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BR9907104A - Compostos de 4-(2-ceto-1-benzimidazolinil)piperidina como agonistas do receptor orl1 - Google Patents

Compostos de 4-(2-ceto-1-benzimidazolinil)piperidina como agonistas do receptor orl1

Info

Publication number
BR9907104A
BR9907104A BR9907104-5A BR9907104A BR9907104A BR 9907104 A BR9907104 A BR 9907104A BR 9907104 A BR9907104 A BR 9907104A BR 9907104 A BR9907104 A BR 9907104A
Authority
BR
Brazil
Prior art keywords
receptor agonists
benzimidazolinyl
keto
orl1 receptor
piperidine compounds
Prior art date
Application number
BR9907104-5A
Other languages
English (en)
Inventor
Fumitaka Ito
Hiroshi Kondo
Hirohide Noguchi
Yoriko Ohashi
Tatsuya Yamagishi
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BR9907104A publication Critical patent/BR9907104A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Patente de Invenção: <B>"COMPOSTOS DE 4-(2-CETO-1-BENZIMIDAZOLINIL) PIPERIDINA COMO AGONISTAS DO RECEPTOR ORL1"<D>. Um composto da fórmula: ou os seus sais farmaceuticamente aceitáveis, em que R¹, R², R³, R^ 4^ e R^ 5^ são aqui definidos, são úteis como agonistas do receptor ORL1 e úteis como analgésicos ou semelhantes em indivíduos mamíferos.
BR9907104-5A 1998-01-19 1999-01-08 Compostos de 4-(2-ceto-1-benzimidazolinil)piperidina como agonistas do receptor orl1 BR9907104A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB9800069 1998-01-19
PCT/IB1999/000012 WO1999036421A1 (en) 1998-01-19 1999-01-08 4-(2-keto-1-benzimidazolinyl)piperidine compounds as orl1-receptor agonists

Publications (1)

Publication Number Publication Date
BR9907104A true BR9907104A (pt) 2000-10-24

Family

ID=11004651

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9907104-5A BR9907104A (pt) 1998-01-19 1999-01-08 Compostos de 4-(2-ceto-1-benzimidazolinil)piperidina como agonistas do receptor orl1

Country Status (30)

Country Link
US (1) US6423725B1 (pt)
EP (1) EP1049689B1 (pt)
JP (1) JP3342478B2 (pt)
CN (1) CN1288464A (pt)
AP (1) AP9901442A0 (pt)
AR (1) AR014421A1 (pt)
AT (1) ATE219772T1 (pt)
AU (1) AU1679099A (pt)
BG (1) BG104670A (pt)
BR (1) BR9907104A (pt)
CA (1) CA2317462C (pt)
CO (1) CO4990962A1 (pt)
DE (1) DE69901934T2 (pt)
DK (1) DK1049689T3 (pt)
EA (1) EA200000683A1 (pt)
ES (1) ES2175925T3 (pt)
GT (1) GT199900008A (pt)
IL (1) IL137149A0 (pt)
IS (1) IS5539A (pt)
MA (1) MA26598A1 (pt)
NO (1) NO20003671L (pt)
OA (1) OA11445A (pt)
PA (1) PA8467101A1 (pt)
PE (1) PE20000166A1 (pt)
PL (1) PL342046A1 (pt)
PT (1) PT1049689E (pt)
TN (1) TNSN99006A1 (pt)
TR (1) TR200002090T2 (pt)
WO (1) WO1999036421A1 (pt)
ZA (1) ZA99314B (pt)

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US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
ES2237047T3 (es) * 1998-10-23 2005-07-16 Pfizer Inc. Compuestos de 1,3,8-triazaespiro(4,5)decanona como agonistas del receptor orl1.
AU1185300A (en) * 1998-11-20 2000-06-13 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazole derivatives
SE9903544D0 (sv) 1999-10-01 1999-10-01 Astra Pharma Prod Novel compounds
EP1221443B1 (en) * 1999-10-13 2004-09-01 Banyu Pharmaceutical Co., Ltd. Substituted imidazolidinone derivatives
AU2063201A (en) 1999-12-06 2001-06-12 Euro-Celtique S.A. Tertiary amino compounds having opioid receptor affinity
EP1537110B1 (en) 1999-12-06 2007-01-17 Euro-Celtique, S.A. Triazospiro compounds having nociceptin receptor affinity
WO2001039775A1 (en) * 1999-12-06 2001-06-07 Euro-Celtique, S.A. Benzimidazole compounds having nociceptin receptor affinity
GB2359078A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB2359081A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active thiazolopyrimidines
GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en) 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
SE0003828D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
AU2403802A (en) 2000-11-15 2002-05-27 Banyu Pharma Co Ltd Benzimidazole derivatives
SE0101322D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
CN1516584A (zh) 2001-04-18 2004-07-28 ŷ�����ǹɷ����޹�˾ 螺吡唑化合物
SI1975164T1 (sl) 2001-04-18 2010-05-31 Euro Celtique Sa Oktahidrobenzimidazolonske spojine kot analgetiki
CZ20032850A3 (cs) * 2001-04-18 2004-02-18 Euro-Celtique, S. A. Analogy nociceptinu
EP1379252A4 (en) * 2001-04-18 2005-11-02 Euro Celtique Sa Nociceptin Analogs
US6828440B2 (en) 2001-04-18 2004-12-07 Euro-Celtique, S.A. Spiroindene and spiroindane compounds
DE10123163A1 (de) 2001-05-09 2003-01-16 Gruenenthal Gmbh Substituierte Cyclohexan-1,4-diaminderivate
JP3896309B2 (ja) 2001-07-09 2007-03-22 ファイザー株式会社 プロテインキナーゼｃ阻害物質としてのピラゾロキノリノン誘導体
DK1491212T3 (da) 2002-03-29 2012-10-29 Mitsubishi Tanabe Pharma Corp Middel til behandling af søvnforstyrrelser
JP2005289816A (ja) * 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
GB0221828D0 (en) 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
AU2003296564A1 (en) 2002-11-12 2004-06-03 Grunenthal Gmbh 4-hydroxymethyl-1-aryl-cyclohexylamine derivatives
SA04250305B1 (ar) 2003-09-25 2008-06-02 سولفاي فارماسوتيكالز بي . في مشتقات بنزيميدازولون cenzimidazolone وكينازولينون quinazolinone كمساعادات على مستقبلات ORL1 البشرية
AR045843A1 (es) * 2003-10-03 2005-11-16 Solvay Pharm Bv Derivados de bencimidazolonas y quinazolinonas sustituidas con hidronopol como agonistas en receptores orl 1 humanos
GB0328243D0 (en) 2003-12-05 2004-01-07 Astrazeneca Ab Methods
AR054816A1 (es) * 2005-07-13 2007-07-18 Banyu Pharma Co Ltd Derivados de n-dihidroxialquil 2-oxo- imidazol sustituidos
US7300947B2 (en) * 2005-07-13 2007-11-27 Banyu Pharmaceutical Co., Ltd. N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives
US20090111778A1 (en) * 2005-11-18 2009-04-30 Richard Apodaca 2-Keto-Oxazoles as Modulators of Fatty Acid Amide Hydrolase
US8354434B2 (en) 2006-01-30 2013-01-15 Purdue Pharma L.P. Cyclourea compounds as calcium channel blockers
GB0605784D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
GB0605786D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
WO2008050698A2 (en) 2006-10-16 2008-05-02 Mitsubishi Tanabe Pharma Corporation Agent for prophylaxis or treatment of alcohol dependence or drug dependence
CN101595100B (zh) * 2007-01-16 2014-06-11 普渡制药公司 作为orl-1配体的杂环取代的哌啶
BRPI0808025A2 (pt) * 2007-03-01 2014-06-24 Mitsubishi Tanabe Pharma Corp Composto de benzimidazol e uso farmacêutico do mesmo
EP3564240B1 (en) 2007-08-31 2022-04-06 Purdue Pharma L.P. Piperidine intermediates
US8119661B2 (en) 2007-09-11 2012-02-21 Astrazeneca Ab Piperidine derivatives and their use as muscarinic receptor modulators
TW201016675A (en) * 2008-09-16 2010-05-01 Mitsubishi Tanabe Pharma Corp Crystalline benzoimidazole compound and salt thereof
JP2013532149A (ja) * 2010-06-17 2013-08-15 ノバルティス アーゲー ピペリジニル置換１，３−ジヒドロ−ベンゾイミダゾール−２−イリデンアミン誘導体
EP2976077A4 (en) 2013-03-22 2016-11-30 Scripps Research Inst SUBSTITUTED BENZIMIDAZOLE AS NOCICEPTIN RECEPTOR MODULATORS
CN110139650A (zh) * 2016-11-28 2019-08-16 田边三菱制药株式会社 可卡因依赖症的治疗或防复发药
EP3740476A1 (en) * 2018-01-19 2020-11-25 Idorsia Pharmaceuticals Ltd C5a receptor modulators
CN116496270B (zh) * 2022-01-27 2024-09-24 四川大学华西医院 一类4-氨基哌啶衍生物及其制备方法和用途
WO2025146193A1 (zh) * 2024-01-05 2025-07-10 宜昌人福药业有限责任公司 一种环己基取代哌啶衍生物、包含其的药物组合物及其用途

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Also Published As

Publication number Publication date
ZA99314B (en) 2000-07-18
EP1049689B1 (en) 2002-06-26
AR014421A1 (es) 2001-02-28
PA8467101A1 (es) 2000-09-29
DK1049689T3 (da) 2002-07-22
JP3342478B2 (ja) 2002-11-11
JP2002509148A (ja) 2002-03-26
TNSN99006A1 (fr) 2005-11-10
PL342046A1 (en) 2001-05-21
EA200000683A1 (ru) 2000-12-25
IS5539A (is) 2000-06-16
NO20003671L (no) 2000-09-18
PE20000166A1 (es) 2000-03-07
AU1679099A (en) 1999-08-02
GT199900008A (es) 2000-07-12
OA11445A (en) 2004-04-30
CA2317462A1 (en) 1999-07-22
DE69901934T2 (de) 2002-11-07
WO1999036421A1 (en) 1999-07-22
CA2317462C (en) 2005-09-13
BG104670A (en) 2001-05-31
EP1049689A1 (en) 2000-11-08
TR200002090T2 (tr) 2000-11-21
ES2175925T3 (es) 2002-11-16
DE69901934D1 (de) 2002-08-01
AP9901442A0 (en) 1999-03-31
PT1049689E (pt) 2002-09-30
US6423725B1 (en) 2002-07-23
IL137149A0 (en) 2001-07-24
ATE219772T1 (de) 2002-07-15
MA26598A1 (fr) 2004-12-20
CN1288464A (zh) 2001-03-21
NO20003671D0 (no) 2000-07-18
CO4990962A1 (es) 2000-12-26

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]