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NO20060558L - Cyklopropylgruppe substituerte oksazolidinon antibiotiske midler og derivater derav - Google Patents

Cyklopropylgruppe substituerte oksazolidinon antibiotiske midler og derivater derav

Info

Publication number
NO20060558L
NO20060558L NO20060558A NO20060558A NO20060558L NO 20060558 L NO20060558 L NO 20060558L NO 20060558 A NO20060558 A NO 20060558A NO 20060558 A NO20060558 A NO 20060558A NO 20060558 L NO20060558 L NO 20060558L
Authority
NO
Norway
Prior art keywords
derivatives
group substituted
cyclopropyl group
antibiotic agents
substituted oxazolidinone
Prior art date
Application number
NO20060558A
Other languages
English (en)
Inventor
Yasumichi Fukuda
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO20060558L publication Critical patent/NO20060558L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Foreliggende oppfinnelse angår nye oksazolidinoner som har en cyklopropyldel, som er effektive ovenfor aerobe og anaerobe patogener slike som multiresistente stafylococci, stieptococci, Bacteroides spp., Clostridia spp., arter, så vel som syrefaste organismer slik som Mycobacterium tuberculosis og andre mykobaktenitale arter. Forbindelsene er representert ved strukturformel: (I):dens enantiomer, diastereomer eller farmasøytisk akseptable salter eller ester derav.
NO20060558A 2003-07-02 2006-02-02 Cyklopropylgruppe substituerte oksazolidinon antibiotiske midler og derivater derav NO20060558L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48390403P 2003-07-02 2003-07-02
US54698404P 2004-02-24 2004-02-24
PCT/US2004/020734 WO2005005398A2 (en) 2003-07-02 2004-06-29 Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof

Publications (1)

Publication Number Publication Date
NO20060558L true NO20060558L (no) 2006-02-02

Family

ID=34068173

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060558A NO20060558L (no) 2003-07-02 2006-02-02 Cyklopropylgruppe substituerte oksazolidinon antibiotiske midler og derivater derav

Country Status (23)

Country Link
US (2) US7462633B2 (no)
EP (1) EP1646629B1 (no)
JP (1) JP4607107B2 (no)
KR (1) KR20060113625A (no)
AR (1) AR044990A1 (no)
AT (1) ATE471937T1 (no)
AU (1) AU2004256083B2 (no)
BR (1) BRPI0411688A (no)
CA (1) CA2530140C (no)
CL (1) CL2004001678A1 (no)
DE (1) DE602004027811D1 (no)
EC (1) ECSP056257A (no)
IL (1) IL172785A0 (no)
IS (1) IS8178A (no)
MA (1) MA27938A1 (no)
MX (1) MXPA06000228A (no)
MY (1) MY140137A (no)
NO (1) NO20060558L (no)
NZ (1) NZ544237A (no)
PE (1) PE20050732A1 (no)
RU (1) RU2348628C2 (no)
TW (1) TW200510421A (no)
WO (1) WO2005005398A2 (no)

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US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
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JP2007521284A (ja) * 2003-07-02 2007-08-02 メルク アンド カンパニー インコーポレーテッド オキサゾリジノン系抗生物質及びその誘導体
BRPI0411688A (pt) 2003-07-02 2006-12-26 Merck & Co Inc antibióticos de oxazolidinona substituìda de grupo de ciclopropil e seus derivados
JP2007514782A (ja) * 2003-12-17 2007-06-07 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ハロゲン化ビアリール複素環式化合物ならびにその作製方法および使用方法
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
EP1799677A1 (en) * 2004-10-08 2007-06-27 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
EP1904489B1 (en) 2005-06-08 2011-01-26 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
EP1912980A2 (en) * 2005-06-20 2008-04-23 Wockhardt Limited Oxazolidinones bearing antimicrobial activity composition and methods of preparation
US7838526B2 (en) * 2005-08-05 2010-11-23 Esther Baldinger Method of treating neurological disorders
AR054608A1 (es) * 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
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KR101674146B1 (ko) 2008-10-10 2016-11-08 머크 샤프 앤드 돔 코포레이션 옥사졸리디논 및 이를 포함하는 조성물을 제조하는 방법
ES2734724T3 (es) 2009-02-03 2019-12-11 Merck Sharp & Dohme Forma cristalina de dihidrogenofosfato de (R)-3-(4-(2-(2-metiltetrazol-5-il)piridin-5-il)-3-fluorofenil)-5-hidroximetiloxazolidin-2-ona
US8580767B2 (en) 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
RU2012102094A (ru) 2009-06-26 2013-08-10 Панацеа Биотек Лтд. Новые азабициклогексаны
BR112013007566A2 (pt) 2010-09-28 2016-08-02 Panacea Biotec Ltd novos compostos bicíclicos
WO2017066964A1 (en) 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents
KR102777328B1 (ko) 2018-07-25 2025-03-10 자이두스 라이프사이언시즈 리미티드 포유류 감염 치료를 위한 신규 화합물
JP2022541954A (ja) * 2019-07-17 2022-09-28 小野薬品工業株式会社 Ｋｄｍ５阻害活性を有する化合物およびその医薬用途
WO2021184339A1 (en) 2020-03-20 2021-09-23 Merck Sharp & Dohme Corp. Oxazolidinone compound and methods of use thereof as an antibacterial agent

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BRPI0411688A (pt) 2003-07-02 2006-12-26 Merck & Co Inc antibióticos de oxazolidinona substituìda de grupo de ciclopropil e seus derivados

Also Published As

Publication number Publication date
JP4607107B2 (ja) 2011-01-05
EP1646629A2 (en) 2006-04-19
KR20060113625A (ko) 2006-11-02
WO2005005398A3 (en) 2005-04-28
DE602004027811D1 (de) 2010-08-05
CA2530140C (en) 2010-11-09
IL172785A0 (en) 2006-06-11
ATE471937T1 (de) 2010-07-15
PE20050732A1 (es) 2005-11-02
US7582659B2 (en) 2009-09-01
BRPI0411688A (pt) 2006-12-26
EP1646629B1 (en) 2010-06-23
US20070203187A1 (en) 2007-08-30
CA2530140A1 (en) 2005-01-20
AR044990A1 (es) 2005-10-12
US20050038092A1 (en) 2005-02-17
AU2004256083A1 (en) 2005-01-20
AU2004256083B2 (en) 2007-10-11
IS8178A (is) 2005-12-13
RU2348628C2 (ru) 2009-03-10
MY140137A (en) 2009-11-30
CL2004001678A1 (es) 2005-05-20
TW200510421A (en) 2005-03-16
WO2005005398A2 (en) 2005-01-20
NZ544237A (en) 2008-09-26
ECSP056257A (es) 2006-04-19
MA27938A1 (fr) 2006-06-01
MXPA06000228A (es) 2006-06-27
US7462633B2 (en) 2008-12-09
RU2005140379A (ru) 2007-08-10
JP2007521281A (ja) 2007-08-02

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