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NO20061766L - 1,1,1-trifluor-4-fenyl-4-metyl-2-(1H-Pyrrolo'2,3-Cl Pyridin-2-ylmetyl)pentan-2-ol derivater og beslektede forbindelser som glukokortikoidligander for behandling av inflammatoriske sykdommer og diabetes - Google Patents

1,1,1-trifluor-4-fenyl-4-metyl-2-(1H-Pyrrolo'2,3-Cl Pyridin-2-ylmetyl)pentan-2-ol derivater og beslektede forbindelser som glukokortikoidligander for behandling av inflammatoriske sykdommer og diabetes

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Publication number
NO20061766L
NO20061766L NO20061766A NO20061766A NO20061766L NO 20061766 L NO20061766 L NO 20061766L NO 20061766 A NO20061766 A NO 20061766A NO 20061766 A NO20061766 A NO 20061766A NO 20061766 L NO20061766 L NO 20061766L
Authority
NO
Norway
Prior art keywords
pentan
pyrrolo
ylmethyl
trifluoro
pyridin
Prior art date
Application number
NO20061766A
Other languages
English (en)
Inventor
Younes Bekkali
Thomas M Kirrane
Daniel Kuzmich
John Robert Proudfoot
Hidenori Takahashi
David Thomson
Ji Wang
Renee Zindell
Christian Hanke Justus Harcken
Doris Riether
Rajashekhar Betageri
Michael Emmanuel
Abdelhakim Hammach
Thomas Wai-Ho Lee
Pingrong Liu
Usha R Patel
Hossein Razavi
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO20061766L publication Critical patent/NO20061766L/no

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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

Forbindelser med formel (IA), (IB), (IC) og (ID) hvor R1, R2, R3, R4, R5 og R6 er som henholdsvis definert her for Formel (IA), (IB), (IC) og (ID) eller en tautomer, prodrug, solvat eller salt derav; farmasøytiske preparater inneholdende slike forbindelser og metoder for å modulere glukokortikoidreseptor-funksjon og metoder for behandling av sykdomstilstander eller lidelser mediert av glukokortikoidreseptor-funksjon eller karakterisert ved inflammatoriske, allergiske eller proliferative prosesser hos en pasient ved anvendelse av disse forbindelser.
NO20061766A 2003-09-24 2006-04-21 1,1,1-trifluor-4-fenyl-4-metyl-2-(1H-Pyrrolo'2,3-Cl Pyridin-2-ylmetyl)pentan-2-ol derivater og beslektede forbindelser som glukokortikoidligander for behandling av inflammatoriske sykdommer og diabetes NO20061766L (no)

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NZ546666A (en) 2010-02-26
TW200526655A (en) 2005-08-16
KR20060115858A (ko) 2006-11-10
SG146694A1 (en) 2008-10-30
PE20050951A1 (es) 2005-12-12
AU2004275757B2 (en) 2011-03-24
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AR046020A1 (es) 2005-11-23
EP1673088A1 (en) 2006-06-28
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UY28526A1 (es) 2005-04-29
RU2006113696A (ru) 2007-11-20
BRPI0414591A (pt) 2006-11-07
US8741897B2 (en) 2014-06-03
PE20090217A1 (es) 2009-03-26
ECSP066459A (es) 2006-09-18
CA2539909C (en) 2012-07-31
KR101152690B1 (ko) 2012-07-05
RS20060201A (sr) 2008-08-07
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