NO304226B1 - FremgangsmÕte for krystallisering av iopamidol, samt anvendelse av butanoler ved krystalliseringen - Google Patents

FremgangsmÕte for krystallisering av iopamidol, samt anvendelse av butanoler ved krystalliseringen

Info

Publication number: NO304226B1
Authority: NO; Norway
Prior art keywords: crystallization; iopamidol; butanols
Prior art date: 1993-07-30

Application number

NO960376A

Other languages

English (en)

Norwegian (no)

Other versions

NO960376D0 (no

NO960376L (no

Inventor

Marco Villa

Maurizio Paiocchi

Original Assignee

Bracco Int Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-30

Filing date

1996-01-29

Publication date

1998-11-16

1993-07-30 Priority claimed from ITMI931720A external-priority patent/IT1257001B/it

1994-04-20 Priority claimed from IT000760 external-priority patent/IT1269339B/it

1996-01-29 Application filed by Bracco Int Bv filed Critical Bracco Int Bv

1996-01-29 Publication of NO960376D0 publication Critical patent/NO960376D0/no

1996-01-29 Publication of NO960376L publication Critical patent/NO960376L/no

1998-11-16 Publication of NO304226B1 publication Critical patent/NO304226B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO960376A 1993-07-30 1996-01-29 FremgangsmÕte for krystallisering av iopamidol, samt anvendelse av butanoler ved krystalliseringen NO304226B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
ITMI931720A IT1257001B (it)	1993-07-30	1993-07-30	Processo per la cristalizzazione dello iopamidolo
IT000760 IT1269339B (it)	1994-04-20	1994-04-20	Processo per la cristallizzazione dello iopamidolo
PCT/EP1994/002415 WO1995004031A1 (en)	1993-07-30	1994-07-22	Process for the crystallization of iopamidol

Publications (3)

Publication Number	Publication Date
NO960376D0 NO960376D0 (no)	1996-01-29
NO960376L NO960376L (no)	1996-01-29
NO304226B1 true NO304226B1 (no)	1998-11-16

Family

ID=26331032

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO960376A NO304226B1 (no)	1993-07-30	1996-01-29	FremgangsmÕte for krystallisering av iopamidol, samt anvendelse av butanoler ved krystalliseringen

Country Status (29)

Country	Link
US (3)	US5571941A (de)
JP (1)	JP3299045B2 (de)
KR (1)	KR100355211B1 (de)
CN (1)	CN1035940C (de)
AT (1)	AT404832B (de)
AU (1)	AU690138B2 (de)
BE (1)	BE1008403A4 (de)
CA (1)	CA2128942C (de)
CH (1)	CH686783A5 (de)
CZ (1)	CZ289300B6 (de)
DE (1)	DE4426818A1 (de)
DK (1)	DK172074B1 (de)
ES (1)	ES2102312B1 (de)
FI (1)	FI960400A7 (de)
FR (1)	FR2708601B1 (de)
GB (1)	GB2280436B (de)
GR (1)	GR940100366A (de)
HU (1)	HU217023B (de)
IE (1)	IE80675B1 (de)
IL (1)	IL110391A (de)
NL (1)	NL194272C (de)
NO (1)	NO304226B1 (de)
NZ (1)	NZ271632A (de)
PT (1)	PT101554B (de)
RU (1)	RU2135462C1 (de)
SE (1)	SE9402595L (de)
SI (1)	SI9420046B (de)
WO (1)	WO1995004031A1 (de)
ZA (1)	ZA945472B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL110391A (en)	1993-07-30	1998-12-06	Zambon Spa	Process for the crystallization of iopamidol
US6310243B1 (en) *	1994-09-23	2001-10-30	Nycomed Imaging As	Iodinated x-ray contrast media
PT101720A (pt) *	1995-06-08	1997-01-31	Hovione Sociedade Quimica S A	Processo para a purificacao e cristalizacao de iopamidol
AU6516196A (en) *	1995-07-04	1997-02-05	Recordati S.A.	A process for preparing iopamidol by using a c1-c5 monoalkylether of a c2-c10 alkylene-glycol
CN1070843C (zh) *	1995-09-08	2001-09-12	伯拉考国际股份公司	(s)-n,n'-二[2-羟基-1-(羟甲基)乙基)-5-[(2-羟基-1-氧代丙基)氨基]-2,4,6-三碘-1,3-苯二羧酰胺从水中结晶的方法
PT101919B (pt) *	1996-09-30	2000-01-31	Hovione Sociedade Quimica Sa	Um processo para a purificacao de tohexol
JP4080545B2 (ja) *	1997-02-11	2008-04-23	ブラッコ・インテルナツイオナル・ベーヴェー	（ｓ）−ｎ，ｎ′−ビス［２−ヒドロキシ−１−（ヒドロキシメチル）エチル］−５−［（２−ヒドロキシ−１−オキソプロピル）アミノ］−２，４，６−トリヨード−１，３−ベンゼンジカルボキシアミドを直鎖状または分岐状の（ｃ５〜ｃ６）アルコールまたはそれらの混合物から結晶化させる方法
GB9720969D0 (en)	1997-10-02	1997-12-03	Nycomed Imaging As	Process
KR20000031642A (ko) *	1998-11-09	2000-06-05	강재헌	이오파미돌의 결정화 방법
US6265610B1 (en)	1999-01-12	2001-07-24	The University Of North Carolina At Chapel Hill	Contrast media for angiography
US6803485B2 (en)	1999-02-26	2004-10-12	Bracco Imaging S.P.A.	Process for the preparation of iopamidol
IT1319671B1 (it)	2000-12-01	2003-10-23	Bracco Spa	Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino)
NO20043305D0 (no) *	2004-08-09	2004-08-09	Amersham Health As	Preparation of lodixanol
DE102005059191B4 (de) *	2005-12-05	2008-02-07	Bayer Schering Pharma Ag	Verfahren zur Rückgewinnung von für pharmazeutische Zwecke geeignetem Iopromid aus Mutterlaugen
KR100976097B1 (ko)	2008-12-05	2010-08-16	주식회사 대웅제약	이오프로마이드의 ｚ 이성체를 선택적으로 결정화하는 방법
CA2757480A1 (en) *	2009-04-02	2010-10-07	Allergan, Inc.	Prostaglandin e receptor antagonists
WO2012136813A2 (en)	2011-04-07	2012-10-11	Universitetet I Oslo	Agents for medical radar diagnosis
DE102012104679A1 (de)	2011-05-30	2012-12-06	Westfälische Wilhelms-Universität Münster	Biotechnologische konversion von glycerin zu 2-amino-1,3-propandiol (serinol) in rekombinanten escherichia coli
KR102180250B1 (ko)	2012-12-19	2020-11-18	지이 헬스케어 에이에스	X-선 조영제 성분의 정제 방법
KR102128423B1 (ko) *	2018-09-17	2020-07-01	(주)유케이케미팜	조영제 이오메프롤의 제조방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH608189A5 (de) *	1974-12-13	1978-12-29	Savac Ag
GB1548594A (en) *	1976-06-11	1979-07-18	Nyegaard & Co As	Triiodoisophthalic acid amides
IT1193211B (it) *	1979-08-09	1988-06-15	Bracco Ind Chimica Spa	Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
DE3150916A1 (de) *	1981-12-18	1983-06-30	Schering Ag, 1000 Berlin Und 4619 Bergkamen	N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
US5204086A (en) *	1982-10-01	1993-04-20	Nycomed Imaging As	X-ray contrast agent
IL86450A (en) *	1987-05-22	1994-05-30	Bracco Int Bv	Process for making a history of 5-acylamino-2,4,6-triiodo and tribromo-benzoic acid, and some such new compounds
IT1248741B (it) *	1991-02-26	1995-01-26	Bracco Spa	Processo di concentrazione e di purificazione di composti organici
IL110391A (en)	1993-07-30	1998-12-06	Zambon Spa	Process for the crystallization of iopamidol

1994
- 1994-07-20 IL IL11039194A patent/IL110391A/en not_active IP Right Cessation
- 1994-07-22 HU HU9600191A patent/HU217023B/hu unknown
- 1994-07-22 KR KR1019960700580A patent/KR100355211B1/ko not_active Expired - Lifetime
- 1994-07-22 SI SI9420046A patent/SI9420046B/sl unknown
- 1994-07-22 GR GR940100366A patent/GR940100366A/el unknown
- 1994-07-22 RU RU96105070A patent/RU2135462C1/ru active
- 1994-07-22 NZ NZ271632A patent/NZ271632A/en not_active IP Right Cessation
- 1994-07-22 AU AU75321/94A patent/AU690138B2/en not_active Expired
- 1994-07-22 FI FI960400A patent/FI960400A7/fi not_active Application Discontinuation
- 1994-07-22 WO PCT/EP1994/002415 patent/WO1995004031A1/en not_active Ceased
- 1994-07-22 CN CN94192930A patent/CN1035940C/zh not_active Expired - Lifetime
- 1994-07-25 GB GB9414912A patent/GB2280436B/en not_active Expired - Lifetime
- 1994-07-25 ZA ZA945472A patent/ZA945472B/xx unknown
- 1994-07-26 FR FR9409238A patent/FR2708601B1/fr not_active Expired - Lifetime
- 1994-07-26 PT PT101554A patent/PT101554B/pt not_active IP Right Cessation
- 1994-07-26 CH CH02354/94A patent/CH686783A5/it not_active IP Right Cessation
- 1994-07-26 NL NL9401229A patent/NL194272C/nl not_active IP Right Cessation
- 1994-07-27 CA CA002128942A patent/CA2128942C/en not_active Expired - Lifetime
- 1994-07-28 DE DE4426818A patent/DE4426818A1/de not_active Ceased
- 1994-07-29 CZ CZ19941831A patent/CZ289300B6/cs not_active IP Right Cessation
- 1994-07-29 AT AT0150594A patent/AT404832B/de not_active IP Right Cessation
- 1994-07-29 DK DK089294A patent/DK172074B1/da not_active IP Right Cessation
- 1994-07-29 BE BE9400717A patent/BE1008403A4/fr not_active IP Right Cessation
- 1994-07-29 US US08/281,985 patent/US5571941A/en not_active Ceased
- 1994-07-29 IE IE940609A patent/IE80675B1/en not_active IP Right Cessation
- 1994-07-29 JP JP17811594A patent/JP3299045B2/ja not_active Expired - Lifetime
- 1994-07-29 ES ES09401679A patent/ES2102312B1/es not_active Expired - Fee Related
- 1994-07-29 SE SE9402595A patent/SE9402595L/xx not_active Application Discontinuation
1996
- 1996-01-29 NO NO960376A patent/NO304226B1/no not_active IP Right Cessation
1997
- 1997-02-07 US US08/797,610 patent/USRE36433E/en not_active Expired - Lifetime
1998
- 1998-08-25 US US09/139,894 patent/US6506938B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
SI9420046A (en)	1996-10-31
CZ289300B6 (cs)	2001-12-12
WO1995004031A1 (en)	1995-02-09
PT101554B (pt)	2000-01-31
BE1008403A4 (fr)	1996-05-07
SI9420046B (sl)	2003-10-31
AU7532194A (en)	1995-02-28
HU9600191D0 (en)	1996-11-28
FR2708601B1 (fr)	1995-12-08
IL110391A0 (en)	1994-10-21
ATA150594A (de)	1998-07-15
ES2102312A1 (es)	1997-07-16
ZA945472B (en)	1995-03-03
GB9414912D0 (en)	1994-09-14
NL194272B (nl)	2001-07-02
NZ271632A (en)	1997-07-27
GB2280436B (en)	1997-08-13
USRE36433E (en)	1999-12-07
CN1035940C (zh)	1997-09-24
US6506938B1 (en)	2003-01-14
CN1128020A (zh)	1996-07-31
RU2135462C1 (ru)	1999-08-27
DE4426818A1 (de)	1995-02-02
IL110391A (en)	1998-12-06
AT404832B (de)	1999-03-25
ES2102312B1 (es)	1998-04-01
CZ183194A3 (en)	1995-02-15
DK89294A (da)	1995-01-31
FI960400A0 (fi)	1996-01-29
FR2708601A1 (fr)	1995-02-10
JPH07145125A (ja)	1995-06-06
KR960703842A (ko)	1996-08-31
IE940609A1 (en)	1995-02-08
GR940100366A (en)	1996-03-31
GB2280436A (en)	1995-02-01
CH686783A5 (it)	1996-06-28
KR100355211B1 (ko)	2003-04-10
AU690138B2 (en)	1998-04-23
PT101554A (pt)	1995-05-04
DK172074B1 (da)	1997-10-13
CA2128942A1 (en)	1995-01-31
NO960376D0 (no)	1996-01-29
FI960400L (fi)	1996-01-29
FI960400A7 (fi)	1996-01-29
JP3299045B2 (ja)	2002-07-08
NO960376L (no)	1996-01-29
CA2128942C (en)	2003-07-15
HUP9774567A2 (en)	1997-01-28
HU217023B (hu)	1999-11-29
SE9402595D0 (sv)	1994-07-29
NL194272C (nl)	2001-11-05
NL9401229A (nl)	1995-02-16
US5571941A (en)	1996-11-05
SE9402595L (sv)	1995-01-31
IE80675B1 (en)	1998-11-18

Publication	Publication Date	Title
NO304226B1 (no)	1998-11-16	FremgangsmÕte for krystallisering av iopamidol, samt anvendelse av butanoler ved krystalliseringen
ZA962344B (en)	1997-09-22	Process and crystal forms of 2-methyl-thieno-benzodiazepine.
HU9401437D0 (en)	1994-08-29	Use of multi-staged betex and process for meting the multi-steged betex
AU6618694A (en)	1995-01-19	Photocatalyst and process for purifying water with same
EP0631365A3 (de)	1995-04-05	Mantel für die Wasserkühlung und Verfahren zur Herstellung derselben.
BR9204375A (pt)	1993-05-11	Composicao e processo para o tratamento de agua de refrigeracao
ITMI921488A1 (it)	1993-12-17	Granulati, processo per la loro preparazione e loro impiego
EP0713054A4 (de)	1997-01-31	Verfahren und vorrichtung zur thermischen zersetzung von abfällen
BR9402361A (pt)	1995-01-17	Processo e reator para o tratamento de gás de processo
AU7612894A (en)	1995-03-14	Molten mass treating agent, its production and use
BR9401955A (pt)	1994-12-13	Processo e aparelho para produzir grânulos de metal reativo
BR9400338A (pt)	1994-08-16	Processo para preparação de 1,1,1,2-tetrafluoro-2-cloroetano e de pentafluoretano
IL111943A0 (en)	1995-03-30	Process and machine for the drying of parts
HU9401208D0 (en)	1994-08-29	2-amino-4-quinoline-dihydropyridines, process for producing them and use of them
GB9413594D0 (en)	1994-08-24	Waveguide and process for the production thereof
EP0615148A3 (de)	1995-06-28	Verfahren und Vorrichtung zur Polarisation von Licht.
GB2277529B (en)	1997-03-05	Inorganic skin film and process for forming the same
DK0583687T3 (da)	1999-08-30	Fremgangsmåde til fremstilling af substituerede methoxyphenoler samt dertil egnede mikroorganismer
ZA947438B (en)	1995-05-24	Process and apparatus for the preparation of mixtures comprising at least one light metal
DE69400672D1 (de)	1996-11-14	Verfahren zur Verminderung des Verunreinigungsniveaus in wässrigen Monomerenlösungen
HRP930131A2 (en)	1997-02-28	Amino-ascorbic acid derivatives, process for the preparation and use thereof
EP0581732A3 (de)	1994-10-12	Farbstoffmischungen, Verfahren zu deren Herstellung und deren Verwendung.
PT101456A (pt)	1994-12-30	Aperfeicoamentos introduzidos no fabrico de capsulas, tampoes e tampas para recipientes
EP0581729A3 (en)	1994-08-10	Reactive dyes, process for their manufacture and their use
EP0675699A4 (de)	1996-12-04	Instrument zum schneiden bei der augen-brechungschirurgie.

Legal Events

Date	Code	Title	Description
2014-08-11	MK1K	Patent expired