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NO20090233L - Ny sammensetning som har affinitet for amyloid - Google Patents

Ny sammensetning som har affinitet for amyloid

Info

Publication number
NO20090233L
NO20090233L NO20090233A NO20090233A NO20090233L NO 20090233 L NO20090233 L NO 20090233L NO 20090233 A NO20090233 A NO 20090233A NO 20090233 A NO20090233 A NO 20090233A NO 20090233 L NO20090233 L NO 20090233L
Authority
NO
Norway
Prior art keywords
amyloid
affinity
salt
carbon atoms
substituent
Prior art date
Application number
NO20090233A
Other languages
English (en)
Inventor
Akio Hayashi
Anthony Eamon Storey
Denis Raymond Christophe Bouvet
Daisaku Nakamura
Shigeyuki Tanifuji
Shinya Takasaki
Original Assignee
Nihon Mediphysics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Mediphysics Co Ltd filed Critical Nihon Mediphysics Co Ltd
Publication of NO20090233L publication Critical patent/NO20090233L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Det beskrives en forbindelse som har affinitet mot amyloid, som viser tilstrekkelig hurtig klaring fra normal vev, og som har lav toksisitet som mutagenisitet, og som har den generelle formel (1): eller et salt derav, der R1 er en gruppe valgt fra hydrogen, hydroksyl, karboksyl, sulfat, amino, nitro, cyano, en alkylsubstituent med ett til 4 karbonatomer eller en alkoksysubstituent med ett til 4 karbonatomer; R2 er en radioaktiv halogensubstituent; og m er et helt tall 0 til 2, og et lav-toksisk diagnostisk middel for Alzheimers sykdom omfattende en forbindelse representert ved formelen ovenfor eller et salt derav.
NO20090233A 2006-06-21 2009-01-14 Ny sammensetning som har affinitet for amyloid NO20090233L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80535606P 2006-06-21 2006-06-21
JP2006188034 2006-07-07
PCT/JP2007/062503 WO2007148755A1 (ja) 2006-06-21 2007-06-21 新規アミロイド親和性化合物

Publications (1)

Publication Number Publication Date
NO20090233L true NO20090233L (no) 2009-02-11

Family

ID=38833493

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20090233A NO20090233L (no) 2006-06-21 2009-01-14 Ny sammensetning som har affinitet for amyloid

Country Status (9)

Country Link
US (1) US8277777B2 (no)
EP (1) EP2042501B1 (no)
KR (1) KR20090025282A (no)
CN (1) CN101501033B (no)
AU (1) AU2007261985B2 (no)
CA (1) CA2655826A1 (no)
IL (1) IL196046A0 (no)
NO (1) NO20090233L (no)
WO (1) WO2007148755A1 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200803903A (en) 2006-04-28 2008-01-16 Nihon Mediphysics Co Ltd Novel compound having affinity to amyloid
TW200808795A (en) * 2006-05-19 2008-02-16 Nihon Mediphysics Co Ltd Novel compound having affinity for amyloid
US8207189B2 (en) 2006-11-30 2012-06-26 Nihon Medi-Physics Co., Ltd. Compound having affinity for amyloid
EP2213672A4 (en) * 2007-10-24 2012-05-02 Nihon Mediphysics Co Ltd NEW CONNECTION WITH AFFINITY TO AMYLOID
EP2213671A4 (en) * 2007-10-26 2012-02-22 Nihon Mediphysics Co Ltd NEW CONNECTION WITH AFFINITY TO AMYLOID
EP2218464A1 (en) * 2009-02-11 2010-08-18 Technische Universität München Compounds for non-invasive measurement of aggregates of amyloid peptides
KR101123178B1 (ko) * 2009-04-09 2012-06-13 (주)에스메디 2-아릴벤조싸이오펜 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물
CA2839199C (en) 2011-06-24 2018-11-06 Nihon Medi-Physics Co., Ltd. Novel compound with amyloid affinity
KR20170094001A (ko) 2013-04-29 2017-08-16 에프. 호프만-라 로슈 아게 2-페닐 또는 2-헤트아릴 이미다졸[1,2-a]피리딘 유도체
CN103724207B (zh) * 2013-12-20 2016-07-06 北京智博高科生物技术有限公司 苯基苄基醚类衍生物及其制备方法和应用
KR102410733B1 (ko) * 2014-08-29 2022-06-20 씨에이치디아이 파운데이션, 인코포레이티드 헌팅틴 단백질을 영상화하기 위한 프로브
US9926316B2 (en) * 2016-03-03 2018-03-27 The Cleveland Clinic Foundation Antitumor derivatives for differentiation therapy
CN108822105A (zh) * 2018-08-14 2018-11-16 河南师范大学 一种由乙苯类化合物合成2-芳基咪唑并[1,2-a]吡啶类化合物的方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791117A (en) * 1986-09-22 1988-12-13 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo[1,2-a]pyridines and their use as calcium channel blockers
US4833149A (en) * 1986-09-22 1989-05-23 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo[1,2-a]pyridines
US4871745A (en) * 1986-09-22 1989-10-03 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo(1,2-A)pyridines and their use as antisecretory agents
US4727145A (en) 1986-09-22 1988-02-23 Ortho Pharmaceutical Corporation 2- Or 3- aryl substituted imidazo [1,2-a]pyridines
JP2000510816A (ja) * 1995-10-17 2000-08-22 ジー．ディー．サール アンド カンパニー シクロオキシゲナーゼ−２の検出法
US6812327B1 (en) * 1996-10-25 2004-11-02 Human Genome Sciences, Inc. Neutrokine-alpha polypeptides
US6274119B1 (en) 1998-08-20 2001-08-14 The Regents Of The Univ. Of California Methods for labeling β-amyloid plaques and neurofibrillary tangles
JP4025468B2 (ja) 1999-07-29 2007-12-19 三井化学株式会社 有機電界発光素子
US20010051632A1 (en) * 2000-03-31 2001-12-13 Wenying Chai Phenyl-substituted indolizines and tetrahydroindolizines
AU2001249679A1 (en) * 2000-03-31 2001-10-15 Ortho-Mcneil Pharmaceutical, Inc. Phenyl-substituted imidazopyridines
AU2001249672A1 (en) * 2000-03-31 2001-10-15 Ortho-Mcneil Pharmaceutical, Inc. Method for using 2- or 3-aryl substituted imidazo(1,2-a) pyridines as h3 antagonists
DE10040016A1 (de) 2000-08-16 2002-02-28 Boehringer Ingelheim Pharma Neue beta-Amyloid Inhibitoren, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US6514969B2 (en) * 2000-08-16 2003-02-04 Boehringer Ingelheim Pharma Kg β-amyloid inhibitors, processes for preparing them, and their use in pharmaceutical compositions
ES2395721T3 (es) 2000-08-24 2013-02-14 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Derivados de tioflavina y su uso en diagnosis y terapia de la enfermedad de alzheimer
BR0207315A (pt) * 2001-02-26 2004-02-10 Bristol Myers Squibb Pharma Co Análogos de ácido ascórbico para metalorradiofármacos
US6596731B2 (en) 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
CN100422180C (zh) 2001-04-23 2008-10-01 宾夕法尼亚州大学理事会 淀粉样斑块聚集抑制剂和诊断成像剂
CN101003526B (zh) 2001-08-27 2012-02-22 宾夕法尼亚州大学理事会 茋衍生物及其用于结合和成像淀粉样蛋白斑的用途
GB0205281D0 (en) * 2002-03-06 2002-04-17 Novartis Ag Organic compounds
EP1356827A1 (en) * 2002-04-24 2003-10-29 Mallinckrodt Inc. Method for obtaining a 2-18F-fluor-2-deoxy-D-glucose (18F-FDG)-solution
AU2003242233A1 (en) * 2002-06-12 2003-12-31 Bf Research Institute, Inc. Probe compound for image diagnosis of disease with amyloid accumulation, compound for staining age spots/diffuse age spots, and remedy for disease with amyloid accumulation
JP2006505610A (ja) 2002-11-05 2006-02-16 イヨン ベアム アプリカスィヨン エッス．アー． １８−ｆ標識放射性製剤の安定化
GB0229695D0 (en) * 2002-12-20 2003-01-29 Amersham Plc Solid-phase preparation of 18F-labelled amino acids
EP1699799B1 (en) * 2003-12-31 2007-05-16 Schering-Plough Ltd. Control of parasites in animals by the use of imidazo [1,2-b]pyridazine derivatives
JP2008546804A (ja) * 2005-06-24 2008-12-25 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア 造影剤として用いるためのリガンドの放射性標識ペグ化
WO2007033080A2 (en) * 2005-09-12 2007-03-22 Emory University Alzheimer's disease imaging agents
TW200808795A (en) * 2006-05-19 2008-02-16 Nihon Mediphysics Co Ltd Novel compound having affinity for amyloid
EP2213672A4 (en) * 2007-10-24 2012-05-02 Nihon Mediphysics Co Ltd NEW CONNECTION WITH AFFINITY TO AMYLOID
EP2213671A4 (en) * 2007-10-26 2012-02-22 Nihon Mediphysics Co Ltd NEW CONNECTION WITH AFFINITY TO AMYLOID
CA2704139A1 (en) * 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. Utilization of novel compounds with amyloid affinity and method of producing the same

Also Published As

Publication number Publication date
AU2007261985A1 (en) 2007-12-27
KR20090025282A (ko) 2009-03-10
EP2042501B1 (en) 2017-04-12
CN101501033A (zh) 2009-08-05
US20100092387A1 (en) 2010-04-15
CA2655826A1 (en) 2007-12-27
HK1133254A1 (en) 2010-03-19
EP2042501A4 (en) 2012-11-21
AU2007261985B2 (en) 2012-04-19
IL196046A0 (en) 2009-09-01
WO2007148755A1 (ja) 2007-12-27
EP2042501A1 (en) 2009-04-01
US8277777B2 (en) 2012-10-02
CN101501033B (zh) 2012-08-01

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