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NO20080475L - Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators - Google Patents

Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators

Info

Publication number
NO20080475L
NO20080475L NO20080475A NO20080475A NO20080475L NO 20080475 L NO20080475 L NO 20080475L NO 20080475 A NO20080475 A NO 20080475A NO 20080475 A NO20080475 A NO 20080475A NO 20080475 L NO20080475 L NO 20080475L
Authority
NO
Norway
Prior art keywords
receptor modulators
glutamate receptor
metabotropic glutamate
tricyclic benzimidazoles
compound
Prior art date
Application number
NO20080475A
Other languages
English (en)
Inventor
Abdelmalik Slassi
Methvin Isaac
Ian Egle
Fupeng Ma
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20080475L publication Critical patent/NO20080475L/no

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    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Oppfinnelsen tilveiebringer en forbindelse med formel I eller et farmasøytisk akseptabelt salt derav: hvori R1, R2, R3, A, B, D, m, n, x og y er som definert i beskrivelsen. Oppfinnelsen tilveiebringer i tillegg en farmasøytisk sammensetning omfattende forbindelsen med formel I, sammen med en fremgangsmåte for anvendelse av den samme til å behandle eller forebygge nevrologiske og psykiatriske lidelser. Forbindelsene er nyttige i terapi forbundet med behandlingen eller forebyggingen av mGIuR2-reseptormedierte lidelser.
NO20080475A 2005-08-05 2008-01-25 Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators NO20080475L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70547105P 2005-08-05 2005-08-05
PCT/US2006/028165 WO2007018998A2 (en) 2005-08-05 2006-07-21 Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators

Publications (1)

Publication Number Publication Date
NO20080475L true NO20080475L (no) 2008-04-15

Family

ID=37607094

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080475A NO20080475L (no) 2005-08-05 2008-01-25 Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators

Country Status (17)

Country Link
US (2) US20070032469A1 (no)
EP (1) EP1912989A2 (no)
JP (1) JP2009503069A (no)
KR (1) KR20080035576A (no)
CN (1) CN101268077A (no)
AR (1) AR055100A1 (no)
AU (1) AU2006279034A1 (no)
BR (1) BRPI0614168A2 (no)
CA (1) CA2616020A1 (no)
EC (1) ECSP088128A (no)
IL (1) IL188809A0 (no)
MX (1) MX2008001152A (no)
NO (1) NO20080475L (no)
RU (1) RU2008101923A (no)
TW (1) TW200745112A (no)
UY (1) UY29710A1 (no)
WO (1) WO2007018998A2 (no)

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