CL2004000400A1 - Compuestos derivados de piridina sustituida con 1,3-oxazol y con isoxazol, composicion farmaceutica, procedimiento de preparacion, utiles como agentes antibacteriano, activo contra la bacteria gram negativa. - Google Patents
Compuestos derivados de piridina sustituida con 1,3-oxazol y con isoxazol, composicion farmaceutica, procedimiento de preparacion, utiles como agentes antibacteriano, activo contra la bacteria gram negativa.Info
- Publication number
- CL2004000400A1 CL2004000400A1 CL200400400A CL2004000400A CL2004000400A1 CL 2004000400 A1 CL2004000400 A1 CL 2004000400A1 CL 200400400 A CL200400400 A CL 200400400A CL 2004000400 A CL2004000400 A CL 2004000400A CL 2004000400 A1 CL2004000400 A1 CL 2004000400A1
- Authority
- CL
- Chile
- Prior art keywords
- sub
- useful
- antibacterial agents
- piridine
- isoxazol
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Chemical group 0.000 title abstract 2
- 241000894006 Bacteria Species 0.000 title 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical group C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 title 1
- AXLOCHLTNQDFFS-BESJYZOMSA-N azastene Chemical group C([C@H]1[C@@H]2CC[C@@]([C@]2(CC[C@@H]1[C@@]1(C)C2)C)(O)C)C=C1C(C)(C)C1=C2C=NO1 AXLOCHLTNQDFFS-BESJYZOMSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000003971 isoxazolinyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 2
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical group O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0304723A GB0304723D0 (en) | 2003-03-01 | 2003-03-01 | Chemical compounds |
| GB0318607A GB0318607D0 (en) | 2003-08-08 | 2003-08-08 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2004000400A1 true CL2004000400A1 (es) | 2005-04-22 |
Family
ID=32964061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL200400400A CL2004000400A1 (es) | 2003-03-01 | 2004-02-27 | Compuestos derivados de piridina sustituida con 1,3-oxazol y con isoxazol, composicion farmaceutica, procedimiento de preparacion, utiles como agentes antibacteriano, activo contra la bacteria gram negativa. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7192974B2 (es) |
| EP (1) | EP1599471B1 (es) |
| JP (1) | JP2006519247A (es) |
| KR (1) | KR20050106064A (es) |
| AT (1) | ATE396991T1 (es) |
| AU (1) | AU2004218206A1 (es) |
| BR (1) | BRPI0407835A (es) |
| CA (1) | CA2517706A1 (es) |
| CL (1) | CL2004000400A1 (es) |
| DE (1) | DE602004014107D1 (es) |
| ES (1) | ES2305732T3 (es) |
| MX (1) | MXPA05009205A (es) |
| NO (1) | NO20054523L (es) |
| TW (1) | TW200500360A (es) |
| UY (1) | UY28211A1 (es) |
| WO (1) | WO2004078753A1 (es) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2248633T3 (es) * | 2001-04-17 | 2006-03-16 | MERCK & CO., INC. | Antibioticos oxazolidinona que contienen biciclo (3,1,o)hexano y derivados de los mismos. |
| AU2003209994A1 (en) | 2002-02-28 | 2003-09-09 | Astrazeneca Ab | Oxazolidinone derivatives, processes for their preparation, and pharmaceutical compositions containing them |
| RU2004129276A (ru) | 2002-02-28 | 2005-06-10 | Астразенека Аб (Se) | Производные 3-циклического-5-(азотсодержащего 5-членного кольцевого) метил-оксазолидинона и их применение в качестве антибактериальных средств |
| US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| PT1656370E (pt) | 2003-06-03 | 2012-11-29 | Rib X Pharmaceuticals Inc | Compostos biaril-heterocíclicos e métodos de os produzir e de os utilizar |
| EP1656357A1 (en) * | 2003-07-02 | 2006-05-17 | Merck & Co., Inc. | Oxazolidinone antibiotics and derivatives thereof |
| US20070185132A1 (en) * | 2003-07-02 | 2007-08-09 | Yasumichi Fukuda | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereo |
| JP2007521284A (ja) * | 2003-07-02 | 2007-08-02 | メルク アンド カンパニー インコーポレーテッド | オキサゾリジノン系抗生物質及びその誘導体 |
| BRPI0411688A (pt) * | 2003-07-02 | 2006-12-26 | Merck & Co Inc | antibióticos de oxazolidinona substituìda de grupo de ciclopropil e seus derivados |
| JP4777246B2 (ja) * | 2003-07-29 | 2011-09-21 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | ビアリールオキサゾリジノンの合成方法 |
| EP1660465B1 (en) * | 2003-07-29 | 2014-12-17 | Melinta Therapeutics, Inc. | Process for the synthesis of biaryl oxazolidinones |
| EP1669348A4 (en) | 2003-09-30 | 2009-03-11 | Eisai R&D Man Co Ltd | NEW ANTIPILIC AGENT CONTAINING A HETEROCYCLIC COMPOUND |
| JP2007514782A (ja) | 2003-12-17 | 2007-06-07 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | ハロゲン化ビアリール複素環式化合物ならびにその作製方法および使用方法 |
| KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
| US20050241110A1 (en) * | 2004-04-09 | 2005-11-03 | Bruce Baker | Ergonomic handles, especially for garden tools |
| MXPA06013540A (es) * | 2004-05-25 | 2007-01-26 | Astrazeneca Ab | Derivados de 3-(4-(2 -dihidroisoxasol -3-ilpiridin-5-il) fenil)-5- triazol-1- ilmetiloxazolidin -2-ona como inhibidores de mao para el tratamiento de infecciones bacterianas. |
| US20080064689A1 (en) * | 2004-05-25 | 2008-03-13 | Astrazeneca Ab | 3-[4-(6-Pyridin-3-Yl)-3-Phenyl] -5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents |
| GB0411596D0 (en) * | 2004-05-25 | 2004-06-30 | Astrazeneca Ab | Chemical process |
| EP1799677A1 (en) * | 2004-10-08 | 2007-06-27 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| US20100047338A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| US7829585B2 (en) | 2005-03-30 | 2010-11-09 | Eisai R&D Management Co., Ltd. | Antifungal agent containing pyridine derivative |
| EP1904489B1 (en) | 2005-06-08 | 2011-01-26 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of triazoles |
| TWI385169B (zh) * | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
| EP1946840B1 (en) * | 2005-11-04 | 2019-08-21 | NGK Insulators, Ltd. | Honeycomb structure and honeycomb catalyst |
| US8119667B2 (en) * | 2005-12-29 | 2012-02-21 | Schering-Plough Animal Health Corporation | Carbonates of fenicol antibiotics |
| US8183264B2 (en) * | 2006-09-21 | 2012-05-22 | Eisai R&D Managment Co., Ltd. | Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same |
| US20100065104A1 (en) * | 2007-08-31 | 2010-03-18 | Baruh Bradford G | Retractable solar panel system |
| US8258394B2 (en) * | 2007-02-08 | 2012-09-04 | Bradford G Baruh | Retractable solar panel system |
| US20080190341A1 (en) * | 2007-02-08 | 2008-08-14 | Baruh Bradford G | System and method of adjusting the location and position of the foresail on a sailboat |
| KR100848232B1 (ko) * | 2007-04-12 | 2008-07-24 | 일동제약주식회사 | 신규 헤테로 고리 또는 알콕시아미노메틸 옥사졸리디논 및그 제조방법 |
| CN101622251B (zh) * | 2007-04-27 | 2012-07-04 | 卫材R&D管理有限公司 | 杂环取代吡啶衍生物的盐或其结晶 |
| TW200841879A (en) | 2007-04-27 | 2008-11-01 | Eisai R&D Man Co Ltd | Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same |
| CA2726420C (en) * | 2007-06-01 | 2018-07-31 | Chx Technologies, Inc. | Topical dental solution of chlorhexidine in sumatra benzoin bp/ep and methods of manufacturing and evaluating same for compliance with international regulatory specifications |
| US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
| GB2470700B (en) | 2008-03-25 | 2012-08-08 | Univ Maryland | C-17 heteroaryl steroidal CYP17 inhibitors |
| CA2712613C (en) | 2008-03-26 | 2017-02-28 | Global Alliance For Tb Drug Development | Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones |
| KR101674146B1 (ko) * | 2008-10-10 | 2016-11-08 | 머크 샤프 앤드 돔 코포레이션 | 옥사졸리디논 및 이를 포함하는 조성물을 제조하는 방법 |
| US8188119B2 (en) * | 2008-10-24 | 2012-05-29 | Eisai R&D Management Co., Ltd | Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same |
| ES2734724T3 (es) | 2009-02-03 | 2019-12-11 | Merck Sharp & Dohme | Forma cristalina de dihidrogenofosfato de (R)-3-(4-(2-(2-metiltetrazol-5-il)piridin-5-il)-3-fluorofenil)-5-hidroximetiloxazolidin-2-ona |
| CA2761389A1 (en) | 2009-02-05 | 2010-08-12 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
| WO2010103281A1 (en) * | 2009-03-13 | 2010-09-16 | Sun Chemical B.V. | Cyclic carbamate compounds useful in energy-curable compositions |
| US8580767B2 (en) * | 2009-05-28 | 2013-11-12 | Trius Therapeutics, Inc. | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
| KR101653570B1 (ko) * | 2011-03-30 | 2016-09-02 | 주식회사 레고켐 바이오사이언스 | 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물 |
| EP2626356A1 (en) * | 2012-02-08 | 2013-08-14 | Rheinische Friedrich-Wilhelms-Universität Bonn | Thiamine analogues and their use as antibiotics |
| AU2014236135A1 (en) | 2013-03-14 | 2015-09-10 | Thomas Jefferson University | Androgen receptor down-regulating agents and uses thereof |
| EP3033088A4 (en) | 2013-08-12 | 2017-03-08 | Tokai Pharmaceuticals, Inc. | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
| WO2021000297A1 (en) | 2019-07-03 | 2021-01-07 | Merck Sharp & Dohme Corp. | Compounds and methods of use thereof as antibacterial agents |
| CN112707779B (zh) * | 2020-12-26 | 2023-06-30 | 蚌埠中实化学技术有限公司 | 一种乙烯基环己烷的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4948801A (en) * | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| KR100257418B1 (ko) * | 1991-11-01 | 2000-05-15 | 로렌스 티. 마이젠헬더 | 치환된 아릴-및 헤테로아릴-페닐옥사졸리디논 |
| JP2003535860A (ja) | 2000-06-05 | 2003-12-02 | ドン・ア・ファーム・カンパニー・リミテッド | 新規なオキサゾリジノン誘導体及びその製造方法 |
| US20020115669A1 (en) * | 2000-08-31 | 2002-08-22 | Wiedeman Paul E. | Oxazolidinone chemotherapeutic agents |
| IL160739A0 (en) * | 2001-09-11 | 2004-08-31 | Astrazeneca Ab | Oxazolidinone and/or isoxazoline as antibacterial agents |
| GB0227701D0 (en) * | 2002-11-28 | 2003-01-08 | Astrazeneca Ab | Chemical compounds |
| US20060116400A1 (en) * | 2002-11-28 | 2006-06-01 | Astrazeneca Ab | Oxazolidinone and/or isoxazoline derivatives as antibacterial agents |
| GB0229526D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
-
2004
- 2004-02-23 TW TW093104447A patent/TW200500360A/zh unknown
- 2004-02-24 BR BRPI0407835-7A patent/BRPI0407835A/pt not_active IP Right Cessation
- 2004-02-24 AT AT04713945T patent/ATE396991T1/de not_active IP Right Cessation
- 2004-02-24 WO PCT/GB2004/000730 patent/WO2004078753A1/en not_active Ceased
- 2004-02-24 ES ES04713945T patent/ES2305732T3/es not_active Expired - Lifetime
- 2004-02-24 JP JP2006505893A patent/JP2006519247A/ja active Pending
- 2004-02-24 EP EP04713945A patent/EP1599471B1/en not_active Expired - Lifetime
- 2004-02-24 CA CA002517706A patent/CA2517706A1/en not_active Abandoned
- 2004-02-24 US US10/546,373 patent/US7192974B2/en not_active Expired - Fee Related
- 2004-02-24 KR KR1020057016202A patent/KR20050106064A/ko not_active Withdrawn
- 2004-02-24 DE DE602004014107T patent/DE602004014107D1/de not_active Expired - Fee Related
- 2004-02-24 AU AU2004218206A patent/AU2004218206A1/en not_active Abandoned
- 2004-02-24 MX MXPA05009205A patent/MXPA05009205A/es not_active Application Discontinuation
- 2004-02-27 UY UY28211A patent/UY28211A1/es not_active Application Discontinuation
- 2004-02-27 CL CL200400400A patent/CL2004000400A1/es unknown
-
2005
- 2005-09-30 NO NO20054523A patent/NO20054523L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20054523L (no) | 2005-12-01 |
| ES2305732T3 (es) | 2008-11-01 |
| CA2517706A1 (en) | 2004-09-16 |
| ATE396991T1 (de) | 2008-06-15 |
| US20060270637A1 (en) | 2006-11-30 |
| JP2006519247A (ja) | 2006-08-24 |
| MXPA05009205A (es) | 2005-10-18 |
| DE602004014107D1 (de) | 2008-07-10 |
| KR20050106064A (ko) | 2005-11-08 |
| HK1083097A1 (en) | 2006-06-23 |
| AU2004218206A1 (en) | 2004-09-16 |
| EP1599471B1 (en) | 2008-05-28 |
| US7192974B2 (en) | 2007-03-20 |
| NO20054523D0 (no) | 2005-09-30 |
| BRPI0407835A (pt) | 2006-02-14 |
| EP1599471A1 (en) | 2005-11-30 |
| WO2004078753A1 (en) | 2004-09-16 |
| TW200500360A (en) | 2005-01-01 |
| UY28211A1 (es) | 2004-09-30 |
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