 mg a 10 mg al día. Reivindicacion 4: El inhibidor de DPP-4 de acuerdo con una cualquiera de las reivindicaciones 1 a 3 para reducir la hemoglobina glucosilada HbA1c y/o la glucosa plasmática en ayunas en pacientes con diabetes de tipo 2 con un control glucémico inadecuado a pesar de la terapia con metformina, caracterizado porque dicho inhibidor de DPP-4 se administra por vía oral en una cantidad de 5 mg por paciente al día en combinacion con metformina. Reivindicacion 7: El inhibidor de DPP-4 segun una cualquiera de las reivindicaciones 1 a 6, caracterizado porque dicho inhibidor de DPP-4 es 1[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(R)-aminopiperidin-1-il)xantina.
ARP100100022A 2009-01-07 2010-01-06 Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina AR074990A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09150159 2009-01-07

Publications (1)

Publication Number Publication Date
AR074990A1 true AR074990A1 (es) 2011-03-02

Family

ID=40374917

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100100022A AR074990A1 (es) 2009-01-07 2010-01-06 Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina

Country Status (15)

Country Link
US (1) US8846695B2 (es)
EP (1) EP2385830A1 (es)
JP (2) JP2012514589A (es)
KR (1) KR20110107810A (es)
CN (1) CN102271673A (es)
AR (1) AR074990A1 (es)
AU (1) AU2010204331A1 (es)
BR (1) BRPI1006144A2 (es)
CA (1) CA2745039A1 (es)
CL (1) CL2011001635A1 (es)
EA (1) EA201101037A1 (es)
IL (1) IL212903A0 (es)
MX (1) MX2011006936A (es)
TW (1) TW201036975A (es)
WO (1) WO2010079197A1 (es)

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IL212903A0 (en) 2011-07-31
CL2011001635A1 (es) 2012-01-27
KR20110107810A (ko) 2011-10-04
CN102271673A (zh) 2011-12-07
CA2745039A1 (en) 2010-07-15
BRPI1006144A2 (pt) 2016-02-23
MX2011006936A (es) 2011-07-20
EA201101037A1 (ru) 2012-02-28
US8846695B2 (en) 2014-09-30
AU2010204331A1 (en) 2010-07-15
TW201036975A (en) 2010-10-16
US20110301182A1 (en) 2011-12-08
JP2012514589A (ja) 2012-06-28
EP2385830A1 (en) 2011-11-16

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