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MX2021010888A - Derivados heteroaromaticos y aromaticos heterobiciclicos para el tratamiento de trastornos relacionados con ferroptosis. - Google Patents

Derivados heteroaromaticos y aromaticos heterobiciclicos para el tratamiento de trastornos relacionados con ferroptosis.

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Publication number
MX2021010888A
MX2021010888A MX2021010888A MX2021010888A MX2021010888A MX 2021010888 A MX2021010888 A MX 2021010888A MX 2021010888 A MX2021010888 A MX 2021010888A MX 2021010888 A MX2021010888 A MX 2021010888A MX 2021010888 A MX2021010888 A MX 2021010888A
Authority
MX
Mexico
Prior art keywords
ferroptosis
heteroaromatic
related disorders
treatment
aromatic derivatives
Prior art date
Application number
MX2021010888A
Other languages
English (en)
Inventor
James Siedlecki
Laura Muollo
John Lee
John Proudfoot
John Warner
Carmen Baldino
Srinivasa Cheruku
Rowan Walker
Shawn Johnstone
Mehdi Numa
Craig Rosenfeld
Original Assignee
Collaborative Medicinal Dev Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Collaborative Medicinal Dev Llc filed Critical Collaborative Medicinal Dev Llc
Publication of MX2021010888A publication Critical patent/MX2021010888A/es

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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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Abstract

La presente solicitud describe compuestos y composiciones de derivados heteroaromáticos y aromáticos heterobicíclicos, y métodos para tratar trastornos y enfermedades relacionados con la ferroptosis en pacientes que usan los compuestos y composiciones como se describen en el presente documento.
MX2021010888A 2019-03-11 2020-03-10 Derivados heteroaromaticos y aromaticos heterobiciclicos para el tratamiento de trastornos relacionados con ferroptosis. MX2021010888A (es)

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Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022020150A1 (en) * 2020-07-21 2022-01-27 Collaborative Medicinal Development, Llc Methods of extending lifespan by administering ferroptosis inhibitors
JPWO2022138888A1 (es) * 2020-12-25 2022-06-30
US20240116923A1 (en) * 2021-01-25 2024-04-11 Seabelife Use of indole, 6- and 7-azaindole derivatives as inhibitors of ferroptosis regulated cell death
WO2023280296A1 (en) * 2021-07-09 2023-01-12 Sironax Ltd. Ferroptosis modulators, preparations, and uses thereof
CA3227251A1 (en) * 2021-08-09 2023-02-16 Jianguang HAN Ferroptosis modulators, preparations, and uses thereof
US11541116B1 (en) 2022-01-07 2023-01-03 Kojin Therapeutics, Inc. Methods and compositions for inducing ferroptosis in vivo
WO2023249105A1 (ja) * 2022-06-24 2023-12-28 東レ株式会社 薬剤性心筋障害の治療剤又は予防剤
WO2023249106A1 (ja) * 2022-06-24 2023-12-28 東レ株式会社 筋萎縮性側索硬化症の治療剤又は予防剤
JPWO2023249107A1 (es) * 2022-06-24 2023-12-28
CN120857986A (zh) 2023-03-29 2025-10-28 日本制铁株式会社 热轧设备及热轧方法

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB573958A (en) * 1943-03-01 1945-12-14 May & Baker Ltd Improvements in or relating to the production of new therapeutically valuable quinoline derivatives
US3657744A (en) 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5040548A (en) 1989-06-01 1991-08-20 Yock Paul G Angioplasty mehtod
US5061273A (en) 1989-06-01 1991-10-29 Yock Paul G Angioplasty apparatus facilitating rapid exchanges
US5350395A (en) 1986-04-15 1994-09-27 Yock Paul G Angioplasty apparatus facilitating rapid exchanges
US4748982A (en) 1987-01-06 1988-06-07 Advanced Cardiovascular Systems, Inc. Reinforced balloon dilatation catheter with slitted exchange sleeve and method
US4992445A (en) 1987-06-12 1991-02-12 American Cyanamid Co. Transdermal delivery of pharmaceuticals
US5001139A (en) 1987-06-12 1991-03-19 American Cyanamid Company Enchancers for the transdermal flux of nivadipine
CA1322628C (en) 1988-10-04 1993-10-05 Richard A. Schatz Expandable intraluminal graft
JP2899757B2 (ja) * 1989-06-26 1999-06-02 持田製薬株式会社 ジヒドロイミダゾキノリノンオキシムスルホン酸誘導体
US5292331A (en) 1989-08-24 1994-03-08 Applied Vascular Engineering, Inc. Endovascular support device
US5674278A (en) 1989-08-24 1997-10-07 Arterial Vascular Engineering, Inc. Endovascular support device
US6344053B1 (en) 1993-12-22 2002-02-05 Medtronic Ave, Inc. Endovascular support device and method
FR2747678B1 (fr) * 1996-04-22 1998-05-22 Synthelabo Composes derives d'imidazobenzoxazine, leurs procedes de preparation et leurs utilisations en therapeutique
US5939431A (en) * 1996-06-20 1999-08-17 Schering Corporation Naphthyridines which affect IL-4 and G-CSF
US20070191447A1 (en) * 2004-02-23 2007-08-16 Toru Kodo Novel heterocyclic compound
US20080176830A1 (en) * 2005-04-14 2008-07-24 Adams Nicholas D Compounds, Compositions, and Methods
CN101268077A (zh) * 2005-08-05 2008-09-17 阿斯利康(瑞典)有限公司 三环苯并咪唑及其作为代谢型谷氨酸受体调节剂的用途
US20090227579A1 (en) * 2006-06-23 2009-09-10 Astrazeneca Ab Pteridine Derivatives and their Use as Cathespin Inhibitors
WO2009022185A2 (en) * 2007-08-16 2009-02-19 Astrazeneca Ab 6, 6-fused heterocycles, their pharmaceutical compositions and methos of use
WO2011078143A1 (ja) * 2009-12-22 2011-06-30 塩野義製薬株式会社 ピリミジン誘導体およびそれらを含有する医薬組成物
RU2606514C2 (ru) * 2010-12-03 2017-01-10 Эпизайм, Инк. Замещенные пуриновые и 7-деазапуриновые соединения
US9580398B2 (en) * 2012-04-02 2017-02-28 The Trustees Of Columbia University In The City Of New York Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders
GB201220157D0 (en) * 2012-11-08 2012-12-26 Selvita Sa Substitute tricyclic benzimidazoles as kinase inhibitors
EP3384908B1 (en) * 2013-12-02 2020-09-30 The Trustees of Columbia University in the City of New York Modulating ferroptosis and treating excitotoxic disorders
KR101922317B1 (ko) * 2014-01-20 2018-11-26 클리브 바이오사이언스 인코포레이티드 (클리브) p97 복합체의 저해제로서 융합된 피리미딘
GB201420235D0 (en) * 2014-11-14 2014-12-31 Vib Vzw And Universiteit Antwerpen And Universiteit Gent Compounds for inhibiting cell death
CA2994472A1 (en) * 2015-08-11 2017-02-16 Neomed Institute Aryl-substituted dihydroquinolinones, their preparation and their use as pharmaceuticals
US10065970B2 (en) * 2015-09-08 2018-09-04 Genentech, Inc. Tricyclic PI3K inhibitor compounds and methods of use
RU2764243C2 (ru) * 2017-09-22 2022-01-14 ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи Гетероциклические соединения в качестве ингибиторов PAD
WO2019106434A1 (en) * 2017-12-01 2019-06-06 Collaborative Medicinal Development Pty. Ltd. Heterobicyclic aromatic derivatives for the treatment of ferroptosis-related disorders
GB201801943D0 (en) * 2018-02-07 2018-03-21 Vib Vzw Compounds for inhibiting cell death
MA52897A (fr) * 2018-06-15 2021-04-21 Flagship Pioneering Innovations V Inc Diminution de l'activité immunitaire par modulation de facteurs de signalisation post-cellulaire
WO2020113028A1 (en) * 2018-11-27 2020-06-04 The Trustees Of Columbia University In The City Of New York Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders
WO2022020150A1 (en) * 2020-07-21 2022-01-27 Collaborative Medicinal Development, Llc Methods of extending lifespan by administering ferroptosis inhibitors

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