NL8001380A - Plasmide dna en werkwijze voor het verkrijgen daarvan. - Google Patents

Plasmide dna en werkwijze voor het verkrijgen daarvan. Download PDF

Info

Publication number: NL8001380A
Authority: NL; Netherlands
Prior art keywords: plasmid; puc8; mycelium; pure; dna
Prior art date: 1979-03-29

Application number

NL8001380A

Other languages

English (en)

Dutch (nl)

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-03-29

Filing date

1980-03-07

Publication date

1980-10-01

1980-03-07 Application filed by Upjohn Co filed Critical Upjohn Co

1980-10-01 Publication of NL8001380A publication Critical patent/NL8001380A/nl

Links

239000013612 plasmid Substances 0.000 title claims description 31
238000000034 method Methods 0.000 title claims description 8
244000005700 microbiome Species 0.000 claims description 12
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 8
108091008146 restriction endonucleases Proteins 0.000 claims description 7
239000004471 Glycine Substances 0.000 claims description 4
239000006166 lysate Substances 0.000 claims description 4
241000187438 Streptomyces fradiae Species 0.000 claims description 3
239000001963 growth medium Substances 0.000 claims 1
108020004414 DNA Proteins 0.000 description 20
108090000623 proteins and genes Proteins 0.000 description 9
239000013598 vector Substances 0.000 description 8
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
102000004190 Enzymes Human genes 0.000 description 5
108090000790 Enzymes Proteins 0.000 description 5
229930006000 Sucrose Natural products 0.000 description 5
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 5
229940088598 enzyme Drugs 0.000 description 5
239000005720 sucrose Substances 0.000 description 5
241000894006 Bacteria Species 0.000 description 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
239000000872 buffer Substances 0.000 description 4
229960005542 ethidium bromide Drugs 0.000 description 4
239000012634 fragment Substances 0.000 description 4
238000002955 isolation Methods 0.000 description 4
239000000047 product Substances 0.000 description 4
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
108020004511 Recombinant DNA Proteins 0.000 description 3
240000004808 Saccharomyces cerevisiae Species 0.000 description 3
241000187747 Streptomyces Species 0.000 description 3
241001655322 Streptomycetales Species 0.000 description 3
239000011543 agarose gel Substances 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
229910052799 carbon Inorganic materials 0.000 description 3
210000004027 cell Anatomy 0.000 description 3
238000010367 cloning Methods 0.000 description 3
ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 3
235000012054 meals Nutrition 0.000 description 3
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241000193830 Bacillus <bacterium> Species 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
JOCBASBOOFNAJA-UHFFFAOYSA-N N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid Chemical compound OCC(CO)(CO)NCCS(O)(=O)=O JOCBASBOOFNAJA-UHFFFAOYSA-N 0.000 description 2
239000001888 Peptone Substances 0.000 description 2
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IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
240000008042 Zea mays Species 0.000 description 2
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
235000002017 Zea mays subsp mays Nutrition 0.000 description 2
AIYUHDOJVYHVIT-UHFFFAOYSA-M caesium chloride Chemical compound [Cl-].[Cs+] AIYUHDOJVYHVIT-UHFFFAOYSA-M 0.000 description 2
FLJPGEWQYJVDPF-UHFFFAOYSA-L caesium sulfate Chemical compound [Cs+].[Cs+].[O-]S([O-])(=O)=O FLJPGEWQYJVDPF-UHFFFAOYSA-L 0.000 description 2
229960005091 chloramphenicol Drugs 0.000 description 2
WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 2
235000005822 corn Nutrition 0.000 description 2
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239000008103 glucose Substances 0.000 description 2
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230000007935 neutral effect Effects 0.000 description 2
235000019319 peptone Nutrition 0.000 description 2
239000013600 plasmid vector Substances 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
238000012360 testing method Methods 0.000 description 2
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
241001515965 unidentified phage Species 0.000 description 2
229920001817 Agar Polymers 0.000 description 1
241000186063 Arthrobacter Species 0.000 description 1
DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
108020004638 Circular DNA Proteins 0.000 description 1
229920002261 Corn starch Polymers 0.000 description 1
102000053602 DNA Human genes 0.000 description 1
102100033195 DNA ligase 4 Human genes 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
102100031780 Endonuclease Human genes 0.000 description 1
108010042407 Endonucleases Proteins 0.000 description 1
241000588722 Escherichia Species 0.000 description 1
241000192125 Firmicutes Species 0.000 description 1
241000606790 Haemophilus Species 0.000 description 1
101000927810 Homo sapiens DNA ligase 4 Proteins 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
108020005196 Mitochondrial DNA Proteins 0.000 description 1
102000016943 Muramidase Human genes 0.000 description 1
108010014251 Muramidase Proteins 0.000 description 1
108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
108091005804 Peptidases Proteins 0.000 description 1
102000035195 Peptidases Human genes 0.000 description 1
108010076181 Proinsulin Proteins 0.000 description 1
239000004365 Protease Substances 0.000 description 1
108700005075 Regulator Genes Proteins 0.000 description 1
102000006382 Ribonucleases Human genes 0.000 description 1
108010083644 Ribonucleases Proteins 0.000 description 1
102000005157 Somatostatin Human genes 0.000 description 1
108010056088 Somatostatin Proteins 0.000 description 1
235000019764 Soybean Meal Nutrition 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
239000007983 Tris buffer Substances 0.000 description 1
241000700605 Viruses Species 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
239000008272 agar Substances 0.000 description 1
238000000246 agarose gel electrophoresis Methods 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
238000003556 assay Methods 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
210000000988 bone and bone Anatomy 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
229940041514 candida albicans extract Drugs 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
230000006037 cell lysis Effects 0.000 description 1
239000006285 cell suspension Substances 0.000 description 1
238000012512 characterization method Methods 0.000 description 1
230000002759 chromosomal effect Effects 0.000 description 1
239000013599 cloning vector Substances 0.000 description 1
229910017052 cobalt Inorganic materials 0.000 description 1
239000010941 cobalt Substances 0.000 description 1
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000008120 corn starch Substances 0.000 description 1
235000012343 cottonseed oil Nutrition 0.000 description 1
239000012531 culture fluid Substances 0.000 description 1
238000012258 culturing Methods 0.000 description 1
238000011161 development Methods 0.000 description 1
230000018109 developmental process Effects 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
108010049705 endonuclease R Proteins 0.000 description 1
238000000855 fermentation Methods 0.000 description 1
230000004151 fermentation Effects 0.000 description 1
239000000499 gel Substances 0.000 description 1
230000014509 gene expression Effects 0.000 description 1
238000007429 general method Methods 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
238000003306 harvesting Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
239000008101 lactose Substances 0.000 description 1
238000000464 low-speed centrifugation Methods 0.000 description 1
230000002934 lysing effect Effects 0.000 description 1
229960000274 lysozyme Drugs 0.000 description 1
239000004325 lysozyme Substances 0.000 description 1
235000010335 lysozyme Nutrition 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
238000013507 mapping Methods 0.000 description 1
239000003550 marker Substances 0.000 description 1
235000013372 meat Nutrition 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
238000013508 migration Methods 0.000 description 1
230000005012 migration Effects 0.000 description 1
239000000203 mixture Substances 0.000 description 1
235000013379 molasses Nutrition 0.000 description 1
229910017464 nitrogen compound Inorganic materials 0.000 description 1
150000002830 nitrogen compounds Chemical class 0.000 description 1
238000010899 nucleation Methods 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
238000000746 purification Methods 0.000 description 1
230000005855 radiation Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
108020004418 ribosomal RNA Proteins 0.000 description 1
238000007363 ring formation reaction Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
229940016590 sarkosyl Drugs 0.000 description 1
108700004121 sarkosyl Proteins 0.000 description 1
KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
229960000553 somatostatin Drugs 0.000 description 1
239000004455 soybean meal Substances 0.000 description 1
241000894007 species Species 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000008399 tap water Substances 0.000 description 1
235000020679 tap water Nutrition 0.000 description 1
229940104230 thymidine Drugs 0.000 description 1
230000009466 transformation Effects 0.000 description 1
239000002699 waste material Substances 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
- C12R2001/54—Streptomyces fradiae

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Tropical Medicine & Parasitology (AREA)
Virology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)

NL8001380A 1979-03-29 1980-03-07 Plasmide dna en werkwijze voor het verkrijgen daarvan. NL8001380A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2488979A	1979-03-29	1979-03-29
US2488979		1979-03-29

Publications (1)

Publication Number	Publication Date
NL8001380A true NL8001380A (nl)	1980-10-01

Family

ID=21822891

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8001380A NL8001380A (nl)	1979-03-29	1980-03-07	Plasmide dna en werkwijze voor het verkrijgen daarvan.

Country Status (6)

Country	Link
JP (1)	JPS55133398A (de)
DE (1)	DE3008646A1 (de)
FR (1)	FR2452518A1 (de)
GB (1)	GB2045251B (de)
IT (1)	IT1130967B (de)
NL (1)	NL8001380A (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4703009A (en) *	1983-03-08	1987-10-27	Merck & Co., Inc.	RDNA cloning vector pVE1, deletion and hybrid mutants and recombinant derivatives thereof products and processes
US5272254A (en) *	1984-10-02	1993-12-21	Biogen Inc.	Production of streptavidin-like polypeptides

1980
- 1980-03-03 GB GB8007078A patent/GB2045251B/en not_active Expired
- 1980-03-06 DE DE19803008646 patent/DE3008646A1/de not_active Withdrawn
- 1980-03-07 NL NL8001380A patent/NL8001380A/nl not_active Application Discontinuation
- 1980-03-14 IT IT20657/80A patent/IT1130967B/it active
- 1980-03-21 JP JP3484680A patent/JPS55133398A/ja active Pending
- 1980-03-28 FR FR8006947A patent/FR2452518A1/fr active Granted

Also Published As

Publication number	Publication date
JPS55133398A (en)	1980-10-17
IT1130967B (it)	1986-06-18
IT8020657A0 (it)	1980-03-14
GB2045251B (en)	1982-11-24
GB2045251A (en)	1980-10-29
FR2452518A1 (fr)	1980-10-24
FR2452518B1 (de)	1983-10-21
DE3008646A1 (de)	1980-10-09

Publication	Publication Date	Title
US4273875A (en)	1981-06-16	Plasmid and process of isolating same
US4332900A (en)	1982-06-01	Construction of co-integrate plasmids from plasmids of Streptomyces and Escherichia
US4338400A (en)	1982-07-06	Co-integrate plasmids and their construction from plasmids of Escherichia and Streptomyces
US4340674A (en)	1982-07-20	Cointegrate plasmids and their construction from plasmids of Escherichia and Streptomyces
US4332898A (en)	1982-06-01	Hybrid plasmid and process of making same
Van Elsas et al.	1986	Occurrence of antibiotic resistance among bacilli in Brazilian soils and the possible involvement of resistance plasmids
EP0213898B1 (de)	1991-06-19	Wirt-Vektor-System
HU197354B (en)	1989-03-28	Process for selecting streptomyces containing recombinant dna
NL8001240A (nl)	1980-10-01	Plasmide dna en werkwijze voor het verkrijgen daarvan.
US4362816A (en)	1982-12-07	Hybrid plasmid and process of making same
NL8001380A (nl)	1980-10-01	Plasmide dna en werkwijze voor het verkrijgen daarvan.
Gusek et al.	1992	Review of the Streptomyces lividans/Vector plJ702 System for Gene Cloning
NL8001379A (nl)	1980-10-01	Plasmide dna en werkwijze voor het verkrijgen daarvan.
NL8001676A (nl)	1980-10-13	Plasmide dna en werkwijze voor het verkrijgen daarvan.
EP0035914A2 (de)	1981-09-16	Plasmid-Vektoren, Plasmide und deren Herstellung sowie Klonierungsverfahren unter Verwendung derselben
NL8001381A (nl)	1980-10-01	Plasmide dna en werkwijze voor het verkrijgen daarvan.
EP0038156A2 (de)	1981-10-21	Ein Plasmid und seine mikrobiologische Herstellung
US4401761A (en)	1983-08-30	Process for stabilizing plasmids by deletion of DNA
MacNeil	1986	A flexible boiling procedure for isolating plasmid DNA from gram-positive microorganisms
US4518698A (en)	1985-05-21	Plasmid and production thereof
US4686184A (en)	1987-08-11	Gene transfer vector
WO2013083566A1 (en)	2013-06-13	New actinomycete integrative and conjugative element from actinoplanes sp. se50/110 as plasmid for genetic transformation of related actinobacteria
EP0251510A1 (de)	1988-01-07	Tylosinresistenzgen, genannt tlrB, zur Verwendung in Streptomyceten und in anderen Organismen
NL8100853A (nl)	1982-06-16	Plasmide dna en werkwijze voor het verkrijgen daarvan.
Sankarasubramanian et al.	2001	Development of genetic markers in cyanobacteria and stability of genetically marked strains in soil

Legal Events

Date	Code	Title	Description
1985-01-01	A85	Still pending on 85-01-01
1985-11-01	BV	The patent application has lapsed