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NO20084897L - Ny forbindelse med affinitet til amuloid - Google Patents

Ny forbindelse med affinitet til amuloid

Info

Publication number
NO20084897L
NO20084897L NO20084897A NO20084897A NO20084897L NO 20084897 L NO20084897 L NO 20084897L NO 20084897 A NO20084897 A NO 20084897A NO 20084897 A NO20084897 A NO 20084897A NO 20084897 L NO20084897 L NO 20084897L
Authority
NO
Norway
Prior art keywords
compound
affinity
carbon
represented
amuloid
Prior art date
Application number
NO20084897A
Other languages
English (en)
Inventor
Daisaku Nakamura
Shigeyuki Tanifuji
Shinya Takasaki
Original Assignee
Nihon Mediphysics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Mediphysics Co Ltd filed Critical Nihon Mediphysics Co Ltd
Publication of NO20084897L publication Critical patent/NO20084897L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Det beskrives en forbindelse som har affinitet med amyloid, viser tilstrekkelig hurtig klaring fra normalvev og har redusert toksisitet som for eksempel mutagenisitet. Det beskrives videre et lavtoksisk, diagnostisk middel mot Alzheimers sykdom inneholdende denne forbindelse. Forbindelsen er representert ved formel (1) eller et salt derav, der A1, A2, A3 og A4 uavhengig er et karbon- eller nitrogenatom, og der R er en radioaktiv halogensubstituent; m er et heltall 0 til 4; og n er et heltall 0 eller 1, forutsatt at minst én av A1, A2, A3 og A4 er et karbonatom, og R3 binder til et karbon-atom representert ved A1, A2, A3 eller A4.
NO20084897A 2006-04-28 2008-11-20 Ny forbindelse med affinitet til amuloid NO20084897L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006124811 2006-04-28
PCT/JP2007/059048 WO2007125988A1 (ja) 2006-04-28 2007-04-26 新規アミロイド親和性化合物

Publications (1)

Publication Number Publication Date
NO20084897L true NO20084897L (no) 2009-01-15

Family

ID=38655513

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084897A NO20084897L (no) 2006-04-28 2008-11-20 Ny forbindelse med affinitet til amuloid

Country Status (16)

Country Link
US (2) US8022207B2 (no)
EP (1) EP2022792B1 (no)
JP (1) JP5048655B2 (no)
KR (1) KR20080112343A (no)
CN (1) CN101472923A (no)
AT (1) ATE493410T1 (no)
AU (1) AU2007244313B2 (no)
CA (1) CA2657312A1 (no)
DE (1) DE602007011601D1 (no)
ES (1) ES2355079T3 (no)
IL (1) IL194889A0 (no)
NO (1) NO20084897L (no)
NZ (1) NZ572741A (no)
RU (1) RU2008147002A (no)
TW (1) TW200803903A (no)
WO (1) WO2007125988A1 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200808795A (en) 2006-05-19 2008-02-16 Nihon Mediphysics Co Ltd Novel compound having affinity for amyloid
WO2008059714A1 (en) * 2006-11-17 2008-05-22 Nihon Medi-Physics Co., Ltd. Novel compounds with affinity for amyloid
US8207189B2 (en) 2006-11-30 2012-06-26 Nihon Medi-Physics Co., Ltd. Compound having affinity for amyloid
EP2213672A4 (en) * 2007-10-24 2012-05-02 Nihon Mediphysics Co Ltd NEW CONNECTION WITH AFFINITY TO AMYLOID
EP2213671A4 (en) * 2007-10-26 2012-02-22 Nihon Mediphysics Co Ltd NEW CONNECTION WITH AFFINITY TO AMYLOID
US20100249408A1 (en) * 2007-10-30 2010-09-30 Nihon Medi-Physics Co., Ltd. Use of novel compound having affinity for amyloid, and process for production of the same
EP2218464A1 (en) * 2009-02-11 2010-08-18 Technische Universität München Compounds for non-invasive measurement of aggregates of amyloid peptides
US9926316B2 (en) * 2016-03-03 2018-03-27 The Cleveland Clinic Foundation Antitumor derivatives for differentiation therapy
CN108822105A (zh) * 2018-08-14 2018-11-16 河南师范大学 一种由乙苯类化合物合成2-芳基咪唑并[1,2-a]吡啶类化合物的方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727145A (en) * 1986-09-22 1988-02-23 Ortho Pharmaceutical Corporation 2- Or 3- aryl substituted imidazo [1,2-a]pyridines
US4871745A (en) * 1986-09-22 1989-10-03 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo(1,2-A)pyridines and their use as antisecretory agents
US4833149A (en) * 1986-09-22 1989-05-23 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo[1,2-a]pyridines
US4791117A (en) * 1986-09-22 1988-12-13 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo[1,2-a]pyridines and their use as calcium channel blockers
JP2000510816A (ja) * 1995-10-17 2000-08-22 ジー．ディー．サール アンド カンパニー シクロオキシゲナーゼ−２の検出法
US6812327B1 (en) * 1996-10-25 2004-11-02 Human Genome Sciences, Inc. Neutrokine-alpha polypeptides
US6274119B1 (en) * 1998-08-20 2001-08-14 The Regents Of The Univ. Of California Methods for labeling β-amyloid plaques and neurofibrillary tangles
US20010051632A1 (en) * 2000-03-31 2001-12-13 Wenying Chai Phenyl-substituted indolizines and tetrahydroindolizines
US6514969B2 (en) * 2000-08-16 2003-02-04 Boehringer Ingelheim Pharma Kg β-amyloid inhibitors, processes for preparing them, and their use in pharmaceutical compositions
DE10040016A1 (de) * 2000-08-16 2002-02-28 Boehringer Ingelheim Pharma Neue beta-Amyloid Inhibitoren, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
ES2395721T3 (es) 2000-08-24 2013-02-14 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Derivados de tioflavina y su uso en diagnosis y terapia de la enfermedad de alzheimer
BR0207315A (pt) * 2001-02-26 2004-02-10 Bristol Myers Squibb Pharma Co Análogos de ácido ascórbico para metalorradiofármacos
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JPWO2004035522A1 (ja) * 2002-08-30 2006-02-16 株式会社 ビーエフ研究所 プリオン蛋白蓄積性疾患の診断プローブおよび治療薬ならびにプリオン蛋白の染色剤
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TW200808795A (en) 2006-05-19 2008-02-16 Nihon Mediphysics Co Ltd Novel compound having affinity for amyloid
KR20090025282A (ko) 2006-06-21 2009-03-10 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물
WO2008059714A1 (en) 2006-11-17 2008-05-22 Nihon Medi-Physics Co., Ltd. Novel compounds with affinity for amyloid
US8207189B2 (en) 2006-11-30 2012-06-26 Nihon Medi-Physics Co., Ltd. Compound having affinity for amyloid
EP2213672A4 (en) * 2007-10-24 2012-05-02 Nihon Mediphysics Co Ltd NEW CONNECTION WITH AFFINITY TO AMYLOID
EP2213671A4 (en) * 2007-10-26 2012-02-22 Nihon Mediphysics Co Ltd NEW CONNECTION WITH AFFINITY TO AMYLOID
CA2704139A1 (en) * 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. Utilization of novel compounds with amyloid affinity and method of producing the same

Also Published As

Publication number Publication date
NZ572741A (en) 2010-07-30
CN101472923A (zh) 2009-07-01
US20110201808A1 (en) 2011-08-18
WO2007125988A1 (ja) 2007-11-08
KR20080112343A (ko) 2008-12-24
EP2022792A8 (en) 2009-04-29
IL194889A0 (en) 2011-08-01
US20100249407A1 (en) 2010-09-30
JP5048655B2 (ja) 2012-10-17
DE602007011601D1 (de) 2011-02-10
EP2022792A4 (en) 2009-11-11
TW200803903A (en) 2008-01-16
ATE493410T1 (de) 2011-01-15
US8022207B2 (en) 2011-09-20
JPWO2007125988A1 (ja) 2009-09-10
AU2007244313B2 (en) 2011-09-08
CA2657312A1 (en) 2007-11-08
RU2008147002A (ru) 2010-06-10
ES2355079T3 (es) 2011-03-22
EP2022792B1 (en) 2010-12-29
AU2007244313A1 (en) 2007-11-08
EP2022792A1 (en) 2009-02-11

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