[go: up one dir, main page]

NO20062134L - Fremgangsmater for syntetisering av heteromultimere polypeptider i gjaer ved anvendelse av haploid parrings strategi - Google Patents

Fremgangsmater for syntetisering av heteromultimere polypeptider i gjaer ved anvendelse av haploid parrings strategi

Info

Publication number
NO20062134L
NO20062134L NO20062134A NO20062134A NO20062134L NO 20062134 L NO20062134 L NO 20062134L NO 20062134 A NO20062134 A NO 20062134A NO 20062134 A NO20062134 A NO 20062134A NO 20062134 L NO20062134 L NO 20062134L
Authority
NO
Norway
Prior art keywords
methods
yeast
hapioid
transformed
synthesizing
Prior art date
Application number
NO20062134A
Other languages
English (en)
Norwegian (no)
Inventor
John Latham
Randall Schatzman
Ilya I Tolstorukov
Mark Litton
James Cregg
Original Assignee
Alder Biopharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alder Biopharmaceuticals Inc filed Critical Alder Biopharmaceuticals Inc
Publication of NO20062134L publication Critical patent/NO20062134L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
NO20062134A 2003-10-22 2006-05-12 Fremgangsmater for syntetisering av heteromultimere polypeptider i gjaer ved anvendelse av haploid parrings strategi NO20062134L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51387603P 2003-10-22 2003-10-22
PCT/US2004/035302 WO2005040395A1 (fr) 2003-10-22 2004-10-22 Methodes de synthese de polypeptides heteromultimeres dans une levure, utilisant une strategie de conjugaison d'haploides

Publications (1)

Publication Number Publication Date
NO20062134L true NO20062134L (no) 2006-06-26

Family

ID=34520146

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062134A NO20062134L (no) 2003-10-22 2006-05-12 Fremgangsmater for syntetisering av heteromultimere polypeptider i gjaer ved anvendelse av haploid parrings strategi

Country Status (16)

Country Link
US (7) US8268582B2 (fr)
EP (2) EP1678314B1 (fr)
JP (3) JP4994038B2 (fr)
CN (2) CN101979650B (fr)
AU (2) AU2004283299B2 (fr)
CA (1) CA2541651C (fr)
DK (2) DK1678314T3 (fr)
ES (2) ES2393555T3 (fr)
HU (1) HUE033349T2 (fr)
IL (2) IL174783A (fr)
NO (1) NO20062134L (fr)
NZ (1) NZ547279A (fr)
PL (1) PL1678314T3 (fr)
PT (1) PT1678314E (fr)
SI (1) SI1678314T1 (fr)
WO (1) WO2005040395A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9139825B2 (en) 2009-10-30 2015-09-22 Novartis Ag Universal fibronectin type III bottom-side binding domain libraries

Families Citing this family (182)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE032131T2 (en) 2005-08-31 2017-09-28 Merck Sharp & Dohme Constructed anti-IL-23 antibodies
NZ572807A (en) * 2006-05-19 2011-10-28 Alder Biopharmaceuticals Inc Culture method for obtaining a clonal population of antigen-specific b cells
KR100778219B1 (ko) 2006-08-28 2007-11-29 한국생명공학연구원 교배형 특이적 유전자에 의해 조절되는 반수체 제조용형질전환 효모 균주의 제조
US7795411B2 (en) 2006-10-05 2010-09-14 Fred Hutchinson Cancer Research Center Vectors for expressing in vivo biotinylated recombinant proteins
BRPI0720271A2 (pt) 2006-12-14 2014-01-28 Schering Corp Anticorpo anti-tslp projetado
AU2008216418A1 (en) * 2007-02-09 2008-08-21 Medimmune, Llc Antibody libray display by yeast cell plasma membrane
CN101663320A (zh) 2007-02-23 2010-03-03 先灵公司 工程改造的抗IL-23p19抗体
DK2426144T3 (en) 2007-02-23 2019-01-07 Merck Sharp & Dohme Manipulated Anti-IL-23P19 Antibodies
EP2057194B1 (fr) 2007-02-28 2013-03-20 Merck Sharp & Dohme Corp. Anticorps anti-il-23r modifies
US8252286B2 (en) * 2007-05-21 2012-08-28 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US20100290993A1 (en) * 2007-05-21 2010-11-18 Leon Garcia-Martinez Antibodies to IL-6 and use thereof
KR20100028571A (ko) * 2007-05-21 2010-03-12 앨더 바이오파마슈티컬즈, 인코포레이티드 신규한 래빗 항체 인간화 방법 및 인간화된 래빗 항체
US8178101B2 (en) 2007-05-21 2012-05-15 Alderbio Holdings Inc. Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
US9056905B2 (en) * 2007-05-21 2015-06-16 Alderbio Holdings Llc Antibodies to TNF-α and use thereof
US9701747B2 (en) 2007-05-21 2017-07-11 Alderbio Holdings Llc Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
US8404235B2 (en) 2007-05-21 2013-03-26 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US7906117B2 (en) 2007-05-21 2011-03-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
US8062864B2 (en) 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US8337847B2 (en) 2008-11-25 2012-12-25 Alderbio Holdings Llc Methods of treating anemia using anti-IL-6 antibodies
US9452227B2 (en) 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
US8323649B2 (en) 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
US9212223B2 (en) 2008-11-25 2015-12-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
JP5898496B2 (ja) 2008-11-25 2016-04-06 アルダーバイオ ホールディングス エルエルシー Il−6に対する抗体およびその使用
US8992920B2 (en) 2008-11-25 2015-03-31 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of arthritis
US8420089B2 (en) 2008-11-25 2013-04-16 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
CA3067609A1 (fr) 2009-09-03 2011-03-10 Merck Sharp & Dohme Corp. Anticorps anti-gitr
WO2011056772A1 (fr) 2009-11-04 2011-05-12 Schering Corporation Anticorps anti-tslp manufacturé
JP5934652B2 (ja) 2009-11-24 2016-06-15 アルダーバイオ ホールディングス エルエルシー Il−6に対する抗体およびその使用
US9775921B2 (en) 2009-11-24 2017-10-03 Alderbio Holdings Llc Subcutaneously administrable composition containing anti-IL-6 antibody
GB201003701D0 (en) * 2010-03-05 2010-04-21 Cilian Ag System for the expression of a protein
PT2566517T (pt) 2010-05-04 2019-01-24 Five Prime Therapeutics Inc Anticorpos que ligam csf1r
AU2011332810A1 (en) 2010-11-23 2013-06-13 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of oral mucositis
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
CA2821515A1 (fr) 2010-12-01 2012-06-07 Alder Biopharmaceuticals, Inc. Compositions anti-ngf et leur utilisation
WO2012097238A2 (fr) 2011-01-14 2012-07-19 Five Prime Therapeutics, Inc. Antagonistes de l'il-27 utilisables en vue du traitement de maladies inflammatoires
CN103748111B (zh) 2011-05-20 2018-04-27 奥尔德生物控股有限责任公司 抗cgrp组合物及其用途
EP2709662B1 (fr) 2011-05-20 2019-07-31 AlderBio Holdings LLC Utilisation d'anticorps ou de fragments d'anticorps anti-cgrp ou anti-cgrp-r dans le traitement ou la prévention de formes chroniques et aiguës de la diarrhée
JP6193220B2 (ja) 2011-05-20 2017-09-06 アルダーバイオ・ホールディングズ・エルエルシー 形質転換されたピキア・パストリス(Pichiapastoris)などの微生物における抗体などのマルチサブユニットタンパク質の高純度生産
KR101965461B1 (ko) 2011-05-20 2019-04-04 앨더바이오 홀딩스 엘엘씨 필요한 대상체, 특히 편두통 환자의 광선공포증 또는 광선 혐오증을 예방 또는 억제하기 위한 항-cgrp 항체 및 항체 단편의 용도
KR101978534B1 (ko) * 2011-08-19 2019-08-28 앨더바이오 홀딩스 엘엘씨 변형된 미생물 이를 테면 피치아 파스토리스(pichia pastoris)에서 다수의 아단위 단백질들, 이를 테면 항체의 고역가 및 고순도 생산을 위한 다중-복사체 전략
US10150968B2 (en) 2011-08-19 2018-12-11 Alderbio Holdings Llc Multi-copy strategy for high-titer and high-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
RU2670743C9 (ru) 2012-05-11 2018-12-19 Файв Прайм Терапьютикс, Инк. Способы лечения состояний антителами, которые связывают рецептор колониестимулирующего фактора 1 (csf1r)
WO2014004436A2 (fr) 2012-06-27 2014-01-03 Merck Sharp & Dohme Corp. Anticorps il-23 anti-humains cristallins
CN107759690A (zh) 2012-08-31 2018-03-06 戊瑞治疗有限公司 用结合群落刺激因子1受体(csf1r)的抗体治疗病状的方法
CN103911371B (zh) * 2013-01-05 2016-05-04 中国科学院微生物研究所 一种酿酒酵母整合型表达载体
US20150366890A1 (en) 2013-02-25 2015-12-24 Trustees Of Boston University Compositions and methods for treating fungal infections
US10202630B2 (en) 2013-03-15 2019-02-12 Alderbio Holdings Llc Temperature shift for high yield expression of polypeptides in yeast and other transformed cells
CA2905531C (fr) 2013-03-15 2023-01-03 Alder Biopharmaceuticals, Inc. Purification d'anticorps et controle de purete
CA2905180C (fr) 2013-03-15 2023-03-07 Alder Biopharmaceuticals, Inc. Changement de temperature pour augmenter le rendement de l'expression de polypeptides dans la levure et d'autres cellules transformees
SG10201906172XA (en) 2013-07-03 2019-08-27 Alder Biopharmaceuticals Inc Regulation of glucose metabolism using anti-cgrp antibodies
US20170114122A1 (en) 2015-10-23 2017-04-27 Alderbio Holdings Llc Regulation of glucose metabolism using anti-cgrp antibodies
CN105517572B (zh) 2013-07-05 2019-05-31 华盛顿大学商业中心 用于治疗癌症的中和可溶性mic的单克隆抗体
PE20210949A1 (es) 2013-08-01 2021-05-24 Five Prime Therapeutics Inc Anticuerpos anti-fgfr2iiib afucosilados
CN103468595B (zh) * 2013-09-24 2016-01-13 浙江海正药业股份有限公司 表达重组人血白蛋白的酵母菌、其构建方法及应用和表达重组人血白蛋白的方法
CN103710278A (zh) * 2013-12-25 2014-04-09 江南大学 一种低产尿素的工业黄酒酵母代谢工程菌及其构建方法
EP3116957B1 (fr) 2014-03-11 2019-06-12 The Chemours Company FC, LLC Dispersion et formation sur mesure de systèmes de particules intégrés par l'intermédiaire de groupes sensibles au ph
EA037561B1 (ru) 2014-06-23 2021-04-14 Файв Прайм Терапьютикс, Инк. Способы лечения заболеваний антителами, которые связывают рецептор колониестимулирующего фактора 1 (csf1r)
TWI805109B (zh) 2014-08-28 2023-06-11 美商奇諾治療有限公司 對cd19具專一性之抗體及嵌合抗原受體
RS61602B1 (sr) 2014-10-29 2021-04-29 Five Prime Therapeutics Inc Kombinovana terapija za kancer
US10626176B2 (en) 2014-10-31 2020-04-21 Jounce Therapeutics, Inc. Methods of treating conditions with antibodies that bind B7-H4
TW201629098A (zh) 2014-12-19 2016-08-16 艾爾德生物製藥股份有限公司 人類化抗 acth 抗體及其用途
HK1245804A1 (zh) 2014-12-22 2018-08-31 Five Prime Therapeutics, Inc. 用於治疗pvns的抗csf1r抗体
US20160200815A1 (en) 2015-01-05 2016-07-14 Jounce Therapeutics, Inc. Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof
CN107428833B (zh) 2015-01-16 2021-11-02 朱诺治疗学股份有限公司 Ror1特异性抗体和嵌合抗原受体
RS60614B1 (sr) 2015-03-23 2020-08-31 Jounce Therapeutics Inc Antitela za icos
CN107709365A (zh) 2015-04-13 2018-02-16 戊瑞治疗有限公司 癌症组合疗法
WO2016179194A1 (fr) 2015-05-04 2016-11-10 Jounce Therapeutics, Inc. Lilra3 et son procédé d'utilisation
WO2017019777A1 (fr) * 2015-07-27 2017-02-02 Washington University Trousse d'outils pour la production de protéines modifiées post-traductionnellement
US10865394B2 (en) 2015-07-27 2020-12-15 Washington University Toolkit for the production of post-translationally modified proteins
HK1258249A1 (zh) 2015-10-22 2019-11-08 震动疗法股份有限公司 用於测定icos表达的基因标志
TWI791422B (zh) 2015-11-23 2023-02-11 美商戊瑞治療有限公司 用於癌症治療之單獨fgfr2抑制劑或與免疫刺激劑組合
TW201738272A (zh) 2016-04-15 2017-11-01 艾爾德生物製藥股份有限公司 抗pacap抗體及其用途
BR112019001327A2 (pt) 2016-07-29 2019-04-30 Juno Therapeutics Inc anticorpos anti-idiotípicos e métodos relacionados
MX2019004834A (es) 2016-11-02 2019-06-20 Jounce Therapeutics Inc Anticuerpos de pd-1 y usos de estos.
BR112019013238A2 (pt) 2017-01-20 2020-02-11 Tayu Huaxia Biotech Medical Group Co., Ltd. Anticorpos anti-pd-1 e usos dos mesmos
WO2018187191A1 (fr) 2017-04-03 2018-10-11 Jounce Therapeutics, Inc Compositions et procédés de traitement du cancer
ES3041987T3 (en) 2017-05-16 2025-11-17 Five Prime Therapeutics Inc Anti-fgfr2 antibodies in combination with chemotherapy agents in cancer treatment
WO2019000223A1 (fr) 2017-06-27 2019-01-03 Nanjing Legend Biotech Co., Ltd. Activateurs de cellules effectrices immunitaires d'anticorps chimériques et leurs procédés d'utilisation
CN111511370A (zh) 2017-11-01 2020-08-07 朱诺治疗学股份有限公司 对b细胞成熟抗原具有特异性的抗体和嵌合抗原受体
JP7447006B2 (ja) 2017-11-01 2024-03-11 ジュノー セラピューティクス インコーポレイテッド B細胞成熟抗原(bcma)に特異的なキメラ抗原受容体
KR102791781B1 (ko) 2017-12-01 2025-04-09 화이자 인코포레이티드 항-cxcr5 항체 및 그의 조성물 및 용도
EP3724225A1 (fr) 2017-12-15 2020-10-21 Juno Therapeutics, Inc. Molécules de liaison à l'anti-cct5 et procédés d'utilisation associés
EP3728318A2 (fr) 2017-12-22 2020-10-28 Jounce Therapeutics, Inc. Anticorps pour lilrb2
EP3774863A1 (fr) 2018-03-29 2021-02-17 Pfizer Inc Variants de lfa3, compositions et utilisations associées
WO2019227490A1 (fr) 2018-06-01 2019-12-05 Tayu Huaxia Biotech Medical Group Co., Ltd. Compositions et procédés d'imagerie
JP2021525806A (ja) 2018-06-01 2021-09-27 タユー ファシャ バイオテック メディカル グループ カンパニー, リミテッド 疾患または状態を処置するための組成物およびそれらの使用
PE20211604A1 (es) 2018-07-09 2021-08-23 Five Prime Therapeutics Inc Anticuerpos de union a ilt4
CN112424231B (zh) 2018-07-19 2022-09-13 大有华夏生物医药集团有限公司 抗pd-1抗体及其剂量和用途
MX2021001703A (es) 2018-08-13 2021-04-19 Inhibrx Inc Polipeptidos de union a ox40 y sus usos.
AU2019336197A1 (en) 2018-09-07 2021-02-18 Pfizer Inc. Anti-avb8 antibodies and compositions and uses thereof
CA3111458A1 (fr) 2018-09-10 2020-03-19 Nanjing Legend Biotech Co., Ltd. Anticorps a domaine unique contre cll1 et leurs constructions
WO2020076970A1 (fr) 2018-10-11 2020-04-16 Inhibrx, Inc. Anticorps b7h3 à domaine unique et compositions thérapeutiques associées
WO2020077257A1 (fr) 2018-10-11 2020-04-16 Inhibrx, Inc. Anticorps pd-1 à domaine unique et compositions thérapeutiques associées
TW202506736A (zh) 2018-10-11 2025-02-16 美商因荷布瑞克斯生物科學公司 5t4單域抗體及其治療性組合物
CA3115089A1 (fr) 2018-10-11 2020-04-16 Inhibrx, Inc. Anticorps a domaine unique dll3 et compositions therapeutiques
AU2019372331A1 (en) 2018-11-01 2021-05-27 Juno Therapeutics, Inc. Methods for treatment using chimeric antigen receptors specific for B-cell maturation antigen
AU2019374103A1 (en) 2018-11-01 2021-05-20 Juno Therapeutics, Inc. Chimeric antigen receptors specific for G Protein-Coupled Receptor Class C Group 5 Member D (GPRC5D)
US20220089667A1 (en) 2019-01-07 2022-03-24 Inhibrx, Inc. Polypeptides Comprising Modified IL-2 Polypeptides and Uses Thereof
BR112020018192A2 (pt) 2019-01-08 2021-08-24 H. Lundbeck A/S Tratamento agudo e tratamento rápido de dor de cabeça com o uso de anticorpos anti-cgrp
JP7538130B2 (ja) 2019-01-23 2024-08-21 タユー ファシャ バイオテック メディカル グループ カンパニー, リミテッド 抗pd-l1ダイアボディおよびその使用
WO2020160050A1 (fr) 2019-01-29 2020-08-06 Juno Therapeutics, Inc. Anticorps et récepteurs antigéniques chimériques spécifiques du récepteur orphelin-1 de type récepteur à tyrosine kinase (ror1)
EP3938396A1 (fr) 2019-03-11 2022-01-19 Jounce Therapeutics, Inc. Anticorps anti-icos pour le traitement du cancer
US11560428B2 (en) 2019-05-04 2023-01-24 Inhibrx, Inc. CD33-binding polypeptides and uses thereof
JP7571347B2 (ja) 2019-05-04 2024-10-23 インヒブルクス バイオサイエンシズ インコーポレイテッド CLEC12a結合性ポリペプチド及びその使用
CA3139061A1 (fr) 2019-05-04 2020-11-12 Inhibrx, Inc. Polypeptides se liant a cd123 et leurs utilisations
CN114787188A (zh) 2019-11-05 2022-07-22 震动疗法股份有限公司 用抗pd-1抗体治疗癌症的方法
KR20220122656A (ko) 2019-12-06 2022-09-02 주노 쎄러퓨티크스 인코퍼레이티드 Gprc5d-표적화 결합 도메인에 대한 항-이디오타입 항체 및 관련 조성물 및 방법
WO2021113776A1 (fr) 2019-12-06 2021-06-10 Juno Therapeutics, Inc. Anticorps anti-idiotypiques dirigés contre des domaines de liaison ciblant bcma et compositions et procédés associés
US20230045791A1 (en) 2020-01-06 2023-02-16 Hifibio (Hk) Limited Anti-tnfr2 antibody and uses thereof
AU2021205143A1 (en) 2020-01-07 2022-07-28 Hifibio, Inc. Anti-Galectin-9 antibody and uses thereof
EP4097129A1 (fr) 2020-01-29 2022-12-07 Inhibrx, Inc. Anticorps cd28 à domaine unique et constructions multivalentes et multispécifiques de ceux-ci
EP4103285A2 (fr) 2020-02-14 2022-12-21 Jounce Therapeutics, Inc. Anticorps et protéines de fusion se liant à ccr8, et leurs utilisations
EP4112642A4 (fr) 2020-02-28 2024-06-26 Shanghai Henlius Biotech, Inc. Construction anti-cd137 et son utilisation
AU2021228078A1 (en) 2020-02-28 2022-09-22 Shanghai Henlius Biotech, Inc. Anti-CD137 constructs, multispecific antibody and uses thereof
AU2020202454A1 (en) 2020-04-06 2021-10-21 H. Lundbeck A/S Treatment of most bothersome symptom (MBS) associated with migraine using anti-CGRP antibodies
AU2021251265A1 (en) 2020-04-10 2022-11-03 Juno Therapeutics, Inc. Methods and uses related to cell therapy engineered with a chimeric antigen receptor targeting B-cell maturation antigen
CA3173134A1 (fr) 2020-04-20 2021-10-28 Jounce Therapeutics, Inc. Compositions et methodes pour la vaccination et le traitement de maladies infectieuses
US20230331846A1 (en) 2020-05-04 2023-10-19 Inhibrx, Inc. Canine PD-1-Binding Polypeptides and Uses Thereof
CN116529260A (zh) 2020-06-02 2023-08-01 当康生物技术有限责任公司 抗cd93构建体及其用途
EP4157462A1 (fr) 2020-06-02 2023-04-05 Dynamicure Biotechnology LLC Constructions anti-cd93 et leurs utilisations
WO2022006380A2 (fr) 2020-07-02 2022-01-06 Inhibrx, Inc. Polypeptides comprenant des polypeptides à il-2 modifiée et leurs utilisations
CA3184940A1 (fr) 2020-07-07 2022-01-13 Jennifer Donglan WU Anticorps mic et agents de liaison et leurs procedes d'utilisation
CA3190328A1 (fr) 2020-07-29 2022-02-03 Dynamicure Biotechnology Llc Constructions anti-cd93 et leurs utilisations
US20230324408A1 (en) 2020-08-05 2023-10-12 Juno Therapeutics, Inc. Anti-idiotypic antibodies to ror1-targeted binding domains and related compositions and methods
CA3188996A1 (fr) 2020-08-10 2022-02-17 Tengfei XIAO Compositions et methodes pour traiter des maladies auto-immunes et des cancers par ciblage de l'igsf8
CN111944708B (zh) * 2020-08-27 2022-04-01 宜宾五粮液股份有限公司 高产乙酸异戊酯的酵母及其应用
CN118146385A (zh) 2020-09-28 2024-06-07 安济盛生物医药有限公司 抗硬骨抑素构建体及其用途
US20240011016A1 (en) * 2020-11-23 2024-01-11 Merck Sharp & Dohme Llc Full-length human immunoglobulin g antibody libraries for surface display and secretion in saccharomyces cerevisiae
US11720540B2 (en) 2020-12-30 2023-08-08 Itron, Inc. Secure blockchain data recovery
WO2022169825A1 (fr) 2021-02-03 2022-08-11 Mozart Therapeutics, Inc. Agents de liaison et leurs méthodes d'utilisation
TW202245839A (zh) 2021-02-19 2022-12-01 美商英伊布里克斯公司 Dr5結合多肽之調配物
US20240141048A1 (en) 2021-03-05 2024-05-02 Dynamicure Biotechnology Llc Anti-vista constructs and uses thereof
US20240150466A1 (en) 2021-03-25 2024-05-09 Dynamicure Biotechnology Llc Anti-igfbp7 constructs and uses thereof
AU2022253902A1 (en) 2021-04-10 2023-11-02 Genmab A/S Folr1 binding agents, conjugates thereof and methods of using the same
WO2022226317A1 (fr) 2021-04-23 2022-10-27 Profoundbio Us Co. Anticorps anti-cd70, leurs conjugués et leurs procédés d'utilisation
WO2022241057A1 (fr) 2021-05-12 2022-11-17 Applied Biomedical Science Institute Polypeptides de liaison dirigés contre le sars-cov-2 et leurs utilisations
EP4355785A1 (fr) 2021-06-17 2024-04-24 Amberstone Biosciences, Inc. Constructions anti-cd3 et utilisations associées
TW202320857A (zh) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 連接子、藥物連接子及其結合物及其使用方法
EP4359794A4 (fr) 2021-07-13 2025-04-16 Keystone Bio, Inc. Diagnostic pour porphyromonas gingivalis
EP4373854A1 (fr) 2021-07-20 2024-05-29 Inhibrx, Inc. Polypeptides se liant à cd8 et leurs utilisations
WO2023004305A1 (fr) 2021-07-20 2023-01-26 Inhibrx, Inc. Polypeptides il-2 modifiés ciblant cd8 et leurs utilisations
WO2023076876A1 (fr) 2021-10-26 2023-05-04 Mozart Therapeutics, Inc. Modulation de réponses immunitaires à des vecteurs viraux
EP4433096A1 (fr) 2021-11-19 2024-09-25 Ardeagen Corporation Agents de liaison de gpc3, leurs conjugués et leurs procédés d'utilisation
EP4460521A1 (fr) 2022-01-05 2024-11-13 Inhibrx Biosciences, Inc. Polypeptides se liant aux lymphocytes t gamma delta et leurs utilisations
US20250109203A1 (en) 2022-01-05 2025-04-03 Inhibrx Biosciences, Inc. Gamma Delta T-Cell-Targeted Modified IL-2 Polypeptides and Uses Thereof
KR20240158391A (ko) 2022-02-18 2024-11-04 라쿠텐 메디칼, 인크. 항-프로그래밍된 사멸-리간드 1(pd-l1) 항체 분자, 암호화 폴리뉴클레오티드 및 사용 방법
CA3247628A1 (fr) 2022-04-08 2023-10-12 Inhibrx Biosciences, Inc. Polythérapie comprenant un agoniste de dr5 et un inhibiteur de plk1 ou de cdk
EP4519311A1 (fr) 2022-05-05 2025-03-12 Inhibrx Biosciences, Inc. Polypeptides de liaison à l'albumine et leurs utilisations
IL316990A (en) 2022-05-23 2025-01-01 Cereius Inc HER2 binding agents and their uses
EP4529455A1 (fr) 2022-05-23 2025-04-02 Inhibrx Biosciences, Inc. Polythérapie à base d'agoniste de dr5 et d'antagoniste d'iap
WO2023235699A1 (fr) 2022-05-31 2023-12-07 Jounce Therapeutics, Inc. Anticorps dirigés contre lilrb4 et leurs utilisations
IL317523A (en) 2022-06-11 2025-02-01 Inhibrx Biosciences Inc FcRn-binding polypeptides and uses thereof
WO2024006975A1 (fr) 2022-07-01 2024-01-04 Bristol-Myers Squibb Company Procédés d'humanisation d'anticorps
WO2024015993A1 (fr) 2022-07-15 2024-01-18 Fibrogen, Inc. Anticorps anti-galectine-9 modifié et ses utilisations
AR129991A1 (es) 2022-07-22 2024-10-23 Bristol Myers Squibb Co Anticuerpos que se unen a la pad4 humana y usos de los mismos
WO2024030956A2 (fr) 2022-08-03 2024-02-08 Mozart Therapeutics, Inc. Agents de liaison se liant spécifiquement à cd39 et leurs méthodes d'utilisation
JP2025525937A (ja) 2022-08-05 2025-08-07 ジュノー セラピューティクス インコーポレイテッド Gprc5dおよびbcmaに特異的なキメラ抗原受容体
KR20250052418A (ko) 2022-08-19 2025-04-18 피브로겐, 인크. 항-ccr8 항체 및 그의 용도
KR20250084921A (ko) 2022-08-26 2025-06-11 주노 쎄러퓨티크스 인코퍼레이티드 델타-유사 리간드 3 (dll3)에 특이적인 항체 및 키메라 항원 수용체
CN120077071A (zh) 2022-09-07 2025-05-30 当康生物技术有限责任公司 抗vista构建体及其用途
WO2024102948A1 (fr) 2022-11-11 2024-05-16 Celgene Corporation Molécules de liaison spécifiques de l'homologue 5 du récepteur fc (fcrh5) et anticorps bispécifiques d'activation des lymphocytes t les comprenant et procédés associés
JP2026500503A (ja) 2022-12-13 2026-01-07 ジュノー セラピューティクス インコーポレイテッド Baff-rおよびcd19に特異的なキメラ抗原受容体、ならびにその方法および使用
WO2024216064A1 (fr) 2023-04-14 2024-10-17 Twist Bioscience Corporation Compositions et procédés associés à des liants dkk1
CN121194993A (zh) 2023-05-24 2025-12-23 莫扎特治疗公司 Cd8特异性结合蛋白及其应用方法
WO2025038492A1 (fr) 2023-08-11 2025-02-20 Abalytics Oncology, Inc. Anticorps anti-ctla-4 et molécules de liaison associées et méthodes et utilisations associés
WO2025048887A1 (fr) 2023-09-01 2025-03-06 Inhibrx Biosciences, Inc. Thérapie à base d'agoniste d'ox40
WO2025048860A1 (fr) 2023-09-01 2025-03-06 Inhibrx Biosciences, Inc. Thérapie à base d'agoniste d'ox40
TW202535954A (zh) 2023-09-26 2025-09-16 丹麥商珍美寶股份有限公司 Ptk7結合劑、其共軛物及使用彼等之方法
WO2025085489A1 (fr) 2023-10-17 2025-04-24 Bristol-Myers Squibb Company Composés de dégradation de gspt1, anticorps anti-cd33 et conjugués anticorps-médicament, et leurs utilisations
WO2025111402A1 (fr) 2023-11-21 2025-05-30 Board Of Regents Of The University Of Nebraska Anticorps anti-amyloïde bêta et compositions associées et méthodes associées
TW202535949A (zh) 2023-12-20 2025-09-16 美商必治妥美雅史谷比公司 靶向IL-18受體β(IL-18RB)之抗體及相關方法
WO2025149661A1 (fr) 2024-01-10 2025-07-17 Genmab A/S Agents de liaison à slitrk6, conjugués de ceux-ci et leurs procédés d'utilisation
WO2025174974A1 (fr) 2024-02-14 2025-08-21 Bristol-Myers Squibb Company Anticorps anti-cd33 et leurs utilisations
WO2025184421A1 (fr) 2024-02-28 2025-09-04 Juno Therapeutics, Inc. Récepteurs antigéniques chimériques et anticorps spécifiques du ligand 3 de type delta (dll3) et procédés associés
WO2025181219A1 (fr) 2024-02-29 2025-09-04 Genmab A/S Agents de liaison bispécifiques egfr et c-met, conjugués de ceux-ci et leurs procédés d'utilisation
WO2025199352A2 (fr) 2024-03-20 2025-09-25 Juno Therapeutics, Inc. Anticorps spécifiques du membre 2 de la famille des transporteurs de solutés 34 (slc34a2)
WO2025222129A2 (fr) 2024-04-19 2025-10-23 Mozart Therapeutics, Inc. Cytokines modifiées et distribution ciblée de cytokines
US12509510B2 (en) 2024-04-23 2025-12-30 Attovia Therapeutics, Inc. IL31-binding polypeptides and uses thereof
WO2025240670A2 (fr) 2024-05-15 2025-11-20 Abalytics Oncology, Inc. Anticorps anti-pd-1 et molécules de liaison associées et procédés et utilisations associés
WO2025255405A1 (fr) 2024-06-06 2025-12-11 Bristol-Myers Squibb Company Anticorps anti-fap et leurs utilisations
WO2025255349A1 (fr) 2024-06-06 2025-12-11 Bristol-Myers Squibb Company Anticorps anti-cd40/anti-fap multispécifiques et leurs utilisations
WO2025262564A1 (fr) 2024-06-17 2025-12-26 Pfizer Inc. Utilisation d'anticorps anti-cxcr5

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
US5618920A (en) * 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
JPS63501765A (ja) * 1985-11-01 1988-07-21 インタ−ナショナル、ジェネティック、エンジニアリング インコ−ポレ−テッド 抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途
US6306625B1 (en) * 1988-12-30 2001-10-23 Smithkline Beecham Biologicals, Sa Method for obtaining expression of mixed polypeptide particles in yeast
US5545727A (en) * 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
WO1991002057A1 (fr) 1989-08-09 1991-02-21 Delta Biotechnology Limited Production de polypeptides a l'interieur de cellules fongiques
GB8927480D0 (en) 1989-12-05 1990-02-07 Delta Biotechnology Ltd Mutant fungal strain detection and new promoter
US5202422A (en) 1989-10-27 1993-04-13 The Scripps Research Institute Compositions containing plant-produced glycopolypeptide multimers, multimeric proteins and method of their use
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
ATE220105T1 (de) * 1991-04-01 2002-07-15 Merck & Co Inc Gene, die die proteolytische aktivitaet von pichia beeinflussen und deren verwendung
US5330901A (en) * 1991-04-26 1994-07-19 Research Corporation Technologies, Inc. Expression of human serum albumin in Pichia pastoris
US5440018A (en) * 1992-05-20 1995-08-08 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
DE69433279T2 (de) 1993-02-10 2004-07-15 Unilever N.V. Isolierungsverfahren verwendend immobilisierte proteine mit spezifischen bindungskapazitäten
AU6445894A (en) 1993-03-19 1994-10-11 Duke University Method of treatment of tumors with an antibody binding to tenascin
ES2251723T3 (es) 1994-08-12 2006-05-01 Immunomedics, Inc. Inmunoconjugados y anticuerpos humanizados especificos para linfoma de celulas b y celulas de leucemia.
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
US6232111B1 (en) * 1996-04-10 2001-05-15 Merck & Co., Inc. Method for improving culture medium for recombinant yeast
WO2000023579A1 (fr) * 1998-10-22 2000-04-27 The Regents Of The University Of California Anticorps monoclonal intact de recombinaison a assemblage fonctionnel specifique d'un antigene, et son procede d'obtention
US6258559B1 (en) * 1999-03-22 2001-07-10 Zymogenetics, Inc. Method for producing proteins in transformed Pichia
WO2003016525A1 (fr) 2001-08-16 2003-02-27 Kansai Chemical Engineering Co., Ltd. Procede de production d'alcool a partir d'amidon
AU2002332598A1 (en) 2001-08-22 2003-03-10 Shengfeng Li Compositions and methods for generating antigen-binding units
EP1438400B1 (fr) 2001-10-01 2009-06-17 Dyax Corp. Vecteurs d'affichage eukaryotes multichaine et leurs utilisations
CA2499467A1 (fr) * 2002-09-20 2004-04-01 Cym1P A/S Procedes pour augmenter la production d'un polypeptide recombinant a partir d'une cellule hote

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9139825B2 (en) 2009-10-30 2015-09-22 Novartis Ag Universal fibronectin type III bottom-side binding domain libraries
US10253313B2 (en) 2009-10-30 2019-04-09 Novartis Ag Universal fibronectin type III bottom-side binding domain libraries

Also Published As

Publication number Publication date
EP1678314B1 (fr) 2012-09-05
EP1678314A4 (fr) 2007-03-07
JP2015062433A (ja) 2015-04-09
IL174783A0 (en) 2006-08-20
PL1678314T3 (pl) 2013-02-28
CA2541651A1 (fr) 2005-05-06
CN1871359A (zh) 2006-11-29
US20160068849A1 (en) 2016-03-10
US8709756B2 (en) 2014-04-29
CN101979650A (zh) 2011-02-23
DK1678314T3 (da) 2012-12-03
DK2330201T3 (en) 2017-07-24
US7927863B2 (en) 2011-04-19
JP2012095669A (ja) 2012-05-24
CN101979650B (zh) 2015-09-16
US20200031949A1 (en) 2020-01-30
US20060270045A1 (en) 2006-11-30
US20140206039A1 (en) 2014-07-24
AU2009213095A1 (en) 2009-10-08
NZ547279A (en) 2008-04-30
SI1678314T1 (sl) 2013-01-31
JP4994038B2 (ja) 2012-08-08
PT1678314E (pt) 2012-11-27
IL211402A0 (en) 2011-04-28
ES2630224T3 (es) 2017-08-18
HUE033349T2 (en) 2017-11-28
AU2004283299B2 (en) 2009-06-18
US10155819B2 (en) 2018-12-18
US10259883B2 (en) 2019-04-16
IL174783A (en) 2012-10-31
WO2005040395A1 (fr) 2005-05-06
CA2541651C (fr) 2011-05-24
EP2330201B1 (fr) 2017-04-05
US20160297887A9 (en) 2016-10-13
AU2004283299A1 (en) 2005-05-06
US20110183402A1 (en) 2011-07-28
US9873746B2 (en) 2018-01-23
EP2330201A1 (fr) 2011-06-08
EP1678314A1 (fr) 2006-07-12
US11447560B2 (en) 2022-09-20
CN1871359B (zh) 2010-11-17
ES2393555T3 (es) 2012-12-26
HK1093222A1 (en) 2007-02-23
US20080003643A1 (en) 2008-01-03
JP5982504B2 (ja) 2016-08-31
AU2009213095B2 (en) 2012-01-19
US8268582B2 (en) 2012-09-18
JP2007508847A (ja) 2007-04-12
US20130029880A1 (en) 2013-01-31
IL211402A (en) 2015-08-31

Similar Documents

Publication Publication Date Title
NO20062134L (no) Fremgangsmater for syntetisering av heteromultimere polypeptider i gjaer ved anvendelse av haploid parrings strategi
EP2351834A3 (fr) Production de protéines biologiquement actives
NO973848D0 (no) Fremgangsmåte til fremstilling av hemoglobinliknende protein
IL184112A0 (en) A method for producing polypeptides or proteins in a disulfide-bridged two-chain form
IL190705A0 (en) A method for the production of a permanent human cell line
NO2012001I1 (no) Ipilimumab (INN) - krav i basispatent
DE60336228D1 (de) Verfahren zur gleichzeitigen herstellung von multiplen proteinen; vektoren und zellen, die hierfür verwendung finden
ATE175446T1 (de) Immunogene peptide, antikörper sowie deren verwendungen im zusammenhang mit der cd4- rezeptorbindung
MX2022004316A (es) Composiciones y metodos para sintesis in vivo de polipeptidos no naturales.
GB2451928A (en) Modified diphtheria toxins
WO2006069403A3 (fr) Procedes pour la production d'une pluralite de proteines transmembranaires solubles
TW200732472A (en) Method for the recombinant expression of a polypeptide
ATE112687T1 (de) Mutanten des hiv-1 hüllproteins mit fehlenden hypervariabelen domänen.
WO2004050859A3 (fr) Recombinaison homologue dans des cellules souches adultes multipotentes
WO2021194826A3 (fr) Protéine de spicule de sars-cov-2 de recombinaison et ses utilisations
WO2005086667A3 (fr) Production de peptides dans des cellules de plantes avec un rendement eleve
DK1137808T3 (da) Fremgangsmåde til fremstilling af rekombinante celler
MX2023002413A (es) Proteinas de fusion inmunogenicas de coronavirus y metodos relacionados.
WO2004111194A3 (fr) Procede d'accroissement de la production en culture de proteines
EP4421180A3 (fr) Compositions comprenant des polypeptides de fusion nkg2d, cxcr2, et dap10/dap12 et leurs procédés d'utilisation
WO2004033627A3 (fr) Procedes permettant de produire efficacement des proteines de recombinaison mammaliennes
WO2006124013A3 (fr) Nouveaux polypeptides du facteur-1 derives de cellules stromales, polynucleotides, leurs modulateurs et methode d'utilisation
WO2023141478A3 (fr) Protéines de fusion cytokine-immunorécepteur et leurs utilisations
WO2020232017A3 (fr) Expression de protéines modifiées dans un peroxisome
WO2018081448A8 (fr) Régions charnières d'immunoglobuline modifiées pour réduire l'hémagglutination

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application