FR2708601B1 - Procédé de cristallisation d'Iopamidol. - Google Patents

Procédé de cristallisation d'Iopamidol.

Info

Publication number: FR2708601B1
Authority: FR; France
Prior art keywords: iopamidol; crystallization process; crystallization; iopamidol crystallization
Prior art date: 1993-07-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

FR9409238A

Other languages

English (en)

Other versions

FR2708601A1 (fr

Inventor

Marco Villa

Maurizio Paiocchi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Zambon Group SpA

Zambon SpA

Original Assignee

Zambon Group SpA

Zambon SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-30

Filing date

1994-07-26

Publication date

1995-12-08

1993-07-30 Priority claimed from ITMI931720A external-priority patent/IT1257001B/it

1994-04-20 Priority claimed from IT000760 external-priority patent/IT1269339B/it

1994-07-26 Application filed by Zambon Group SpA, Zambon SpA filed Critical Zambon Group SpA

1995-02-10 Publication of FR2708601A1 publication Critical patent/FR2708601A1/fr

1995-12-08 Application granted granted Critical

1995-12-08 Publication of FR2708601B1 publication Critical patent/FR2708601B1/fr

2014-07-26 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

FR9409238A 1993-07-30 1994-07-26 Procédé de cristallisation d'Iopamidol. Expired - Lifetime FR2708601B1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI931720A IT1257001B (it)	1993-07-30	1993-07-30	Processo per la cristalizzazione dello iopamidolo
IT000760 IT1269339B (it)	1994-04-20	1994-04-20	Processo per la cristallizzazione dello iopamidolo

Publications (2)

Publication Number	Publication Date
FR2708601A1 FR2708601A1 (fr)	1995-02-10
FR2708601B1 true FR2708601B1 (fr)	1995-12-08

Family

ID=26331032

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR9409238A Expired - Lifetime FR2708601B1 (fr)	1993-07-30	1994-07-26	Procédé de cristallisation d'Iopamidol.

Country Status (29)

Country	Link
US (3)	US5571941A (fr)
JP (1)	JP3299045B2 (fr)
KR (1)	KR100355211B1 (fr)
CN (1)	CN1035940C (fr)
AT (1)	AT404832B (fr)
AU (1)	AU690138B2 (fr)
BE (1)	BE1008403A4 (fr)
CA (1)	CA2128942C (fr)
CH (1)	CH686783A5 (fr)
CZ (1)	CZ289300B6 (fr)
DE (1)	DE4426818A1 (fr)
DK (1)	DK172074B1 (fr)
ES (1)	ES2102312B1 (fr)
FI (1)	FI960400L (fr)
FR (1)	FR2708601B1 (fr)
GB (1)	GB2280436B (fr)
GR (1)	GR940100366A (fr)
HU (1)	HU217023B (fr)
IE (1)	IE80675B1 (fr)
IL (1)	IL110391A (fr)
NL (1)	NL194272C (fr)
NO (1)	NO304226B1 (fr)
NZ (1)	NZ271632A (fr)
PT (1)	PT101554B (fr)
RU (1)	RU2135462C1 (fr)
SE (1)	SE9402595L (fr)
SI (1)	SI9420046B (fr)
WO (1)	WO1995004031A1 (fr)
ZA (1)	ZA945472B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL110391A (en)	1993-07-30	1998-12-06	Zambon Spa	Process for the crystallization of iopamidol
US6310243B1 (en) *	1994-09-23	2001-10-30	Nycomed Imaging As	Iodinated x-ray contrast media
PT101720A (pt) *	1995-06-08	1997-01-31	Hovione Sociedade Quimica S A	Processo para a purificacao e cristalizacao de iopamidol
EP0842141A1 (fr) *	1995-07-04	1998-05-20	RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY	Procede de preparation d'iopamidol au moyen d'un monoalkylether c1-c5 d'un alkylene-glycol c2-c10
BR9606624A (pt) *	1995-09-08	1997-11-11	Bracco Int Bv	Processo para a cristalização de (s)-n,n'-bisÚ2-hidróxi-1-(hidroximetil)etil¾-5-Ú(2-hidróxi-1-oxopropil)amino¾-2,4,6-triiodo-1,3-benzonodicar-boxamida a partir de água
PT101919B (pt) *	1996-09-30	2000-01-31	Hovione Sociedade Quimica Sa	Um processo para a purificacao de tohexol
CZ299420B6 (cs) *	1997-02-11	2008-07-23	Bracco International B. V.	Zpusob krystalizace iopamidolu
GB9720969D0 (en) *	1997-10-02	1997-12-03	Nycomed Imaging As	Process
KR20000031642A (ko) *	1998-11-09	2000-06-05	강재헌	이오파미돌의 결정화 방법
US6265610B1 (en)	1999-01-12	2001-07-24	The University Of North Carolina At Chapel Hill	Contrast media for angiography
US6803485B2 (en)	1999-02-26	2004-10-12	Bracco Imaging S.P.A.	Process for the preparation of iopamidol
IT1319671B1 (it)	2000-12-01	2003-10-23	Bracco Spa	Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino)
NO20043305D0 (no) *	2004-08-09	2004-08-09	Amersham Health As	Preparation of lodixanol
DE102005059191B4 (de) *	2005-12-05	2008-02-07	Bayer Schering Pharma Ag	Verfahren zur Rückgewinnung von für pharmazeutische Zwecke geeignetem Iopromid aus Mutterlaugen
KR100976097B1 (ko) *	2008-12-05	2010-08-16	주식회사 대웅제약	이오프로마이드의 ｚ 이성체를 선택적으로 결정화하는 방법
EP2414367B1 (fr) *	2009-04-02	2014-08-13	Allergan, Inc.	Antagonistes du récepteur de la prostaglandine e
WO2012136813A2 (fr)	2011-04-07	2012-10-11	Universitetet I Oslo	Agents pour un diagnostic par radar médical
DE102012104679A1 (de)	2011-05-30	2012-12-06	Westfälische Wilhelms-Universität Münster	Biotechnologische konversion von glycerin zu 2-amino-1,3-propandiol (serinol) in rekombinanten escherichia coli
JP6342421B2 (ja)	2012-12-19	2018-06-13	ジーイー・ヘルスケア・アクスイェ・セルスカプ	Ｘ線造影剤の精製
KR102128423B1 (ko) *	2018-09-17	2020-07-01	(주)유케이케미팜	조영제 이오메프롤의 제조방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH608189A5 (fr) *	1974-12-13	1978-12-29	Savac Ag
GB1548594A (en) *	1976-06-11	1979-07-18	Nyegaard & Co As	Triiodoisophthalic acid amides
IT1193211B (it) *	1979-08-09	1988-06-15	Bracco Ind Chimica Spa	Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
DE3150916A1 (de) *	1981-12-18	1983-06-30	Schering Ag, 1000 Berlin Und 4619 Bergkamen	N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
US5204086A (en) *	1982-10-01	1993-04-20	Nycomed Imaging As	X-ray contrast agent
WO1988009328A1 (fr) *	1987-05-22	1988-12-01	Bracco Industria Chimica S.P.A.	Preparation de derives de 5-acylamino-2,4,6-triiodo- ou tribromo-acide benzoique
IT1248741B (it) *	1991-02-26	1995-01-26	Bracco Spa	Processo di concentrazione e di purificazione di composti organici
IL110391A (en)	1993-07-30	1998-12-06	Zambon Spa	Process for the crystallization of iopamidol

1994
- 1994-07-20 IL IL11039194A patent/IL110391A/en not_active IP Right Cessation
- 1994-07-22 FI FI960400A patent/FI960400L/fi not_active Application Discontinuation
- 1994-07-22 NZ NZ271632A patent/NZ271632A/en not_active IP Right Cessation
- 1994-07-22 WO PCT/EP1994/002415 patent/WO1995004031A1/fr not_active Ceased
- 1994-07-22 SI SI9420046A patent/SI9420046B/sl unknown
- 1994-07-22 KR KR1019960700580A patent/KR100355211B1/ko not_active Expired - Lifetime
- 1994-07-22 RU RU96105070A patent/RU2135462C1/ru active
- 1994-07-22 HU HU9600191A patent/HU217023B/hu unknown
- 1994-07-22 AU AU75321/94A patent/AU690138B2/en not_active Expired
- 1994-07-22 CN CN94192930A patent/CN1035940C/zh not_active Expired - Lifetime
- 1994-07-22 GR GR940100366A patent/GR940100366A/el unknown
- 1994-07-25 ZA ZA945472A patent/ZA945472B/xx unknown
- 1994-07-25 GB GB9414912A patent/GB2280436B/en not_active Expired - Lifetime
- 1994-07-26 FR FR9409238A patent/FR2708601B1/fr not_active Expired - Lifetime
- 1994-07-26 PT PT101554A patent/PT101554B/pt not_active IP Right Cessation
- 1994-07-26 NL NL9401229A patent/NL194272C/nl not_active IP Right Cessation
- 1994-07-26 CH CH02354/94A patent/CH686783A5/it not_active IP Right Cessation
- 1994-07-27 CA CA002128942A patent/CA2128942C/fr not_active Expired - Lifetime
- 1994-07-28 DE DE4426818A patent/DE4426818A1/de not_active Ceased
- 1994-07-29 IE IE940609A patent/IE80675B1/en not_active IP Right Cessation
- 1994-07-29 US US08/281,985 patent/US5571941A/en not_active Ceased
- 1994-07-29 BE BE9400717A patent/BE1008403A4/fr not_active IP Right Cessation
- 1994-07-29 SE SE9402595A patent/SE9402595L/xx not_active Application Discontinuation
- 1994-07-29 AT AT0150594A patent/AT404832B/de not_active IP Right Cessation
- 1994-07-29 DK DK089294A patent/DK172074B1/da not_active IP Right Cessation
- 1994-07-29 ES ES09401679A patent/ES2102312B1/es not_active Expired - Fee Related
- 1994-07-29 JP JP17811594A patent/JP3299045B2/ja not_active Expired - Lifetime
- 1994-07-29 CZ CZ19941831A patent/CZ289300B6/cs not_active IP Right Cessation
1996
- 1996-01-29 NO NO960376A patent/NO304226B1/no not_active IP Right Cessation
1997
- 1997-02-07 US US08/797,610 patent/USRE36433E/en not_active Expired - Lifetime
1998
- 1998-08-25 US US09/139,894 patent/US6506938B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
GB9414912D0 (en)	1994-09-14
FI960400A7 (fi)	1996-01-29
JPH07145125A (ja)	1995-06-06
CZ183194A3 (en)	1995-02-15
HUP9774567A2 (en)	1997-01-28
DK172074B1 (da)	1997-10-13
PT101554A (pt)	1995-05-04
US6506938B1 (en)	2003-01-14
IL110391A0 (en)	1994-10-21
FI960400A0 (fi)	1996-01-29
US5571941A (en)	1996-11-05
NL194272C (nl)	2001-11-05
ZA945472B (en)	1995-03-03
AU690138B2 (en)	1998-04-23
JP3299045B2 (ja)	2002-07-08
CN1128020A (zh)	1996-07-31
NO960376L (no)	1996-01-29
WO1995004031A1 (fr)	1995-02-09
KR960703842A (ko)	1996-08-31
IE940609A1 (en)	1995-02-08
BE1008403A4 (fr)	1996-05-07
CH686783A5 (it)	1996-06-28
NL194272B (nl)	2001-07-02
SE9402595D0 (sv)	1994-07-29
HU9600191D0 (en)	1996-11-28
IE80675B1 (en)	1998-11-18
DE4426818A1 (de)	1995-02-02
KR100355211B1 (ko)	2003-04-10
FR2708601A1 (fr)	1995-02-10
SI9420046B (sl)	2003-10-31
GB2280436A (en)	1995-02-01
GR940100366A (en)	1996-03-31
DK89294A (da)	1995-01-31
ES2102312A1 (es)	1997-07-16
GB2280436B (en)	1997-08-13
NO960376D0 (no)	1996-01-29
FI960400L (fi)	1996-01-29
CZ289300B6 (cs)	2001-12-12
RU2135462C1 (ru)	1999-08-27
SI9420046A (en)	1996-10-31
CN1035940C (zh)	1997-09-24
NZ271632A (en)	1997-07-27
AT404832B (de)	1999-03-25
AU7532194A (en)	1995-02-28
SE9402595L (sv)	1995-01-31
NO304226B1 (no)	1998-11-16
HU217023B (hu)	1999-11-29
USRE36433E (en)	1999-12-07
CA2128942A1 (fr)	1995-01-31
CA2128942C (fr)	2003-07-15
PT101554B (pt)	2000-01-31
ATA150594A (de)	1998-07-15
ES2102312B1 (es)	1998-04-01
NL9401229A (nl)	1995-02-16
IL110391A (en)	1998-12-06

Publication	Publication Date	Title
FR2708601B1 (fr)	1995-12-08	Procédé de cristallisation d'Iopamidol.
EP0613873A3 (fr)	1995-02-01	Procédé d'oligomérisation.
FR2695230B1 (fr)	1994-11-04	Procédé de création d'images animées.
FR2777562B1 (fr)	2002-07-19	Procede de purification d'aminonitriles aliphatiques
FR2673186B1 (fr)	1993-08-20	Procede de fabrication d'organopolysiloxanes.
BR9400616A (pt)	1994-09-27	Processo para a preparação de 1,1,1,4,4,4-hexafluorbuteno-2
FR2707087B1 (fr)	1995-10-13	Nouveau procédé de préparation de l'ergothionéine.
EP0603865A3 (fr)	1995-06-28	Procédé de production d'alanine.
FR2690357B1 (fr)	1994-09-16	Procédé d'épuration d'air.
BR9400604A (pt)	1994-08-23	Processo para a preparação de 1,1,1,3,3-pentafluorpropano
FR2716881B1 (fr)	1996-08-02	Procédé de préparation et de purification d'Iopamidol.
FR2694211B1 (fr)	1995-03-10	Procédé d'élimination de catalyseur.
FR2711365B1 (fr)	1995-12-15	Procédé d'hydroxycarbonylation du butadiène.
MA23179A1 (fr)	1994-12-31	Procede de preparation d'un monohydrate cristallin d'un spirostanylglycoside
FR2689501B1 (fr)	1994-05-20	Procede de fabrication d'ethylbenzene.
FR2694556B1 (fr)	1994-09-23	Procédé de purification du 1,1,1,2-tétrafluoroéthane.
FR2708266B1 (fr)	1997-01-10	Procédé de préparation d'alcanesulfonamides.
FI960332A7 (fi)	1996-01-24	Menetelmä substituoitujan 4,6-diamino-5-syanopyrinidiinien valmistamiseksi
MA21849A1 (fr)	1990-12-31	Procede de fabrication d'alkyl - ethoxy - carboxylates .
FR2689885B1 (fr)	1994-10-21	Procédé pour inhiber la décomposition du 1,1-dichloro-1-fluoréthane.
EP0736508A4 (fr)	1997-04-02	Procede de purification de 1,1,1,3,3-pentafluoro-2,3-dichloropropane
OA09798A (fr)	1994-04-15	"Procédé de désalcoolisation".
FR2664279B1 (fr)	1994-05-13	Procede d'obtention de kappa carraghenanes.
FR2711648B1 (fr)	1996-01-05	Procédé de purification du 1,1,1,2-tétrafluoroéthane.
FR2712214B1 (fr)	1996-01-19	Procédé de cristallisation des déchets.

Legal Events

Date	Code	Title	Description
1998-06-26	TP	Transmission of property