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MXPA03006363A - Derivados de urea como antagonistas de integrinas alfa-4. - Google Patents

Derivados de urea como antagonistas de integrinas alfa-4.

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Publication number
MXPA03006363A
MXPA03006363A MXPA03006363A MXPA03006363A MXPA03006363A MX PA03006363 A MXPA03006363 A MX PA03006363A MX PA03006363 A MXPA03006363 A MX PA03006363A MX PA03006363 A MXPA03006363 A MX PA03006363A MX PA03006363 A MXPA03006363 A MX PA03006363A
Authority
MX
Mexico
Prior art keywords
antagonists
urea derivatives
integrin alpha
integrin
4bgr
Prior art date
Application number
MXPA03006363A
Other languages
English (en)
Inventor
Miguel Jimenez Mayorga Juan
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of MXPA03006363A publication Critical patent/MXPA03006363A/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
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    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

Se describen nuevos antagonistas de integrina a4'1 y/o integrina a4' 7 de la Formula general I: en donde R1, R2, R5, L1, L2, Rb, W y Z son como se definen en cualquiera de las reivindicaciones 1 a 13, A representa -CH- o un atomo de nitrogeno, y p es de 0 a 4.
MXPA03006363A 2001-01-19 2002-01-15 Derivados de urea como antagonistas de integrinas alfa-4. MXPA03006363A (es)

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ES200100126A ES2200617B1 (es) 2001-01-19 2001-01-19 Derivados de urea como antagonistas de integrinas alfa 4.
PCT/EP2002/000331 WO2002057242A2 (en) 2001-01-19 2002-01-15 Urea derivatives as integrin alpha 4 antagonists

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WO2002057242A3 (en) 2003-11-27
US20040142982A1 (en) 2004-07-22
US7253171B2 (en) 2007-08-07
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CZ20031964A3 (cs) 2004-01-14
ES2291448T3 (es) 2008-03-01
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ECSP034707A (es) 2003-10-28
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