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NO20003671L - 4-(2-keto-1-benzimidazolinyl)piperidin-forbindelser som orl1- reseptor agonister - Google Patents

4-(2-keto-1-benzimidazolinyl)piperidin-forbindelser som orl1- reseptor agonister

Info

Publication number
NO20003671L
NO20003671L NO20003671A NO20003671A NO20003671L NO 20003671 L NO20003671 L NO 20003671L NO 20003671 A NO20003671 A NO 20003671A NO 20003671 A NO20003671 A NO 20003671A NO 20003671 L NO20003671 L NO 20003671L
Authority
NO
Norway
Prior art keywords
benzimidazolinyl
keto
receptor agonists
piperidine compounds
aryl
Prior art date
Application number
NO20003671A
Other languages
English (en)
Norwegian (no)
Other versions
NO20003671D0 (no
Inventor
Fumitaka Ito
Hiroshi Kondo
Hirohide Noguchi
Yoriko Ohashi
Tatsuya Yamagishi
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO20003671D0 publication Critical patent/NO20003671D0/no
Publication of NO20003671L publication Critical patent/NO20003671L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
NO20003671A 1998-01-19 2000-07-18 4-(2-keto-1-benzimidazolinyl)piperidin-forbindelser som orl1- reseptor agonister NO20003671L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB9800069 1998-01-19
PCT/IB1999/000012 WO1999036421A1 (fr) 1998-01-19 1999-01-08 Composes de 4-(2-ceto-1-benzimidazolinyl)piperidine, utiles comme agonistes du recepteur orl1

Publications (2)

Publication Number Publication Date
NO20003671D0 NO20003671D0 (no) 2000-07-18
NO20003671L true NO20003671L (no) 2000-09-18

Family

ID=11004651

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20003671A NO20003671L (no) 1998-01-19 2000-07-18 4-(2-keto-1-benzimidazolinyl)piperidin-forbindelser som orl1- reseptor agonister

Country Status (30)

Country Link
US (1) US6423725B1 (fr)
EP (1) EP1049689B1 (fr)
JP (1) JP3342478B2 (fr)
CN (1) CN1288464A (fr)
AP (1) AP9901442A0 (fr)
AR (1) AR014421A1 (fr)
AT (1) ATE219772T1 (fr)
AU (1) AU1679099A (fr)
BG (1) BG104670A (fr)
BR (1) BR9907104A (fr)
CA (1) CA2317462C (fr)
CO (1) CO4990962A1 (fr)
DE (1) DE69901934T2 (fr)
DK (1) DK1049689T3 (fr)
EA (1) EA200000683A1 (fr)
ES (1) ES2175925T3 (fr)
GT (1) GT199900008A (fr)
IL (1) IL137149A0 (fr)
IS (1) IS5539A (fr)
MA (1) MA26598A1 (fr)
NO (1) NO20003671L (fr)
OA (1) OA11445A (fr)
PA (1) PA8467101A1 (fr)
PE (1) PE20000166A1 (fr)
PL (1) PL342046A1 (fr)
PT (1) PT1049689E (fr)
TN (1) TNSN99006A1 (fr)
TR (1) TR200002090T2 (fr)
WO (1) WO1999036421A1 (fr)
ZA (1) ZA99314B (fr)

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US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
EP0997464B1 (fr) * 1998-10-23 2005-02-16 Pfizer Inc. 1,3,8-Triazaspiro[4,5] decanones utiles comme agonistes du récepteur orl1
WO2000031061A1 (fr) * 1998-11-20 2000-06-02 Banyu Pharmaceutical Co., Ltd. Derives de 2-oxo-imidazole
SE9903544D0 (sv) 1999-10-01 1999-10-01 Astra Pharma Prod Novel compounds
EP1221443B1 (fr) 1999-10-13 2004-09-01 Banyu Pharmaceutical Co., Ltd. Derives d'imidazolidinone a substitution
WO2001039767A1 (fr) 1999-12-06 2001-06-07 Euro-Celtique, S.A. Composes amino tertiaires presentant une affinite pour le recepteur opioide
WO2001039775A1 (fr) * 1999-12-06 2001-06-07 Euro-Celtique, S.A. Composes de benzimidazole a affinite vis-a-vis du recepteur de la nociceptine
US6686370B2 (en) 1999-12-06 2004-02-03 Euro-Celtique S.A. Triazospiro compounds having nociceptin receptor affinity
GB2359078A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB2359081A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active thiazolopyrimidines
GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en) 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
SE0003828D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
JP4155029B2 (ja) * 2000-11-15 2008-09-24 萬有製薬株式会社 ベンズイミダゾール誘導体
SE0101322D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
SI1385514T1 (sl) 2001-04-18 2009-04-30 Euro Celtique Sa Spiroindenske in spiroindanske spojine
CA2444634C (fr) 2001-04-18 2011-06-07 R. Richard Goehring Composes de spiropyrazole
US6861421B2 (en) * 2001-04-18 2005-03-01 Euro-Celtique S.A Nociceptin analogs
EP2172468A1 (fr) * 2001-04-18 2010-04-07 Euro-Celtique S.A. Composés de benzimidazolone
DK1598339T3 (da) * 2001-04-18 2009-09-28 Euro Celtique Sa 1-(4-amino-cyclohexyl)-1,3-dihydro-2H-benzimidazol-2-on derivater og beslægtede forbindelser som nociceptin analoger og ORL1-ligander til behandling af smerte
DE10123163A1 (de) * 2001-05-09 2003-01-16 Gruenenthal Gmbh Substituierte Cyclohexan-1,4-diaminderivate
JP3896309B2 (ja) 2001-07-09 2007-03-22 ファイザー株式会社 プロテインキナーゼｃ阻害物質としてのピラゾロキノリノン誘導体
DK1491212T3 (da) 2002-03-29 2012-10-29 Mitsubishi Tanabe Pharma Corp Middel til behandling af søvnforstyrrelser
JP2005289816A (ja) 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
GB0221828D0 (en) 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
WO2004043902A1 (fr) 2002-11-12 2004-05-27 Grünenthal GmbH Derives de 4-hydroxymethyl-1-aryl-cyclohexylamine
SA04250305B1 (ar) * 2003-09-25 2008-06-02 سولفاي فارماسوتيكالز بي . في مشتقات بنزيميدازولون cenzimidazolone وكينازولينون quinazolinone كمساعادات على مستقبلات ORL1 البشرية
AR045843A1 (es) 2003-10-03 2005-11-16 Solvay Pharm Bv Derivados de bencimidazolonas y quinazolinonas sustituidas con hidronopol como agonistas en receptores orl 1 humanos
GB0328243D0 (en) 2003-12-05 2004-01-07 Astrazeneca Ab Methods
US7300947B2 (en) * 2005-07-13 2007-11-27 Banyu Pharmaceutical Co., Ltd. N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives
AR054816A1 (es) * 2005-07-13 2007-07-18 Banyu Pharma Co Ltd Derivados de n-dihidroxialquil 2-oxo- imidazol sustituidos
US20090111778A1 (en) * 2005-11-18 2009-04-30 Richard Apodaca 2-Keto-Oxazoles as Modulators of Fatty Acid Amide Hydrolase
JP2009525269A (ja) 2006-01-30 2009-07-09 ユーロ−セルティーク エス．エイ． カルシウムチャネルブロッカーとしての環状尿素化合物
GB0605784D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
GB0605786D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
WO2008050698A2 (fr) 2006-10-16 2008-05-02 Mitsubishi Tanabe Pharma Corporation Agent de prévention ou de traitement de la toxicomanie
CA2675419C (fr) * 2007-01-16 2013-11-12 Purdue Pharma L.P. Composes de piperidine substituee heterocycliques et leurs utilisations
AU2008219980B2 (en) 2007-03-01 2012-01-12 Mitsubishi Tanabe Pharma Corporation Benzimidazole compound and pharmaceutical use thereof
RU2488585C2 (ru) 2007-08-31 2013-07-27 Пэдью Фарма Л.П. Замещенные пиперидиновые соединения хиноксалинового типа и их применение
US8119661B2 (en) 2007-09-11 2012-02-21 Astrazeneca Ab Piperidine derivatives and their use as muscarinic receptor modulators
TW201016675A (en) * 2008-09-16 2010-05-01 Mitsubishi Tanabe Pharma Corp Crystalline benzoimidazole compound and salt thereof
US20130085161A1 (en) * 2010-06-17 2013-04-04 Novartis Ag Piperidinyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
EP2976077A4 (fr) 2013-03-22 2016-11-30 Scripps Research Inst Benzimidazoles substitués en tant que modulateurs d'un récepteur de nociceptine
CN110139650A (zh) * 2016-11-28 2019-08-16 田边三菱制药株式会社 可卡因依赖症的治疗或防复发药
JP7281469B2 (ja) * 2018-01-19 2023-05-25 イドーシア ファーマシューティカルズ リミテッド Ｃ５ａ受容体調節剤
CN116496270B (zh) * 2022-01-27 2024-09-24 四川大学华西医院 一类4-氨基哌啶衍生物及其制备方法和用途
WO2025146193A1 (fr) * 2024-01-05 2025-07-10 宜昌人福药业有限责任公司 Dérivé de pipéridine substitué par cyclohexyle, composition pharmaceutique le comprenant et son utilisation

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US3318900A (en) 1964-05-06 1967-05-09 Janssen Pharmaceutica Nv Derivatives of benzimidazolinyl piperidine
JPS58180481A (ja) 1982-04-15 1983-10-21 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体
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US6258825B1 (en) 1997-05-30 2001-07-10 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazole derivatives

Also Published As

Publication number Publication date
CN1288464A (zh) 2001-03-21
BR9907104A (pt) 2000-10-24
AR014421A1 (es) 2001-02-28
EP1049689A1 (fr) 2000-11-08
MA26598A1 (fr) 2004-12-20
CA2317462C (fr) 2005-09-13
DK1049689T3 (da) 2002-07-22
OA11445A (en) 2004-04-30
EP1049689B1 (fr) 2002-06-26
ZA99314B (en) 2000-07-18
JP2002509148A (ja) 2002-03-26
AU1679099A (en) 1999-08-02
TNSN99006A1 (fr) 2005-11-10
EA200000683A1 (ru) 2000-12-25
GT199900008A (es) 2000-07-12
CA2317462A1 (fr) 1999-07-22
AP9901442A0 (en) 1999-03-31
WO1999036421A1 (fr) 1999-07-22
JP3342478B2 (ja) 2002-11-11
TR200002090T2 (tr) 2000-11-21
PE20000166A1 (es) 2000-03-07
PL342046A1 (en) 2001-05-21
ES2175925T3 (es) 2002-11-16
CO4990962A1 (es) 2000-12-26
IL137149A0 (en) 2001-07-24
PA8467101A1 (es) 2000-09-29
DE69901934T2 (de) 2002-11-07
US6423725B1 (en) 2002-07-23
IS5539A (is) 2000-06-16
ATE219772T1 (de) 2002-07-15
BG104670A (en) 2001-05-31
DE69901934D1 (de) 2002-08-01
PT1049689E (pt) 2002-09-30
NO20003671D0 (no) 2000-07-18

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