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NO20025525L - Substituerte pyrrolpyridinonderivater, brukbare som fosfordiesterase-inhibitorer - Google Patents

Substituerte pyrrolpyridinonderivater, brukbare som fosfordiesterase-inhibitorer

Info

Publication number
NO20025525L
NO20025525L NO20025525A NO20025525A NO20025525L NO 20025525 L NO20025525 L NO 20025525L NO 20025525 A NO20025525 A NO 20025525A NO 20025525 A NO20025525 A NO 20025525A NO 20025525 L NO20025525 L NO 20025525L
Authority
NO
Norway
Prior art keywords
useful
substituted pyrrole
pyridinone derivatives
diesterase inhibitors
phosphorus
Prior art date
Application number
NO20025525A
Other languages
English (en)
Other versions
NO324843B1 (no
NO20025525D0 (no
Inventor
Zhihua Sui
Mark J Macielag
Jihua Guan
Weiqin Jiang
James C Lanter
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of NO20025525D0 publication Critical patent/NO20025525D0/no
Publication of NO20025525L publication Critical patent/NO20025525L/no
Publication of NO324843B1 publication Critical patent/NO324843B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20025525A 2000-05-17 2002-11-18 Substituerte pyrrolpyridinonderivater nyttige som fosfordiesterase-inhibitorer, og farmasoytiske preparater som innbefatter slike NO324843B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20464600P 2000-05-17 2000-05-17
PCT/US2001/014391 WO2001087882A2 (en) 2000-05-17 2001-05-03 Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors

Publications (3)

Publication Number Publication Date
NO20025525D0 NO20025525D0 (no) 2002-11-18
NO20025525L true NO20025525L (no) 2003-01-03
NO324843B1 NO324843B1 (no) 2007-12-17

Family

ID=22758822

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20025525A NO324843B1 (no) 2000-05-17 2002-11-18 Substituerte pyrrolpyridinonderivater nyttige som fosfordiesterase-inhibitorer, og farmasoytiske preparater som innbefatter slike

Country Status (29)

Country Link
US (3) US6635638B2 (no)
EP (1) EP1296981B1 (no)
JP (1) JP5366349B2 (no)
KR (2) KR100854050B1 (no)
CN (1) CN1280291C (no)
AR (1) AR028575A1 (no)
AT (1) ATE278690T1 (no)
AU (1) AU6117801A (no)
BG (1) BG65925B1 (no)
CA (1) CA2409743C (no)
CZ (1) CZ20023945A3 (no)
DE (1) DE60106252T2 (no)
ES (1) ES2230316T3 (no)
GE (1) GEP20053510B (no)
HK (1) HK1054034B (no)
HR (1) HRP20020911B1 (no)
HU (1) HUP0302226A3 (no)
IL (2) IL152872A0 (no)
MX (1) MXPA02011425A (no)
MY (1) MY126917A (no)
NO (1) NO324843B1 (no)
NZ (1) NZ522732A (no)
PL (1) PL363150A1 (no)
PT (1) PT1296981E (no)
RU (1) RU2267490C2 (no)
SK (1) SK286992B6 (no)
UA (1) UA72611C2 (no)
WO (1) WO2001087882A2 (no)
ZA (1) ZA200210114B (no)

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UA72611C2 (uk) 2000-05-17 2005-03-15 Орто-Макнейл Фармацевтикал, Інк. Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази
AU2002246728A1 (en) * 2001-02-12 2002-08-28 Lilly Icos Llc Carboline derivatives
DE60216233T2 (de) 2001-02-12 2007-09-27 Lilly Icos Llc, Wilmington Carbolinderivate
ES2289159T3 (es) * 2001-11-14 2008-02-01 Ortho-Mcneil Pharmaceutical Corporation Derivados tetraciclicos sustituidos de pirroloquinolona utilizados como inhibidores de fosfodiesterasa.
CN100349893C (zh) * 2002-06-19 2007-11-21 詹森药业有限公司 用作磷酸二酯酶抑制剂的取代2,4－二氢－吡咯并[3,4－b]喹啉－9－酮衍生物
US7045652B2 (en) * 2002-07-03 2006-05-16 Pfizer Inc Processes for preparing substituted aryl boronic acids
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
AU2005222632B2 (en) 2004-03-15 2012-02-09 Ptc Therapeutics, Inc. Carboline derivatives useful in the inhibition of angiogenesis
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
JP2008531570A (ja) * 2005-02-25 2008-08-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ３−（ｒ）−３−（２，３−ジヒドロベンゾフラン−５−イル）−１，２，３，４−テトラヒドロピロロ［３，４−ｂ］キノリン−９−オンの有効かつ立体選択的大規模合成方法
WO2006093719A1 (en) * 2005-02-25 2006-09-08 Janssen Pharmaceutica, N.V. An efficient and stereoselective process for large scale synthesis of 3-(r)-3- (2,3-dihydrobenzofuran-5-yl)-1,2,3,4- tetrahydropyrrolo{3,4-b}quinolin-9-one
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
MX2009002496A (es) 2006-09-08 2009-07-10 Braincells Inc Combinaciones que contienen un derivado de 4-acilaminopiridina.
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
JP2012513464A (ja) 2008-12-23 2012-06-14 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク ホスホジエステラーゼ阻害剤及びその使用
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
RU2451686C1 (ru) * 2010-12-27 2012-05-27 Александр Васильевич Иващенко ЗАМЕЩЕННЫЕ ГИДРИРОВАННЫЕ ТИЕНО-ПИРРОЛО [3,2-c] ПИРИДИНЫ, ЛИГАНДЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ИХ ПРИМЕНЕНИЯ
KR101236188B1 (ko) * 2011-03-10 2013-02-22 한국화학연구원 신규한 피롤로피리디논 유도체 및 그의 ｍｃｈ 수용체-1 관련 질환에 대한 치료학적 용도
EP2757887B1 (en) * 2011-09-22 2017-04-26 VIIV Healthcare UK Limited Pyrrolopyridinone compounds and methods for treating hiv
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
PT3160964T (pt) 2014-06-27 2024-06-07 Nogra Pharma Ltd Moduladores dos receptores de arilo e métodos de fabrico e utilização dos mesmos
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN107216327A (zh) * 2017-06-27 2017-09-29 山东大学 5型磷酸二酯酶抑制剂及其制备方法和用途
CN108752340B (zh) * 2018-07-18 2020-09-01 山东中医药大学附属医院 吡咯并喹啉衍生物及其在治疗心律失常中的用途
CN109134463B (zh) * 2018-09-17 2020-05-08 山东大学 β-咔啉类5型磷酸二酯酶抑制剂及其制备方法和用途

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Also Published As

Publication number Publication date
JP5366349B2 (ja) 2013-12-11
AR028575A1 (es) 2003-05-14
CN1280291C (zh) 2006-10-18
HUP0302226A2 (hu) 2003-11-28
WO2001087882A3 (en) 2002-05-23
HRP20020911A2 (en) 2004-12-31
BG107284A (bg) 2003-07-31
US20050113402A1 (en) 2005-05-26
NO324843B1 (no) 2007-12-17
JP2003533524A (ja) 2003-11-11
ES2230316T3 (es) 2005-05-01
GEP20053510B (en) 2005-05-10
PL363150A1 (en) 2004-11-15
HK1054034A1 (en) 2003-11-14
ATE278690T1 (de) 2004-10-15
CA2409743A1 (en) 2001-11-22
KR20020094063A (ko) 2002-12-16
DE60106252T2 (de) 2006-03-02
WO2001087882A2 (en) 2001-11-22
CA2409743C (en) 2010-10-19
IL152872A (en) 2010-11-30
ZA200210114B (en) 2004-03-12
US6635638B2 (en) 2003-10-21
MY126917A (en) 2006-10-31
US20040044021A1 (en) 2004-03-04
PT1296981E (pt) 2004-12-31
BG65925B1 (bg) 2010-05-31
HUP0302226A3 (en) 2012-12-28
CN1441801A (zh) 2003-09-10
KR20030031483A (ko) 2003-04-21
US20020010183A1 (en) 2002-01-24
DE60106252D1 (de) 2004-11-11
AU6117801A (en) 2001-11-26
RU2267490C2 (ru) 2006-01-10
MXPA02011425A (es) 2004-09-06
HRP20020911B1 (en) 2009-01-31
CZ20023945A3 (cs) 2003-10-15
EP1296981A2 (en) 2003-04-02
NZ522732A (en) 2004-10-29
SK286992B6 (sk) 2009-09-07
HK1054034B (en) 2005-04-29
IL152872A0 (en) 2003-06-24
KR100854050B1 (ko) 2008-08-26
US6818646B2 (en) 2004-11-16
UA72611C2 (uk) 2005-03-15
NO20025525D0 (no) 2002-11-18
SK17132002A3 (sk) 2003-12-02
EP1296981B1 (en) 2004-10-06

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