[go: up one dir, main page]

NO20006295L - Struktur til anvendelse i screeningsprosess, screeningsapparat som omfatter strukturen og anvendelse av strukturen i screening. - Google Patents

Struktur til anvendelse i screeningsprosess, screeningsapparat som omfatter strukturen og anvendelse av strukturen i screening.

Info

Publication number
NO20006295L
NO20006295L NO20006295A NO20006295A NO20006295L NO 20006295 L NO20006295 L NO 20006295L NO 20006295 A NO20006295 A NO 20006295A NO 20006295 A NO20006295 A NO 20006295A NO 20006295 L NO20006295 L NO 20006295L
Authority
NO
Norway
Prior art keywords
substrate
screening
membrane
ion channel
biological membrane
Prior art date
Application number
NO20006295A
Other languages
English (en)
Other versions
NO20006295D0 (no
Inventor
David Geraint Owen
Nicholas Gerard Byrne
Original Assignee
Xention Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xention Ltd filed Critical Xention Ltd
Publication of NO20006295D0 publication Critical patent/NO20006295D0/no
Publication of NO20006295L publication Critical patent/NO20006295L/no

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438Electrodes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/48707Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728Investigating individual cells, e.g. by patch clamp, voltage clamp
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0829Multi-well plates; Microtitration plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0848Specific forms of parts of containers
    • B01L2300/0851Bottom walls
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0893Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/16Surface properties and coatings
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00Metal working
    • Y10T29/49Method of mechanical manufacture
    • Y10T29/49826Assembling or joining

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Electrochemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Maintenance And Management Of Digital Transmission (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Devices For Checking Fares Or Tickets At Control Points (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
NO20006295A 1998-06-12 2000-12-11 Struktur til anvendelse i screeningsprosess, screeningsapparat som omfatter strukturen og anvendelse av strukturen i screening. NO20006295L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9812783.0A GB9812783D0 (en) 1998-06-12 1998-06-12 High throuoghput screen
PCT/GB1999/001871 WO1999066329A1 (en) 1998-06-12 1999-06-14 High throughput screen

Publications (2)

Publication Number Publication Date
NO20006295D0 NO20006295D0 (no) 2000-12-11
NO20006295L true NO20006295L (no) 2001-02-12

Family

ID=10833717

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20006295A NO20006295L (no) 1998-06-12 2000-12-11 Struktur til anvendelse i screeningsprosess, screeningsapparat som omfatter strukturen og anvendelse av strukturen i screening.

Country Status (17)

Country Link
US (5) US6936462B1 (no)
EP (2) EP1621888B1 (no)
JP (1) JP4499284B2 (no)
AT (2) ATE302951T1 (no)
AU (1) AU768862B2 (no)
CA (1) CA2334770C (no)
DE (2) DE69926883T3 (no)
DK (2) DK1621888T3 (no)
ES (1) ES2249041T3 (no)
GB (1) GB9812783D0 (no)
HU (1) HUP0102915A3 (no)
IL (2) IL140199A0 (no)
MX (1) MXPA00012345A (no)
NO (1) NO20006295L (no)
PL (1) PL201770B1 (no)
WO (1) WO1999066329A1 (no)
ZA (1) ZA200007296B (no)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7244349B2 (en) 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
US20020144905A1 (en) 1997-12-17 2002-10-10 Christian Schmidt Sample positioning and analysis system
GB9812783D0 (en) 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
US7384733B1 (en) 1998-12-05 2008-06-10 Xention Discovery Limited Interface patch clamping
US6488829B1 (en) 1999-08-05 2002-12-03 Essen Instruments Inc High-throughput electrophysiological measurement apparatus
US6682649B1 (en) 1999-10-01 2004-01-27 Sophion Bioscience A/S Substrate and a method for determining and/or monitoring electrophysiological properties of ion channels
GB9930719D0 (en) * 1999-12-24 2000-02-16 Central Research Lab Ltd Apparatus for and method of making electrical measurements on an object in a m edium
CA2411891A1 (en) * 2000-06-08 2001-12-13 1428388 Ontario Limited Spatially addressable electrolysis platform and methods of use
JP2004514417A (ja) * 2000-07-07 2004-05-20 ブリストル−マイヤーズ スクイブ カンパニー 薬品発見用化合物の高速処理スクリーニングに適した電気生理学的配置
ES2273873T3 (es) * 2000-07-14 2007-05-16 Transform Pharmaceuticals, Inc. Sistema y procedimiento para la optimizacion de la transferencia de compuestos a traves de una barrera de tejido.
EP1178315A1 (de) 2000-07-31 2002-02-06 Albrecht Dr.med. Priv.Doz. Lepple-Wienhues Verfahren und Vorrichtung zur Untersuchung von Zellen mit Hilfe der Patch Clamp-Methode
US7067046B2 (en) * 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
US7270730B2 (en) 2000-08-04 2007-09-18 Essen Instruments, Inc. High-throughput electrophysiological measurement system
US6932893B2 (en) 2000-10-02 2005-08-23 Sophion Bioscience A/S System for electrophysiological measurements
EP1225216A1 (de) * 2001-01-08 2002-07-24 Niels Fertig Vorrichtung zur Untersuchung von Ionenkanälen in Membranen
EP1352952A1 (en) * 2001-01-09 2003-10-15 Matsushita Electric Industrial Co., Ltd. Device for measuring extracellular potential, method of measuring extracellular potential by using the same and apparatus for quickly screening drug provided therewith
US20050009004A1 (en) * 2002-05-04 2005-01-13 Jia Xu Apparatus including ion transport detecting structures and methods of use
US20050058990A1 (en) * 2001-03-24 2005-03-17 Antonio Guia Biochip devices for ion transport measurement, methods of manufacture, and methods of use
WO2002077259A2 (en) * 2001-03-24 2002-10-03 Aviva Biosciences Corporation Biochips including ion transport detecting structures and methods of use
US20050196746A1 (en) * 2001-03-24 2005-09-08 Jia Xu High-density ion transport measurement biochip devices and methods
US20060029955A1 (en) 2001-03-24 2006-02-09 Antonio Guia High-density ion transport measurement biochip devices and methods
WO2003006103A2 (en) * 2001-07-12 2003-01-23 Merck & Co., Inc. Electrical field stimulation of eukaryotic cells
JP2003043009A (ja) * 2001-07-30 2003-02-13 Matsushita Electric Ind Co Ltd 生体試料の発する物理化学的変化を検出するデバイスおよび装置
DE10150971B8 (de) * 2001-10-05 2006-11-09 Technische Universität Dresden Verfahren und Vorrichtung zur Messung der Rezeptoraktivität an transfizierten Zellen
US7429316B1 (en) * 2001-10-09 2008-09-30 Yuri Osipchuk Planar patch-clamp cartridge with integrated electrode
JP4192097B2 (ja) * 2001-10-25 2008-12-03 バル−イラン ユニバーシティ 相互作用型透明個別細胞バイオチッププロセッサー
US7241565B2 (en) 2001-11-30 2007-07-10 Bristol-Myers Squibb Company Liquid interface configurations for automated patch clamp recording
AU2002352988A1 (en) 2001-11-30 2003-06-17 Bristol-Myers Squibb Company Pipette configurations and arrays thereof for measuring cellular electrical properties
DE10202094B4 (de) * 2002-01-21 2006-09-28 Eppendorf Ag Verfahren und Vorrichtung zur Elektroporation biologischer Zellen
DE10248333A1 (de) 2002-01-25 2003-12-04 Bayer Ag Dynamischer Mischer
DE10202887B4 (de) * 2002-01-25 2004-05-06 Advalytix Ag Zellanalyseverfahren
DE10203686A1 (de) * 2002-01-31 2003-08-07 Bayer Ag Verfahren zur Durchführung von elektrischen Messungen an biologischen Membrankörpern
AU2003205132A1 (en) 2002-02-12 2003-09-04 Celectricon AB Systems and methods for rapidly changing the solution environment around sensors
US7470518B2 (en) 2002-02-12 2008-12-30 Cellectricon Ab Systems and method for rapidly changing the solution environment around sensors
AU2003224817B2 (en) * 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
WO2003093494A2 (en) * 2002-05-04 2003-11-13 Aviva Biosciences Corporation Apparatus including ion transport detecting structures and methods of use
WO2003096002A1 (en) * 2002-05-13 2003-11-20 Matsushita Electric Industrial Co., Ltd. Instrument and method for measuring action signal of biological sample
US8202439B2 (en) 2002-06-05 2012-06-19 Panasonic Corporation Diaphragm and device for measuring cellular potential using the same, manufacturing method of the diaphragm
JP4691407B2 (ja) * 2005-06-29 2011-06-01 パナソニック株式会社 細胞電位測定用容器
JP3945338B2 (ja) * 2002-08-01 2007-07-18 松下電器産業株式会社 細胞外電位測定デバイスおよびその製造方法
JP3945317B2 (ja) * 2002-06-05 2007-07-18 松下電器産業株式会社 細胞外電位測定デバイスおよびその製造方法
WO2007072790A1 (ja) 2005-12-20 2007-06-28 Matsushita Electric Industrial Co., Ltd. 細胞電気生理センサ
WO2007001091A1 (en) * 2005-06-29 2007-01-04 Matsushita Electric Industrial Co., Ltd. Cellular potential measurement container
JP4834335B2 (ja) * 2005-06-29 2011-12-14 パナソニック株式会社 細胞電位測定用容器
CN100487456C (zh) * 2002-06-05 2009-05-13 松下电器产业株式会社 细胞外电位测量装置及其制造方法
JP2005537498A (ja) * 2002-07-20 2005-12-08 アセア バイオサイエンシーズ,インク. インピーダンスによる測定装置および方法
US8263375B2 (en) 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
US7560269B2 (en) 2002-12-20 2009-07-14 Acea Biosciences, Inc. Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays
US7732127B2 (en) 2002-12-20 2010-06-08 Acea Biosciences, Inc. Dynamic monitoring of cell adhesion and spreading using the RT-CES system
US8206903B2 (en) 2002-12-20 2012-06-26 Acea Biosciences Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses
US7470533B2 (en) 2002-12-20 2008-12-30 Acea Biosciences Impedance based devices and methods for use in assays
US7468255B2 (en) 2002-12-20 2008-12-23 Acea Biosciences Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology
DE10236528A1 (de) * 2002-08-09 2004-02-19 Bayer Ag Vorrichtung und Methoden zur Durchführung von elektrischen Messungen an Membrankörpern
EP1801586B1 (en) * 2002-08-21 2010-10-13 Cellectricon Ab System for obtaining and maintaining high-resistance seals in patch clamp recordings
WO2004018690A1 (en) 2002-08-21 2004-03-04 Cellectricon Ab System and method for obtaining and maintaining high resistance seals in patch clamp recordings
FR2844052B1 (fr) 2002-08-28 2005-07-01 Commissariat Energie Atomique Dispositif de mesure de l'activite electrique d'elements biologiques et ses applications
WO2004036202A1 (en) 2002-10-16 2004-04-29 Cellectricon Ab Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells
DE10251767A1 (de) * 2002-11-07 2004-05-27 Forschungszentrum Jülich GmbH Vorrichtung und Verfahren zur Messung elektrischer Vorgänge an biologischen Membranen
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
US10539523B2 (en) 2002-12-20 2020-01-21 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties
US10551371B2 (en) 2003-11-10 2020-02-04 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
US9612234B2 (en) 2008-05-05 2017-04-04 Acea Biosciences, Inc. Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments
US10215748B2 (en) 2002-12-20 2019-02-26 Acea Biosciences, Inc. Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
US9200245B2 (en) 2003-06-26 2015-12-01 Seng Enterprises Ltd. Multiwell plate
EP1692258A4 (en) 2003-11-12 2007-03-21 Xiao Xu REAL-TIME ELECTRONIC CELL DETECTION SYSTEMS FOR CELL-BASED TESTS
US8058056B2 (en) * 2004-03-12 2011-11-15 The Regents Of The University Of California Method and apparatus for integrated cell handling and measurements
US7169609B2 (en) * 2004-03-31 2007-01-30 Vertex Pharmaceutcals, Inc. Multiwell plate assembly for use in high throughput assays
EP1751267A4 (en) * 2004-05-06 2009-10-28 Ca Nat Research Council PATTERNED CELLULAR NETWORK SUBSTRATE INTERFACE AND METHODS AND USES THEREOF
US6897069B1 (en) 2004-06-08 2005-05-24 Ambion, Inc. System and method for electroporating a sample
RU2006143560A (ru) 2004-06-12 2008-07-20 Диджитал Био Технолоджи Ко Устройство для электропорации с удлиненным полым элементом
DE102004030524A1 (de) * 2004-06-18 2006-01-05 Siemens Ag Reaktorenarray zum Testen von Oberflächenreaktionen
JP4587281B2 (ja) * 2004-06-21 2010-11-24 則男 長尾 癌転移抑制能測定する方法およびその測定器
DK1802752T3 (da) * 2004-09-10 2012-07-23 Molecular Devices Llc Parallelt patch-clamp-system
JP2006184207A (ja) * 2004-12-28 2006-07-13 Matsushita Electric Ind Co Ltd 細胞膜の特性および状態の少なくとも一方の電気的測定方法および電気的測定装置
US7473533B2 (en) * 2004-12-30 2009-01-06 Corning Incorporated Membrane arrays and methods of manufacture
US7608417B2 (en) 2005-11-14 2009-10-27 Panasonic Corporation Cell electro-physiological sensor and method of manufacturing the same
PT1977241E (pt) * 2006-01-04 2010-09-16 Novartis Ag Ensaio de citotoxicidade celular dependente de anticorpos
JP4858870B2 (ja) * 2006-02-16 2012-01-18 財団法人生産技術研究奨励会 培養細胞の電気シグナル計測デバイスおよび該デバイスを用いる電気シグナル計測方法
US8293524B2 (en) * 2006-03-31 2012-10-23 Fluxion Biosciences Inc. Methods and apparatus for the manipulation of particle suspensions and testing thereof
JP4582146B2 (ja) * 2006-05-17 2010-11-17 パナソニック株式会社 細胞電位測定デバイスとそれに用いる基板、細胞電位測定デバイス用基板の製造方法
US8445263B2 (en) 2006-07-06 2013-05-21 Panasonic Corporation Device for cellular electrophysiology sensor, cellular electrophysiology sensor using the device, and method for manufacturing the cellular electrophysiology sensor device
US8041515B2 (en) 2006-09-20 2011-10-18 Acea Biosciences, Inc. Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents
JP5233187B2 (ja) 2007-07-11 2013-07-10 パナソニック株式会社 細胞電気生理センサ
WO2009033226A1 (en) * 2007-09-14 2009-03-19 Inphaze Pty Ltd In situ membrane monitoring
US9975118B2 (en) 2007-11-15 2018-05-22 Seng Enterprises Ltd. Device for the study of living cells
US9145540B1 (en) 2007-11-15 2015-09-29 Seng Enterprises Ltd. Device for the study of living cells
JP4973618B2 (ja) 2007-12-20 2012-07-11 パナソニック株式会社 細胞電気生理センサの製造方法および製造装置
EP2103933B1 (en) * 2008-02-25 2011-07-27 Universität Leipzig Device and method for measuring impedance in organotypic tissues
KR101084528B1 (ko) 2008-04-15 2011-11-18 인비트로겐 싱가포르 피티이. 엘티디. 전기천공 장치용 파이펫 팁
WO2009137440A1 (en) 2008-05-05 2009-11-12 Acea Biosciences, Inc. Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution
WO2010016193A1 (ja) * 2008-08-04 2010-02-11 パナソニック株式会社 細胞電気生理センサ用チップとこれを用いた細胞電気生理センサ、および細胞電気生理センサ用チップの製造方法
US8092739B2 (en) * 2008-11-25 2012-01-10 Wisconsin Alumni Research Foundation Retro-percussive technique for creating nanoscale holes
DE102009035502A1 (de) * 2009-07-30 2011-02-03 Universitätsklinikum Jena Verfahren und Vorrichtung zur Erfassung der Bewegung und Anlagerung von Zellen und Partikeln an Zell-, Gewebe- und Implantatschichten bei der Simulation von Flussbedingungen
WO2011135802A1 (ja) * 2010-04-27 2011-11-03 パナソニック株式会社 測定デバイス
EP2650678B1 (en) 2011-01-13 2016-09-14 Panasonic Intellectual Property Management Co., Ltd. Sensor chip
CN103477223B (zh) 2011-03-01 2015-01-14 索菲昂生物科学有限公司 用于电生理学分析的手持装置
US8912006B2 (en) * 2012-02-03 2014-12-16 The Charles Stark Draper Laboratory, Inc. Microfluidic device for generating neural cells to simulate post-stroke conditions
US9186669B2 (en) 2012-02-10 2015-11-17 Applied Biophysics, Inc. Filter device for facilitating characterizing behavior of cells
US9423234B2 (en) 2012-11-05 2016-08-23 The Regents Of The University Of California Mechanical phenotyping of single cells: high throughput quantitative detection and sorting
US9790465B2 (en) 2013-04-30 2017-10-17 Corning Incorporated Spheroid cell culture well article and methods thereof
DE102014001916B4 (de) * 2014-02-13 2015-12-03 Christoph Methfessel Messkammer zur biophysikalischen Untersuchung von Zellen
DE102014203280B4 (de) * 2014-02-24 2015-12-17 Cytocentrics Bioscience Gmbh Vorrichtung zur Bestimmung von Messgrößen an Membranen
JP6731916B2 (ja) 2014-10-29 2020-07-29 コーニング インコーポレイテッド 細胞培養インサート
CN113481097A (zh) 2014-10-29 2021-10-08 康宁股份有限公司 灌注生物反应器平台
WO2016069930A1 (en) 2014-10-29 2016-05-06 Corning Incorporated Microwell design and fabrication for generation of cell culture aggregates
US10167502B2 (en) 2015-04-03 2019-01-01 Fluxion Biosciences, Inc. Molecular characterization of single cells and cell populations for non-invasive diagnostics
EP3357998A4 (en) * 2015-09-29 2019-06-12 Tokyo Ohka Kogyo Co., Ltd. SUBSTRATE, STRUCTURE, STRUCTURE MANUFACTURING METHOD, CELL SORTING METHOD, CELL MANUFACTURING METHOD AND SECRETION MANUFACTURING METHOD
US12066428B2 (en) 2015-11-20 2024-08-20 Agilent Technologies, Inc. Cell-substrate impedance monitoring of cancer cells
AU2017216079B9 (en) 2016-02-01 2021-11-04 Elanco Animal Health Gmbh Rhipicephalus nicotinic acetylcholine receptor and pest control acting thereon
EP3589299B1 (en) 2017-03-03 2025-04-09 Agilent Technologies, Inc. METHODS AND SYSTEMS FOR FUNCTIONAL MATURATION OF iPSC AND ESC DERIVED CARDIOMYOCYTES
WO2018202471A1 (en) 2017-05-02 2018-11-08 Bayer Aktiengesellschaft Tmem16a modulation for diagnostic or therapeutic use in pulmonary hypertension (ph)
DE102017004567A1 (de) * 2017-05-11 2018-11-15 Innome Gmbh Gerät zur Analyse von biologischen Proben
JP6931220B2 (ja) * 2017-06-01 2021-09-01 学校法人立命館 液滴処理方法、液滴処理基板、及び液滴接触用治具
CN108020490A (zh) * 2017-06-23 2018-05-11 中国科学院天津工业生物技术研究所 一种使用液滴微流控芯片的高通量筛选设备
CN111094536B (zh) 2017-07-14 2024-03-29 康宁股份有限公司 用于3d培养的细胞培养容器及培养3d细胞的方法
WO2019014636A1 (en) 2017-07-14 2019-01-17 Corning Incorporated CONTAINER FOR CELL CULTURE
EP3652290B1 (en) 2017-07-14 2022-05-04 Corning Incorporated 3d cell culture vessels for manual or automatic media exchange
US11857970B2 (en) 2017-07-14 2024-01-02 Corning Incorporated Cell culture vessel
EP3658602B1 (en) * 2017-07-25 2024-09-18 Solventum Intellectual Properties Company Photopolymerizable compositions including a urethane component and a reactive diluent, orthodontic articles, and methods
WO2020013851A1 (en) 2018-07-13 2020-01-16 Corning Incorporated Fluidic devices including microplates with interconnected wells
CN111051493B (zh) 2018-07-13 2023-11-03 康宁股份有限公司 具有稳定器装置的细胞培养容器
WO2020013847A1 (en) 2018-07-13 2020-01-16 Corning Incorporated Microcavity dishes with sidewall including liquid medium delivery surface
JP7369417B2 (ja) * 2019-02-26 2023-10-26 国立大学法人東北大学 細胞培養用インサート及び電気刺激用培養装置
US20210301245A1 (en) 2020-03-29 2021-09-30 Agilent Technologies, Inc. Systems and methods for electronically and optically monitoring biological samples
US12498294B2 (en) 2022-01-24 2025-12-16 123 SEE, Inc. Binocular auto-lensmeter

Family Cites Families (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US67A (en) * 1836-10-24 robert mayo and robert mills
US3856633A (en) 1971-01-07 1974-12-24 Foxboro Co Concentration measurements utilizing coulometric generation of reagents
US3799743A (en) * 1971-11-22 1974-03-26 Alexander James Stable lysis responsive lipid bilayer
US4062750A (en) 1974-12-18 1977-12-13 James Francis Butler Thin film electrochemical electrode and cell
DE2502621C3 (de) 1975-01-23 1978-09-14 Kernforschungsanlage Juelich Gmbh, 5170 Juelich Messung elastischer und dielektrischer Eigenschaften der Membran lebender Zellen
FR2353856A1 (fr) 1976-06-02 1977-12-30 Chateau Guy Ruban destine a servir de support a une reaction par exemple chimique ou biochimique, et procede d'analyse le mettant en oeuvre
US4111754A (en) 1976-11-29 1978-09-05 Hydow Park Immunological testing devices and methods
US4128456A (en) 1977-10-11 1978-12-05 Lee Kai S Suction electrode for intracellular potential measurement
US4225410A (en) 1978-12-04 1980-09-30 Technicon Instruments Corporation Integrated array of electrochemical sensors
US4456522A (en) 1981-09-23 1984-06-26 Critikon, Inc. Support and anchoring mechanism for membranes in selectively responsive field effect devices
DE3144003C2 (de) 1981-11-04 1984-11-08 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Meßanordnung für extrem kleine Ströme
US4441507A (en) 1981-11-30 1984-04-10 Morris Steffin High speed single electrode membrane voltage clamp
IL68507A (en) 1982-05-10 1986-01-31 Univ Bar Ilan System and methods for cell selection
US5310674A (en) 1982-05-10 1994-05-10 Bar-Ilan University Apertured cell carrier
US4490216A (en) 1983-02-03 1984-12-25 Molecular Devices Corporation Lipid membrane electroanalytical elements and method of analysis therewith
EP0162907B1 (en) 1983-11-08 1992-01-15 Bar Ilan University System and methods for cell selection
US4661235A (en) 1984-08-03 1987-04-28 Krull Ulrich J Chemo-receptive lipid based membrane transducers
US4952518A (en) 1984-10-01 1990-08-28 Cetus Corporation Automated assay machine and assay tray
JPS61247965A (ja) 1985-04-25 1986-11-05 Susumu Kogyo Kk 酵素免疫測定法
US4897426A (en) * 1986-03-06 1990-01-30 New York University Method for blocking calcium channels
US5026649A (en) * 1986-03-20 1991-06-25 Costar Corporation Apparatus for growing tissue cultures in vitro
US5110556A (en) 1986-10-28 1992-05-05 Costar Corporation Multi-well test plate
JP2662215B2 (ja) 1986-11-19 1997-10-08 株式会社日立製作所 細胞保持装置
US4911806A (en) 1987-02-27 1990-03-27 Biotronics Method and apparatus for separating particles in liquid suspension utilizing oscillating electric and magnetic fields
US5079600A (en) 1987-03-06 1992-01-07 Schnur Joel M High resolution patterning on solid substrates
US5001048A (en) 1987-06-05 1991-03-19 Aurthur D. Little, Inc. Electrical biosensor containing a biological receptor immobilized and stabilized in a protein film
US4812221A (en) 1987-07-15 1989-03-14 Sri International Fast response time microsensors for gaseous and vaporous species
US5169600A (en) 1987-07-15 1992-12-08 Fuji Photo Film Co., Ltd. Biochemical analysis apparatus for incubating and analyzing test sites on a long tape test film
US4874500A (en) 1987-07-15 1989-10-17 Sri International Microelectrochemical sensor and sensor array
WO1989001159A1 (en) * 1987-07-27 1989-02-09 Commonwealth Scientific And Industrial Research Or Receptor membranes
US5111221A (en) 1988-05-13 1992-05-05 United States Of America As Represented By The Secretary Of The Navy Receptor-based sensor
US5225374A (en) * 1988-05-13 1993-07-06 The United States Of America As Represented By The Secretary Of The Navy Method of fabricating a receptor-based sensor
US4874499A (en) 1988-05-23 1989-10-17 Massachusetts Institute Of Technology Electrochemical microsensors and method of making such sensors
JP2695024B2 (ja) * 1988-08-18 1997-12-24 オーストラリアン メンブレイン アンド バイオテクノロジィ リサーチ インスティチュート リミテッド イオンチャンネル膜バイオセンサーの感受性およびイオン選択性の改善
EP0432188B1 (en) * 1988-08-18 1996-03-27 AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY RESEARCH INSTITUTE LTD. Commonwealth Scientific and Industrial Research Organization Improvements in sensitivity and selectivity of ion channel membrane biosensors
FR2637687B1 (fr) 1988-10-11 1991-01-11 Inst Textile De France Dispositif a usage unique pour tests biologiques
CA2045640C (en) 1989-01-27 1999-01-05 Bruce Andrew Cornell Receptor membranes and ionophore gating
US4912060A (en) 1989-02-17 1990-03-27 World Precision Instruments, Inc. Method and apparatus for electrical testing of membranes
US5262128A (en) 1989-10-23 1993-11-16 The United States Of America As Represented By The Department Of Health And Human Services Array-type multiple cell injector
US5368712A (en) * 1989-11-02 1994-11-29 Synporin Technologies, Inc. Biologically mimetic synthetic ion channel transducers
US5229163A (en) 1989-12-21 1993-07-20 Hoffmann-La Roche Inc. Process for preparing a microtiter tray for immunometric determinations
US5041266A (en) 1989-12-21 1991-08-20 Hoffmann-La Roche Inc. Tray for immunometric determinations
IL93020A (en) * 1990-01-09 1995-06-29 Yeda Res & Dev Biosensors comprising a lipid bilayer doped with ion channels anchored to a recording electrode by bridging molecules
US5750015A (en) 1990-02-28 1998-05-12 Soane Biosciences Method and device for moving molecules by the application of a plurality of electrical fields
FR2659347B1 (fr) 1990-03-12 1994-09-02 Agronomique Inst Nat Rech Dispositif de culture de cellules assurant leur immobilisation.
AU656520B2 (en) 1990-03-12 1995-02-09 Institut National De La Recherche Agronomique Process for the artificial stimulation of cells and cyte culture device
FR2660323B1 (fr) * 1990-03-30 1992-07-24 Bertin & Cie Dispositif de culture cellulaire.
US5470743A (en) * 1991-03-06 1995-11-28 Becton, Dickinson And Company Transmembrane cell culture device
JPH04338240A (ja) 1991-05-14 1992-11-25 Kiminori Ito 低温電離プラズマを利用したマイクロピペットポリッシングによるパッチクランプ法の高能率化
US5460945A (en) * 1991-05-30 1995-10-24 Center For Blood Research, Inc. Device and method for analysis of blood components and identifying inhibitors and promoters of the inflammatory response
US5173158A (en) * 1991-07-22 1992-12-22 Schmukler Robert E Apparatus and methods for electroporation and electrofusion
US5187096A (en) 1991-08-08 1993-02-16 Rensselaer Polytechnic Institute Cell substrate electrical impedance sensor with multiple electrode array
JP3095464B2 (ja) * 1991-08-08 2000-10-03 宇宙開発事業団 細胞培養装置
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
JP2869246B2 (ja) 1992-03-26 1999-03-10 三洋電機株式会社 神経モデル素子
US5508200A (en) 1992-10-19 1996-04-16 Tiffany; Thomas Method and apparatus for conducting multiple chemical assays
US5810725A (en) 1993-04-16 1998-09-22 Matsushita Electric Industrial Co., Ltd. Planar electrode
US6258325B1 (en) * 1993-04-19 2001-07-10 Ashok Ramesh Sanadi Method and apparatus for preventing cross-contamination of multi-well test plates
WO1994025862A1 (en) 1993-05-04 1994-11-10 Washington State University Research Foundation Biosensor substrate for mounting bilayer lipid membrane containing a receptor
US5415747A (en) 1993-08-16 1995-05-16 Hewlett-Packard Company Capillary electrophoresis using zwitterion-coated capillary tubes
US6225059B1 (en) 1993-11-01 2001-05-01 Nanogen, Inc. Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US6068818A (en) 1993-11-01 2000-05-30 Nanogen, Inc. Multicomponent devices for molecular biological analysis and diagnostics
US6287517B1 (en) 1993-11-01 2001-09-11 Nanogen, Inc. Laminated assembly for active bioelectronic devices
US6099803A (en) 1994-07-07 2000-08-08 Nanogen, Inc. Advanced active electronic devices for molecular biological analysis and diagnostics
DE4400955C2 (de) 1993-12-23 1999-04-01 Fraunhofer Ges Forschung Adhäsionssteuerbare Oberflächenstruktur
US5547833A (en) * 1994-01-04 1996-08-20 Intracel Corporation Radial flow assay, delivering member, test kit, and methods
US5563067A (en) 1994-06-13 1996-10-08 Matsushita Electric Industrial Co., Ltd. Cell potential measurement apparatus having a plurality of microelectrodes
US5521702A (en) * 1994-06-14 1996-05-28 Salamon; Zdzislaw Reusable biocompatible interface for immobilization of materials on a solid support
US6071394A (en) 1996-09-06 2000-06-06 Nanogen, Inc. Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
US6403367B1 (en) 1994-07-07 2002-06-11 Nanogen, Inc. Integrated portable biological detection system
US5585249A (en) * 1994-10-03 1996-12-17 Board Of Trustees Operating Michigan State University Polyhydroxybutyrate and polyphosphate membranes with channels
US5643796A (en) 1994-10-14 1997-07-01 University Of Washington System for sensing droplet formation time delay in a flow cytometer
AT402935B (de) * 1994-10-19 1997-09-25 Pittner Fritz Biorekognitions-gesteuerter, ionenfluss-modulirender biosensor
CA2203886C (en) * 1994-10-28 2003-09-02 Soren-Peter Olesen Patch clamp apparatus and technique having high throughput and low fluid volume requirements
US5955352A (en) 1994-12-22 1999-09-21 Showa Yakuhin Kako Co., Ltd. Instruments for chemical and microbiological tests
US5795782A (en) 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US5583037A (en) * 1995-03-30 1996-12-10 Becton, Dickinson And Company Trans-membrane co-culture insert and method for using
CN1181720A (zh) * 1995-04-25 1998-05-13 伊萝莉公司 可远程编程的存储器材料及其应用
JP3643863B2 (ja) 1995-08-09 2005-04-27 アークレイ株式会社 液体保持具とその製造方法
DE19529371C3 (de) 1995-08-10 2003-05-28 Nmi Univ Tuebingen Mikroelektroden-Anordnung
AU1059997A (en) * 1995-11-08 1997-05-29 Trustees Of Boston University Cellular physiology workstations for automated data acquisition and perfusion control
DE19544127C1 (de) 1995-11-27 1997-03-20 Gimsa Jan Dr Verfahren und Vorrichtung zur Erzeugung von Resonanzerscheinungen in Partikelsuspensionen und ihre Verwendung
WO1997020203A1 (de) 1995-11-28 1997-06-05 Thomas Schalkhammer Neuartige membranen und membran-dna/rna-sensoren
DE19601054C1 (de) 1996-01-05 1997-04-10 Inst Bioprozess Analysenmesst Verfahren und Vorrichtung zur Bestimmung von Parametern von Partikeln in Elektrolyten
AU1360297A (en) 1996-01-11 1997-08-01 Australian Membrane And Biotechnology Research Institute Ion channel sensor typing
DE19605830C1 (de) 1996-01-22 1997-02-13 Fraunhofer Ges Forschung Lagestabile Positionierung aktiv beweglicher Einzeller
JPH09211010A (ja) 1996-02-06 1997-08-15 Bunshi Bio Photonics Kenkyusho:Kk 電気生理特性測定装置
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
CA2257287A1 (en) 1996-05-30 1997-12-04 D. Lansing Taylor Miniaturized cell array methods and apparatus for cell-based screening
US6103479A (en) 1996-05-30 2000-08-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6235520B1 (en) 1996-06-27 2001-05-22 Cellstat Technologies, Inc. High-throughput screening method and apparatus
DE19628928A1 (de) 1996-07-18 1998-01-22 Basf Ag Feste Träger für analytische Meßverfahren, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung
DE19646505A1 (de) 1996-11-12 1998-05-14 Itt Ind Gmbh Deutsche Vorrichtung zur Durchführung von Untersuchungen an Zellproben und dergleichen
DE19712309A1 (de) 1996-11-16 1998-05-20 Nmi Univ Tuebingen Mikroelementenanordnung, Verfahren zum Kontaktieren von in einer flüssigen Umgebung befindlichen Zellen und Verfahren zum Herstellen einer Mikroelementenanordnung
EP0938674B1 (de) 1996-11-16 2005-06-01 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen in Reutlingen Stiftung Bürgerlichen Rechts Mikroelementenanordnung, verfahren zum kontaktieren von in einer flüssigen umgebung befindlichen zellen und verfahren zum herstellen einer mikroelementenanordnung
ATE322010T1 (de) 1996-11-29 2006-04-15 Anordnungen von unabhängig voneinander ansteuerbaren, gestützten flüssigbilayer- membranen und ihre anwendungsverfahren
US5904824A (en) 1997-03-07 1999-05-18 Beckman Instruments, Inc. Microfluidic electrophoresis device
US5958345A (en) 1997-03-14 1999-09-28 Moxtek, Inc. Thin film sample support
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
AU729397B2 (en) 1997-05-01 2001-02-01 Sophion Bioscience A/S An automatic electrode positioning apparatus
US5981268A (en) * 1997-05-30 1999-11-09 Board Of Trustees, Leland Stanford, Jr. University Hybrid biosensors
SE9702112D0 (sv) 1997-06-04 1997-06-04 Holdingbolaget Vid Goeteborgs Method and apparatus for detection of a receptor antagonist
GB9712386D0 (en) 1997-06-14 1997-08-13 Univ Coventry Biosensor
US6163719A (en) 1997-09-09 2000-12-19 Sherman; Adam Jacob Biological membrane voltage estimator
US6207031B1 (en) 1997-09-15 2001-03-27 Whitehead Institute For Biomedical Research Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device
AU744879B2 (en) 1997-09-19 2002-03-07 Aclara Biosciences, Inc. Apparatus and method for transferring liquids
US6070004A (en) 1997-09-25 2000-05-30 Siemens Aktiengesellschaft Method of maximizing chip yield for semiconductor wafers
DE19744649C2 (de) 1997-10-09 2003-03-27 Fraunhofer Ges Forschung Verfahren zur Messung bioelektrischer Signale von Zellen nach der Patch-Clamp-Methode sowie Verwendung einer Vorrichtung hierzu
DE19753598C1 (de) 1997-12-03 1999-07-01 Micronas Intermetall Gmbh Vorrichtung zum Messen physiologischer Parameter
DE59801410D1 (de) 1997-12-17 2001-10-11 Ecole Polytech Positionierung und elektrophysiologische charakterisierung einzelner zellen und rekonstituierter membransysteme auf mikrostrukturierten trägern
DE19841337C1 (de) 1998-05-27 1999-09-23 Micronas Intermetall Gmbh Verfahren und Vorrichtung zur intrazellulären Manipulation einer biologischen Zelle
EP0962524B1 (de) 1998-05-27 2004-11-03 Micronas GmbH Verfahren und Vorrichtung zur intrazellulären Manipulation einer biologischen Zelle
GB9812783D0 (en) 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
US6787111B2 (en) 1998-07-02 2004-09-07 Amersham Biosciences (Sv) Corp. Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US20020119579A1 (en) 1998-07-14 2002-08-29 Peter Wagner Arrays devices and methods of use thereof
US6132582A (en) 1998-09-14 2000-10-17 The Perkin-Elmer Corporation Sample handling system for a multi-channel capillary electrophoresis device
CA2348002A1 (en) 1998-10-27 2000-05-04 Malcolm W. Mcgeoch Biological ion channels in nanofabricated detectors
US6267872B1 (en) 1998-11-06 2001-07-31 The Regents Of The University Of California Miniature support for thin films containing single channels or nanopores and methods for using same
US6064260A (en) 1998-12-04 2000-05-16 Lucent Technologies, Inc. RF amplifier network with a redundant power supply
US7384733B1 (en) 1998-12-05 2008-06-10 Xention Discovery Limited Interface patch clamping
US6377057B1 (en) 1999-02-18 2002-04-23 The Board Of Trustees Of The Leland Stanford Junior University Classification of biological agents according to the spectral density signature of evoked changes in cellular electric potential
CN1185492C (zh) 1999-03-15 2005-01-19 清华大学 可单点选通式微电磁单元阵列芯片、电磁生物芯片及应用
US6927049B2 (en) 1999-07-21 2005-08-09 The Regents Of The University Of California Cell viability detection using electrical measurements
US6488829B1 (en) 1999-08-05 2002-12-03 Essen Instruments Inc High-throughput electrophysiological measurement apparatus
US6682649B1 (en) 1999-10-01 2004-01-27 Sophion Bioscience A/S Substrate and a method for determining and/or monitoring electrophysiological properties of ion channels
JP3525837B2 (ja) 1999-12-24 2004-05-10 株式会社日立製作所 電気生理自動計測装置及び電気生理自動計測方法
GB0006748D0 (en) 2000-03-21 2000-05-10 Cenes Ltd Improved interface patch clamping
GB0013584D0 (en) 2000-06-06 2000-07-26 Cenes Ltd Automated flow patch-clamp system
US6455007B1 (en) 2000-06-13 2002-09-24 Symyx Technologies, Inc. Apparatus and method for testing compositions in contact with a porous medium
US7312043B2 (en) 2000-07-10 2007-12-25 Vertex Pharmaceuticals (San Diego) Llc Ion channel assay methods
US6699665B1 (en) 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays
US6815197B2 (en) 2001-02-16 2004-11-09 Multi Channel System Mcs Gmbh Apparatus for conducting electrophysiological measurements on cells
PT1427528E (pt) 2001-05-30 2006-09-29 Biolex Inc Placa e processo para filtragem com caudal de saida elevado
JP2005528582A (ja) 2001-09-07 2005-09-22 コーニング インコーポレイテッド ハイスループット分析のためのマイクロカラム・プラットフォームに基づくアレイ
US20040191621A1 (en) 2003-03-24 2004-09-30 Medtronic, Inc. Polyimide protected battery feedthrough
US20050148064A1 (en) 2003-12-29 2005-07-07 Intel Corporation Microfluid molecular-flow fractionator and bioreactor with integrated active/passive diffusion barrier
US7297552B2 (en) 2004-04-08 2007-11-20 Sysmex Corporation Instruments for forming an immobilized sample on a porous membrane, and methods for quantifying target substances in immobilized samples

Also Published As

Publication number Publication date
EP1084410A1 (en) 2001-03-21
ES2249041T3 (es) 2006-03-16
DK1084410T3 (da) 2006-01-02
PL345272A1 (en) 2001-12-03
US8759017B2 (en) 2014-06-24
US20150068925A1 (en) 2015-03-12
DK1084410T5 (da) 2009-12-21
ATE302951T1 (de) 2005-09-15
US20160054298A9 (en) 2016-02-25
AU4283599A (en) 2000-01-05
CA2334770A1 (en) 1999-12-23
DE69940707D1 (de) 2009-05-20
US20110048939A1 (en) 2011-03-03
EP1084410B1 (en) 2005-08-24
EP1621888A1 (en) 2006-02-01
DE69926883T2 (de) 2006-06-01
US20130288289A1 (en) 2013-10-31
US20050221282A1 (en) 2005-10-06
WO1999066329A1 (en) 1999-12-23
HUP0102915A3 (en) 2006-02-28
EP1621888B1 (en) 2009-04-08
JP4499284B2 (ja) 2010-07-07
US8449825B2 (en) 2013-05-28
DE69926883T3 (de) 2010-03-11
IL140199A (en) 2007-02-11
GB9812783D0 (en) 1998-08-12
AU768862B2 (en) 2004-01-08
DE69926883D1 (de) 2005-09-29
DK1621888T3 (da) 2009-07-20
ATE428115T1 (de) 2009-04-15
HUP0102915A2 (hu) 2001-12-28
ZA200007296B (en) 2001-06-19
IL140199A0 (en) 2002-02-10
PL201770B1 (pl) 2009-05-29
NO20006295D0 (no) 2000-12-11
CA2334770C (en) 2011-04-12
JP2002518678A (ja) 2002-06-25
US7846389B2 (en) 2010-12-07
MXPA00012345A (es) 2002-04-24
US10006902B2 (en) 2018-06-26
EP1084410B3 (en) 2009-08-12
US6936462B1 (en) 2005-08-30

Similar Documents

Publication Publication Date Title
NO20006295L (no) Struktur til anvendelse i screeningsprosess, screeningsapparat som omfatter strukturen og anvendelse av strukturen i screening.
DE69837544D1 (de) Testgerät und methode zur entdeckung von analyten in proben
DE60326482D1 (de) Testverfahren für zustandsabhängige calciumkanal-agonisten/-antagonisten
WO2008049133A3 (en) Method for creating s/tem sample and sample structure
ATE343425T1 (de) Fasermatrix zum zusammenbringen von chemischen stoffen, sowie verfahren zur herstellung und anwendung davon
SG131861A1 (en) Methods and systems for integrity testing of porous materials
ATE220341T1 (de) Verfahren zur trennung doppelsträngiger dna von einzelsträngiger dna oder rna
WO2003100390A3 (en) High throughput microbalance and methods of using same
DE60044078D1 (de) Screeningverfahren mit porösen mikrokügelchen und zusammensetzungen
ATE348152T1 (de) Verfahren zum screening von diabetes- heilverfahren
EP1088229A4 (en) HIGH THROUGHPUT METHODS, SYSTEMS AND APPARATUS FOR CELL SCREENING TEST
ATE434053T1 (de) Elektrochemische nachweissystemen
AU2003303886A1 (en) Method for inspection, process for making analytic piece, method for analysis, analyzer, process for producing soi wafer, and soi wafer
FI20050385A0 (fi) Menetelmä ja laitteisto kiinteän aineen liuottamiseksi nesteeseen
WO2004077015A3 (en) Method for analysis of contaminants in a process fluid stream
ATE239274T1 (de) Proteom-analyse zum charakterisieren von auf- und abgeregelten proteinen in biologischen proben
ATE235307T1 (de) Thermomembranverfahren und -vorrichtung
WO2001073126A3 (en) Diagnostic devices containing porous material
MXPA03011898A (es) Ensayo de seleccion in vitro para ?- secretasa.
WO2001032829A3 (en) Methods to screen microorganisms or gene libraries for products secreted from a cell
DE69817818D1 (de) Einstufige vorrichtung und verfahren zur konzentration und säuberung biologischer moleküle
DE60036794D1 (de) Proteomabbau
DE50208261D1 (de) Verfahren zur verringerung einer adsorptionsneigung von molekülen oder biologischen zellen an einer materialoberfläche
WO2002076608A3 (de) Verfahren zur herstellung eines arrays zur detektion von komponenten aus einer biologischen probe
DE602004010364D1 (de) Enzymsubstrate, diese enthaltende kulturmedien und deren verwendung zum nachweis von aminopeptidaseaktivität und/oder zur differenzierung von grampositiven bakterien von gramnegativenbakterien

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application