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TNSN99006A1 - 4-(2-ceto-1-benzimidazolinyl) piperidines nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

4-(2-ceto-1-benzimidazolinyl) piperidines nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
TNSN99006A1
TNSN99006A1 TNTNSN99006A TNSN99006A TNSN99006A1 TN SN99006 A1 TNSN99006 A1 TN SN99006A1 TN TNSN99006 A TNTNSN99006 A TN TNSN99006A TN SN99006 A TNSN99006 A TN SN99006A TN SN99006 A1 TNSN99006 A1 TN SN99006A1
Authority
TN
Tunisia
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
ceto
benzimidazolinyl
Prior art date
Application number
TNTNSN99006A
Other languages
English (en)
Inventor
Ito Fumitaka
Kondo Hiroshi
Noguchi Hirohide
Ohashi Yoriko
Yamagishi Tatsuya
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN99006A1 publication Critical patent/TNSN99006A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

-L'INVENTION CONCERNE UN COMPOSE DE FORMULE (I) DANS LAQUELLE R1, R2, R3, R4 ET R5 REPRESENTENT DIVERS RADICAUX. ELLE CONCERNE EGALEMENT UN PROCEDE POUR SA PREPARATION, AINSI QUE DES COMPOSITIONS PHARMACEUTIQUES LE CONTENANT. APPLICATION : UTILISATION POUR LE TRAITEMENT DE DIVERSES MALADIES, NOTAMMENT COMME ANALGESIQUE, CHEZ DES MAMMIFERES.
TNTNSN99006A 1998-01-19 1999-01-15 4-(2-ceto-1-benzimidazolinyl) piperidines nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant TNSN99006A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9800069 1998-01-19

Publications (1)

Publication Number Publication Date
TNSN99006A1 true TNSN99006A1 (fr) 2005-11-10

Family

ID=11004651

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN99006A TNSN99006A1 (fr) 1998-01-19 1999-01-15 4-(2-ceto-1-benzimidazolinyl) piperidines nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (30)

Country Link
US (1) US6423725B1 (fr)
EP (1) EP1049689B1 (fr)
JP (1) JP3342478B2 (fr)
CN (1) CN1288464A (fr)
AP (1) AP9901442A0 (fr)
AR (1) AR014421A1 (fr)
AT (1) ATE219772T1 (fr)
AU (1) AU1679099A (fr)
BG (1) BG104670A (fr)
BR (1) BR9907104A (fr)
CA (1) CA2317462C (fr)
CO (1) CO4990962A1 (fr)
DE (1) DE69901934T2 (fr)
DK (1) DK1049689T3 (fr)
EA (1) EA200000683A1 (fr)
ES (1) ES2175925T3 (fr)
GT (1) GT199900008A (fr)
IL (1) IL137149A0 (fr)
IS (1) IS5539A (fr)
MA (1) MA26598A1 (fr)
NO (1) NO20003671L (fr)
OA (1) OA11445A (fr)
PA (1) PA8467101A1 (fr)
PE (1) PE20000166A1 (fr)
PL (1) PL342046A1 (fr)
PT (1) PT1049689E (fr)
TN (1) TNSN99006A1 (fr)
TR (1) TR200002090T2 (fr)
WO (1) WO1999036421A1 (fr)
ZA (1) ZA99314B (fr)

Families Citing this family (47)

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US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
ATE289307T1 (de) * 1998-10-23 2005-03-15 Pfizer 1,3,8-triazaspiro(4,5) decanon verbindungen als orl1-receptor agonisten
WO2000031061A1 (fr) * 1998-11-20 2000-06-02 Banyu Pharmaceutical Co., Ltd. Derives de 2-oxo-imidazole
SE9903544D0 (sv) 1999-10-01 1999-10-01 Astra Pharma Prod Novel compounds
EP1221443B1 (fr) * 1999-10-13 2004-09-01 Banyu Pharmaceutical Co., Ltd. Derives d'imidazolidinone a substitution
DE60022226D1 (de) 1999-12-06 2005-09-29 Euro Celtique Sa Benzimidazolverbindungen die nociceptinrezeptoraffinität haben
WO2001039767A1 (fr) 1999-12-06 2001-06-07 Euro-Celtique, S.A. Composes amino tertiaires presentant une affinite pour le recepteur opioide
US6686370B2 (en) 1999-12-06 2004-02-03 Euro-Celtique S.A. Triazospiro compounds having nociceptin receptor affinity
GB2359078A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB2359081A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active thiazolopyrimidines
GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en) 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
SE0003828D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
CA2428787A1 (fr) * 2000-11-15 2002-05-23 Banyu Pharmaceutical Co., Ltd. Derives benzimidazoles
SE0101322D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
BR0209129A (pt) * 2001-04-18 2005-12-20 Euro Celtique Sa Compostos, composições farmacêuticas, métodos para tratamento de dores, métodos para modulação de uma resposta farmacológica e usos de compostos
WO2002085355A1 (fr) 2001-04-18 2002-10-31 Euro-Celtique, S.A. Composes de spiropyrazole
ATE413175T1 (de) 2001-04-18 2008-11-15 Euro Celtique Sa Spiroinden- und spiroindan-verbindungen
DK1385518T3 (da) * 2001-04-18 2008-10-27 Euro Celtique Sa Benzimidazolon-forbindelser
KR100855204B1 (ko) 2001-04-18 2008-09-01 유로-셀티크 소시에떼 아노뉨 노시셉틴 유사체
DE10123163A1 (de) * 2001-05-09 2003-01-16 Gruenenthal Gmbh Substituierte Cyclohexan-1,4-diaminderivate
JP3896309B2 (ja) 2001-07-09 2007-03-22 ファイザー株式会社 プロテインキナーゼｃ阻害物質としてのピラゾロキノリノン誘導体
EP1491212B1 (fr) * 2002-03-29 2012-08-08 Mitsubishi Tanabe Pharma Corporation Remede contre les troubles du sommeil
JP2005289816A (ja) * 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
GB0221828D0 (en) 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
ES2340766T3 (es) 2002-11-12 2010-06-09 Grunenthal Gmbh Derivados de 4-hidroximetil-1-aril-ciclohexilamina.
TW200519101A (en) 2003-09-25 2005-06-16 Solvay Pharm Bv Benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors
AR045843A1 (es) * 2003-10-03 2005-11-16 Solvay Pharm Bv Derivados de bencimidazolonas y quinazolinonas sustituidas con hidronopol como agonistas en receptores orl 1 humanos
GB0328243D0 (en) 2003-12-05 2004-01-07 Astrazeneca Ab Methods
AR054816A1 (es) * 2005-07-13 2007-07-18 Banyu Pharma Co Ltd Derivados de n-dihidroxialquil 2-oxo- imidazol sustituidos
US7300947B2 (en) * 2005-07-13 2007-11-27 Banyu Pharmaceutical Co., Ltd. N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives
WO2007061862A2 (fr) * 2005-11-18 2007-05-31 Janssen Pharmaceutica N.V. 2-ceto-oxazoles en tant que modulateurs d'amide d'acide gras hydrolase
EP1987009A1 (fr) 2006-01-30 2008-11-05 Euro-Celtique S.A. Composes cyclo-uree utilises en tant que bloqueurs des canaux calciques
GB0605784D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
GB0605786D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
CA2666630C (fr) 2006-10-16 2012-01-24 Mitsubishi Tanabe Pharma Corporation Agent de prevention ou de traitement de la toxicomanie
NZ578078A (en) * 2007-01-16 2011-11-25 Purdue Pharma Lp Heterocyclic-substituted piperidine as orl-1 ligands
CA2679530C (fr) 2007-03-01 2012-09-25 Mitsubishi Tanabe Pharma Corporation Compose de benzimidazole et utilisation pharmaceutique de celui-ci
BRPI0815327A2 (pt) 2007-08-31 2015-12-15 Purdue Pharma Lp "compostos de piperidina do tipo quinoxalina substituída e os usos destes"
US8119661B2 (en) 2007-09-11 2012-02-21 Astrazeneca Ab Piperidine derivatives and their use as muscarinic receptor modulators
TW201016675A (en) 2008-09-16 2010-05-01 Mitsubishi Tanabe Pharma Corp Crystalline benzoimidazole compound and salt thereof
WO2011157793A1 (fr) * 2010-06-17 2011-12-22 Novartis Ag Dérivés de 1,3‑dihydro-benzoimidazol-2-ylidène-amine à substitution pipéridinyle
US9656994B2 (en) 2013-03-22 2017-05-23 The Scripps Research Institute Substituted benzimidazoles as nociceptin receptor modulators
BR112019010719A2 (pt) * 2016-11-28 2019-10-01 Mitsubishi Tanabe Pharma Corp composição farmacêutica para tratar a dependência de cocaína ou prevenir a recaída da dependência de cocaína, métodos para tratar a dependência e para prevenir a recaída da dependência de cocaína de cocaína, uso de (r)-2-{3-[1-(5-metil-1,2,3,4-tetra-hidronaftalen-1-il)piperidina-4-il]-2,3-di-hidro-2-oxo-benzimidazol-1-il}-n-metilacetamida ou um sal farmaceuticamente aceitável do mesmo, e, (r)-2-{3-[1-(5-metil-1,2,3,4-tetra-hidronaftalen-1-il)piperidina-4-il]-2,3-di-hidro-2-oxo-benzimidazol-1-il}-n-metilacetamida ou um sal farmaceuticamente aceitável do mesmo.
WO2019141803A1 (fr) * 2018-01-19 2019-07-25 Idorsia Pharmaceuticals Ltd Modulateurs du récepteur c5a
CN116496270B (zh) * 2022-01-27 2024-09-24 四川大学华西医院 一类4-氨基哌啶衍生物及其制备方法和用途
TW202527948A (zh) * 2024-01-05 2025-07-16 大陸商宜昌人福藥業有限責任公司 一種環己基取代呱啶衍生物、包含其的藥物組合物及其用途

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CA2291094C (fr) 1997-05-30 2008-02-26 Banyu Pharmaceutical Co., Ltd. Derive de 2-0xoimidazole

Also Published As

Publication number Publication date
BR9907104A (pt) 2000-10-24
GT199900008A (es) 2000-07-12
US6423725B1 (en) 2002-07-23
EP1049689A1 (fr) 2000-11-08
CO4990962A1 (es) 2000-12-26
IS5539A (is) 2000-06-16
ES2175925T3 (es) 2002-11-16
BG104670A (en) 2001-05-31
MA26598A1 (fr) 2004-12-20
PT1049689E (pt) 2002-09-30
AP9901442A0 (en) 1999-03-31
AU1679099A (en) 1999-08-02
ATE219772T1 (de) 2002-07-15
NO20003671D0 (no) 2000-07-18
AR014421A1 (es) 2001-02-28
ZA99314B (en) 2000-07-18
DE69901934T2 (de) 2002-11-07
EP1049689B1 (fr) 2002-06-26
CN1288464A (zh) 2001-03-21
PL342046A1 (en) 2001-05-21
EA200000683A1 (ru) 2000-12-25
OA11445A (en) 2004-04-30
CA2317462C (fr) 2005-09-13
CA2317462A1 (fr) 1999-07-22
DE69901934D1 (de) 2002-08-01
JP2002509148A (ja) 2002-03-26
PE20000166A1 (es) 2000-03-07
TR200002090T2 (tr) 2000-11-21
WO1999036421A1 (fr) 1999-07-22
PA8467101A1 (es) 2000-09-29
DK1049689T3 (da) 2002-07-22
IL137149A0 (en) 2001-07-24
JP3342478B2 (ja) 2002-11-11
NO20003671L (no) 2000-09-18

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